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An adapted passive model of anti-MPO dependent crescentic glomerulonephritis reveals matrix dysregulation and is amenable to modulation by CXCR4 inhibition.

Matrix Biol 2022 Jan 12. Epub 2022 Jan 12.

Department of Pathology, Medical University of Vienna, Vienna, Austria. Electronic address:

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAV) are severe inflammatory disorders that often involve focal necrotizing glomerulonephritis (FNGN) and consequent glomerular scarring, interstitial fibrosis, and chronic kidney disease. Robust murine models of scarring in FNGN that may help to further our understanding of deleterious processes are still lacking. Here, we present a murine model of severe FNGN based on combined administration of antibodies against the glomerular basement membrane (GBM) and myeloperoxidase (MPO), and bacterial lipopolysaccharides (LPS), that recapitulates acute injury and was adapted to investigate subsequent glomerular and interstitial scarring. Read More

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January 2022

Impacts of COVID-19 on Sustainable Development Goals and effective approaches to maneuver them in the post-pandemic environment.

Environ Sci Pollut Res Int 2022 Jan 15. Epub 2022 Jan 15.

The Institute of the Middle and Far East, Jagiellonian University, Oleandry 2a, 30-063, Kraków, Poland.

In the pursuit of constructing a sustainable world for all through the instrumental seventeen Sustainable Development Goals, the COVID-19 pandemic emerged and affected the efforts concentrated on these goals. Therefore, there is a pressing need to analyze the extent of the impact that unfolded from the pandemic on each Sustainable Development Goal and further to direct the post-pandemic situation to accelerate the progress in every goal. Besides, there exists a knowledge gap in understanding the Sustainable Development Goals and its interaction with each goal through synergic and trade-off effects. Read More

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January 2022

[Nutritional status of preschool children of Moscow megalopolis at the beginning of the 21st century (somatometric aspects)].

Vopr Pitan 2021 26;90(6):67-76. Epub 2021 Oct 26.

D. Anuchin Institute and Museum of Anthropology, Lomonosov Moscow State University, 125009, Moscow, Russian Federation.

Obesity is one of the most important and actual problems of public health, of healthcare, which dramatically expanded through the latest four decades. of the study was the analysis of physical conditions of Moscow preschoolers at the beginning of 21th century as the indicator of nutritional status in «obesogenic» environment of megalopolis. . Read More

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October 2021

An exploration of error-driven learning in simple two-layer networks from a discriminative learning perspective.

Behav Res Methods 2022 Jan 14. Epub 2022 Jan 14.

Department of Artificial Intelligence, University of Groningen, Groningen, The Netherlands.

Error-driven learning algorithms, which iteratively adjust expectations based on prediction error, are the basis for a vast array of computational models in the brain and cognitive sciences that often differ widely in their precise form and application: they range from simple models in psychology and cybernetics to current complex deep learning models dominating discussions in machine learning and artificial intelligence. However, despite the ubiquity of this mechanism, detailed analyses of its basic workings uninfluenced by existing theories or specific research goals are rare in the literature. To address this, we present an exposition of error-driven learning - focusing on its simplest form for clarity - and relate this to the historical development of error-driven learning models in the cognitive sciences. Read More

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January 2022

Critical changes in hypothalamic gene networks in response to pancreatic cancer as found by single-cell RNA sequencing.

Mol Metab 2022 Jan 11:101441. Epub 2022 Jan 11.

Papé Family Pediatric Research Institute, Oregon Health & Science University, Portland, United States; Knight Cancer Institute, Oregon Health & Science University, Portland, United States; Brenden-Colson Center for Pancreatic Care, Oregon Health and & Science University Portland, Portland, United States. Electronic address:

Objective: Cancer cachexia is a devastating chronic condition characterized by involuntary weight loss, muscle wasting, abnormal fat metabolism, anorexia, and fatigue. However, the molecular mechanisms underlying this syndrome remain poorly understood. In particular, the hypothalamus may play a central role in cachexia, given that it has direct access to peripheral signals due to its anatomical location and attenuated blood-brain barrier. Read More

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January 2022

Fuchs Endothelial Corneal Dystrophy associated risk variant, rs3768617 in LAMC1 shows allele specific binding of GFI1B.

Gene 2022 Jan 11:146179. Epub 2022 Jan 11.

School of Biological Sciences, National Institute of Science Education and Research (NISER) Bhubaneswar, Homi Bhabha National Institute (HBNI), P.O. Bhimpur-Padanpur, Jatni, Khurda, Odisha, 752050, India. Electronic address:

Aims: To investigate the genetic and functional association of an intronic variant of LAMC1, rs3768617 with Fuchs endothelial corneal dystrophy (FECD) in the Indian population.

