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Postoperative Rehabilitation Following Achilles Tendon Repair: A Systematic Review.

Sports Med Arthrosc Rev 2021 Jun;29(2):130-145

MedStar Union Memorial Hospital, Baltimore, MD.

The optimal postoperative management of Achilles tendon (AT) rupture remains unknown. The past 2 decades have witnessed a trend toward less rigid immobilization, earlier weightbearing, and accelerated functional rehabilitation postoperatively. The objective of this study was to identify all high-quality studies pertaining to rehabilitation after AT repair and characterize the various rehabilitation protocols that have been described. Read More

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Variability of extracorporeal cardiopulmonary resuscitation practice in patients with out-of-hospital cardiac arrest from the emergency department to intensive care unit in Japan.

Acute Med Surg 2021 Jan-Dec;8(1):e647. Epub 2021 May 1.

Department of Emergency and Critical Care Medicine Keio University School of Medicine Tokyo Japan.

Aim: A lack of known guidelines for the provision of extracorporeal cardiopulmonary resuscitation (ECPR) to patients with out-of-hospital cardiac arrest (OHCA) has led to variability in practice between hospitals even in the same country. Because variability in ECPR practice has not been completely examined, we aimed to describe the variability in ECPR practice in patients with OHCA from the emergency department (ED) to the intensive care units (ICU).

Methods: An anonymous online questionnaire to examine variability in ECPR practice was completed in January 2020 by 36 medical institutions who participated in the SAVE-J II study. Read More

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Winter melt trends portend widespread declines in snow water resources.

Nat Clim Chang 2021 5;2021. Epub 2021 Apr 5.

Institute of Arctic and Alpine Research, University of Colorado Boulder, CO.

In many mountainous regions, winter precipitation accumulates as snow that melts in spring and summer, providing water to one billion people globally. Climate warming and earlier snowmelt compromises this natural water storage. While snowpack trend analyses commonly focus on snow water equivalent (SWE), we propose that trends in accumulation season snowmelt serve as a critical indicator of hydrologic change. Read More

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Longitudinal study based on a safety registry for malaria patients treated with artenimol-piperaquine in six European countries.

Malar J 2021 May 8;20(1):214. Epub 2021 May 8.

TropNet, A European Network for Tropical and Travel Medicine, Verona, Italy.

Background: European travellers to endemic countries are at risk of malaria and may be affected by a different range of co-morbidities than natives of endemic regions. The safety profile, especially cardiac issues, of artenimol (previously dihydroartemisinin)-piperaquine (APQ) Eurartesim during treatment of uncomplicated imported falciparum malaria is not adequately described due to the lack of longitudinal studies in this population. The present study was conducted to partially fill this gap. Read More

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Safety and efficacy of autologous whole cell vaccines in hematologic malignancies: A systematic review and meta-analysis.

Hematol Oncol 2021 May 8. Epub 2021 May 8.

Cancer Therapeutics Program, The Ottawa Hospital Research Institute, Ottawa, ON, Canada.

Autologous cell vaccines use a patient's tumor cells to stimulate a broad antitumor response in vivo. This approach shows promise for treating hematologic cancers in early phase clinical trials, but overall safety and efficacy remain poorly described. We conducted a systematic review assessing the use of autologous cell vaccination in treating hematologic cancers. Read More

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Global burden of acute viral hepatitis and its association with socioeconomic development status, 1990-2019.

J Hepatol 2021 May 4. Epub 2021 May 4.

Department of Hepatology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China; Hepatology Research Institute, Fujian Medical University, Fuzhou, Fujian, China. Electronic address:

Background & Aims: Acute viral hepatitis (AVH) represents an important global health problem; however, the progress in understanding AVH is limited because of the priority of combating persistent hepatitis B (HBV) and C (HCV) virus infections. Therefore, an improved understanding of the burden of AVH is required to help design strategies for global intervention.

Methods: Data of four major AVH types, including acute hepatitis A (AHA), AHB, AHC, and AHE, excluding AHD, were collected by the Global Burden of Disease (GBD) 2019 database. Read More

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Metabolic tradeoffs control biodiversity gradients through geological time.

Curr Biol 2021 May 3. Epub 2021 May 3.

Department of Geological Sciences, Stanford University, Stanford, CA 94305, USA.

The latitudinal gradient of increasing marine biodiversity from the poles to the tropics is one of the most conspicuous biological patterns in modern oceans. Low-latitude regions of the global ocean are often hotspots of animal biodiversity, yet they are set to be most critically affected by anthropogenic climate change. As ocean temperatures rise and deoxygenation proceeds in the coming centuries, the volume of aerobically viable habitat is predicted to decrease in these zones. Read More

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Bibliography of published COVID-19 in children literature.

Arch Dis Child 2021 May 6. Epub 2021 May 6.

Department of Health Sciences, University of Leicester, Leicester, UK.

Background: The COVID-19 pandemic is the biggest worldwide health challenge in this century. Research concerning the role of children in the spread of SARS-CoV-2, and investigating the clinical effects of infection in children, has been vital. This paper describes the publication trend for pertinent scientific literature relating to COVID-19 in children during the first 6 months of the pandemic. Read More

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The Utility of a Novel Mapping Algorithm Utilizing Vectors and Global Pattern of Propagation for Scar-Related Atrial Tachycardias.

J Cardiovasc Electrophysiol 2021 May 5. Epub 2021 May 5.

Section of Cardiac Pacing and Electrophysiology, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH.

Background: Activation maps of scar-related atrial tachycardias (AT) can be challenging to interpret due to difficulty in inaccurate annotation of electrograms, and an arbitrarily predefined mapping window. A novel mapping software integrating vector data and applying an algorithmic solution taking into consideration global activation pattern has been recently described (Coherent™, Biosense Webster "Investigational").

Objective: We aimed to assess the investigational algorithm to determine the mechanism of AT compared with the standard algorithm. Read More

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Digital biomarkers and algorithms for detection of atrial fibrillation using surface electrocardiograms: A systematic review.

Comput Biol Med 2021 Apr 15;133:104404. Epub 2021 Apr 15.

Faculty of Electrical Engineering, Mathematics and Computer Science, Delft University of Technology, Delft, the Netherlands.

Aims: Automated detection of atrial fibrillation (AF) in continuous rhythm registrations is essential in order to prevent complications and optimize treatment of AF. Many algorithms have been developed to detect AF in surface electrocardiograms (ECGs) during the past few years. The aim of this systematic review is to gain more insight into these available classification methods by discussing previously used digital biomarkers and algorithms and make recommendations for future research. Read More

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Manipulation of CO adsorption over Me/CeO by heterocation doping: Key roles of single-atom adsorption energy.

J Chem Phys 2021 Apr;154(16):164705

Applied Chemistry, Waseda University, 3-4-1, Okubo, Shinjuku, Tokyo 169-8555, Japan.

The performance of metal atoms chemically bonded to oxide supports cannot be explained solely by the intrinsic properties of the metals such as the d-band center. Herein, we present an in-depth study of the correlation between metal-oxide interactions and the properties of the supported metal using CO adsorption on Me (Fe, Co, and Ni) loaded over CeO (111) doped with divalent (Ca, Sr, and Ba), trivalent (Al, Ga, Sc, Y, and La), and quadrivalent (Hf and Zr) heterocations. CO adsorption over Me is strongly dependent on the binding energies of Me. Read More

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Being a Myeloproliferative Patient in COVID-19 Era: The Mytico Study.

Front Oncol 2021 15;11:668261. Epub 2021 Apr 15.

Hematology Division and Bone Marrow Unit, San Gerardo Hospital, ASST Monza, Monza, Italy.

Introduction: The Coronavirus disease 2019 (COVID-19) pandemic and the resulting social distancing, determined a reduction in access to care and limitations of individual freedom, with a consequent strong impact on quality of life (QoL), anxiety levels and medical management of onco-hematological people. In particular, in the case of patients with chronic myeloproliferative neoplasm (MPN), concern about SARS-CoV-2 infection added to the burden of symptoms (BS) which already weights on the QoL of these patients. We designed a cross-sectional survey in order to investigate the impact of the COVID-19 pandemic on status of anxiety, BS and QoL in MPN patients. Read More

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Treatment Strategies for GLILD in Common Variable Immunodeficiency: A Systematic Review.

Front Immunol 2021 15;12:606099. Epub 2021 Apr 15.

Department of Pediatric Immunology and Rheumatology, Wilhelmina Children's Hospital, