Med Sci Sports Exerc 2021 Sep 20. Epub 2021 Sep 20.
Gerontology Research Center, Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, FINLAND Institute for Molecular Medicine Finland, HiLIFE, Helsinki, FINLAND Department of Public Health, University of Helsinki, Helsinki, FINLAND, University of Helsinki Broad Institute of MIT & Harvard, Cambridge, MA Faculty of Sport and Health Sciences, University of Jyväskylä, Jyväskylä, FINLAND.
Introduction: Genetic pleiotropy, in which the same genes affect two or more traits, may partially explain the frequently observed associations between high physical activity (PA) and later reduced morbidity or mortality. This study investigated associations between PA polygenic risk scores (PRSs) and cardiometabolic diseases among the Finnish population.
Methods: PRSs for device-measured overall PA were adapted to a FinnGen study cohort of 218,792 individuals with genome-wide genotyping and extensive digital longitudinal health register data. Read More