4,569 results match your criteria deserve studies

Are Metropolitan Areas Primed for Success? A Prosperity Risk Index for Evaluating Economic Development Patterns.

Urban Plan 2020 29;5(3):323-337. Epub 2020 Sep 29.

Division of Public Health, Michigan State University, Flint, MI 48502, USA.

Urban areas differ greatly in their exposure to economic change, their trajectory toward recovery and growth, and the extent to which development and equity are paired. Some of this differentiation can be explained by regional dynamics, policies, and migration flows that influence the composition of economic activity, land use, and population characteristics. Simultaneously, the fortunes of center cities are known to often correlate with metropolitan characteristics, yet the interaction of socio-spatial conditions with multi-level governance and development processes-particularly with respect to how prosperity is shared across municipal lines and is distributed among communities-is under-researched. Read More

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September 2020

Systematic review: duodenogastroesophageal (biliary) reflux prevalence, symptoms, oesophageal lesions and treatment.

Aliment Pharmacol Ther 2021 Jul 27. Epub 2021 Jul 27.

Department of Chronic Diseases, Metabolism and Ageing (ChroMetA), Translational Research Center for Gastrointestinal Disorders (TARGID), Katholieke Universiteit Leuven, Leuven, Belgium.

Background: The prevalence of duodenogastroesophageal reflux (DGER) and its effect on symptoms and oesophageal lesions in gastroesophageal reflux disease (GERD) is unclear.

Aims: To conduct a systematic review to determine the prevalence of DGER among patients with GERD, the effect of DGER on symptoms and oesophageal lesions, and the treatment of DGER.

Methods: We searched Pubmed and MEDLINE for full text, English language articles until October 2020 that evaluated DGER prevalence among patients with GERD, the effect of DGER on symptoms and oesophageal lesions, and the treatment of DGER. Read More

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Association between multiple sleep dimensions and functional bowel disorders among Chinese college freshmen.

Sleep Med 2021 May 21. Epub 2021 May 21.

Division of Gastroenterology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 1277 Jiefang Avenue, 430022, Hubei Province, China. Electronic address:

Background: Although sleep disorder is thought as a risk factor for functional bowel disorders, its impact role in adolescents remains unknown and the contribution of different sleep dimensions may deserve further attention. This study aimed to evaluate the relationship between multiple sleep dimensions and functional bowel disorders among Chinese college freshmen.

Methods: A cross-sectional survey was conducted in college freshmen from Huazhong University of Science and Technology in Wuhan, China in September 2019 with random cluster sampling method. Read More

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Pre-graduation grade inflation in medical training in Turkey: a longitudinal study from 2005 to 2020.

Engin Karadag

BMC Med Educ 2021 Jul 22;21(1):395. Epub 2021 Jul 22.

Akdeniz University, Campus, 07070, Antalya, Turkey.

Background: Grade inflation which is known as the awarding of higher grades than students deserve in higher education has been observed since the 1960s. There is comprehensive evidence that document the allegations, prevalence, and severity of grade inflation in higher education in universities around the world for the past 10 years.

Methods: This study analyzes the change in the ratio of graduates with a "very good (>2. Read More

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Preventive behaviours and family inequalities during the COVID-19 pandemic: a cross-sectional study in China.

Infect Dis Poverty 2021 Jul 20;10(1):100. Epub 2021 Jul 20.

School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan, China.

Background: The coronavirus disease 2019 (COVID-19) pandemic is an international public health threat, and people's participation in disease-related preventive behaviours is the key to controlling infectious diseases. This study aimed to assess the differences in adopting preventive behaviours among populations to explore potential individual and household factors and inequalities within families.

Methods: This online survey was conducted in April 2020. Read More

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Long-term determinants of the seroprevalence of the bluetongue virus in deer species in southern Spain.

Res Vet Sci 2021 Jul 5;139:102-111. Epub 2021 Jul 5.

Instituto de Investigación en Recursos Cinegéticos (IREC) CSIC-UCLM-JCCM, 13071 Ciudad Real, Spain; Escuela Técnica Superior de Ingenieros Agrónomos, UCLM, 13071 Ciudad Real, Spain.

Bluetongue is a vector-borne disease affecting domestic and wild ruminants, with a major socioeconomic impact. Endemic circulation of the bluetongue virus serotype 4 (BTV-4) and BTV-1 have occurred in Spain since 2004 and 2007, respectively. However, epidemiological studies have seldom been approached from a long-term perspective in wild ruminants. Read More

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Brief comments on three existing approaches for managing neonates at risk of early-onset sepsis.

Ital J Pediatr 2021 Jul 18;47(1):159. Epub 2021 Jul 18.

Neonatal Intensive Care Unit, Department of Medical and Surgical Sciences of the Mothers, Children and Adults, University of Modena and Reggio Emilia, via del Pozzo 71, 41124, Modena, Italy.

Background: Growing concerns regarding the adverse effects of antibiotics during the first days of life and the marked reduction in the incidence of early-onset sepsis (EOS) are changing the clinical practice for managing neonates at risk of EOS. Strategies avoiding unnecessary antibiotics while promoting mother-infant bonding and breastfeeding deserve to be considered.

Main Body: We compare strategies for managing newborns at risk of EOS recommended by the American Academy of Pediatrics, which are among the most followed recommendations worldwide. Read More

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Correlation between targeted RNAseq signature of breast cancer CTCs and onset of bone-only metastases.

Br J Cancer 2021 Jul 16. Epub 2021 Jul 16.

Department of Biomedical Sciences and Human Oncology-Section of Internal Medicine and Clinical Oncology, University of Bari Aldo Moro, Bari, Italy.

Background: Bone is the most frequent site of metastases from breast cancer (BC), but no biomarkers are yet available to predict skeletal dissemination.

Methods: We attempted to identify a gene signature correlated with bone metastasis (BM) onset in circulating tumour cells (CTCs), isolated by a DEPArray-based protocol from 40 metastatic BC patients and grouped according to metastasis sites, namely "BM" (bone-only), "ES" (extra-skeletal) or BM + ES (bone + extra-skeletal).

Results: A 134-gene panel was first validated through targeted RNA sequencing (RNAseq) on sub-clones of the MDA-MB-231 BC cell line with variable organotropism, which successfully shaped their clustering. Read More

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Ethical issues in two parallel trials of personalised criteria for implantation of implantable cardioverter defibrillators for primary prevention: the PROFID project-a position paper.

Open Heart 2021 Jul;8(2)

Leipzig Heart Institute GmbH, Leipzig, Sachsen, Germany.

Aim: To discuss ethical issues related to a complex study (PROFID) involving the development of a new, partly artificial intelligence-based, prediction model to enable personalised decision-making about the implantation of an implantable cardioverter defibrillator (ICD) in postmyocardial infarction patients, and a parallel non-inferiority and superiority trial to test decision-making informed by that model.

Method: The position expressed in this paper is based on an analysis of the PROFID trials using concepts from high-profile publications in the ethical literature.

Results: We identify ethical issues related to the testing of the model in the treatment setting, and to both the superiority and the non-inferiority trial. Read More

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Validation of the FACIT-Sp-12 in a Dutch cohort of patients with advanced cancer.

Psychooncology 2021 Jul 13. Epub 2021 Jul 13.

Department of Religion, Health and Human Values, Rush University Medical Center, Chicago, Illinois, USA.

Objective: Although the Dutch Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being 12 Item Scale (FACIT-Sp-12) has been used in several Dutch studies, no study has assessed the measurement properties of the translation. The aim of this study was to perform an item-reduction analysis, confirmatory factor analysis (CFA), test of reliability, and test of convergent validity.

Methods: From the baseline data of a cohort study on experienced quality of care and quality of life (eQuiPe study), 400 advanced cancer patients without missing values on any of the variables were selected. Read More

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"Unheard minds, again and again": autistic insider perspectives and theory of mind.

Disabil Rehabil 2021 Jul 13:1-11. Epub 2021 Jul 13.

Department of Occupational Science and Occupational Therapy, University of Toronto, Toronto, Canada.

Purpose: The Theory of Mind (ToM) deficit hypothesis is a dominant construct used to explain the social and communication difficulties observed in autistic individuals. This hypothesis was based on an interpretation of autistic individuals' observable behavior, not based on insider accounts. Insider perspectives still remain mostly absent in research on ToM. Read More

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Diagnosis, biology and epidemiology of oligometastatic breast cancer.

Breast 2021 Jul 1;59:144-156. Epub 2021 Jul 1.

Institut Claudius Regaud (ICR), Institut Universitaire du Cancer de Toulouse-Oncopole (IUCT-O), Département d'Oncologie Médicale, Université de Toulouse, UPS, 1 av. Irène Joliot Curie, 31059, Toulouse Cedex 9, France.

Does oligometastatic breast cancer (OMBC) deserve a dedicated treatment? Although some authors recommend multidisciplinary management of OMBC with a curative intent, there is no evidence proving this strategy beneficial in the absence of a randomized trial. The existing literature sheds little light on OMBC. Incidence is unknown; data available are either obsolete or biased; there is no consensus on the definition of OMBC and metastatic sites, nor on necessary imaging techniques. Read More

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Examining the Components of Integrity.

Integr Psychol Behav Sci 2021 Jul 12. Epub 2021 Jul 12.

Accounting Research Institute, Universiti Teknologi MARA, 40450, Shah Alam, Malaysia.

The purpose of this paper is to understand the underlying components of integrity and examine its value. The approach is through identifying and expanding on the common values of integrity such as honesty, conscientiousness and principle. There is a need to find a common ground in the sense of giving specific values towards integrity. Read More

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Wheat Rhizosphere Metagenome Reveals Newfound Potential Soil Zn-Mobilizing Bacteria Contributing to Cultivars' Variation in Grain Zn Concentration.

Front Microbiol 2021 23;12:689855. Epub 2021 Jun 23.

State Key Laboratory of Crop Stress Biology in Arid Areas, Northwest A&F University, Yangling, China.

An effective solution to global human zinc (Zn) deficiency is Zn biofortification of staple food crops, which has been hindered by the low available Zn in calcareous soils worldwide. Many culturable soil microbes have been reported to increase Zn availability in the laboratory, while the status of these microbes in fields and whether there are unculturable Zn-mobilizing microbes remain unexplored. Here, we use the culture-independent metagenomic sequencing to investigate the rhizosphere microbiome of three high-Zn (HZn) and three low-Zn (LZn) wheat cultivars in a field experiment with calcareous soils. Read More

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Factors associated with childhood sexual abuse and adolescent pregnancy.

Child Abuse Negl 2021 Jul 7;120:105183. Epub 2021 Jul 7.

University of Vermont, School of Nursing, Burlington, VT, United States of America.

Background: People who experience childhood sexual abuse (CSA) have a higher rate of adolescent pregnancy than people who do not experience CSA. The purpose of this integrative review was to identify risk or protective factors that are associated with this group to help understand the high rate of adolescent pregnancy in people with CSA histories.

Methods: This review was conducted using strategies described by Whittemore and Knafl (2005). Read More

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Unveiling the role of exercise training in targeting the inflammatory paradigm of heart failure with preserved ejection fraction: a narrative review.

Heart Fail Rev 2021 Jul 10. Epub 2021 Jul 10.

Centre of Physical Activity, Health and Leisure (CIAFEL), Faculty of Sport, University of Porto, Porto, Portugal.

Heart failure with preserved ejection fraction (HFpEF) is currently lacking an effective pharmacological treatment with impact on major outcomes such as hospitalization and mortality. Exercise training (EXT) is recognized as an important nonpharmacological tool, capable of improving exercise capacity and quality of life, and has even been associated with a reduction in hospitalization and cardiovascular mortality risk. However, this positive impact largely lacks a physiological explanation. Read More

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In silico analysis of echinocandins binding to the main proteases of coronaviruses PEDV (3CL) and SARS-CoV-2 (M).

In Silico Pharmacol 2021 1;9(1):41. Epub 2021 Jul 1.

OncoWitan, 59290 Lille, Wasquehal France.

The porcine epidemic diarrhea virus (PEDV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are two highly pathogenic viruses causing tremendous damages to the swine and human populations, respectively. Vaccines are available to prevent contamination and to limit dissemination of these two coronaviruses, but efficient and widely affordable treatments are needed. Recently, four natural products targeting the 3C-like protease (3CL) of PEDV and inhibiting replication of the virus in vitro have been identified: tomatidine, epigallocatechin-3-gallate, buddlejasaponin IVb and pneumocandin B0. Read More

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Role of B Cells in Responses to Checkpoint Blockade Immunotherapy and Overall Survival of Cancer Patients.

Clin Cancer Res 2021 Jul 6. Epub 2021 Jul 6.

Department of Radiation Medicine and Applied Sciences, Moores Cancer Center, University of California, San Diego, California.

The role of B cells in the tumor microenvironment and B-cell-mediated antitumor immune responses remains relatively understudied. Recent seminal studies have discovered that B cells and associated tertiary lymphoid structures correlate with responses to checkpoint blockade immunotherapy and are prognostic for overall survival of cancer patients. B-cell subsets have remarkable functional diversity and include professional antigen-presenting cells, regulatory cells, memory populations, and antibody-producing plasma cells. Read More

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Difficulties encountered by public health workers in COVID-19 outbreak: a cross-sectional study based on five provinces.

