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A comparative study to evaluate the effects of antibiotics, plant extracts and fluoride-based toothpaste on the oral pathogens isolated from patients with gum diseases in Pakistan.

Braz J Biol 2021 26;83:e242703. Epub 2021 Jul 26.

Hazara University Mansehra, Department of Biotechnology and Genetic Engineering , Hazara, Pakistan.

Oral diseases caused by various microorganisms are common around the world. Scientific research has now been focusing on novel medicines to overcome bacterial resistance and antibiotics side effects; therefore, the current study was designed to assess the efficacy of certain antibiotics, toothpaste, and medicinal plant extracts (Ajuga bracteosa and Curcuma longa) versus the bacterial pathogens isolated from the human oral cavity. A total of 130 samples were collected from Khyber Teaching Hospital Peshawar, Pakistan, among those 27 species isolated, and eight bacterial species were identified from the samples. Read More

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Student perceptions on synchronous virtual versus face-to-face teaching for leader-centered and participant-centered postgraduate activities during COVID-19.

Adv Physiol Educ 2021 Sep;45(3):554-562

Department of Physiology, All India Institute of Medical Sciences, New Delhi, India.

Consequent to the unprecedented COVID-19 pandemic, pedagogic changes were introduced in postgraduate courses in Physiology, where face-to-face teaching was replaced with synchronous virtual mode for leader-centered (seminar, symposium) and participant-centered (journal club, group discussion) academic activities. We hypothesized that the effectiveness of virtual and face-to-face modes as perceived by postgraduate students in terms of facilitating their overall learning may differ across the spectrum of leader-centered and participant-centered activities. To assess the same, we designed and administered a comprehensive, structured, and validated feedback questionnaire. Read More

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September 2021

Assay Harmonization and Use of Biological Standards To Improve the Reproducibility of the Hemagglutination Inhibition Assay: a FLUCOP Collaborative Study.

mSphere 2021 Jul 28:e0056721. Epub 2021 Jul 28.

Sanofi Pasteur, Swiftwater, Pennsylvania, USA.

The hemagglutination inhibition (HAI) assay is an established technique for assessing influenza immunity, through measurement of antihemagglutinin antibodies. Improved reproducibility of this assay is required to provide meaningful data across different testing laboratories. This study assessed the impact of harmonizing the HAI assay protocol/reagents and using standards on interlaboratory variability. Read More

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Pulmonary surveillance in pediatric hematopoietic stem cell transplant: A multinational multidisciplinary survey.

Cancer Rep (Hoboken) 2021 Jul 28:e1501. Epub 2021 Jul 28.

Division of Pulmonary and Sleep Medicine, Department of Pediatrics, School of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.

Background: Hematopoietic Stem Cell Transplant (HSCT) is an established treatment for malignant and non-malignant conditions and pulmonary disease is a leading cause of late term morbidity and mortality. Accurate and early detection of pulmonary complications is a critical step in improving long term outcomes. Existing guidelines for surveillance of pulmonary complications post-HSCT contain conflicting recommendations. Read More

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Ivermectin for preventing and treating COVID-19.

Cochrane Database Syst Rev 2021 Jul 28;7:CD015017. Epub 2021 Jul 28.

Department of Anaesthesiology, Intensive Care, Emergency and Pain Medicine, University Hospital Wuerzburg, Wuerzburg, Germany.

Background: Ivermectin, an antiparasitic agent used to treat parasitic infestations, inhibits the replication of viruses in vitro. The molecular hypothesis of ivermectin's antiviral mode of action suggests an inhibitory effect on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication in the early stages of infection. Currently, evidence on efficacy and safety of ivermectin for prevention of SARS-CoV-2 infection and COVID-19 treatment is conflicting. Read More

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Combat and Operational Stress Control Interventions and PTSD: A Systematic Review and Meta-Analysis.

Mil Med 2021 Jul 28. Epub 2021 Jul 28.

The Gehr Family Center for Health Systems Science and Innovation, Keck School of Medicine, RAND Corporation, Santa Monica, CA 90407, USA.

Introduction: Military personnel must prepare for and respond to life-threatening crises on a daily basis. This lifestyle places stress on personnel, and particularly so on deployed service members who are isolated from support systems and other resources. As part of a larger systematic review on the acceptability, efficacy, and comparative effectiveness of interventions designed to prevent, identify, and manage stress reactions, we assessed posttraumatic stress disorder (PTSD) outcomes. Read More

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Clinical implications of photophobia in progressive supranuclear palsy.

Clin Park Relat Disord 2021 1;4:100097. Epub 2021 Jun 1.

Department of Neurology, Vanderbilt University Medical Center, Nashville, TN, United States.

Objective: To determine the impact of photophobia on persons with Progressive Supranuclear Palsy (pwPSP) by determining the functional impact of light sensitivity using methods established in migraine research.

Methods: All 60 participants (pwPSP = 15, persons with Parkinson Disease (pwPD) = 15, Older adults = 30) completed a series of questionnaires designed to assess the impact of photophobia on activities of daily living. Group comparisons were controlled for multiple comparisons using a false discovery rate of 0. Read More

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Developing a dementia inclusive hospital environment using an Integrated Care Pathway design: research protocol.

PeerJ 2021 14;9:e11589. Epub 2021 Jul 14.

Nursing Management, HLA Vistahermosa Hospital, Alicante, Spain.

People with dementia occupy 25% of the hospital beds. When they are admitted to hospitals their cognitive impairment is not considered in most of the cases. Some European and North American countries already have experience of implementing national plans about Alzheimer's disease and dementia. Read More

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Novel humanized mesothelin-expressing genetically engineered mouse models underscore challenges in delivery of complex therapeutics to pancreatic cancers.

Mol Cancer Ther 2021 Jul 26. Epub 2021 Jul 26.

Laboratory of Molecular Biology, NIH- National Cancer Institute Center for Cancer Research

Antibody-based therapies designed for human use frequently fail to cross-react with the murine isoform of their target. Due to this problem, pre-clinical studies of antibody-based mesothelin-targeted therapeutics in immune competent systems have been limited by the lack of suitable mouse models. Here, we describe two immune-competent humanized mesothelin transgenic mouse lines that can act as tolerant hosts for C57Bl/6-syngeneic cell lines expressing the human isoform of mesothelin. Read More

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Comparison of mass spectrometry data and bioinformatics predictions to assess the bona fide localization of proteins identified in cell wall proteomics studies.

Plant Sci 2021 Sep 18;310:110979. Epub 2021 Jun 18.

Laboratoire de Recherche en Sciences Végétales, Université de Toulouse, CNRS, UPS, Auzeville Tolosane, France. Electronic address:

Plant cell walls have complex architectures made of polysaccharides among which cellulose, hemicelluloses, pectins and cell wall proteins (CWPs). Some CWPs are anchored in the plasma membrane through a glycosylphosphatidylinositol (GPI)-anchor. The secretion pathway is the classical route to reach the extracellular space. Read More

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September 2021

Feasibility and acceptability of instructions of daily care in overweight and obese knee osteoarthritis participants.

Curr Rheumatol Rev 2021 Jul 26. Epub 2021 Jul 26.

Department of Physical Medicine and Rehabilitation, Mayo Hospital Lahore. Pakistan.

Introduction: Knee osteoarthritis (OA) is a weight-bearing joint disease and more common in the overweight and obese persons. The objective of the study was to assess the feasibility and acceptability of instructions of daily care (IDC) on pain, mobility and body mass index (BMI) among knee OA participants who are overweight or obese.

Material And Method: The study was an open-label randomized controlled trial of six-weeks. Read More

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Designing the biomethane production chain from urban wastes at the regional level: An application to the Rome Metropolitan Area.

J Environ Manage 2021 Jul 26;297:113328. Epub 2021 Jul 26.

Department of Computer, Control, and Management Engineering "Antonio Ruberti", Sapienza University of Rome, Rome, Italy.

This paper proposes a methodology to design the biomethane production chain from MSW at the regional level and to assess the environmental and economic performance of the chain. In the design phase, the following parameters are considered: number and production capacity of biomethane plants, localization of plants, waste flows among municipalities and plants. The model is adopted to design the biomethane chain in the Rome Metropolitan Area (Italy). Read More

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[Muscle Relaxant And Reversal Practices And Impact Of Reversal Modalities On Operating Room And Postoperative Room Duration - Results Of A Delphi Study].

Ann Pharm Fr 2021 Jul 24. Epub 2021 Jul 24.

Department of Anesthesia, Hospital Paris Saint Joseph, 185 Rue Raymond Losserand, 75014 Paris, France.

Objective: The objectives of this Delphi study are to describe muscle relaxant and reversal practices in France and to seek a consensus on the impact of the reversal method on the time spent in the OR and PACU.

Method: A two-round Delphi survey was conducted on a panel of French anesthetists involved in colectomies, hysterectomies or bariatric surgery. The questionnaire was designed in collaboration with a scientific committee and was intended to assess neuromuscular blockade reversal techniques and their impact on time spent in the OR and PACU. Read More

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Carbon myopia: the urgent need for integrated social, economic and environmental action in the livestock sector.

Glob Chang Biol 2021 Jul 27. Epub 2021 Jul 27.

Faculty of Veterinary and Agricultural Sciences, University of Melbourne, Parkville, Victoria, 3010, Australia.

Livestock have long been integral to food production systems, often not by choice but by need. While our knowledge of livestock greenhouse gas emissions (GHG) mitigation has evolved, the prevailing focus has been - somewhat myopically - on technology applications associated with mitigation. Here, we (1) examine the global distribution of livestock GHG emissions, (2) explore social, economic and environmental co-benefits and trade-offs associated with mitigation interventions, and (3) critique approaches for quantifying GHG emissions. Read More

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Beneficial Use of Dredged Sediment as a Sustainable Practice for Restoring Coastal Marsh Habitat.

Integr Environ Assess Manag 2021 Jul 27. Epub 2021 Jul 27.

US Army Corps of Engineers, New Orleans District, 7400 Leake Ave., New Orleans, LA, 70118, USA.

Coastal Louisiana (USA) continues to sustain immense land and habitat losses due to subsidence, sea-level rise, and storm events. Approximately 65 million cubic meters (85 million cubic yards) of sediment is dredged annually from Gulf coast Federal navigation channels to maintain safe waterway passage. The beneficial use of these sediments continues to increase and now this sediment is recognized as a critical resource in large-scale (estimated multi-billion dollar) ecosystem restoration efforts to mitigate land and habitat losses along the U. Read More

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Decision-support tools via mobile devices to improve quality of care in primary healthcare settings.

Cochrane Database Syst Rev 2021 Jul 27;7:CD012944. Epub 2021 Jul 27.

Norwegian Institute of Public Health, Oslo, Norway.

Background: The ubiquity of mobile devices has made it possible for clinical decision-support systems (CDSS) to become available to healthcare providers on handheld devices at the point-of-care, including in low- and middle-income countries. The use of CDSS by providers can potentially improve adherence to treatment protocols and patient outcomes. However, the evidence on the effect of the use of CDSS on mobile devices needs to be synthesized. Read More

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Face, Content, and Construct Validity of a Virtual Reality Otoscopy Simulator and Applicability to Medical Training.

Otolaryngol Head Neck Surg 2021 Jul 27:1945998211032897. Epub 2021 Jul 27.

Department of Otorhinolaryngology-Head and Neck Surgery, Medical Center-University of Hamburg, Hamburg, Germany.

