112,275 results match your criteria described years

A descriptive study of the surge response and outcomes of ICU patients with COVID-19 during first wave in Nordic countries.

Acta Anaesthesiol Scand 2021 Sep 27. Epub 2021 Sep 27.

Department of Anaesthesiology and Critical Care, Perioperative services, Landspitali - The National University Hospital of Iceland, Reykjavik, Iceland.

Background: We sought to provide a description of surge response strategies and characteristics, clinical management and outcomes of patients with severe COVID-19 in the intensive care unit (ICU) during the first wave of the pandemic in Denmark, Finland, Iceland, Norway and Sweden.

Methods: Representatives from the national ICU registries for each of the five countries provided clinical data and a description of the strategies to allocate ICU resources and increase the ICU capacity during the pandemic. All adult patients admitted to the ICU for COVID-19 disease during the first wave of COVID-19 were included. Read More

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September 2021

Development and validation of a one year predictive model for secondary fractures in osteoporosis.

PLoS One 2021 27;16(9):e0257246. Epub 2021 Sep 27.

Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America.

The number of osteoporosis-related fractures in the United States is no longer declining. Existing risk-based assessment tools focus on long-term risk. Payers and prescribers need additional tools to identify patients at risk for imminent fracture. Read More

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September 2021

Molecular profiling of pediatric and adolescent ependymomas: identification of genetic variants using a next-generation sequencing panel.

J Neurooncol 2021 Sep 27. Epub 2021 Sep 27.

Department of Pediatrics, Pediatric Oncology Institute-GRAACC, Federal University of Sao Paulo, Sao Paulo, SP, Brazil.

Purpose: Ependymoma (EPN) accounts for approximately 10% of all primary central nervous system (CNS) tumors in children and in most cases, chemotherapy is ineffective and treatment remains challenging. We investigated molecular alterations, with a potential prognostic marker and therapeutic target in EPNs of childhood and adolescence, using a next-generation sequencing (NGS) panel specific for pediatric neoplasms.

Methods: We selected 61 samples with initial diagnosis of EPN from patients treated at Pediatric Oncology Institute-GRAACC/UNIFESP. Read More

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September 2021

Risk factors in pediatric melanoma: a retrospective study of 39 cases.

Melanoma Res 2021 Sep 23. Epub 2021 Sep 23.

Department of Dermatology, University of Pisa Institute of Life Sciences, Scuola Superiore Sant'Anna Pediatric, Adolescent and Young Adults Surgery Division, Department of Surgical, Medical, Pathological, Molecular and Critical Area, University of Pisa, Pisa Department of Health Sciences, Anna Meyer Children's University Hospital, University of Florence, Florence Statistical Support to Clinical Trials Department, University of Pisa, Pisa Clinical Pathology Departmental Area, Services Department, Operative Union Of Pathological Anatomy, Livorno Hospital Melanoma and Skin Cancer Unit AVNO (Area Vasta Nord Ovest) and Unit of Dermatology, Specialist Surgery Area, Department Of General Surgery, Livorno Hospital, Livorno, Italy.

Pediatric melanoma is a rare form of the tumor whose epidemiology is widely increasing thanks to the improvement of dermoscopic and anatomopathologic diagnostic techniques. Although it is a tumor of considerable interest in adults, little has been described about the pediatric field. The objective of our study was then to identify the possible risk factors for the development of melanoma in the pediatric population. Read More

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September 2021

Chemical Biology Tools for Modulating and Visualizing Gram-Negative Bacterial Surface Polysaccharides.

ACS Chem Biol 2021 Sep 27. Epub 2021 Sep 27.

Department of Chemistry, New York University, New York, 10003 New York, United States.

Bacterial cells present a wide diversity of saccharides that decorate the cell surface and help mediate interactions with the environment. Many Gram-negative cells express O-antigens, which are long sugar polymers that makeup the distal portion of lipopolysaccharide (LPS) that constitutes the surface of the outer membrane. This review highlights chemical biology tools that have been developed in recent years to facilitate the modulation of O-antigen synthesis and composition, as well as related bacterial polysaccharide pathways, and the detection of unique glycan sequences. Read More

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September 2021

McCune-Albright syndrome, a rare form of precocious puberty: Diagnosis, treatment, and follow-up.

Arch Argent Pediatr 2021 Oct;119(5):e420-e427

Centro de Investigaciones Endocrinológicas "Dr. César Bergadá" (CEDIE).

Introduction: McCune-Albright syndrome (MAS) is a genetic disorder defined by fibrous dysplasia of bone, café-au-lait skin spots, and autonomous hyperfunction of one or more endocrine organs. MAS is caused by activating mutations of the GNAS1 gene. The most frequent type of endocrinopathy is gonadal endocrinopathy in the form of peripheral precocious puberty. Read More

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October 2021

Comorbidity increases the risk of invasive meningococcal disease in adults.

Clin Infect Dis 2021 Sep 27. Epub 2021 Sep 27.

Centre of Research and Disruption of Infectious Disease, Department of Infectious Diseases, Copenhagen University Hospital - Amager and Hvidovre, Hvidovre.

Background: Risk of invasive meningococcal disease (IMD) is increased in patients with complement deficiency and HIV infection. Risk associated with comorbidity is not well described.

Methods: Nationwide adult case-control study. Read More

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September 2021

Systematic Review on the Mid-Term Outcomes of Elective Endovascular Aneurysm Sealing in Comparison to Endovascular Aneurysm Repair.

J Endovasc Ther 2021 Sep 27:15266028211047941. Epub 2021 Sep 27.

Department of Surgery, Division of Vascular Surgery, Universitair Medisch Centrum Groningen, Groningen, The Netherlands.

Introduction: The Nellix endovascular aneurysm sealing (EVAS) system has been a topic of discussion. Early results were promising but did not deliver on the long-term and the device has been recalled from the market. This study compares literature for EVAS and conventional endovascular aneurysm repair (EVAR). Read More

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September 2021

Headache in progressive facial hemiatrophy (Parry-Romberg syndrome): A paradigmatic case and systematic review of the literature.

Cephalalgia 2021 Sep 26:3331024211043452. Epub 2021 Sep 26.

Pediatric Clinic, Maggiore Hospital, ASST Crema, Crema, Italy.

Background: Parry-Romberg syndrome is a neuro-cutaneous disease characterized by progressive hemifacial atrophy. Although common, headache in this population is scarcely reported in the literature.

Objective: To evaluate the clinical features of headache in pediatric and adult patients with Parry-Romberg syndrome, and to discuss diagnostic and treatment approaches of headache in Parry-Romberg syndrome. Read More

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September 2021

Health System-Level Evaluation of Tele-Mental Health Services Among Children and Adolescents in Ontario, Canada : Évaluation au niveau du système de santé des services de télésanté mentale chez les enfants et les adolescents de l'Ontario, Canada.

Can J Psychiatry 2021 Sep 27:7067437211043395. Epub 2021 Sep 27.

Department of Psychiatry, Faculty of Medicine, 7938University of Toronto, Toronto, Ontario.

Objective: To describe the characteristics of children and adolescents receiving tele-mental health services in Ontario, Canada and examine access to a psychiatrist, in-person or via tele-mental health services, following a mental health and addictions (MHA)-related emergency department (ED) visit or hospitalization.

Method: Using linked health and administrative data, we described two cohorts: (1) children and adolescents (1-18 years) who used a provincial tele-mental health programme from January 1, 2013 to March 31, 2017, comparing their MHA-related service use (outpatient, ED, hospitalization) in the 1 year prior to and the 1 year following initial consultation; (2) children and adolescents with high mental health service needs, defined as those with an incident MHA-related ED visit or hospitalization between January 1, 2013 and December 31, 2016, examining their 1-year follow-up with telemedicine and other health care utilization.

Results: In the first cohort, 7,216 children and adolescents (mean age 11. Read More

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September 2021

Weaning from cardiopulmonary bypass, decannulation, and closure.

Multimed Man Cardiothorac Surg 2021 Sep 13;2021. Epub 2021 Sep 13.

Department of Cardio-Thoracic Surgery Erasmus University Medical Center Rotterdam The Netherlands.

In 1952, John Gibbon performed the first successful cardiac procedure using cardiopulmonary bypass, which turned out to be one of the most important clinical advances of that year. Cardiopulmonary bypass has also been described as "One of the most impressive evidences of the role of investigative surgery in the history of medicine in the persevering efforts of Dr. Gibbon for more than 20 years, which finally culminated in a practical heart-lung machine," at the first John H. Read More

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September 2021

Cardiovascular Manifestations of COVID-19: Insights into a Single-Center Experience.

TH Open 2021 Jul 9;5(3):e329-e334. Epub 2021 Aug 9.

Department of Cardiology, Hospital and University Fribourg, Fribourg, Switzerland.

