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Catalytic Clusterbody for Enhanced Quantitative Protein Immunoblot.

Anal Chem 2021 Jul 30. Epub 2021 Jul 30.

Department of Chemistry and Biology, Faculty of Environment and Life Science, Beijing University of Technology, Beijing 100124, China.

To assess low-abundance protein biomarkers associated with tumor progression, we have developed artificial catalytic antibodies based on well-defined metal clusters modified with rationally designed peptides, termed clusterbodies. Such clusterbodies possess favorable integrated features of matched ultrasmall sizes, intrinsic fluorescence, and enzyme-like catalytic and selective recognition properties that are inaccessible to traditional antibodies. Consequently, a quantitative assay with high accuracy and high sensitivity is established by measuring the fluorescence and catalytic chemiluminescence of metal clusters preferentially recognizing the protein biomarker, which is confirmed by the molecular-weight marker references of immunoblotting. Read More

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ADVANCED MACHINE LEARNING APPLICATION FOR ODOR AND CORROSION CONTROL AT A WATER RESOURCE RECOVERY FACILITY.

Water Environ Res 2021 Jul 30. Epub 2021 Jul 30.

School of Information Technology, Illinois State University, Normal, Illinois.

The objective of this study was to develop a machine learning (ML) application to determine the optimal dosage of sodium hypochlorite (NaOCl) to curtail corrosion and odor by H S in the headworks of a water resource recovery facility (WRRF) without overly consuming volatile fatty acids (VFAs) that are essential for the enhanced biological phosphorus removal. Given the highly diverse datasets available, three subproblems were formulated, and three cascaded ML modules were developed accordingly. The final ML models, chosen based on performance, were able to predict various targeted variables. Read More

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Atomic-Scale Layer-by-Layer Deposition of [email protected]@AlO Hybrid with Threshold Anti-Corrosion and Ultra-High Microwave Absorption Properties in Low-Frequency Bands.

Nanomicro Lett 2021 Jul 30;13(1):161. Epub 2021 Jul 30.

National Engineering Researching Centre of Electromagnetic Radiation Control Materials, Key Laboratory of Multi-Spectral Absorbing Materials and Structures of Ministry of Education, State Key Laboratory of Electronic Thin Films and Integrated Devices, School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, 611731, People's Republic of China.

Developing highly efficient magnetic microwave absorbers (MAs) is crucial, and yet challenging for anti-corrosion properties in extremely humid and salt-induced foggy environments. Herein, a dual-oxide shell of ZnO/AlO as a robust barrier to FeSiAl core is introduced to mitigate corrosion resistance. The [email protected]@AlO layer by layer hybrid structure is realized with atomic-scale precision through the atomic layer deposition technique. Read More

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Enzyme-Free Molecularly Imprinted and Graphene-Functionalized Photoelectrochemical Sensor Platform for Pollutants.

ACS Appl Mater Interfaces 2021 Jul 30. Epub 2021 Jul 30.

School of Chemical Science and Engineering, Shanghai Key Lab of Chemical Assessment and Sustainability, Tongji University, Siping Road 1239, Shanghai 200092, China.

In this work, a label-free nonenzymatic photoelectrochemical (PEC) sensor is successfully developed for the detection of a typical pollutant, microcystin-LR (MC-LR), based on a visible-light-responsive alloy oxide, with highly ordered and vertically aligned Ti-Fe-O nanotubes (NTs) as substrates. Ti-Fe-O NTs consisting mainly of TiO and atomically doped FeO are prepared on a Ti-Fe alloy by electrochemical anodic oxidation. Using a simple electrochemical deposition technique, reduced graphene oxide (RGO) could be grown onto Ti-Fe-O NTs, exhibiting significant bifunctions. Read More

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Tissue Engineering of Corneal Stroma via Melt Electrowriting.

J Tissue Eng Regen Med 2021 Jul 29. Epub 2021 Jul 29.

Ocular Surface Center, Department of Ophthalmology, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.

The cornea serves as the main refractive component of the eye with the corneal stroma constituting the thickest component in a stratified layered system of epithelia, stroma and endothelium. Current treatment options for patients suffering from corneal diseases are limited to transplantation of a human donor cornea (keratoplasty) or to implantation of an artificial cornea (keratoprosthesis). Nevertheless, donor shortage and failure of artificial corneas to integrate with local tissue constitute important problems that have not been yet circumvented. Read More

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Disentangled Intensive Triplet Autoencoder for Infant Functional Connectome Fingerprinting.

Med Image Comput Comput Assist Interv 2020 29;12267:72-82. Epub 2020 Sep 29.

Department of Radiology and BRIC, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

Functional connectome "fingerprint" is a highly characterized brain pattern that distinguishes one individual from others. Although its existence has been demonstrated in adults, an unanswered but fundamental question is whether such individualized pattern emerges since infancy. This problem is barely investigated despites its importance in identifying the origin of the intrinsic connectome patterns that mirror distinct behavioral phenotypes. Read More

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September 2020

Development and Implementation of Couple-Based Collaborative Management Model of Type 2 Diabetes Mellitus for Community-Dwelling Chinese Older Adults: A Pilot Randomized Trial.

Front Public Health 2021 13;9:686282. Epub 2021 Jul 13.

Department of Medical Statistics, School of Public Health, Sun Yat-sen University, Guangzhou, China.

To mobilize family's positive involvement in improving and sustaining self-management activities of older adults with diabetes, we developed a couple-based collaborative management model (CCMM) for community-dwelling older Chinese. The model was developed stepwise through applying theoretical models, interviewing older couples and community healthcare workers, as well as incorporating expert reviews. A 3-month pilot study was conducted to test the model's feasibility and its treatment effects by linear regression on 18 pairs of older couples aged 60 years+, who were equally divided into a couple-based intervention arm and a patient-only control arm. Read More

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The ROCK Tool: A Novel Method for the Structural Exploration of Schemata.

Front Psychol 2021 13;12:675938. Epub 2021 Jul 13.

Department of Psychology and Behavioral Sciences, Zhejiang University, Zhejiang, China.

Information stored in the human memory is organized in the form of mental schemata. In this paper we report on the Reproduction of Categorical Knowledge (ROCK) tool, a novel method for uncovering the structure of mental schemata of memorized information. The tool applies serial reproduction and hierarchical clustering to magnify memory bias and uncover inner configurations of fragmented information, using strength of association. Read More

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Hyaluronic Acid Coated Liposomes Co-Delivery of Natural Cyclic Peptide RA-XII and Mitochondrial Targeted Photosensitizer for Highly Selective Precise Combined Treatment of Colon Cancer.

Int J Nanomedicine 2021 22;16:4929-4942. Epub 2021 Jul 22.

State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, People's Republic of China.

Background: Natural cyclopeptide RA-XII, isolated from , is a promising chemotherapeutic agent for colon cancer. The photosensitizer protoporphyrin-IX attached with triphenylphosphonium (TPP) could possess mitochondria targeting capacity and exert photodynamic therapy (PDT) by inducing oxidizing damage to the mitochondria and cell apoptosis eventually. In this work, pH-sensitive liposomes were constructed to simultaneously deliver RA-XII as a chemotherapeutic drug and modified porphyrin as a mitochondria-targeting photosensitizer to treat colon cancer, and verified its mechanism of action and antitumor therapeutic efficacy. Read More

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Effectiveness of Sealants Treatment in Permanent Molars: A Longitudinal Study.

Int J Clin Pediatr Dent 2021 Jan-Feb;14(1):41-45

Department of Innovative Technologies in Medicine and Dentistry, University "Gabriele D'Annunzio" Chieti, Italy.

Background: Our study gives a clear result about sealants treatment in preventing dental caries manifestation and reducing its prevalence in children aged 6-11 years old.

Aim And Objective: This study aims to compare and evaluate the progress of dental caries in the first and second permanent molars and also to evaluate, within a period of 24 months, the clinical effects of dental sealants, used in the treatment of occlusive cavities, among children 6-11 years old.

Materials And Methods: Participants: The overall sample was composed of 120 children, to whom we randomly chose 480 posterior teeth, which were divided into two groups. Read More

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Tumor collagen framework from bright-field histology images predicts overall survival of breast carcinoma patients.

Sci Rep 2021 Jul 29;11(1):15474. Epub 2021 Jul 29.

National Center of Pathology, Affiliate of Vilnius University Hospital Santaros Klinikos, P. Baublio Str. 5, Vilnius, Lithuania.

Within the tumor microenvironment, specifically aligned collagen has been shown to stimulate tumor progression by directing the migration of metastatic cells along its structural framework. Tumor-associated collagen signatures (TACS) have been linked to breast cancer patient outcome. Robust and affordable methods for assessing biological information contained in collagen architecture need to be developed. Read More

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Rationally Designed Galactose Dendrimer for Hepatocyte-Specific Targeting and Intracellular Drug Delivery for the Treatment of Liver Disorders.

Biomacromolecules 2021 Jul 29. Epub 2021 Jul 29.

Center for Nanomedicine, Department of Ophthalmology, Wilmer Eye Institute Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, United States.

Over two million people die of liver disorders every year globally. Hepatocytes are the key cells affected in several acute and chronic liver diseases. The current clinical outcomes of liver-targeted nanoparticles are limited, necessitating the need to develop smart hepatocyte-targeted drug delivery systems. Read More

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Identification of Thieno[3,2-]pyrimidine Derivatives as Dual Inhibitors of Focal Adhesion Kinase and FMS-like Tyrosine Kinase 3.

J Med Chem 2021 Jul 29. Epub 2021 Jul 29.

Severance Biomedical Science Institute, Graduate School of Medical Science, Brain Korea 21 Project, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 03722, Republic of Korea.

Focal adhesion kinase (FAK) is overexpressed in highly invasive and metastatic cancers. To identify novel FAK inhibitors, we designed and synthesized various thieno[3,2-]pyrimidine derivatives. An intensive structure-activity relationship (SAR) study led to the identification of as a lead. Read More

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Design of High-Performance Pyridine/Quinoline Hydrazone Photoswitches.

J Org Chem 2021 Jul 29. Epub 2021 Jul 29.

Department of Organic Chemistry, Faculty of Natural Sciences, Comenius University, Ilkovičova 6, 84215 Bratislava, Slovakia.

The design of P-type photoswitches with thermal stability of the metastable form of hundreds of years that would efficiently transform using excitation wavelengths above 350 nm remains a challenge in the field of photochromism. In this regard, we designed and synthesized an extended set of 13 pyridine/quinoline hydrazones and systematically investigated the structure-property relationships, defining their kinetic and photoswitching parameters. We show that the operational wavelengths of the pyridine hydrazone structural motif can be effectively shifted toward the visible region without simultaneous loss of their high thermal stability. Read More

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Multichromophore Molecular Design for Thermally Activated Delayed-Fluorescence Emitters with Near-Unity Photoluminescence Quantum Yields.

J Org Chem 2021 Jul 29. Epub 2021 Jul 29.

Organic Semiconductor Centre, EaStCHEM School of Chemistry, University of St Andrews, St Andrews, Fife KY16 9ST, U.K.

Three multichromophore thermally activated delayed fluorescence (TADF) molecules, , , and , were synthesized and characterized. These molecules were designed by connecting the TADF moiety 4,5-di(9-carbazol-9-yl)phthalonitrile () to different positions of a central benzene ring scaffold. Three highly soluble emitters all exhibited near-quantitative photoluminescence quantum yields (Φ) in toluene. Read More

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Rapid, Simple, and Inexpensive Spatial Patterning of Wettability in Microfluidic Devices for Double Emulsion Generation.

Anal Chem 2021 Jul 29. Epub 2021 Jul 29.

School of Engineering, Macquarie University, Balaclava Road, North Ryde, New South Wales 2109, Australia.

Water-in-oil-in-water (w/o/w) double emulsion (DE) encapsulation has been widely used as a promising platform technology for various applications in the fields of food, cosmetics, pharmacy, chemical engineering, materials science, and synthetic biology. Unfortunately, DEs formed by conventional emulsion generation approaches in most cases are highly polydisperse, making them less desirable for quantitative assays, controlled biomaterial synthesis, and entrapped ingredient release. Microfluidic devices can generate monodisperse DEs with controllable size, morphology, and production rate, but these generally require multistep fabrication processes and use of different solvents or bulky external instrumentation to pattern channel wettability. Read More

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Superstructured Macroporous Carbon Rods Composed of Defective Graphitic Nanosheets for Efficient Oxygen Reduction Reaction.

Adv Sci (Weinh) 2021 Jul 29:e2100120. Epub 2021 Jul 29.

School of Chemistry and Molecular Engineering, East China Normal University, Shanghai, 200241, P. R. China.

Rationally designed carbon materials with superstructures are promising candidates in applications such as electrocatalysis. However, the synthesis of highly porous carbon superstructures with macropores and carbon defects from a simple crystalline solid remains challenging. In this work, superstructured macroporous carbon rods composed of defective graphitic nanosheets are synthesized by direct carbonization of crystalline poly tannic acid (PTA) rods as precursors. Read More

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Single-Molecule Binding Assay Using Nanopores and Dimeric NP Conjugates.

Adv Mater 2021 Jul 29:e2103067. Epub 2021 Jul 29.

Department of Chemistry, Molecular Science Research Hub, Imperial College London, White City Campus, 82 Wood Lane, London, W12 0BZ, UK.

The ability to measure biomarkers, both specifically and selectively at the single-molecule level in biological fluids, has the potential to transform the diagnosis, monitoring, and therapeutic intervention of diseases. The use of nanopores has been gaining prominence in this area, not only for sequencing but more recently in screening applications. The selectivity of nanopore sensing can be substantially improved with the use of labels, but substantial challenges remain, especially when trying to differentiate between bound from unbound targets. Read More

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Happy Talk: A pilot effectiveness study of a targeted-selective speech-language and communication intervention for children from areas of social disadvantage.

Int J Lang Commun Disord 2021 Jul 28. Epub 2021 Jul 28.

Newcastle University, Newcastle upon Tyne, Newcastle, UK.

Background: Despite the public health implications of language difficulties associated with social disadvantage, there is a dearth of effectiveness studies investigating the effects of targeted speech and language programmes in this area.

Aims: To determine the effects of a targeted selective community-based child language intervention programme (Happy Talk), which simultaneously engaged with parents and early childhood educators, in the Republic of Ireland.

Methods & Procedures: A mixed methods methodology was applied with quantitative outcome and qualitative process data collected. Read More

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Predicting Age From Behavioral Test Performance for Screening Early Onset of Cognitive Decline.

Front Aging Neurosci 2021 12;13:661514. Epub 2021 Jul 12.

INSERM, COMETE, GIP CYCERON, Normandie University, UNICAEN, Caen, Research Unit: Aging, Health and Diseases, Caen, France.

Neuronal reactions and cognitive processes slow down during aging. The onset, rate, and extent of changes vary considerably from individual to individual. Assessing the changes throughout the lifespan is a challenging task. Read More

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Disassembly of HIV envelope glycoprotein trimer immunogens is driven by antibodies elicited via immunization.

Sci Adv 2021 Jul 28;7(31). Epub 2021 Jul 28.

Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.

Rationally designed protein subunit vaccines are being developed for a variety of viruses including influenza, RSV, SARS-CoV-2, and HIV. These vaccines are based on stabilized versions of the primary targets of neutralizing antibodies on the viral surface, namely, viral fusion glycoproteins. While these immunogens display the epitopes of potent neutralizing antibodies, they also present epitopes recognized by non-neutralizing or weakly neutralizing ("off-target") antibodies. Read More

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Promoting Pore-Level Mass Transport/Reaction in Flow Batteries: Bi Nanodot/Vertically Standing Carbon Nanosheet Composites on Carbon Fibers.

ACS Appl Mater Interfaces 2021 Jul 28. Epub 2021 Jul 28.

Shenzhen Key Laboratory of New Lithium-ion Batteries and Mesoporous Materials, College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, People's Republic of China.

Elaborate nanoarchitectured solid/liquid interface design of felt electrodes is arguably the most effective pathway to promote the pore-level transport-reaction processes of redox flow batteries. Herein, we conceive a new type of nanocatalytic-layer-architectured graphite felt via introducing the vertically standing carbon nanosheet-confined Bi nanodots onto carbon fiber surfaces. The vertically standing carbon nanosheets construct a nanoporous layer with straight channels for vanadium ion shuttling, where highly dispersed Bi nanodots are stiffly confined to afford abundant active sites. Read More

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Triangulation of multiple meaningful change thresholds for patient-reported outcome scores.

Qual Life Res 2021 Jul 28. Epub 2021 Jul 28.

IQVIA, Reading, Berkshire, UK.

Purpose: The notion of what constitutes meaningful differences or changes in patient-reported outcome scores is represented by meaningful change thresholds (MCTs). Applying multiple methods to estimate MCTs inevitably results in a range of estimates; however, a single estimate or small range is sought in practice to enable consistent interpretation of scores. While current recommendations for triangulation are appropriate in principle, the vital step of moving from all estimates to a value or small range lacks clarity and is subjective in nature. Read More

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Medical Students' Perceptions of Play and Learning: Qualitative Study With Focus Groups and Thematic Analysis.

JMIR Serious Games 2021 Jul 28;9(3):e25637. Epub 2021 Jul 28.

Department of Biomedical Sciences of Cells and Systems, Section Anatomy & Medical Physiology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands.