Objective: Otologic diseases are common in all age groups and can significantly impair the function of this important sensory organ. To make a correct diagnosis, the correct handling of the otoscope and a correctly performed examination are essential. A virtual reality simulator could make it easier to teach this difficult-to-teach skill. Read More

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CHECK UP: A student-designed model for creating innovative patient education materials that your patients will actually use.

Int J Psychiatry Med 2021 Jul 27:912174211035214. Epub 2021 Jul 27.

Department of Family & Community Medicine, Medical College of Wisconsin, Milwaukee, WI, USA.

Objective: As appointments become more rushed, it is crucial that primary care clinicians consider new and effective ways to provide preventive health education to patients. Currently, patient education is often handouts printed from the electronic medical record system; however, these pieces of paper often do not have the desired impact. Well-established advertising methods reveal that repeated exposure is key in recall and swaying consumer decisions. Read More

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In-vitro Thrombogenicity Testing of Pulsatile Mechanical Circulatory Support Systems: Design and Proof-of-Concept.

Artif Organs 2021 Jul 27. Epub 2021 Jul 27.

Department of Cardiovascular Engineering, Institute of Applied Medical Engineering, Medical Faculty.

Objectives: Thrombogenic complications are a main issue in mechanical circulatory support (MCS). There is no validated in-vitro method available to quantitatively assess the thrombogenic performance of pulsatile MCS devices under realistic hemodynamic conditions. The aim of this study is to propose a method to evaluate the thrombogenic potential of new designs without the use of complex in-vivo trials. Read More

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Saffron for COVID-19-related cytokine storm: Hype or hope? A mini-review of current evidence.

Metabol Open 2021 Sep 21;11:100111. Epub 2021 Jul 21.

Laboratory of Chemistry, Department of Food Science and Human Nutrition, School of Food, Biotechnology and Development, Agricultural University of Athens, Athens, Greece.

Aim: To assess the potential role of saffron in downregulating inflammation and cytokine storm during COVID-19.

Main Findings: Three main compounds of saffron, i.e. Read More

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September 2021

Assessing exposure to Kilkari: a big data analysis of a large maternal mobile messaging service across 13 states in India.

BMJ Glob Health 2021 Jul;6(Suppl 5)

School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.

The Kilkari programme is being implemented by the Government of India in 13 states. Designed by BBC Media Action and scaled in collaboration with the Ministry of Health and Family Welfare from January 2016, Kilkari had provided mobile health information to over 10 million subscribers by the time BBC Media Action transitioned the service to the government in April 2019. Despite the reach of Kilkari in terms of the absolute number of subscribers, no longitudinal analysis of subscriber exposure to health information content over time has been conducted, which may underpin effectiveness and changes in health outcomes. Read More

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The effect of counting duration on quantitative fecal egg count test performance.

Vet Parasitol 2019 18;276S:100020. Epub 2019 Nov 18.

M.H. Gluck Equine Research Center, Department of Veterinary Science, University of Kentucky, 1400 Nicholasville Road, Lexington, KY 40546, USA. Electronic address:

Fecal egg counts are the primary diagnostic tools of equine parasitology and use of the McMaster test and its variants in clinical practice is widely recommended. Manual counting is, however, prone to various sources of human error. For example, in real-world situations analysts can be under significant pressure to process high numbers of samples in a limited time. Read More

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November 2019

Interprofessional clinical training based in a federally qualified health center: a short report.

J Interprof Care 2021 Jul 26:1-4. Epub 2021 Jul 26.

Comprehensive Care, Interprofessional Education, Arizona School of Dentistry & Oral Health, A.T. Still University, Kirksville, MO, USA.

A.T. Still University and HealthPoint, a federally qualified health center, worked together to develop novel interprofessional educational clinical experiences for dental and medical students. Read More

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Additively Manufactured Dental Crown with Color Gradient and Graded Structure: A Technique Report.

J Prosthodont 2021 Jul 23. Epub 2021 Jul 23.

College of Dentistry, Texas A&M University, Dallas, TX.