 Since December 2019, an emerging outbreak of novel coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2). The aim of the present report is to describe a population with elevated levels of high-sensitive cardiac troponin T (hs-cTnT) and report on their management during the pandemic of COVID-19.  In this retrospective cohort, we collected data from all patients with hs-cTnT levels of >50 ng/mL admitted to Fribourg Hospital between February 15, 2020, and April 15, 2020. Read More

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Plasticized magnetic starch-based FeO clay polymer nanocomposites for phosphate adsorption from aqueous solution.

Heliyon 2021 Sep 10;7(9):e07973. Epub 2021 Sep 10.

Center for Environmental Science, Addis Ababa University, P.O.Box 1176, Addis Ababa, Ethiopia.

Plastics contribute a magnificent role to modern civilization, but the waste becomes a huge burden to ecology and remains intact for a thousand years. Hence, the recent movement is shifted to biodegradable plastic. In this study, an attempt was made to introduce an added value to the environment where the bio-plasticized materials were used for phosphate removal. Read More

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September 2021

Dreaming during the COVID-19 lockdown: a comparison of Italian adolescents and adults.

Res Psychother 2021 Aug 12;24(2):536. Epub 2021 Aug 12.

Department of Humanities, University of Naples Federico II, Naples, Italy.

Based on the continuity hypothesis of dreaming, we have studied the effects of lockdown measures on Italian adolescents' and adults' dreams during the first wave of the coronavirus disease 2019 (COVID-19) pandemic. A sample of 475 subjects (73.9% women; 48. Read More

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Clinical Characteristics of Confirmed Cases of COVID-19 Admitted at Al Nahdha Hospital, Oman: A Cross-Sectional Descriptive Study.

Cureus 2021 Aug 21;13(8):e17343. Epub 2021 Aug 21.

Epidemiology and Public Health, Oman Ministry of Health, Directorate of Health Services, Muscat, OMN.

Background and objective Coronavirus disease 2019 (COVID-19) has become a public health emergency of international concern. Several characteristics of hospitalised cases, including variations in symptoms as well as radiological and laboratory findings, have been described. However, the exact clinical spectrum of hospitalised patients with COVID-19 in Oman is currently unclear. Read More

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Short-term patient-reported outcomes following concomitant hip arthroscopy and the endoscopic modified shelf procedure for the treatment of acetabular dysplasia and intra-articular pathology.

J Hip Preserv Surg 2021 Jan 19;8(1):105-118. Epub 2021 May 19.

American Hip Institute Research Foundation, 999 E Touhy Ave Des Plaines, Chicago, IL 60018, USA.

The shelf procedure is a treatment of acetabular dysplasia, with the aim of increasing weight-bearing acetabular coverage. Although several shelf techniques have been described, the endoscopic procedure with concomitant hip arthroscopy is a new, less invasive alternative. Outcomes following this procedure are scarce. Read More

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January 2021

A Decade of Research on Coffee as an Anticarcinogenic Beverage.

Oxid Med Cell Longev 2021 15;2021:4420479. Epub 2021 Sep 15.

Departamento de Química Biológica Ranwel Caputto, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba-CIQUIBIC, CONICET, Córdoba, Argentina.

Coffee consumption has been investigated as a protective factor against cancer. Coffee is a complex beverage that contains more than 1000 described phytochemicals, which are responsible for its pleasant taste, aroma, and health-promoting properties. Many of these compounds have a potential therapeutic effect due to their antioxidant, anti-inflammatory, antifibrotic, and anticancer properties. Read More

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September 2021

Community organization feedback about an undergraduate medical education service learning program Rétroaction d'un organisme communautaire sur apprentissage en milieu de travail d'un programme d'études médicales de premier cycle.

Can Med Educ J 2021 Sep 14;12(4):70-78. Epub 2021 Sep 14.

Department of Community Health Sciences, Rady Faculty of Health Sciences, University of Manitoba, Manitoba, Canada.

Background: In 2016, Service Learning (SL) became a curricular requirement for undergraduate medical education (UGME) students at the University of Manitoba. Students partner with a community-based organization for two years to engage in non-clinical activities in community settings. Significant feedback has been collected from students re: their SL experiences. Read More

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September 2021

Treatment of Tinnitus in Children-A Systematic Review.

Front Neurol 2021 10;12:726803. Epub 2021 Sep 10.

Department of Otorhinolaryngology, Head and Neck Surgery, University Medical Center Utrecht, Utrecht, Netherlands.

To systematically review studies on the effect of treatment of subjective tinnitus in children. We searched for studies in MEDLINE and EMBASE databases, after which additional studies were hand searched using Scopus databases. The methods are described in the study protocol, which has been registered in the PROSPERO register. Read More

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September 2021

Microbiome in Eosinophilic Esophagitis-Metagenomic, Metatranscriptomic, and Metabolomic Changes: A Systematic Review.

Front Physiol 2021 10;12:731034. Epub 2021 Sep 10.

Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.

Our understanding of human gut microbiota has expanded in recent years with the introduction of high-throughput sequencing methods. These technologies allow for the study of metagenomic, metatranscriptomic, and metabolomic bacterial alterations as they relate to human disease. Work in this area has described the human gut microbiome in both healthy individuals and those with chronic gastrointestinal diseases, such as eosinophilic esophagitis (EoE). Read More

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September 2021

A Pilot Study on Electrical Impedance Tomography During CPAP Trial in Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia: The Bright Side of Non-invasive Ventilation.

Front Physiol 2021 9;12:728243. Epub 2021 Sep 9.

Department of Anesthesia and Intensive Care, University of Foggia, Foggia, Italy.

Different severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia phenotypes were described that match with different lung compliance and level of oxygenation, thus requiring a personalized ventilator setting. The burden of so many patients and the lack of intensive care unit (ICU) beds often force physicians to choose non-invasive ventilation (NIV) as the first approach, even if no consent has still been reached to discriminate whether it is safer to choose straightforward intubation, paralysis, and protective ventilation. Under such conditions, electrical impedance tomography (EIT), a non-invasive bedside tool to monitor lung ventilation and perfusion defects, could be useful to assess the response of patients to NIV and choose rapidly the right ventilatory strategy. Read More

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September 2021

Neurodevelopmental Disorders (NDD) Caused by Genomic Alterations of the Ubiquitin-Proteasome System (UPS): the Possible Contribution of Immune Dysregulation to Disease Pathogenesis.

Front Mol Neurosci 2021 8;14:733012. Epub 2021 Sep 8.

Institute of Medical Biochemistry and Molecular Biology, University Medicine Greifswald, Greifswald, Germany.

Over thirty years have passed since the first description of ubiquitin-positive structures in the brain of patients suffering from Alzheimer's disease. Meanwhile, the intracellular accumulation of ubiquitin-modified insoluble protein aggregates has become an indisputable hallmark of neurodegeneration. However, the role of ubiquitin and a fortiori the ubiquitin-proteasome system (UPS) in the pathogenesis of neurodevelopmental disorders (NDD) is much less described. Read More

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September 2021

SLAM Project - Long Term Ecological Study of the Impacts of Climate Change in the natural forest of Azores: I - the spiders from native forests of Terceira and Pico Islands (2012-2019).

Biodivers Data J 2021 1;9:e69924. Epub 2021 Sep 1.

cE3c - Centre for Ecology, Evolution and Environmental Changes / Azorean Biodiversity Group and Universidade dos Açores, Rua Capitão João d'Ávila, São Pedro, 9700-042, Angra do Heroismo, Azores, Portugal cE3c - Centre for Ecology, Evolution and Environmental Changes / Azorean Biodiversity Group and Universidade dos Açores, Rua Capitão João d'Ávila, São Pedro, 9700-042 Angra do Heroismo, Azores Portugal.

Background: Long-term monitoring of invertebrate communities is needed to understand the impact of key biodiversity erosion drivers (e.g. habitat fragmentation and degradation, invasive species, pollution, climatic changes) on the biodiversity of these high diverse organisms. Read More

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September 2021

A Pilot Study to Compare Therapeutic Efficacy and Safety of Combined Treatment of Skin Microneedling and Depigmenting Cream versus Depigmenting Cream Alone in Facial Melasma at Tertiary Care Center.

J Cutan Aesthet Surg 2021 Apr-Jun;14(2):156-159

Department of Dermatology, Venereology, and Leprosy, Surat Municipal Institute of Medical Education and Research (SMIMER), Surat, Gujarat, India.

Background: Melasma is a commonly acquired, chronic, and relapsing disorder that results in symmetrical, brownish facial pigmentation. It is more common in women than in men, which generally starts between 20 and 40 years of age, and it can lead to considerable embarrassment and distress. Managing melasma is a difficult challenge that requires long-term treatment with a number of topical agents. Read More

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September 2021

High Accuracy Spectrophotometry at the National Physical Laboratory.

