294,670 results match your criteria design synthesis


Effectiveness of technology-assisted cardiac rehabilitation: A systematic review and meta-analysis.

Int J Nurs Stud 2021 Sep 5;124:104087. Epub 2021 Sep 5.

The Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR.

Objectives: The objectives of this review were to identify different technology-assisted interventions in cardiac rehabilitation, to explore and examine the effectiveness of technology-assisted cardiac rehabilitation.

Design: A systematic review and meta-analysis.

Methods: A systematic search was performed on six electronic databases: CINALH Complete, Cochrane Library, PubMed, MEDLINE via OvidSP, British Nursing Index and PsycINFO to identify randomised controlled trials from 2010 to 2020. Read More

View Article and Full-Text PDF
September 2021

Design, synthesis, and antiviral activity of phenylalanine derivatives as HIV-1 capsid inhibitors.

Bioorg Med Chem 2021 Sep 17;48:116414. Epub 2021 Sep 17.

Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Culture Road, 250012 Ji'nan, Shandong, PR China. Electronic address:

The HIV-1 Capsid (CA) is considered as a promising target for the development of potent antiviral drugs, due to its multiple roles during the viral life cycle. Herein, we report the design, synthesis, and antiviral activity evaluation of series of novel phenylalanine derivatives as HIV-1 CA protein inhibitors. Among them, 4-methoxy-N-methylaniline substituted phenylalanine (II-13c) and indolin-5-amine substituted phenylalanine (V-25i) displayed exceptional anti-HIV-1 activity with the EC value of 5. Read More

View Article and Full-Text PDF
September 2021

Dual targeting of acetylcholinesterase and tau aggregation: Design, synthesis and evaluation of multifunctional deoxyvasicinone analogues for Alzheimer's disease.

Bioorg Chem 2021 Sep 11;116:105354. Epub 2021 Sep 11.

Drug Design and Synthesis Laboratory, Department of Chemistry, Jamia Millia Islamia, New Delhi 110025, India. Electronic address:

Development of multitargeted ligands have demonstrated remarkable efficiency as potential therapeutics for Alzheimer's disease (AD). Herein, we reported a new series of deoxyvasicinone analogues as dual inhibitor of acetylcholinesterase (AChE) and tau aggregation that function as multitargeted ligands for AD. All the multitargeted ligands 11(a-j) and 15(a-g) were designed, synthesized, and validated by HNMR, CNMR and mass spectrometry. Read More

View Article and Full-Text PDF
September 2021

Discovery of 3,4-dichloro-N-(1H-indol-5-yl)benzamide: A highly potent, selective, and competitive hMAO-B inhibitor with high BBB permeability profile and neuroprotective action.

Bioorg Chem 2021 Sep 11;116:105352. Epub 2021 Sep 11.

Chemical Kinomics Research Center, Korea Institute of Science and Technology (KIST), Seoul 02792, Republic of Korea; Division of Bio-Medical Science & Technology, KIST School, University of Science and Technology, Seoul 02792, Republic of Korea. Electronic address:

Since there is no disease-modifying treatment discovered yet for Parkinson's disease (PD), there is still a vital need to develop novel selective monoamine oxidase B (MAO-B) inhibitors as promising therapeutically active candidates for PD patients. Herein, we report the design, synthesis, and full characterization of new twenty-six indole derivatives as potential human MAO-B (hMAO-B) selective inhibitors. Six compounds (2i, 3b-e, and 5) exhibited low micromolar to nanomolar inhibitory activities over hMAO-B; compared to our recently reported N-substituted indole-based lead compound VIII (hMAO-B IC = 777 nM), compound 5 (3,4-dichloro-N-(1H-indol-5-yl)benzamide) exhibited 18-fold increase in potency (IC = 42 nM). Read More

View Article and Full-Text PDF
September 2021

Synthesis of N-methylpyridine-chlorofuranformamide analogs as novel OPG up-regulators and inhibitors of RANKL-induced osteoclastogenesis.

Bioorg Chem 2021 Sep 15;116:105361. Epub 2021 Sep 15.

NHC Key Laboratory of Biotechnology of Antibiotics, National Center for Screening Novel Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), 1# Tiantan Xili, Beijing 100050, China. Electronic address:

The OPG/RANKL/RANK pathway is a promising target for the design of therapeutic agents used in the treatment of osteoporosis. E09241 with an N-methylpyridine-chlorofuranformamide structural skeleton was previously identified to decrease bone loss and thus protect against osteoporosis in ovariectomized rats through increasing osteoprotegerin (OPG) expression. In this study, 36 derivatives of E09241 (3a) were prepared. Read More

View Article and Full-Text PDF
September 2021

Rational design of biogenic PdAu nanoparticles with enhanced catalytic performance for electrocatalysis and azo dyes degradation.

Environ Res 2021 Sep 22:112086. Epub 2021 Sep 22.

Key Laboratory of Environmental Biotechnology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, 100085, China.

The green biogenic PdAu nanoparticles (bio-PdAu NPs) exhibits remarkable catalytic performance in hydrogenation, which is highly desired. However, the catalytic principles and effectiveness of bio-PdAu NPs in response to various catalytic systems (electrocatalysis and suspension-catalysis) are unclear. Herein, a facile synthetic strategy for bio-PdAu NPs synthesis with controlled size and the catalytic principles for hydrogen evolution reaction (HER) and azo dye degradation is reported. Read More

View Article and Full-Text PDF
September 2021

The standard of integrity may be useful when assessing arguments over qualitative review methods: The case of the Joanna Briggs Institute's rebuttal of a fundamental critique.

Nurs Inq 2021 Sep 25:e12465. Epub 2021 Sep 25.

Department of Plant Sciences, Division of Mathematical and Statistical Methods-Biometris, Wageningen University & Research, Wageningen, The Netherlands.

One challenge for those reading methodological debates in low consensus fields is determining the outcome when participants do not share standards. When parties to a debate do not agree on the standards to be used in assessing their arguments (i.e. Read More

View Article and Full-Text PDF
September 2021

ACE2 function in pancreatic islet: Implications for relationship between SARS-CoV-2 and diabetes.

Acta Physiol (Oxf) 2021 Sep 24:e13733. Epub 2021 Sep 24.

College of Health and Life Sciences, Hamad Bin Khalifa University (HBKU), Qatar Foundation, Education City, Doha, Qatar.

The molecular link between SARS-CoV-2 infection and susceptibility is not well understood. Nonetheless, a bi-directional relationship between SARS-CoV-2 and diabetes has been proposed. The angiotensin converting enzyme 2 (ACE2) is considered as the primary protein facilitating SARS-CoV and SARS-CoV-2 attachment and entry into the host cells. Read More

View Article and Full-Text PDF
September 2021

Controllable Synthesis of COFs-Based Multicomponent Nanocomposites from Core-Shell to Yolk-Shell and Hollow-Sphere Structure for Artificial Photosynthesis.

Adv Mater 2021 Sep 24:e2105002. Epub 2021 Sep 24.

School of Chemistry, South China Normal University, Guangzhou, 510006, China.

The precise tuning and multi-dimensional processing of covalent organic frameworks (COFs)-based materials into multicomponent superstructures with appropriate diversity are essential to maximize their advantages in catalytic reactions. However, up to now, it remains an ongoing challenge for the precise design of COFs-based multicomponent nanocomposites with diverse architectures. Herein, a metal organic framework (MOF)-sacrificed in situ acid-etching (MSISAE) strategy that enables continuous synthesis of core-shell, yolk-shell, and hollow-sphere COFs-based nanocomposites through tuning of core decomposition (NH -MIL-125 into TiO ) rate is developed. Read More

View Article and Full-Text PDF
September 2021

Is it safe to place implants in patients at risk of MRONJ?

Evid Based Dent 2021 Jan;22(3):108-109

Restorative Dentistry DCT3, Aberdeen Dental Hospital, Aberdeen, UK.

Data sources Four electronic databases, namely PubMed, Scopus, Web of Science and the Cochrane Central Register of Controlled Trials, were searched from their inception to 16 July 2019. The OpenGrey database was also used to identify unpublished studies.Study selection Eligible study designs included randomised controlled trials, cohort studies, case-control studies and case series with a retrospective, cross-sectional or prospective design related to implant placement in patients with a history of anti-angiogenic or antiresorptive medications. Read More

View Article and Full-Text PDF
January 2021

What are the implications of flap design on post-operative complications when carrying out third molar surgery?

Authors:
Sean Dolan Euan Rae

Evid Based Dent 2021 Jan;22(3):104-105

Post DCT Fellow, OMFS, Victoria Hospital, Kirkaldy, UK.

Data sources The review carried out electronic searches using several online databases through November 2018, namely PubMed, Virtual Health Library, Cochrane Library and Scopus. Terms searched for on these databases included third molar, flap and variations thereof. A grey literature search was also conducted. Read More

View Article and Full-Text PDF
January 2021

All-optical synthesis of an arbitrary linear transformation using diffractive surfaces.

Light Sci Appl 2021 Sep 24;10(1):196. Epub 2021 Sep 24.

Electrical and Computer Engineering Department, University of California, Los Angeles, CA, 90095, USA.

Spatially-engineered diffractive surfaces have emerged as a powerful framework to control light-matter interactions for statistical inference and the design of task-specific optical components. Here, we report the design of diffractive surfaces to all-optically perform arbitrary complex-valued linear transformations between an input (N) and output (N), where N and N represent the number of pixels at the input and output fields-of-view (FOVs), respectively. First, we consider a single diffractive surface and use a matrix pseudoinverse-based method to determine the complex-valued transmission coefficients of the diffractive features/neurons to all-optically perform a desired/target linear transformation. Read More

View Article and Full-Text PDF
September 2021

Assessment of time-related deficits in older adults: a scoping review protocol.

BMJ Open 2021 Sep 24;11(9):e050521. Epub 2021 Sep 24.

School of Health and Welfare, Dalarna University, Falun, Dalarna, Sweden

Introduction: People with cognitive impairments often have difficulties in managing their time for daily activities. In older adults with cognitive impairments such as dementia and stroke, these may present as disorientation, poor time awareness, time perception, daily time management and so on. Time-related deficits and associated behaviours impede independent living and add considerably to caregiver strain. Read More

View Article and Full-Text PDF
September 2021

Role of neutrophil-to-lymphocyte ratio as a prognostic biomarker in patients with breast cancer receiving neoadjuvant chemotherapy: a meta-analysis.

BMJ Open 2021 Sep 24;11(9):e047957. Epub 2021 Sep 24.

Division of Life Sciences and Medicine, The First Affiliated Hospital of USTC, Hefei, Anhui, China

Objective: The neutrophil-to-lymphocyte ratio (NLR) is recognised as a suitable prognostic biomarker in patients with breast cancer. Nevertheless, the efficacy of this biomarker in predicting the pathological complete response (pCR) and survival in patients with breast cancer receiving neoadjuvant chemotherapy (NACT) is still controversial. This meta-analysis aimed to identify the association between baseline NLR and the prognosis of patients with breast cancer treated with NACT. Read More

View Article and Full-Text PDF
September 2021

Barriers and facilitators of rendering HIV services by community health workers in sub-Saharan Africa: a meta-synthesis.

Fam Med Community Health 2021 Sep;9(4)

Faculty of Health Sciences, University of Pretoria, Johannesburg, Gauteng, South Africa.

Objectives: To synthesise qualitative studies that address the barriers to and facilitators of providing HIV services by community health workers (CHWs) in sub-Saharan Africa (SSA).

Design: This meta-synthesis was guided by Preferred Reporting Items for Systematic Reviews and Meta-Analyses. We included studies that were published between 2009 and 2019. Read More

View Article and Full-Text PDF
September 2021

A multifunctional, one-step gas foaming strategy for antimicrobial silver nanoparticle-decorated 3D cellulose nanofiber scaffolds.

Carbohydr Polym 2021 Dec 25;273:118603. Epub 2021 Aug 25.

Department of Bionanotechnology and Bioconvergence Engineering, Graduate School, Jeonbuk National University, Jeonju 54896, Republic of Korea; Division of Mechanical Design Engineering, Jeonbuk National University, Jeonju 54896, Republic of Korea. Electronic address:

Creating nanoparticle-decorated nanofibers in a single step can greatly speed up and scale up the production of scaffolds for various applications. In this study, we report a facile multifunctional method for the simultaneous foaming and synthesis of silver nanoparticles-covered three-dimensional cellulose using sodium borohydride (NaBH4). The physicochemical properties of the 3D cellulose-Ag scaffold were evaluated and compared to 2D CA membranes, including morphology (porous 3D vs flat 2D), mechanical properties (22. Read More

View Article and Full-Text PDF
December 2021

Rational enzyme design for controlled functionalization of acetylated xylan for cell-free polymer biosynthesis.

Carbohydr Polym 2021 Dec 19;273:118564. Epub 2021 Aug 19.

Complex Carbohydrate Research Center, University of Georgia, 315 Riverbend Road, Athens, GA 30602, USA; Department of Biochemistry and Molecular Biology, University of Georgia, 315 Riverbend Road, Athens, GA 30602, USA. Electronic address:

Xylan O-acetyltransferase 1 (XOAT1) is involved in O-acetylating the backbone of hemicellulose xylan. Recent structural analysis of XOAT1 showed two unequal lobes forming a cleft that is predicted to accommodate and position xylan acceptors into proximity with the catalytic triad. Here, we used docking and molecular dynamics simulations to investigate the optimal orientation of xylan in the binding cleft of XOAT1 and identify putative key residues (Gln445 and Arg444 on Minor lobe & Asn312, Met311 and Asp403 on Major lobe) involved in substrate interactions. Read More

View Article and Full-Text PDF
December 2021

Key elements and effects of cardiovascular disease management programs based on community-based participatory research: protocol for a scoping review.

Syst Rev 2021 Sep 24;10(1):256. Epub 2021 Sep 24.

Department of Nursing, Changwon National University, Gyeongnam, 51140, Republic of Korea.

Background: Cardiovascular diseases (CVDs) are health problems that demonstrate high death and prevalence rates, and exhibit large health inequalities across different socio-economic status. Although interest in community-based participatory research (CBPR) is increasing because of the efforts to improve health equity, not enough literature review has been conducted on CBPR-based CVD management programs. The objective of this scoping review is to identify the key elements that should be considered when developing CBPR-based CVD management programs, and explore the effects of CBPR-based CVD management programs. Read More

View Article and Full-Text PDF
September 2021

Factors that impact burnout and psychological wellbeing in Australian postgraduate medical trainees: a systematic review protocol.

Syst Rev 2021 Sep 24;10(1):257. Epub 2021 Sep 24.

University of Wollongong, Northfields Avenue, Wollongong, 2522, Australia.

Background: The stressful nature of medical training and other work-related factors put postgraduate medical trainees at high risk of burnout and poor psychological wellbeing. This has negative implications for patient care and the effectiveness of the healthcare system. The structure of the healthcare system and postgraduate medical education in Australia is different to that of other countries. Read More

View Article and Full-Text PDF
September 2021

AZD5438-PROTAC: A selective CDK2 degrader that protects against cisplatin- and noise-induced hearing loss.

Eur J Med Chem 2021 Sep 20;226:113849. Epub 2021 Sep 20.

