54,339 results match your criteria designed chemical

Photocatalytic hydrogen evolution over a nickel complex anchoring to thiophene embedded g-CN.

J Colloid Interface Sci 2021 Mar 19;596:75-88. Epub 2021 Mar 19.

Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, PR China. Electronic address:

Evolution of hydrogen from water by utilizing solar energy and photocatalysts is one of the most promising ways to solve energy crisis. However, designing a cost-effective and stable photocatalyst without any noble metals is of vital importance for this process. Herein, an extremely active molecular complex cocatalyst NiL(Cl) is successfully designed. Read More

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Controlling the coordination environment of Co atoms derived from Co/ZIF-8 for boosting photocatalytic H evolution of CdS.

J Colloid Interface Sci 2021 Mar 24;596:139-147. Epub 2021 Mar 24.

Key Laboratory of Eco-Chemical Engineering, Ministry of Education, State Laboratory of Inorganic Synthesis and Applied Chemistry, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China. Electronic address:

Regulating the coordination environment of metal-N species by replacing N with low electronegativity atoms is an approach of tuning the electrocatalytic performance of metal-based sites. However, such effects on the enhancement of photocatalytic H evolution over semiconductors are not discussed yet. Herein, we designed and prepared Co-based cocatalysts with controlled coordination environment via calcination Co/ZIF-8 loaded with triphenylphosphine followed by a sulfurization treatment. Read More

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Preparation of novel nanostructured WO/CuMnO p-n heterojunction nanocomposite for photoelectrochemical detection of nitrofurazone.

J Colloid Interface Sci 2021 Mar 19;596:108-118. Epub 2021 Mar 19.

Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei, Taiwan, ROC.

Herein this research, a visible light active tungsten oxide/copper manganate (WO/CuMnO) p-n heterojunction nanocomposite was prepared and has been applied for a signal on photoelectrochemical sensing of antibiotic nitrofurazone (NFZ). Firstly, the n-WO nanotiles were synthesized from the cetrimonium bromide (CTAB) assisted hydrothermal method and the p-CuMnO nanoparticles were synthesized by using the ultrasound-assisted hydrothermal method. The photoelectrochemical NFZ sensing performance of WO/CuMnO nanocomposite was 1. Read More

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Development and clinical validation of loop-mediated isothermal amplification (LAMP) assay to diagnose high HBV DNA levels in resource-limited settings.

Clin Microbiol Infect 2021 Apr 7. Epub 2021 Apr 7.

Unité d'Epidémiologie des Maladies Émergentes, Institut Pasteur, Paris, France. Electronic address:

Objectives: A massive scale-up of testing and treatment is indicated to globally eliminate hepatitis B virus (HBV) infection. However, access to a polymerase chain reaction (PCR), a key test to quantify HBV DNA levels and determine treatment eligibility, is limited in resource-limited countries. We developed and evaluated loop-mediated isothermal amplification (LAMP) assay to diagnose clinically important HBV DNA thresholds defined by WHO (≥20,000 and ≥200,000 IU/mL). Read More

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A general chemical crosslinking strategy for structural analyses of weakly interacting proteins applied to preTCR-pMHC complexes.

J Biol Chem 2021 Jan 8;296:100255. Epub 2021 Jan 8.

Laboratory of Immunobiology, Dana Farber Cancer Institute, Boston, Massachusetts, USA; Department of Medical Oncology, Dana Farber Cancer Institute, Boston, Massachusetts, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts, USA; Department of Dermatology, Harvard Medical School, Boston, Massachusetts, USA. Electronic address:

T lymphocytes discriminate between healthy and infected or cancerous cells via T-cell receptor-mediated recognition of peptides bound and presented by cell-surface-expressed major histocompatibility complex molecules (MHCs). Pre-T-cell receptors (preTCRs) on thymocytes foster development of αβT lymphocytes through their β chain interaction with MHC displaying self-peptides on thymic epithelia. The specific binding of a preTCR with a peptide-MHC complex (pMHC) has been identified previously as forming a weak affinity complex with a distinct interface from that of mature αβTCR. Read More

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January 2021

Stablity based on PI control of three-dimensional chaotic oscillatory system via DNA chemical reaction networks.

IEEE Trans Nanobioscience 2021 Apr 9;PP. Epub 2021 Apr 9.