BMC Health Serv Res 2021 Jul 5;21(1):656. Epub 2021 Jul 5.

School of Public Health, Global Health Institute, Key Laboratory of Tropical Disease Control, Sun Yat-sen University, 510080, Guangzhou, China.

Objectives: The aim of this study is to address the difficulties encountered by public health workers in the early and middle stages of their efforts to combat COVID-19, compare the gaps among different types of institutions, and identify shortcomings in epidemic control.

Methods: Using multi-stage sampling, a survey of public health workers involved in the prevention and control of COVID-19 was conducted from 18 February to 1 March 2020 through a self-administered questionnaire. These public health workers were from the primary health care center (defined as "primary-urban" and "primary-rural" for those in urban and rural areas, respectively) and the center for disease control and prevention (defined as "non-primary") in five provinces including Hubei, Guangdong, Sichuan, Jiangsu and Gansu, China. Read More

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Dispersion of Natural Airborne TiO Fibres in Excavation Activity as a Potential Environmental and Human Health Risk.

Int J Environ Res Public Health 2021 06 18;18(12). Epub 2021 Jun 18.

Department of Earth, Environment and Life Sciences, University of Genoa, 16132 Genoa, Italy.

Titanium is the ninth most abundant element, approximately 0.7% of the Earth crust. It is used worldwide in large quantities for various applications. Read More

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The Anti-Tumor Activity of the NEDD8 Inhibitor Pevonedistat in Neuroblastoma.

Int J Mol Sci 2021 Jun 18;22(12). Epub 2021 Jun 18.

Texas Children's Cancer and Hematology Centers, Department of Pediatrics, Section of Hematology and Oncology, Baylor College of Medicine, Houston, TX 77030, USA.

Pevonedistat is a neddylation inhibitor that blocks proteasomal degradation of cullin-RING ligase (CRL) proteins involved in the degradation of short-lived regulatory proteins, including those involved with cell-cycle regulation. We determined the sensitivity and mechanism of action of pevonedistat cytotoxicity in neuroblastoma. Pevonedistat cytotoxicity was assessed using cell viability assays and apoptosis. Read More

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Polysaccharides with Antitumor Effect in Breast Cancer: A Systematic Review of Non-Clinical Studies.

Nutrients 2021 Jun 10;13(6). Epub 2021 Jun 10.

Instituto de Pesquisa Pelé Pequeno Príncipe, Faculdades Pequeno Príncipe, Curitiba 80250-060, PR, Brazil.

To review the effects of polysaccharides and their proposed mechanisms of action in breast cancer experimental models. Articles were selected by using PubMed, ScienceDirect, Scopus, and Medline, assessed from 1 May 2019 to 1 July 2020. The systematic review was registered in the International Prospective Register of Systematic Reviews (Prospero) under the number CRD42020169103. Read More

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Phantom Phone Signal: why it should be of interest for psychiatry.

Riv Psichiatr 2021 May-Jun;56(3):138-142

Department of Translational Medical Sciences, Federico II University, Naples, Italy.

Phantom Phone Signal (PPS) refers to the false perception of a mobile phone ringing, vibrating and blinking, when in fact it did not. A recent literature about PPS is growing, parallel to an increasing interest about its possible psychopathological implications. The present review aims to synthesize the current knowledge about the phenomenon, and to present a conceptual framework that integrates PPS as a putative index of psychopathology. Read More

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Disorders of sex development and female reproductive capacity: A literature review.

Syst Biol Reprod Med 2021 Jul 1:1-14. Epub 2021 Jul 1.

Department of Anatomy and Physiology, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Victoria, Australia.

Disorders of sex development (DSD) are a wide-ranging group of complex conditions that influence chromosomal, gonadal, and phenotypic sex. The prevalence of DSD is very low, but affected patients deserve individualized management to improve psychological, sexual, and reproductive outcomes. This review aims to clarify the fertility potential of DSD patients who can be reared as females and their chance of becoming pregnant, especially using assisted reproductive techniques (ART). Read More

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Thanatechnology and the Living Dead: New Concepts in Digital Transformation and Human-Computer Interaction.

OMICS 2021 Jul 29;25(7):401-407. Epub 2021 Jun 29.

Department of Food Engineering, Faculty of Engineering, Gaziantep University, Gaziantep, Turkey.

