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Clinical-radiological characteristics and intestinal microbiota in patients with pancreatic immune-related adverse events.

Thorac Cancer 2021 May 4. Epub 2021 May 4.

Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, China.

Background: The pancreatic immune-related adverse event (irAE) is a rare but increasingly occurrence disease with limited knowledge, which was associated with the use of immune checkpoint inhibitors (ICIs).

Methods: In this case series study of pancreatic irAE patients, clinical and radiological manifestations are summarized. Baseline and post-treatment fecal microbiota of immune-related acute pancreatitis (irAP) patients were analyzed by the 16 s rDNA amplicon sequencing method. Read More

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Identifying the Range of Micro-Events Preceding the Critical Point in the Destruction Process in Traditional and Quasi-Brittle Cement Composites with the Use of a Sound Spectrum.

Materials (Basel) 2021 Apr 6;14(7). Epub 2021 Apr 6.

Faculty of Civil Engineering, Brno University of Technology, Veveří 331/95, 602 00 Brno, Czech Republic.

This paper presents the possibilities of determining the range of stresses preceding the critical destruction process in cement composites with the use of micro-events identified by means of a sound spectrum. The presented test results refer to the earlier papers in which micro-events (destruction processes) were identified but without determining the stress level of their occurrence. This paper indicates a correlation of 2/3 of the stress level corresponding to the elastic range with the occurrence of micro-events in traditional and quasi-brittle composites. Read More

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Effects of denosumab in Japanese rheumatoid arthritis patients treated with conventional anti-rheumatic drugs: 36-month extension of a phase 3 study.

J Rheumatol 2021 Apr 15. Epub 2021 Apr 15.

First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan; Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan; Department of Orthopedics and Rheumatology, Kindai University Nara Hospital, Ikoma, Japan; Director of Rheumatology, Sanno Medical Center, Tokyo, Japan; Department of Biochemistry, Osaka University Graduate School of Dentistry, Osaka, Japan; Orthopedic Surgery and Spinal Surgery, The University of Tokyo, Tokyo, Japan; Daiichi Sankyo Co., Ltd, Japan; Departments of Radiology, Medicine and Orthopedic Surgery, University of California, California, USA; Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands. This study was funded by Daiichi Sankyo Co., Ltd. Address correspondence to Yoshiya Tanaka First Department of Internal Medicine, University of Occupational and Environmental Health, Japan, Kitakyushu, Japan. E-mail:

Objective: To evaluate safety and efficacy of long-term denosumab 60 mg every 6 (Q6M) or 3 months (Q3M) in rheumatoid arthritis (RA) patients.

Methods: This 12-month, randomised, double-blind, placebo-controlled, multicentre phase 3 trial with an open-label extension period from 12 to 36 months (DESIRABLE) enrolled Japanese RA patients treated with placebo for 12 months then denosumab Q6M (P/Q6M) or denosumab Q3M (P/Q3M); denosumab Q6M for 36 months (Q6M/Q6M); or denosumab Q3M for 36 months (Q3M/Q3M). Efficacy was assessed by van der Heijde modified total Sharp (mTSS), bone erosion (ES), and joint space narrowing (JSN) scores. Read More

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20 Years of Radiographic Imaging: Crystalline Deposits Causing Severe Arthropathy and Erosions.

Mil Med 2021 Apr 7. Epub 2021 Apr 7.

Department of Rheumatology, Tripler Army Medical Center, Honolulu, HI 96859, USA.

Urate crystal gout arthritis and calcium pyrophosphate deposition disease (CPPD) are crystalline arthropathies seen in middle age to elderly patients, but are also seen in the active duty military population. Flares of either can be identified by acute joint pain, associated swelling, tenderness, and warmth. Definitive diagnosis involves synovial analysis from arthrocentesis. Read More

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Synthetic Analogs of Capsular Polysaccharides and Immunogenic Activities of Glycoconjugates.

Russ J Bioorg Chem 2021 20;47(1):1-25. Epub 2021 Mar 20.

Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russia.

is a Gram-positive bacterium (pneumococcus) that causes severe diseases in adults and children. It was established that some capsular polysaccharides of the clinically significant serotypes of in the composition of commercial pneumococcal polysaccharide or conjugate vaccines exhibit low immunogenicity. The review considers production methods and structural features of the synthetic oligosaccharides from the problematic pneumococcal serotypes that are characterized with low immunogenicity due to destruction or detrimental modification occurring in the process of their preparation and purification. Read More

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[Bushentongluo recipe (BSTL) attenuates bone destruction by inhibiting NF-κB/RANK/RANKL pathway in collagen-induced arthritis (CIA) rats].

Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 2021 Mar;37(3):205-211

Department of Rheumatology and Bone Disease, Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China.

Objective To investigate the therapeutic effect of Bushentongluo recipe (BSTL) on bone destruction and its inhibiting effect on NF-κB/RANK/RANKL pathway in collagen-induced arthritis (CIA) rats. Methods SD rats were randomly divided into blank control group, CIA model group, methotrexate (MTX, 1 mg/kg) group, BSTL 0.5 g/kg and 2 g/kg groups, with 10 rats in each. Read More

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Large Lytic Defects Produce Kinematic Instability and Loss of Compressive Strength in Human Spines: An in Vitro Study.

J Bone Joint Surg Am 2021 Mar 23. Epub 2021 Mar 23.

Center for Advanced Orthopedic Studies, Department of Orthopedic Surgery (R.N.A. and R.A.), Division of General Medicine (R.B.D.), and Department of Radiology (D.B.H.), Beth Israel Deaconess Medical Center (BIDMC) and Harvard Medical School, Boston, Massachusetts.

Background: In patients with spinal metastases, kinematic instability is postulated to be a predictor of pathologic vertebral fractures. However, the relationship between this kinematic instability and the loss of spinal strength remains unknown.

Methods: Twenty-four 3-level thoracic and lumbar segments from 8 cadaver spines from female donors aged 47 to 69 years were kinematically assessed in axial compression (180 N) and axial compression with a flexion or extension moment (7. Read More

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BMP5 silencing inhibits chondrocyte senescence and apoptosis as well as osteoarthritis progression in mice.

Aging (Albany NY) 2021 Mar 19;13(7):9646-9664. Epub 2021 Mar 19.

Department of Orthopedics, Orthopedic Hospital of Guangdong Province, Academy of Orthopedics Guangdong Province, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.

In this study, we using the destabilization of the medial meniscus (DMM) mouse model to investigate the role of bone morphogenetic protein 5 (BMP5) in osteoarthritis (OA) progression mediated via chondrocyte senescence and apoptosis. BMP5 expression was significantly higher in knee articular cartilage tissues of OA patients and DMM model mice than the corresponding controls. The Osteoarthritis Research Society International scores based on histological staining of knee articular cartilage sections were lower in DMM mice where BMP5 was knocked down in chondrocytes than the corresponding controls 4 weeks after DMM surgery. Read More

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Increased xerotolerance of Saccharomyces cerevisiae during an osmotic pressure ramp over several generations.

Microb Biotechnol 2021 Mar 19. Epub 2021 Mar 19.

Univ. Bourgogne Franche-Comté, AgroSup Dijon, PAM UMR A 02.102, Dijon, F-21000, France.

Although mechanisms involved in response of Saccharomyces cerevisiae to osmotic challenge are well described for low and sudden stresses, little is known about how cells respond to a gradual increase of the osmotic pressure (reduced water activity; a ) over several generations as it could encounter during drying in nature or in food processes. Using glycerol as a stressor, we propagated S. cerevisiae through a ramp of the osmotic pressure (up to high molar concentrations to achieve testing-to-destruction) at the rate of 1. Read More

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Ratchet universality in the bidirectional escape from a symmetric potential well.