The classical proportional integral (PI) controller of SISO linear system is realized by DNA chemical reaction networks (CRNs) in the previous work. Up to now, few works have been done to realize PI controller of chaotic system through DNA CRNs. In this paper, a three-dimensional chaotic oscillatory system and a PI controller of three-dimensional chaotic oscillatory system are proposed by DNA CRNs. Read More

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Investigation of metals accumulation in soil dumpsites using proton-induced X-ray emission.

Environ Geochem Health 2021 Apr 9. Epub 2021 Apr 9.

Department of Chemical Sciences, Olusegun Agagu University of Science and Technology, Okitipupa, Ondo State, Nigeria.

This work was designed to examine the elemental constituents and physiochemical parameters of dumpsites in four local government areas in Ondo State. Elemental composition and physiochemical parameters such as pH, electrical conductivity, temperature, chloride and nitrate were analyzed in soil samples. The data were analyzed using the windows version 24. Read More

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Correlative Light and Electron Microscopy for Nanoparticle-Cell Interaction and Protein Localization.

Adv Exp Med Biol 2021 ;1310:115-132

Convergence Medicine Research Center (CREDIT), Asan Institute for Life Sciences, Asan Medical Center, Seoul, South Korea.

Various silica-based fluorescent nanoparticles ((Si-FNP)) with magnetic or metal cores represent a standard class of nanoparticles offering new opportunities for high-resolution cellular imaging and biomedicine applications, such as drug delivery. Their high solubility, homogeneity, biocompatibility, and chemical inertness Si-FNPs make them attractive probes for correlative light and electron microscopy (CLEM) studies, offering novel insights into nanoparticle-cell interactions in detail. In the present chapter, we present a procedure for imaging silica-based fluorescent magnetic core-shell nanoparticles (Si-FMNP) at the single-particle scale in cells. Read More

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January 2021

i6mA-VC: A Multi-Classifier Voting Method for the Computational Identification of DNA N6-methyladenine Sites.

Interdiscip Sci 2021 Apr 8. Epub 2021 Apr 8.

School of Mathematics and Statistics, Xidian University, Xi'an, 710071, People's Republic of China.

DNA N6-methyladenine (6 mA), as an essential component of epigenetic modification, cannot be neglected in genetic regulation mechanism. The efficient and accurate prediction of 6 mA sites is beneficial to the development of biological genetics. Biochemical experimental methods are considered to be time-consuming and laborious. Read More

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Neovascularization of engineered tissues for clinical translation: Where we are, where we should be?

APL Bioeng 2021 Jun 5;5(2):021503. Epub 2021 Apr 5.

Biomedical Sciences and Engineering, Koç University, Istanbul 34450, Turkey.

One of the key challenges in engineering three-dimensional tissue constructs is the development of a mature microvascular network capable of supplying sufficient oxygen and nutrients to the tissue. Recent angiogenic therapeutic strategies have focused on vascularization of the constructed tissue, and its integration ; these strategies typically combine regenerative cells, growth factors (GFs) with custom-designed biomaterials. However, the field needs to progress in the clinical translation of tissue engineering strategies. Read More

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Stepwise Self-Assembly and Dynamic Exchange of Supramolecular Snowflakes.

Isr J Chem 2019 Mar 24;59(3-4):237-247. Epub 2018 Aug 24.

Department of Chemistry, University of South Florida, Tampa 33620, United States.

Snowflake, a highly symmetrical hexagram figure, is challenging to be expressed by chemistry/supramolecular chemistry due to the complex structure. Herein, we have constructed super snowflake supramolecules using terpyridine (tpy)-based metal-organic building blocks with and connectivities through stepwise strategies in high yield. The structures were characterized by multi-dimensional mass spectrometry and multi-dimensional NMR spectrometry. Read More

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Derivatives of diisopropyl phenoxyphosphate with controlled reactivity for enhancement of Acetylcholine (ACh) neurotransmitter.

Pak J Pharm Sci 2020 Sep;33(5(Supplementary)):2239-2242

Department of Pharmacognosy, Faculty of Pharmacy and Pharmaceutical Sciences, University of Karachi, Karachi, Pakistan.