F J J Clarke

J Res Natl Bur Stand A Phys Chem 1972 Sep-Oct;76A(5):375-403

National Physical Laboratory, Teddington, Middlesex, UK.

The techniques and equipment used at the National Physical Laboratory (NPL) to achieve high accuracy spectrophotometric measurements are described and discussed. The emphasis at NPL has always been on the determination of systematic components of error and their elimination or correction rather than on the attainment of mere precision, which is largely a matter of variance and resolution. The scales of regular transmittance, diffuse transmittance, total transmittance of scattering samples, regular reflectance, diffuse reflectance, total reflectance and radiance factor are determined, maintained, and made available in practical form to industry by combined use of a reference NPL manual spectrophotometer and commercial recording spectrophotometers. Read More

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September 2021

[Effect of the guideline implementation "Risk assessment and prevention of pressure ulcers" of the Registered Nurses'Association of Ontario (RNAO).]

Rev Esp Salud Publica 2021 Sep 27;95. Epub 2021 Sep 27.

Departamento de Enfermería Universidad de Sevilla. Grupo de investigación CTS-1050 Cuidados Complejos, Cronicidad y Resultados en Salud adscrito al Instituto de Biomedicina de Sevilla (IBIS). Sevilla. España.

Objective: The Best Practice Spotlight Organizations Program is being developed in Spain to reduce the variability of clinical practice by implementing clinical practice guidelines from the Registered Nurses' Association of Ontario. This study described the results of the implementation of the guide "Risk assessment and prevention of pressure ulcers".

Methods: We carried out a retrospective observational study (2015-2018) at the Hospital Universitario Virgen de las Nieves on 4,464 patients from 22 hospitalization units, analyzing type of unit, risk assessment, preventive measures, origin and category of ulcers. Read More

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September 2021

Validation of a non-motor fluctuations questionnaire in Parkinson's disease.

Rev Neurol (Paris) 2021 Sep 24. Epub 2021 Sep 24.

Service de Neurologie et Pathologies du Mouvement, CHU Timone, APHM, Marseille, France. Electronic address:

Introduction: Non-motor fluctuations (NMF) in Parkinson's disease (PD) remain poorly recognized but have a high impact on patients' quality of life. The lack of assessment tools limits our understanding of NMF, compromising appropriate management. Our objective was to validate a hetero-questionnaire for NMF in PD patients at different stages of the disease: without treatment, without motor fluctuations, with motor fluctuations. Read More

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September 2021

Risk factors for local recurrence of early bilateral vocal cord carcinoma treated with transoral CO laser microsurgery.

Acta Otolaryngol 2021 Sep 26:1-5. Epub 2021 Sep 26.

Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China.

Background: The incidence of local recurrence after transoral CO laser microsurgery for T1b-T2 glottic carcinoma is relatively low. Multiple risk factors have been described for the development of local recurrence after treatment. However, to date, there is no analysis or systematic review investigating the relationships between clinical and histopathological factors and the appearance of local recurrence after transoral CO laser microsurgery in T1b-T2 glottic carcinoma patients. Read More

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September 2021

A newly described imaging finding for Idiopathic Normal Pressure Hydrocephalus: Can Hummingbird sign contribute to the diagnosis?

Turk J Med Sci 2021 Sep 27. Epub 2021 Sep 27.

Background/aim In this study, we aimed to evaluate whether morphological changes in the mesencephalon which were previously described as a diagnostic tool for progressive supranuclear palsy could be associated also with idiopathic normal pressure hydrocephalus. Materials and Methods Consecutive 52 patients with a possible diagnosis of idiopathic normal pressure hydrocephalus (32 female, mean age 73.6 years) and 40 controls (23 female, mean age 72. Read More

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September 2021

Trends and distribution of coronary heart disease mortality rate in Hexi Corridor, Gansu, China from 2006 to 2015.

Rev Cardiovasc Med 2021 Sep;22(3):1003-1008

Department of Cardiology, Gansu Provincial People's Hospital, 730000 Lanzhou, Gansu, China.

This study described the trend and distribution of coronary heart disease (CHD) in the Hexi Corridor region of Gansu. The CHD mortality rates from 2006-2015 were obtained through the Death Reporting System of Gansu Centers for Disease Control (CDC) for 2006-2015. The overall mortality rate of CHD in the Hexi Corridor showed a decreasing trend, increasing in winter and spring and lowest in summer. Read More

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September 2021