Phys Rev E 2021 Feb;103(2-1):022203

Departamento de Ingeniería Eléctrica, Electrónica y Automática, Escuela de Ingenieros Industriales, Universidad de Castilla-La Mancha, E-02071 Albacete, Spain.

The present work discusses symmetry-breaking-induced bidirectional escape from a symmetric metastable potential well by the application of zero-average periodic forces in the presence of dissipation. We characterized the interplay between heteroclinic instabilities leading to chaotic escape and breaking of a generalized parity symmetry leading to directed ratchet escape to an attractor either at ∞ or at -∞. Optimal enhancement of directed ratchet escape is found to occur when the wave form of the zero-average periodic force acting on the damped driven oscillator matches as closely as possible to a universal wave form, as predicted by the theory of ratchet universality. Read More

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February 2021

[Research progress of pyroptosis in acute respiratory distress syndrome].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Feb;33(2):249-251

Department of Critical Care Medicine, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010000, Inner Mongolia Autonomous Region, China. Corresponding author: Zhang Lipeng, Email:

The main pathophysiological changes of acute respiratory distress syndrome (ARDS) are massive destruction of pulmonary vascular endothelial barrier, pulmonary edema, infiltration of inflammatory cells, and refractory hypoxemia in severe cases. Pyroptosis is programmed cell necrosis, triggered by caspase and mediated by proteins in a member of conserved protein family Gasdermin D (GSDMD), which manifests as continuous cell expansion until cell membrane rupture, leading to release of cell contents and activation of a strong inflammatory response. Pyroptosis plays a key role in the development of septic ARDS. Read More

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February 2021

Analyzing Longitudinal wb-MRI Data and Clinical Course in a Cohort of Former Smoldering Multiple Myeloma Patients: Connections between MRI Findings and Clinical Progression Patterns.

Cancers (Basel) 2021 Feb 25;13(5). Epub 2021 Feb 25.

Diagnostic and Interventional Radiology, University Hospital Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany.

The purpose of this study was to analyze size and growth dynamics of focal lesions (FL) as well as to quantify diffuse infiltration (DI) in untreated smoldering multiple myeloma (SMM) patients and correlate those MRI features with timepoint and cause of progression. We investigated 199 whole-body magnetic resonance imaging (wb-MRI) scans originating from longitudinal imaging of 60 SMM patients and 39 computed tomography (CT) scans for corresponding osteolytic lesions (OL) in 17 patients. All FLs >5 mm were manually segmented to quantify volume and growth dynamics, and DI was scored, rating four compartments separately in T1- and fat-saturated T2-weighted images. Read More

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February 2021

Surgical Treatment and Proposed Modified Classification for Harrington Class III Periacetabular Metastases.

Orthop Surg 2021 Apr 4;13(2):553-562. Epub 2021 Mar 4.

Musculoskeletal Tumor Center, Beijing Key Laboratory of Musculoskeletal Tumor, Peking University People's Hospital, Beijing, China.

Objectives: This study aims to: (i) evaluate the outcome of patients with Harrington class III lesions who were treated according to Harrington classification; (ii) propose a modified surgical classification for Harrington class III lesions; and (iii) assess the efficiency of the proposed modified classification.

Methods: This study composes two phases. During phase 1 (2006 to 2011), the clinical data of 16 patients with Harrington class III lesions who were treated by intralesional excision followed by reconstruction of antegrade/retrograde Steinmann pins/screws with cemented total hip arthroplasty (Harrington/modified Harrington procedure) were retrospectively reviewed and further analyzed synthetically to design a modified surgical classification system. Read More

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Bubbling transition as a mechanism of destruction of synchronous oscillations of identical microbubble contrast agents.

Chaos 2021 Feb;31(2):023130

Department of Applied Mathematics, HSE University, Moscow 123458, Russia.

We study the process of the destruction of synchronous oscillations in a model of two interacting microbubble contrast agents exposed to an external ultrasound field. Completely synchronous oscillations in this model are possible in the case of identical bubbles when the governing system of equations possess a symmetry leading to the existence of a synchronization manifold. Such synchronous oscillations can be destructed without breaking the corresponding symmetry of the governing dynamical system. Read More

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February 2021

Proteolysis targeting chimera technology: a novel strategy for treating diseases of the central nervous system.