Here, new phenoxide derivatives of diisopropyl flourophosphate for reaction with Lewis basic sites on acetyl cholinesterase (AChE) were designed. Such binding interaction or reaction inhibits the hydrolysis of the acetylcholine (ACh) neurotransmitter thus enhancing its concentration. This increased neurotransmitter concentration can enhance memory and cognition thus improving symptoms of neurodegenerative diseases such as Alzheimer disease and down syndrome. Read More

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September 2020

Flexible graphene/GO electrode for gel-free EEG.

J Neural Eng 2021 Apr 8. Epub 2021 Apr 8.

Mechanical Engineering, National Taiwan University of Science and Technology, Room 710, T3, No.43, Keelung Rd., Sec.4, Taipei City, Taiwan, R.O.C., Taipei City, Taiwan, 10607, TAIWAN.

Objective: Developments in electroencephalography (EEG) technology has allowed the use of brain-computer interface (BCI) outside dedicated labs. In order to achieve long-time monitoring and detection of EEG signals for BCI application, dry electrodes with good signal quality and high bio compatibility are essential. In 2016, we proposed a flexible dry electrode made of silicone gel and Ag flakes, which showed good signal quality and mechanical robustness. Read More

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Integration of CW-MFC and anaerobic granular sludge to explore the intensified ammonification-nitrification-denitrification processes for nitrogen removal.

Chemosphere 2021 Apr 1;278:130428. Epub 2021 Apr 1.

State Key Laboratory of Water Environment Simulation, School of Environment, Beijing Normal University, Beijing, 100875, China. Electronic address:

The integration of constructed wetland-microbial fuel cell (CW-MFC) and anaerobic granular sludge (AGS) is an important way to promote its ammonification efficiency and decrease the land use scale. This study explored the integration of CW-MFC and AGS for nitrogen removal via the intensified ammonification-nitrification-denitrification processes with initial NH-N, NO-N, Org-N and total nitrogen (TN) concentrations of 10.5, 13. Read More

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Nanocrystal Quantum Dots: From Discovery to Modern Development.

ACS Nano 2021 Apr 8. Epub 2021 Apr 8.

Department of Chemistry, Columbia University, New York, New York 10027, United States.

This review traces nanocrystal quantum dot (QD) research from the early discoveries to the present day and into the future. We describe the extensive body of theoretical and experimental knowledge that comprises the modern science of QDs. Indeed, the spatial confinement of electrons, holes, and excitons in nanocrystals, coupled with the ability of modern chemical synthesis to make complex designed structures, is today enabling multiple applications of QD size-tunable electronic and optical properties. Read More

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Recent Advances in Design Strategies for Tough and Stretchable Hydrogels.

Chempluschem 2021 Apr;86(4):601-611

Graduate Department of Chemical Materials, and Institute for Plastic Information and Energy Materials, Sustainable Utilization of Photovoltaic Energy Research Center, Pusan National University, Busan, 46241, Republic of Korea.

The development of multifunctional hydrogels with excellent stretchability and toughness is one of the most fascinating subjects in soft matter research. Numerous research efforts have focused on the design of new hydrogel systems with superior mechanical properties because of their potential applications in diverse fields. In this Minireview, we consider the most up-to-date mechanically strong hydrogels and summarize their design strategies based on the formation of double networks and dual physical crosslinking. Read More

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Efficient Direct Reverse Intersystem Crossing between Charge Transfer-Type Singlet and Triplet States in a Purely Organic Molecule.

Chemphyschem 2021 Apr;22(7):621

Institute for Chemical Research, Kyoto University, Uji, Kyoto, 611-0011, Japan.

The front cover artwork is provided by the group of Prof. Hironori Kaji, Dr. Yoshimasa Wada, and Mr. Read More

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Asymmetric Catalytic Approach to Multi-Layer 3D Chirality.

Chemistry 2021 Apr 8. Epub 2021 Apr 8.

Texas Tech University, Mechanical Engineering, UNITED STATES.

The first asymmetric catalytic approach to multi-layer 3D chirality has been achieved via Suzuki-Miyaura cross-couplings. New chiral catalysts were designed and screened under various catalytic systems that proved chiral amide-phosphines to be more efficient ligands than other candidates. The multi-layer 3D framework was unambiguously determined by X-ray structural analysis showing a parallel pattern of three layers consisting top, middle and bottom aromatic rings. Read More

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Tramadol Biological Effects: 4: Effective Therapeutic Efficacy of Preparation (Gamal & Aref1) and Melatonin on Cell Biological, Histochemical, and Histopathological Changes in the Kidney of Tramadol-Induced Male Mice.