Background: In times where distance learning is becoming the norm, game-based learning (GBL) is increasingly applied to health profession education. Yet, decisions for if, when, how, and for whom GBL should be designed cannot be made on a solid empirical basis. Though the act of play seems to be intertwined with GBL, it is generally ignored in the current scientific literature. Read More

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Self-Cycling Free Radical Generator from LDH-Based Nanohybrids for Ferroptosis-Enhanced Chemodynamic Therapy.

Adv Healthc Mater 2021 Jul 28:e2100539. Epub 2021 Jul 28.

State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, P. O. Box 98, Beisanhuan East Road 15, Beijing, 100029, P. R. China.

Nonapoptotic ferroptosis has been a novel form of programmed cell death, which provides a new solution to enrich the anticancer treatment efficacy of traditional apoptotic therapeutic modality. Herein, a novel nanohybrid is designed by loading the PEG-encapsulated Artemisinin (denoted as [email protected]) on the ultrathin MgFe-LDH nanosheets (denoted as uLDHs) for improved chemodynamic therapy (CDT). The [email protected]/uLDHs cannot only realize the self-assembly between the Art and carrier but also be regarded as free radical generator. Read More

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Highly Efficient Oxidative-Cyanation of Aldehydes to Nitriles over Se,S,N-tri-Doped Hierarchically Porous Carbon Nanosheets.

Angew Chem Int Ed Engl 2021 Jul 28. Epub 2021 Jul 28.

Chinese Academy of Sciences, Institute of Chemistry, Beiyijie number 2, Zhongguancun, 100190, Beijing, CHINA.

Oxidative-cyanation of aldehydes provides a promising strategy for the cyanide-free synthesis of organic nitriles. Design of robust and cost-effective catalysts is the key for this route. Herein, we designed a series of Se,S,N- tri -doped carbon nanosheets with a hierarchical porous structure (denoted as Se,S,N-CNs- x , x represents the pyrolysis temperature). Read More

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The reliability of low-dose chest CT for the initial imaging of COVID-19: comparison of structured findings, categorical diagnoses and dose levels.

Diagn Interv Radiol 2021 Jul 28. Epub 2021 Jul 28.

Department of Radiology, University of Health Sciences, Istanbul Fatih Sultan Mehmet Training and Research Hospital, Istanbul, Turkey.

Purpose: The widespread use of computed tomography (CT) in COVID-19 may cause adverse biological effects. Many recommend to minimize radiation dose while maintaining diagnostic quality. This study was designed to evaluate the difference between findings of COVID-19 pneumonia on standard and low-dose protocols to provide data on the utility of the latter during initial imaging of COVID-19. Read More

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Plant type I metacaspases are proteolytically active proteases despite their hydrophobic nature.

FEBS Lett 2021 Jul 28. Epub 2021 Jul 28.

Department of Chemistry and Biochemistry, Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana, Slovenia.

Plant metacaspases type I (MCA-Is), the closest structural homologs of caspases, are key proteases in stress-induced regulated cell death processes in plants. However, no plant MCA-Is have been characterised in vitro to date. Here we show that only plant MCA-Is contain a highly hydrophobic loop within the C-terminus of their p10 domain. Read More

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The Promise of the Dual Prevention Pill: A Framework for Development and Introduction.

Front Reprod Health 2021 Jun 23;3. Epub 2021 Jun 23.

Population Council, Center for Biomedical Research, New York, NY, United States.

Women of reproductive age need multipurpose prevention technology (MPT) products to address two overlapping health risks: unintended pregnancy and HIV. Currently, condoms are the only available MPT, however male condoms are not within the control of a woman, and the use of female condoms has been limited by low acceptability and cost. Oral pre-exposure prophylaxis (PrEP) is highly effective for HIV prevention, yet uptake and adherence among women have been low to date. Read More

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Introducing High Density of Very Active Sites and Stepwise Postmodification for Tailoring the Porosity of Highly Demanding Cr-Based Metal-Organic Frameworks.

Inorg Chem 2021 Jul 27. Epub 2021 Jul 27.

Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and Applications, Jinan University, Guangzhou 510632, China.

Chromium(III)-based metal-organic frameworks (Cr-MOFs) are highly robust and porous and have been very attractive in a wide range of investigations. However, the harsh direct synthetic conditions not only impede the synthesis of new Cr-MOFs but also restrict the introduction of functional groups into them. Postsynthetic modification has somewhat alleviated such difficulties; nevertheless, it still suffered from procedures that are tedious and conditions that are not mild, which often result in low concentration of the functional groups introduced. Read More

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