Neural Regen Res 2021 Oct;16(10):1944-1949

Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong, Jiangsu Province, China.

Neurological diseases such as stroke, Alzheimer's disease, Parkinson's disease, and Huntington's disease are among the intractable diseases for which appropriate drugs and treatments are lacking. Proteolysis targeting chimera (PROTAC) technology is a novel strategy to solve this problem. PROTAC technology uses the ubiquitin-protease system to eliminate mutated, denatured, and harmful proteins in cells. Read More

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October 2021

Behavioral disorders caused by nonylphenol and strategies for protection.

Chemosphere 2021 Feb 15;275:129973. Epub 2021 Feb 15.

State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, China; National Engineering Research Center for Functional Food, Jiangnan University, Wuxi, Jiangsu, 214122, China; (Yangzhou) Institute of Food Biotechnology, Jiangnan University, Yangzhou, 225004, China; Beijing Innovation Centre of Food Nutrition and Human Health, Beijing Technology & Business University, Beijing, 100048, China.

Nonylphenol (NP) is widely used in daily production and life due to its good emulsification. In this review, we discuss toxicology studies that examined behavioral disorders caused by NP, the corresponding toxicological mechanisms in the central nervous system (CNS), and strategies for protection. Available in vitro and in vivo evidence suggests that exposure to NP during adulthood or early childhood is associated with cognitive dysfunction, including depression-like behaviors, anxiety-like behaviors, and impaired learning and memory. Read More

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February 2021

MicroRNAs target on cartilage extracellular matrix degradation of knee osteoarthritis.

Authors:
S-H Li Q-F Wu

Eur Rev Med Pharmacol Sci 2021 Feb;25(3):1185-1197

Acupuncture and Moxibustion College, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.

Objective: Knee osteoarthritis (KOA) is currently indicated to be characterized by destruction of articular cartilage. The destruction can be described as an imbalance between synthesis and degradation of extracellular matrix (ECM) components. It is accompanied with changes of pro-inflammatory cytokines and degradation enzymes dominated by matrix metalloproteinase (MMP) and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS). Read More

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February 2021

What does climate change have to do with bushfires?

Aust Health Rev 2021 Feb;45(1):4-6

Centre for Air pollution, energy and health Research (CAR), 431 Glebe Point Road, Glebe, NSW 2037, Australia; and Sydney School of Public Health, University of Sydney, Camperdown, NSW 2006, Australia. Email:

A warming climate is increasing the duration of fire seasons and the risk of more extensive and intense bushfires. The Black Summer bushfires that occurred in Australia from September 2019 to early February 2020 were unprecedented in their scale and intensity. The fires led to loss of lives and homes, and widespread destruction of flora, fauna and ecosystems. Read More

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February 2021

A Stem Cell Surge During Thyroid Regeneration.

Front Endocrinol (Lausanne) 2020 21;11:606269. Epub 2021 Jan 21.

Thyroid Research Unit, Department of Medicine, The Icahn School of Medicine at Mount Sinai and the James J. Peters VA Medical Center, New York, NY, United States.

Background: Many tissues, including the thyroid, contain resident (adult) stem cells that are responsible for regeneration and repair after injury. The mechanisms of thyroid regeneration and the role of thyroid stem cells and thyroid progenitor cells in this process are not well understood. We have now used a new mouse thyroid injury model to gain insight into this phenomenon. Read More

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January 2021

Repeated Administration of Clinically Relevant Doses of the Prescription Opioids Tramadol and Tapentadol Causes Lung, Cardiac, and Brain Toxicity in Wistar Rats.

Pharmaceuticals (Basel) 2021 Jan 27;14(2). Epub 2021 Jan 27.