Microsc Microanal 2021 Apr 8:1-13. Epub 2021 Apr 8.

Histology Department, Faculty of Veterinary, South Valley University, Qena, Egypt.

Tramadol is used worldwide and is listed in many medical guidelines to treat both acute and chronic pains. There is a growing evidence of abuse of tramadol in some African and West Asian countries. Tramadol has some side effects. Read More

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Design and synthesis of novel tacrine-indole hybrids as potential multitarget-directed ligands for the treatment of Alzheimer's disease.

Future Med Chem 2021 Apr 8. Epub 2021 Apr 8.

Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, Hradec Kralove 500 05, Czech Republic.

The authors report on the synthesis and biological evaluation of new compounds whose structure combines tacrine and indole moieties. Tacrine-indole heterodimers were designed to inhibit cholinesterases and β-amyloid formation, and to cross the blood-brain barrier. The most potent new acetylcholinesterase inhibitors were compounds and (IC = 25 and 39 nM, respectively). Read More

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Photothermometric analysis of bismuth ions using aggregation-induced nanozyme system with a target-triggered surface cleaning effect.

Anal Bioanal Chem 2021 Apr 7. Epub 2021 Apr 7.

Key Laboratory of Bioelectrochemistry & Environmental Analysis of Gansu Province, College of Chemistry & Chemical Engineering, Northwest Normal University, Lanzhou, 730070, China.

The development of nanozyme-based photothermometric sensing for point-of-care testing (POCT) heavy metal ions is of great significance for disease diagnosis and health management. Considering the low catalytic activity of most nanozymes at physiological pH, we found bismuth ions (Bi) could effectively enhance the peroxidase (POX)-like activity of cetyltrimethylammonium bromide and citrate-capped octahedral gold nanoparticle (CTAB/Cit-AuNP) nanozymes. It is mainly based on Biions being able to trigger the surface cleaning effect of CTAB/Cit-AuNPs. Read More

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Library Creation of Ultrasmall Multi-metallic Nanoparticles Confined in Mesoporous MFI Zeolites.

Angew Chem Int Ed Engl 2021 Apr 7. Epub 2021 Apr 7.

Shanghai JiaoTong University, School of Chemistry and Chemical Engineering, 800 Dongchuan Road, 200240, Shanghai, CHINA.

The development of materials integrated with ultrasmall multi-metal nanoparticles (UMMNs) and mesoporous zeolite is a considerable challenge in chemistry and materials science. We designed trifunctional surfactant, in which the pyridyl benzimidazole in the hydrophobic tail generates the mesopores through π-π stacking; the diquaternary ammonium in the hydrophilic headgroup direct the formation of MFI zeolite sheets and the nitrogen atoms in heterocyclic ringscoordinate with various metal ions to form UMMNs confined in the zeolite matrix after calcination and reduction. A library of 56 UMMNs confined within both micropores and mesopores of MFI zeolites (MMZs) with 4 mono-, 14 bi- and 38 tri-metallic nanoparticles (sizes of 1. Read More

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A Sensitive Fluorescent Sensor for Highly Sensitive Detection of Water in Organic Solvents Based on Substituted Imidazole.

J Fluoresc 2021 Apr 7. Epub 2021 Apr 7.

College of Chemistry and Chemical Engineering, Qiqihar University, 161006, Qiqihar, People's Republic of China.

A novel substituted imidazole derivative 1a with carboxyl and quinoline structure has been designed and synthesized. And our initial discovery is that this compound can effectively detect water in ethanol. And the metal in solution couldn't affect the absorption and fluorescence Spectra of 1a. Read More

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Study on the activity of recombinant mutant tissue-type plasminogen activator fused with the C-terminal fragment of hirudin.

J Thromb Thrombolysis 2021 Apr 7. Epub 2021 Apr 7.

School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, People's Republic of China.

In the present study, bifunctional fusion proteins were designed by fusing the kringle 2 and protease domains of tissue-type plasminogen activator (tPA) to the C-terminal fragment of hirudin. The thrombolytic and anticoagulant activities of these recombinant proteins from mammalian cells were investigated using in vitro coagulation models and chromogenic assays. The results showed that all assayed tPA mutants retained catalytic activity. Read More

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Automated Calibration of a Poly(oxymethylene) Dimethyl Ether Oxidation Mechanism Using the Knowledge Graph Technology.