Methods: Blood samples were collected from age and sex matched 356 controls and 120 FECD patients after a detailed assessment via specular microscopy. Genomic DNA was extracted and genotyping was done by fluorescence based capillary electrophoresis. Read More

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January 2022

Implications of Cardiovascular Disease for Assessment and Treatment of Nocturia in Primary Care: Systematic Review and Nominal Group Technique Consensus.

Eur Urol Focus 2022 Jan 11. Epub 2022 Jan 11.

Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.

Context: Heart conditions affect salt and water homeostasis as a consequence of the underlying condition, compensatory processes, and therapy, and can result in nocturnal polyuria. These processes need to be identified as part of a full evaluation of nocturia.

Objective: To conduct a systematic review of nocturia in cardiovascular disease and achieve expert consensus for primary care management. Read More

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January 2022

Comparing Modeling Approaches for Discrete Event Simulations With Competing Risks Based on Censored Individual Patient Data: A Simulation Study and Illustration in Colorectal Cancer.

Value Health 2022 Jan 8;25(1):104-115. Epub 2021 Sep 8.

Department of Health Technology and Services Research, Faculty of Behavioural, Management, and Social Sciences, Technical Medical Centre, University of Twente, Enschede, The Netherlands.

Objectives: This study aimed to provide detailed guidance on modeling approaches for implementing competing events in discrete event simulations based on censored individual patient data (IPD).

Methods: The event-specific distributions (ESDs) approach sampled times from event-specific time-to-event distributions and simulated the first event to occur. The unimodal distribution and regression approach sampled a time from a combined unimodal time-to-event distribution, representing all events, and used a (multinomial) logistic regression model to select the event to be simulated. Read More

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January 2022

Veteran families with complex needs: a qualitative study of the veterans' support system.

BMC Health Serv Res 2022 Jan 15;22(1):74. Epub 2022 Jan 15.

Gallipoli Medical Research Foundation, Greenslopes Private Hospital, Brisbane, Australia.

Background: Families with complex needs face significant challenges accessing and navigating health and social services. For veteran families, these challenges are exacerbated by interactions between military and civilian systems of care, and the density of the veterans' non-profit sector. This qualitative study was designed to gather rich, detailed information on complex needs in veteran families; and explore service providers' and families' experiences of accessing and navigating the veterans' support system. Read More

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January 2022

Do pharmacy practice standards effectively describe behaviour? Reviewing practice standards using a behavioural specificity framework.

BMC Health Serv Res 2022 Jan 14;22(1):71. Epub 2022 Jan 14.

Centre for Behaviour Change, Department of Clinical, Educational and Health Psychology, University College London, London, UK.

Background: Guidelines and practice standards exist to communicate the conduct and behaviour expected of health care professionals and ensure consistent quality practice. It is important that they describe behaviours explicitly so they can be interpreted, enacted and measured with ease. The AACTT framework specifies behaviour in terms of the: Action to be performed, Actor who performs the action, Context where the action occurs, Target who the action is performed with/for and Time when the action is performed (AACTT). Read More

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January 2022

The association between chronic deciduitis and preeclampsia.

J Reprod Immunol 2022 Jan 7;150:103474. Epub 2022 Jan 7.

Department of Obstetrics and Gynecology, Shiga University of Medical Science, Seta Tsukinowa-cho, Otsu, Shiga 520-2192, Japan. Electronic address:

Chronic deciduitis (CD) is slight inflammation of the decidua found during pregnancy. The cause of preeclampsia is thought to be placental hypoplasia, and various theories have been proposed to explain the detailed mechanism; however, its association with decidual inflammation is unclear. A retrospective case control study was conducted in a single university. Read More

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January 2022

Youtube for information on pediatric oral health instructions.

Int J Dent Hyg 2022 Jan 14. Epub 2022 Jan 14.

University of Health Sciences, Gülhane Faculty of Dental Medicine, Department of Orthodontics, Ankara, Turkey.

Introduction: Parents and caregivers of pediatric patients usually tend to search for health information on social networks and other online platforms. At this point, the quality and reliability of these sources play an essential part in maintaining the oral health of pediatric patients.

Aim: The recent study aimed to analyze the reliability, quality, and content of YouTube videos on pediatric oral health instructions, assess the efficacy of these videos, and help health providers lead the parents accessing accurate information on the subject mentioned. Read More

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January 2022

Insights into cell wall disintegration of Chlorella vulgaris.