IINFACTS-Institute of Research and Advanced Training in Health Sciences and Technologies, Department of Sciences, University Institute of Health Sciences (IUCS), CESPU, CRL, 4585-116 Gandra, Portugal.

Tramadol and tapentadol, two structurally related synthetic opioid analgesics, are widely prescribed due to the enhanced therapeutic profiles resulting from the synergistic combination between μ-opioid receptor (MOR) activation and monoamine reuptake inhibition. However, the number of adverse reactions has been growing along with their increasing use and misuse. The potential toxicological mechanisms for these drugs are not completely understood, especially for tapentadol, owing to its shorter market history. Read More

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January 2021

IVIg increases interleukin-11 levels, which in turn contribute to increased platelets, VWF and FVIII in mice and humans.

Clin Exp Immunol 2021 May 22;204(2):258-266. Epub 2021 Feb 22.

Department of Internal Medicine and Clinical Immunology, Normandy University, Caen, France.

The mechanisms of action of intravenous immunoglobulins (IVIg) in autoimmune diseases are not fully understood. The fixed duration of efficacy and noncumulative effects of IVIg in immune thrombocytopenia (ITP) and acquired von Willebrand disease (AVWD) suggest other mechanisms besides immunological ones. Additionally to the peripheral destruction of platelets in ITP, their medullary hypoproduction emerged as a new paradigm with rescue of thrombopoietin receptor agonists (TPO-RA). Read More

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Privacy Policy Compliance of Chronic Disease Management Apps in China: Scale Development and Content Evaluation.

JMIR Mhealth Uhealth 2021 01 28;9(1):e23409. Epub 2021 Jan 28.

School of Information Management, Wuhan University, Wuhan, China.

Background: With the development of mobile health (mHealth), chronic disease management apps have brought not only the possibility of reducing the burden of chronic diseases but also huge privacy risks to patients' health data.

Objective: The purpose of the study was to analyze the extent to which chronic disease management apps in China comply with the Personal Information Security Specification (PI Specification).

Methods: The compliance of 45 popular chronic disease management apps was evaluated from the perspective of the information life cycle. Read More

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January 2021

Technology, Privacy, and User Opinions of COVID-19 Mobile Apps for Contact Tracing: Systematic Search and Content Analysis.

J Med Internet Res 2021 02 9;23(2):e23467. Epub 2021 Feb 9.

Department of Computer Science and Software Engineering, College of Information Technology, United Arab Emirates University, Alain, United Arab Emirates.

Background: Many countries across the globe have released their own COVID-19 contact tracing apps. This has resulted in the proliferation of several apps that used a variety of technologies. With the absence of a standardized approach used by the authorities, policy makers, and developers, many of these apps were unique. Read More

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February 2021

Chondroprotective effects of purple corn anthocyanins on advanced glycation end products induction through suppression of NF-κB and MAPK signaling.

Sci Rep 2021 Jan 21;11(1):1895. Epub 2021 Jan 21.

Thailand Excellence Center for Tissue Engineering and Stem Cells, Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.

Formation of advanced glycation end products (AGEs), which are associated with diabetes mellitus, contributes to prominent features of osteoarthritis, i.e., inflammation-mediated destruction of articular cartilage. Read More

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January 2021

Therapeutic effects of pentoxifylline on invasive pulmonary aspergillosis in immunosuppressed mice.

BMC Pulm Med 2021 Jan 19;21(1):31. Epub 2021 Jan 19.

Department of Respiratory Medicine, The Third Affiliated Hospital of Soochow University, 185 Juqian Street, Changzhou, 213003, China.

Background: The most common and severe infection of Aspergillus fumigatus is invasive pulmonary aspergillosis (IPA), which is usually seen in immunocompromised patients. Neutropenia is the primary risk factor implicated in IPA; however, IPA also occurs in patients without neutropenia, namely, those who are immunosuppressed owing to long-term corticosteroid use. With IPA-associated mortality as high as 51-79%, novel and effective treatment strategies are urgently needed. Read More

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January 2021

IL-1β promotes disk degeneration and inflammation through direct injection of intervertebral disk in a rat lumbar disk herniation model.