J Chem Inf Model 2021 Apr 7. Epub 2021 Apr 7.

Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, U.K.

In this paper, we develop a knowledge graph-based framework for the automated calibration of combustion reaction mechanisms and demonstrate its effectiveness on a case study of poly(oxymethylene)dimethyl ether (PODE, where = 3) oxidation. We develop an ontological representation for combustion experiments, OntoChemExp, that allows for the semantic enrichment of experiments within the J-Park simulator (JPS, theworldavatar.com), an existing cross-domain knowledge graph. Read More

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Design and Identification of Novel Annomontine Analogues Against SARS-CoV-2: An Approach.

Heliyon 2021 Apr 2:e06657. Epub 2021 Apr 2.

Amity Institute of Biotechnology, Amity University Uttar Pradesh, Noida -125, 201301.

Aims: COVID-19 has currently emerged as the major global pandemic affecting the lives of people across the globe. It broke out from Wuhan Province of China, first reported to WHO on 31 December 2019 as "Pneumonia of unknown cause". Over time more people were infected with this virus, and the only tactic to ensure safety was to take precautionary measures due to the lack of any effective treatment or vaccines. Read More

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Dimethyl Sulfoxide-Free and Water-Soluble Fluorescent Probe for Detection of Bovine Serum Albumin Prepared by Ionic Co-assembly of Amphiphiles.

Langmuir 2021 Apr 6. Epub 2021 Apr 6.

College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China.

Detection of bovine serum albumin (BSA) is an important issue in the sense of medical applications and enzymatic reactions; however, the recently developed fluorescent probes require the involvement of dimethyl sulfoxide (DMSO), which may be detrimental to proteins. In this study, we demonstrated a DMSO-free and water-soluble fluorescent probe prepared by ionic co-assembly of amphiphiles. The cationic amphiphile is a newly designed molecule (denoted by DPP-12) bearing a conjugated diketopyrrolopyrrole (DPP) and two tetraphenylethylene groups. Read More

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Tailoring of Peptide Vesicles: A Bottom-Up Chemical Approach.

V Haridas

Acc Chem Res 2021 Apr 6. Epub 2021 Apr 6.

Department of Chemistry, Indian Institute of Technology Delhi (IITD), New Delhi 110016, India.

ConspectusSpherical ordering from small molecules is a subject of intense interest to chemists. The inherent capability of amphiphiles to assemble spontaneously is the unique feature of the evolutionary process of life. Self-assembly is prevalent in biology and has attracted the interest of scientists across several disciplines. Read More

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Influencing factors and growth kinetics analysis of carbon nanotube growth on the surface of continuous fibers.

Nanotechnology 2021 Apr 6. Epub 2021 Apr 6.

Shandong University, Jinan, Shandong, CHINA.

Carbon nanotubes (CNTs) were continuously grown on the surface of the moving carbon fiber by chemical vapor deposition (CVD) method using a custom-designed production line to prepare composite reinforcements on a large-scale. The systematic study of different parameters affecting the CNT growth revealed simple growth kinetics, which helps to control the surface morphology and structural quality of CNTs. Since hydrogen maintains the activity of the catalyst, it promotes the growth of CNTs in a continuous process. Read More

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Luminescent lanthanide(III) complexes of DTPA-bis(amido-phenyl-terpyridine) for bioimaging and phototherapeutic applications.

Spectrochim Acta A Mol Biomol Spectrosc 2021 Mar 18;256:119709. Epub 2021 Mar 18.

Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, UP, India. Electronic address:

We report here a series of coordinatively-saturated and thermodynamically stable luminescent [Ln(dtntp)(HO)] [Ln(III) = Eu (1), Tb (2), Gd (3), Sm (4) and Dy (5)] complexes using an aminophenyl-terpyridine appended-DTPA (dtntp) chelating ligand as cell imaging and photocytotoxic agents. The N,N″-bisamide derivative of HDTPA named as dtntp is based on 4'-(4-aminophenyl)-2,2':6',2″-terpyridine conjugated to diethylenetriamine-N,N',N″-pentaacetic acid. The structure, physicochemical properties, detailed photophysical aspects, interaction with DNA and serum proteins, and photocytotoxicity were studied. Read More

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