In a digital society, shall we be the authors of our own experience, not only during our lifetime but also after we die? We ask this question because dying and bereavement have become even harder, and much less private, in the digital age. New big data-driven digital industries and technologies are on the rise, with promises of interactive 3D avatars and storage of digital memories of the deceased, so they can continue to exist online as the "living dead" in a digital afterlife. Famous rock and roll icons like Roy Orbison, Frank Zappa, Ronnie James Dio, and Amy Winehouse have famously been turned into holograms that can once again give "live" performances on the touring circuit, often pulling in large audiences. Read More

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Checklist of decapod crustaceans from the coast of the São Paulo state (Brazil) supported by integrative molecular and morphological data: IV. Infraorder Anomura: Superfamilies Chirostyloidea, Galatheoidea, Hippoidea and Paguroidea.

Zootaxa 2021 Apr 29;4965(3):558600. Epub 2021 Apr 29.

Laboratory of Carcinology, Zoology - Biological Science Graduate Program, Institute of Biosciences of Botucatu, São Paulo State University (UNESP), 18618-689, Botucatu (SP), Brazil.

This checklist is the fourth contribution resulting from a long-term multidisciplinary project which combined morphological analyses and molecular techniques (mitochondrial DNA markers) for accurate identification of marine and coastal decapod crustaceans of São Paulo State (Brazil). We provide a list of 63 species of the following 11 families of 4 superfamilies of Anomura: Albuneidae (4 spp.), Blepharipodidae (1 sp. Read More

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Upregulation of oxidative stress gene markers during SARS-COV-2 viral infection.

Free Radic Biol Med 2021 Jun 26;172:688-698. Epub 2021 Jun 26.

Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates; Prince Abdullah Ben Khaled Celiac Disease Research Chair, Department of Pediatrics, Faculty of Medicine, King Saud University, Saudi Arabia. Electronic address:

Severe viral infections, including SARS-COV-2, could trigger disruption of the balance between pro-oxidant and antioxidant mediators; the magnitude of which could reflect the severity of infection and lung injury. Using publicly available COVID-19 transcriptomic datasets, we conducted an in-silico analyses to evaluate the expression levels of 125 oxidative stress genes, including 37 pro-oxidant genes, 32 oxidative-responsive genes, and 56 antioxidant genes. Seven oxidative stress genes were found to be upregulated in whole blood and lung autopsies (MPO, S100A8, S100A9, SRXN1, GCLM, SESN2, and TXN); these genes were higher in severe versus non-severe COVID-19 leucocytes. Read More

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Assessing the Possible Influence of Residues of Ractopamine, a Livestock Feed Additive, in Meat on Alzheimer Disease.

Frank S Fan

Dement Geriatr Cogn Dis Extra 2021 May-Aug;11(2):110-113. Epub 2021 May 7.

Section of Hematology and Oncology, Department of Medicine, Ministry of Health and Welfare Taitung Hospital, Taitung, Taiwan.

The feed additive ractopamine, a β-adrenergic agonist, has been approved for use in livestock for nearly 2 decades. Studies of its possible adverse effects in humans have concentrated exclusively on cardiovascular disease and cardiovascular functional disorders in the past. In this article, whether and how ractopamine may affect neurodegeneration, either to promote or to reduce the incidence of Alz-heimer disease, will be discussed based on the recent controversial findings that β-adrenoreceptor activation not only can stimulate Alzheimer-pathogenic amyloid-β accumulation but also are able to enhance hippocampal neurogenesis and ameliorate mouse memory deficits in independent laboratory studies. Read More

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The effect of prenatal music therapy on fetal and neonatal status: A systematic review and meta-analysis.

Complement Ther Med 2021 Aug 24;60:102756. Epub 2021 Jun 24.

Department of Anesthesiology, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China. Electronic address:

Objectives: This study aims to investigate the effects of prenatal music therapy on fetal and neonatal status.

Design And Setting: A systematic review and meta-analysis of randomized controlled trials.

Interventions: Ovid MEDLINE, Embase, Web of Science, Cochrane Library, and Chinese Biomedical Literature Database were searched for studies investigating the effects of prenatal music therapy. Read More

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Three genes associated with anterior and posterior cruciate ligament injury : a genome-wide association analysis.

Bone Jt Open 2021 Jun;2(6):414-421

Orthopaedic Surgery, Stanford University School of Medicine, Stanford, California, USA.

Aims: The aim of this study was to screen the entire genome for genetic markers associated with risk for anterior cruciate ligament (ACL) and posterior cruciate ligament (PCL) injury.

Methods: Genome-wide association (GWA) analyses were performed using data from the Kaiser Permanente Research Board (KPRB) and the UK Biobank. ACL and PCL injury cases were identified based on electronic health records from KPRB and the UK Biobank. Read More

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