Spine J 2021 Jan 16. Epub 2021 Jan 16.

Jaseng Spine and Joint Research Institute, Jaseng Medical Foundation, Seoul 135-896, Republic of Korea. Electronic address:

Background Context: Lumbar intervertebral disk herniation (LDH) is a common disease that causes low back pain, radiating leg pain, and sensory impairment. Preclinical studies rely heavily upon standardized animal models of human diseases to predict clinical treatment efficacy and to identify and investigate potential adverse events in human subjects. The current method for making the LDH model involves harvesting the nucleus pulposus (NP) from autologous coccygeal disks and applying to the lumbar nerve roots just proximal to the corresponding dorsal root ganglion. Read More

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January 2021

Risk assessment of resurfacing implant loosening and femur fracture under low-energy impacts taking into account degenerative changes in bone tissues. Computer simulation.

Comput Methods Programs Biomed 2021 Mar 6;200:105929. Epub 2021 Jan 6.

Institute of Strength Physics and Materials Science of SB RAS, 2/4, pr. Akademicheskii, Tomsk, 634055, Russia. Electronic address:

Background And Objective: Degenerative diseases of the musculoskeletal system significantly reduce the quality of human life. Hip resurfacing is used to treat degenerative diseases in the later stages. After surgery, there is a risk of endoprosthesis loosening and low-energy fracture during daily physical activity. Read More

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Ternary cancer comprising prostatic cancer, esophageal cancer, and gastric cardia cancer: a case report and literature review.

Int J Clin Exp Pathol 2020 1;13(12):3181-3186. Epub 2020 Dec 1.

Department of Oncology, The Third Affiliated Hospital of Soochow University 185 Juqian Street, Changzhou, Jiangsu Province, P. R. China.

A 61-year-old male patient was admitted to our hospital with frequent urination, urgency, and increased nocturia for more than 3 months, and the symptoms were aggravated for 1 week. Prostate biopsy revealed prostatic adenocarcinoma. After 5 months, the patient developed dysphagia and gastroscopy showed a middle and lower esophageal cancer (squamous cell carcinoma). Read More

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December 2020

Computer-aided diagnosis based on hand thermal, RGB images, and grip force using artificial intelligence as screening tool for rheumatoid arthritis in women.

Med Biol Eng Comput 2021 Feb 8;59(2):287-300. Epub 2021 Jan 8.

Facultad de Ingeniería, Universidad Autónoma de Guerrero, Chilpancingo, Mexico.

Rheumatoid arthritis (RA) is an autoimmune disorder that typically affects people between 23 and 60 years old causing chronic synovial inflammation, symmetrical polyarthritis, destruction of large and small joints, and chronic disability. Clinical diagnosis of RA is stablished by current ACR-EULAR criteria, and it is crucial for starting conventional therapy in order to minimize damage progression. The 2010 ACR-EULAR criteria include the presence of swollen joints, elevated levels of rheumatoid factor or anti-citrullinated protein antibodies (ACPA), elevated acute phase reactant, and duration of symptoms. Read More

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February 2021

Active matrix metalloproteinase-8 and interleukin-6 detect periodontal degeneration caused by radiotherapy of head and neck cancer: a pilot study.

Expert Rev Proteomics 2020 10 7;17(10):777-784. Epub 2021 Jan 7.

Department of Oral and Maxillofacial Diseases, University of Helsinki, Helsinki University Hospital , Helsinki, Finland.

: This cohort study investigated the role of the active matrix metalloproteinase-8 (aMMP-8) and interleukin-6 (IL-6) as oral fluid biomarkers for monitoring the periodontal degeneration occurring in head and neck cancer (HNC) patients treated by radiotherapy. : Eleven patients, aged 28-74, diagnosed with HNC were included in the study. Complete periodontal and oral examinations were performed pre-radiotherapy and 1 month after radiotherapy. Read More

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October 2020