To assess the feasibility of manufacturing a dental crown with internal color gradient and graded structure design using additive manufacturing technology, a mandibular first molar was prepared and a monolayer dental crown with 1.5 mm uniform thickness was designed in a dental software (STL ). The monolayer (MOL) crown design was sliced into multiple layers of 0. Read More

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Stealth vaping among college students on four geographically distinct tobacco-free college campuses: prevalence and practices.

Nicotine Tob Res 2021 Jul 23. Epub 2021 Jul 23.

Department of Applied Health Science, School of Public Health, Indiana University, Bloomington, IN, USA.

Introduction: To offset tobacco use among college students, many universities have implemented tobacco-free campus policies. Given how easily e-cigarette users can discreetly vape in places where it is prohibited without being detected (i.e. Read More

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Cep63 knockout inhibits the malignant phenotypes of papillary thyroid cancer cell line TPC‑1.

Oncol Rep 2021 Sep 23;46(3). Epub 2021 Jul 23.

Department of Thyroid Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.

The present study was designed to observe the expression of the centrosomal protein 63 in papillary thyroid cancer (PTC) tissues and cells and to explore the clinical significance of Cep63 expression in PTC. Primary PTC tissues and matched normal thyroid tissues were collected, and the Cep63 expression level was determined by reverse transcription‑quantitative PCR and western blotting. A stable Cep63‑knockout cell line was constructed to assess the proliferation, invasion, migration and apoptosis abilities . Read More

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September 2021

Preoperative Osteoarthritic Grade Affects Forgotten Joint Status and Patient Acceptable Symptom State After Robotic Arm-Assisted Unicompartmental Knee Arthroplasty.

J Arthroplasty 2021 Jun 29. Epub 2021 Jun 29.

Department of Orthopaedic Surgery, Azienda Ospedaliero Universitaria di Modena, University of Modena and Reggio Emilia, Modena, Italy.

Background: This retrospective observational study was designed to investigate the association between radiographic Ahlbäck osteoarthritis (OA) grade and postoperative joint perception in a cohort of patients undergoing medial robotic arm-assisted unicompartmental knee arthroplasty (RA-UKA), using the Forgotten Joint Status and Patient Acceptable Symptom State (PASS) as outcomes.

Methods: Between January 2014 and May 2019, 660 patients (719 knees) underwent medial RA-UKA at 2 centers. Ahlbäck OA grade was measured on preoperative knee radiographs. Read More

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Burnout assessment at a college of pharmacy, college of optometry, and school of physician assistant studies.

Curr Pharm Teach Learn 2021 Aug 18;13(8):914-921. Epub 2021 Jun 18.

Department of Pharmacy Practice, Marshall B. Ketchum University College of Pharmacy, 2575 Yorba Linda Boulevard, Fullerton, California 92831, United States. Electronic address:

Introduction: There is limited research on burnout among students and faculty of health professions programs. This study was designed to assess burnout among students and faculty at a college of pharmacy (COP), college of optometry (COO), and school of physician assistant studies (SPAS).

Methods: The Professional Quality of Life Scale (ProQOL) was distributed to faculty and students at Marshall B Ketchum University (MBKU) COP, COO, and SPAS. Read More

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ABC-SPH risk score for in-hospital mortality in COVID-19 patients: development, external validation and comparison with other available scores.

Int J Infect Dis 2021 Jul 23. Epub 2021 Jul 23.

Infectious Diseases Physician, Hospital Eduardo de Menezes, R. Dr. Cristiano Rezende, 2213 - Bonsucesso, Belo Horizonte, Brazil. Electronic address:

Objectives: The majority of available scores to assess mortality risk of coronavirus disease 19 (COVID-19) patients in the emergency department have high risk of bias. Therefore, our aim was to develop and validate a score at hospital admission for predicting in-hospital mortality in COVID-19 patients, and to compare this score with other existing ones.

Methods: Consecutive patients (≥18 years) with confirmed COVID-19 admitted to the participating hospitals were included. Read More

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