PLoS One 2022 14;17(1):e0262500. Epub 2022 Jan 14.

Institute for Bio- and Geosciences, Plantsciences-IBG-2, Forschungszentrum Jülich GmbH, Jülich, Germany.

With their ability of CO2 fixation using sunlight as an energy source, algae and especially microalgae are moving into the focus for the production of proteins and other valuable compounds. However, the valorization of algal biomass depends on the effective disruption of the recalcitrant microalgal cell wall. Especially cell walls of Chlorella species proved to be very robust. Read More

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January 2022

Why did hunting weapon design change at Abri Pataud? Lithic use-wear data on armature use and hafting around 24,000-22,000 BP.

PLoS One 2022 14;17(1):e0262185. Epub 2022 Jan 14.

TraceoLab / Prehistory, University of Liège, Liège, Belgium.

Projectile technology is commonly viewed as a significant contributor to past human subsistence and, consequently, to our evolution. Due to the allegedly central role of projectile weapons in the food-getting strategies of Upper Palaeolithic people, typo-technological changes in the European lithic record have often been linked to supposed developments in hunting weaponry. Yet, relatively little reliable functional data is currently available that would aid the detailed reconstruction of past weapon designs. Read More

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January 2022

Development of a sample preparation procedure for Sr isotope analysis of Portland cements.

Anal Bioanal Chem 2022 Jan 14. Epub 2022 Jan 14.

Division 7.4 Technology of Construction Materials, Federal Institute for Materials Research and Testing, Unter den Eichen 87, 12205, Berlin, Germany.

The Sr/Sr isotope ratio can, in principle, be used for provenancing of cement. However, while commercial cements consist of multiple components, no detailed investigation into their individual Sr/Sr isotope ratios or their influence on the integral Sr/Sr isotope ratio of the resulting cement was conducted previously. Therefore, the present study aimed at determining and comparing the conventional Sr/Sr isotope ratios of a diverse set of Portland cements and their corresponding Portland clinkers, the major component of these cements. Read More

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January 2022

Role of Advective Inertia in Active Nematic Turbulence.

Phys Rev Lett 2021 Dec;127(26):268005

Max Planck Institute for Dynamics and Self-Organization, Am Faßberg 17, 37077 Göttingen, Germany and Faculty of Physics, Georg-August-Universität Göttingen, Friedrich-Hund-Platz 1, 37077 Göttingen, Germany.

Suspensions of active agents with nematic interactions exhibit complex spatiotemporal dynamics such as mesoscale turbulence. Since the Reynolds number of microscopic flows is very small on the scale of individual agents, inertial effects are typically excluded in continuum theories of active nematic turbulence. Whether active stresses can collectively excite inertial flows is currently unclear. Read More

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December 2021

Unveiling the Genesis and Effectiveness of Negative Fading in Nanostructured Iron Oxide Anode Materials for Lithium-Ion Batteries.

ACS Nano 2022 Jan 14. Epub 2022 Jan 14.

Department of Chemistry, Sungkyunkwan University, Suwon, 16419, Republic of Korea.

Iron oxide anode materials for rechargeable lithium-ion batteries have garnered extensive attention because of their inexpensiveness, safety, and high theoretical capacity. Nanostructured iron oxide anodes often undergo negative fading, that is, unconventional capacity increase, which results in a capacity increasing upon cycling. However, the detailed mechanism of negative fading still remains unclear, and there is no consensus on the provenance. Read More

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January 2022

Characteristics and accurate identification of Pantoea dispersa with a case of spontaneous rupture of hepatocellular carcinoma in China: A case report.

Medicine (Baltimore) 2022 Jan;101(2):e28541

Clinical Laboratory Center, Jiangsu Taizhou People's Hospital, Taizhou, Jiangsu, PR China.

Introduction: Pantoea dispersa belongs to the genus Pantoea, which is isolated from Enterobacteriaceae. It has been reported to cause some kinds of infections, but there are few detailed studies on it, especially its characteristics and identification methods, which has caused a lot of trouble in clinical work.

Patient Concerns: A 51-year-old Chinese man was admitted to our hospital with a 7-hour history of progressive abdominal pain. Read More

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January 2022

Colonoscopy related adverse events in patients with abnormal stool-based tests - A systematic review of literature and meta-analysis of outcomes.

Am J Gastroenterol 2021 Dec 29. Epub 2021 Dec 29.