Department of Biomedical Sciences, School of Medicine, Creighton University, Omaha, NE, 68178, USA. Electronic address:

Cyclin-dependent kinase 2 (CDK2) is a potential therapeutic target for the treatment of hearing loss and cancer. Previously, we identified AZD5438 and AT7519-7 as potent inhibitors of CDK2, however, they also targeted additional kinases, leading to unwanted toxicities. Proteolysis Targeting Chimeras (PROTACs) are a new promising class of small molecules that can effectively direct specific proteins to proteasomal degradation. Read More

View Article and Full-Text PDF
September 2021

Design, synthesis and evaluation of 2'-acetylene-7-deaza-adenosine phosphoamidate derivatives as anti-EV71 and anti-EV-D68 agents.

Eur J Med Chem 2021 Sep 17;226:113852. Epub 2021 Sep 17.

National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing, 100850, PR China. Electronic address:

A series of phosphoamidate derivatives of nucleoside 2'-acetylene-7-deaza-adenosine (NITD008) were synthesized and evaluated for their in vitro antiviral activities against the enteroviruses EV71 and EV-D68. The phosphoamidate (15f) containing a hexyl ester of l-alanine exhibited the most promising activity against EV71 (IC = 0.13 ± 0. Read More

View Article and Full-Text PDF
September 2021

A pre-specified analysis of the Dapagliflozin and Prevention of Adverse Outcomes in Chronic Kidney Disease (DAPA-CKD) randomized controlled trial on the incidence of abrupt declines in kidney function.

Kidney Int 2021 Sep 21. Epub 2021 Sep 21.

The George Institute for Global Health, Sydney, Australia; Department of Renal Medicine, University College London, London, UK.

This pre-specified analysis of DAPA-CKD assessed the impact of sodium-glucose cotransporter 2 inhibition on abrupt declines in kidney function in high risk patients based on having chronic kidney disease (CKD) and severe albuminuria. DAPA-CKD was a randomized, double-blind, placebo-controlled trial had a median follow-up of 2.4 years. Read More

View Article and Full-Text PDF
September 2021

The unexplored role of sedentary time and physical activity in glucose and lipid metabolism related placental mRNAs in obese pregnant women: The DALI Lifestyle Randomized Controlled Trial.

BJOG 2021 Sep 24. Epub 2021 Sep 24.

Institute of Human Movement Science, Sport and Health, University of Graz, Austria.

Objectives: To explore i) the association of sedentary time (ST) and physical activity (PA) during pregnancy with placental expression of genes related to glucose and lipid metabolism in obese pregnant women; ii) maternal metabolic factors mediating changes in these placental transcripts; and iii) cord blood markers related to these mRNAs mediating neonatal adiposity.

Study Design: Multicentre-randomized controlled trial.

Setting: Hospitals; 9-European countries. Read More

View Article and Full-Text PDF
September 2021

Polygenic Score for Physical Activity Is Associated with Multiple Common Diseases.

Med Sci Sports Exerc 2021 Sep 20. Epub 2021 Sep 20.

Gerontology Research Center, Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, FINLAND Institute for Molecular Medicine Finland, HiLIFE, Helsinki, FINLAND Department of Public Health, University of Helsinki, Helsinki, FINLAND, University of Helsinki Broad Institute of MIT & Harvard, Cambridge, MA Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, FINLAND.

Introduction: Genetic pleiotropy, in which the same genes affect two or more traits, may partially explain the frequently observed associations between high physical activity (PA) and later reduced morbidity or mortality. This study investigated associations between PA polygenic risk scores (PRSs) and cardiometabolic diseases among the Finnish population.

Methods: PRSs for device-measured overall PA were adapted to a FinnGen study cohort of 218,792 individuals with genome-wide genotyping and extensive digital longitudinal health register data. Read More

View Article and Full-Text PDF
September 2021

Gentle, Massage-like, Head Stroking Provokes Salivary Oxytocin Release.

Altern Ther Health Med 2021 Sep 24. Epub 2021 Sep 24.

Context: The evidence is growing that oxytocin (OXT), a hypothalamic hormone, can induce parturition and lactation, modulate affiliative behavior, and regulate stress and energy metabolism. Although the physiological effects of massage aren't fully understood, massage may affect OXT release and facilitate adaptive responses to stressors.

Objectives: This study intended to examine the effects of gentle, massage-like head, stroking to determine whether it could have a direct influence on the release of OXT. Read More

View Article and Full-Text PDF
September 2021

SDHC phaeochromocytoma and paraganglioma: A UK-wide case series.

Clin Endocrinol (Oxf) 2021 Sep 24. Epub 2021 Sep 24.

Department of Clinical Genetics, Birmingham Women's Hospital, Birmingham, UK.

Objective: Phaeochromocytomas and paragangliomas (PPGL) are rare, but strongly heritable tumours. Variants in succinate dehydrogenase (SDH) subunits are identified in approximately 25% of cases. However, clinical and genetic information of patients with SDHC variants are underreported. Read More

View Article and Full-Text PDF
September 2021

Caged Oxime Reactivators Designed for the Light Control of Acetylcholinesterase Reactivation.

Photochem Photobiol 2021 Sep 24. Epub 2021 Sep 24.

Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan Medical School, Ann Arbor, Michigan, 48109, United States of America.

Despite its promising role in the active control of biological functions by light, photocaging remains untested in acetylcholinesterase (AChE), a key enzyme in the cholinergic family. Here, we describe synthesis, photochemical properties, and biochemical activities of two caged oxime compounds applied in the photocontrolled reactivation of the AChE inactivated by reactive organophosphate. Each of these consists of a photocleavable coumarin cage tethered to a known oxime reactivator for AChE that belongs in an either 2-(hydroxyimino)acetamide or pyridiniumaldoxime class. Read More

View Article and Full-Text PDF
September 2021

Association of Sugar-sweetened Beverage Consumption with Prediabetes and Glucose Metabolism Markers in Hispanic/Latino Adults in the United States: Results from HCHS/SOL.

J Nutr 2021 Sep 24. Epub 2021 Sep 24.

Department of Medicine, Division of Endocrinology, Metabolims and Nutrition, Duke University School of Medicine, Durham NC.

Background: Diabetes mellitus and consumption of sugar-sweetened beverages is high in the Hispanic/Latino population in the United States. The associations between consumption of sugar-sweetened beverages, artificially sweetened beverages, and 100% fruit juice with prediabetes and glucose metabolism markers in the diverse Hispanic/Latino population in the US are unknown.

Objective: To examine the cross-sectional associations between consumption of sugar-sweetened beverages, artificially sweetened beverages, and 100% fruit juice with prediabetes and glucose metabolism markers such as fasting glucose and insulin, 2-hour oral glucose tolerance test (OGTT) glucose, HOMA index for insulin resistance (HOMA-IR), HOMA index for β-cell function (HOMA-B), and hemoglobin A1C (HbA1c) among US Hispanic/Latino adults. Read More

View Article and Full-Text PDF
September 2021

A framework to guide the implementation of lean management in emergency department.

J Health Organ Manag 2021 Sep;35(9):315-337

Department of Management and Engineering, University of Padova, Padova, Italy.

Purpose: The paper aims at enriching the knowledge of the application of lean management (LM) in emergency department (ED), structuring the methodology for implementing LM projects and summarizing the relevant dimensions of LM adoption in ED.

Design/methodology/approach: In accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, a systematic literature review has been performed, extracting a database of 34 papers. To answer the research purpose, a descriptive and content analyses have been carried out. Read More

View Article and Full-Text PDF
September 2021

Optimized Extraction and Characterization of Folates From Date Palm Fruits and Their Tracking During Fruits Wine Fermentation.

Front Nutr 2021 7;8:699555. Epub 2021 Sep 7.

Department of Food Science and Technology, Jinan University, Guangzhou, China.

Folates belong to the essential B vitamins group and participate in one-carbon metabolism. Date palm fruits ( L. family ) are consumed by millions of people and are good sources of folates. Read More

View Article and Full-Text PDF
September 2021