Division of Gastroenterology, University of Minnesota & Minneapolis VA Health Care System, Minneapolis, Minnesota, USA.

Introduction: Colorectal cancer (CRC) screening programs based on the fecal immunochemical test (FIT) and guaiac-based fecal occult blood (gFOBT) are associated with a substantial reduction in CRC incidence and mortality. We conducted a systematic review and comprehensive meta-analysis to evaluate colonoscopy related adverse events in individuals with a positive FIT or gFOBT.

Methods: A systematic and detailed search was run in January 2021 with the assistance of a medical librarian for studies reporting on colonoscopy related adverse events as part of organized colorectal cancer screening programs. Read More

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December 2021

Correlation of Serum Selenium in Asthma Patients with Severity of the Disorder.

Biol Trace Elem Res 2022 Jan 13. Epub 2022 Jan 13.

School of Energy and Environment, Department of Biotechnology, Thapar Institute of Engineering and Technology, Patiala, India.

Asthma is characterized by reversible airway obstruction, increased bronchial hyper-responsiveness and chronic inflammation, as well as higher levels of oxidative stress mainly due to decreased antioxidant defenses. Our primary aim was to investigate the correlation of serum selenium (Se) levels with the severity of asthma across gender, age, family history, and prevalence from childhood. Selenium levels in blood samples in 103 asthmatic patients and 103 healthy individuals were evaluated. Read More

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January 2022

Diagnosing COVID-19 in human serum using Raman spectroscopy.

Lasers Med Sci 2022 Jan 14. Epub 2022 Jan 14.

Universidade Anhembi Morumbi - UAM, Rua Casa Do Ator, 275, São Paulo, SP, 04546-001, Brazil.

This study proposed the diagnosis of COVID-19 by means of Raman spectroscopy. Samples of blood serum from 10 patients positive and 10 patients negative for COVID-19 by RT-PCR RNA and ELISA tests were analyzed. Raman spectra were obtained with a dispersive Raman spectrometer (830 nm, 350 mW) in triplicate, being submitted to exploratory analysis with principal component analysis (PCA) to identify the spectral differences and discriminant analysis with PCA (PCA-DA) and partial least squares (PLS-DA) for classification of the blood serum spectra into Control and COVID-19. Read More

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January 2022

Longitudinal metabolomics profiling of serum amino acids in rotenone-induced Parkinson's mouse model.

Amino Acids 2022 Jan 14. Epub 2022 Jan 14.

First Affiliated Hospital of Harbin Medical University, Harbin, China.

Recently, the detailed etiology and pathogenesis of Parkinson's disease (PD) have not been fully clarified yet. Increasing evidences suggested that the disturbance of peripheral branched-chain amino acids (BCAAs) metabolism can promote the occurrence and progression of neurodegenerative diseases through neuroinflammatory signaling. Although there are several studies on the metabolomics of PD, longitudinal study of metabolic pathways is still lacking. Read More

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January 2022

Rewards of divergence in sequences, 3-D structures and dynamics of yeast and human spliceosome SF3b complexes.

Curr Res Struct Biol 2021 15;3:133-145. Epub 2021 Jun 15.

Molecular Biophysics Unit, Indian Institute of Science, Bangalore, Karnataka, 560012, India.

The evolution of homologous and functionally equivalent multiprotein assemblies is intriguing considering sequence divergence of constituent proteins. Here, we studied the implications of protein sequence divergence on the structure, dynamics and function of homologous yeast and human SF3b spliceosomal subcomplexes. Human and yeast SF3b comprise of 7 and 6 proteins respectively, with all yeast proteins homologous to their human counterparts at moderate sequence identity. Read More

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Fungal glycoside hydrolase family 44 xyloglucanases are restricted to the phylum Basidiomycota and show a distinct xyloglucan cleavage pattern.

iScience 2022 Jan 21;25(1):103666. Epub 2021 Dec 21.

Department of Microbiology, University of Helsinki, Viikinkaari 9, 00790 Helsinki, Finland.

Xyloglucan is a prominent matrix heteropolysaccharide binding to cellulose microfibrils in primary plant cell walls. Hence, the hydrolysis of xyloglucan facilitates the overall lignocellulosic biomass degradation. Xyloglucanases (XEGs) are key enzymes classified in several glycoside hydrolase (GH) families. Read More

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January 2022

Electrocatalytic reduction of protons to dihydrogen by the cobalt tetraazamacrocyclic complex [Co(NH)Cl]: mechanism and benchmarking of performances.

Sustain Energy Fuels 2021 Dec 22;6(1):143-149. Epub 2021 Nov 22.

Univ. Grenoble Alpes, CNRS, CEA, IRIG, Laboratoire de Chimie et Biologie des Métaux 17 Rue des Martyrs F-38054 Grenoble, Cedex France

The cobalt tetraazamacrocyclic [Co(NH)Cl] complex is becoming a popular and versatile catalyst for the electrocatalytic evolution of hydrogen, because of its stability and superior activity in aqueous conditions. We present here a benchmarking of its performances based on the thorough analysis of cyclic voltammograms recorded under various catalytic regimes in non-aqueous conditions allowing control of the proton concentration. This allowed a detailed mechanism to be proposed with quantitative determination of the rate-constants for the various protonation steps, as well as identification of the amine function of the tetraazamacrocyclic ligand to act as a proton relay during H evolution. Read More

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December 2021

Bone-related polymorphisms and dental status in older men and women. Results of the longitudinal Pro.V.A. study.

J Dent Sci 2022 Jan 5;17(1):528-534. Epub 2021 Aug 5.

Department of Medicine DIMED, University of Padova, Padova, Italy.

Background/purpose: Genetics plays a role in the susceptibility to periodontitis and tooth loss. Several studies examined the involvement of polymorphisms in candidate genes. We hypothesize that bone metabolism-related polymorphisms could be associated with the number of remaining teeth. Read More

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January 2022

A Single-Cell Transcriptome Profiling of Anterior Kidney Leukocytes From Nile Tilapia ().

Front Immunol 2021 28;12:783196. Epub 2021 Dec 28.

Guangdong Provincial Key Laboratory for Healthy and Safe Aquaculture, Institute of Modern Aquaculture Science and Engineering, School of Life Sciences, South China Normal University, Guangzhou, China.

Teleost fish anterior kidney (AK) is an important hematopoietic organ with multifarious immune cells, which have immune functions comparable to mammalian bone marrow. Myeloid and lymphoid cells locate in the AK, but the lack of useful specific gene markers and antibody-based reagents for the cell subsets makes the identification of the different cell types difficult. Single-cell transcriptome sequencing enables single-cell capture and individual library construction, making the study on the immune cell heterogeneity of teleost fish AK possible. Read More

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December 2021

SynCoPa: Visualizing Connectivity Paths and Synapses Over Detailed Morphologies.

Front Neuroinform 2021 27;15:753997. Epub 2021 Dec 27.

Ciencias de la Computación, Arquitectura de Computado, Lenguajes y Sistemas Informáticos y Estadística e Investigación Operativa, Esc. Tec. Sup. de Ingeniería Informática, Rey Juan Carlos University, Madrid, Spain.

Brain complexity has traditionally fomented the division of neuroscience into somehow separated compartments; the coexistence of the anatomical, physiological, and connectomics points of view is just a paradigmatic example of this situation. However, there are times when it is important to combine some of these standpoints for getting a global picture, like for fully analyzing the morphological and topological features of a specific neuronal circuit. Within this framework, this article presents SynCoPa, a tool designed for bridging gaps among representations by providing techniques that allow combining detailed morphological neuron representations with the visualization of neuron interconnections at the synapse level. Read More

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December 2021

Morphological investigation of genital organs and first insights into the phylogeny of the genus Vest, 1867 as a basis for a taxonomic revision (Mollusca, Gastropoda, Clausiliidae).

Zookeys 2021 14;1077:1-175. Epub 2021 Dec 14.

Central Research Laboratories, of Natural History Museum Vienna, Burgring 7, 1010 Vienna, Austria Central Research Laboratories, of Natural History Museum Vienna Vienna Austria.

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December 2021

Revealing lost secrets about Yingpan Man and the Silk Road.

Sci Rep 2022 Jan 13;12(1):669. Epub 2022 Jan 13.

Institute of Archaeological Science, Fudan University, Shanghai, 200433, People's Republic of China.

Yingpan Man, is one of the most exquisitely preserved mummies found in the Xinjiang Uyghur Autonomous Region of China. Here links between Yingpan Man and the Silk Road are explored through a detailed isotopic and bioarchaeological investigation of his life history. Analytical techniques of carbon, nitrogen, and sulfur stable isotope ratio analysis on hair, teeth, muscle and bones as well as associated animal and plant remains, radiocarbon dating and starch grain analysis of dental calculus are presented to visualize never before seen aspects of Yingpan Man's life, including: environment, breastfeeding and weaning practices, adolescent and adult diet, disease and nutritional status as well as season of death. Read More

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January 2022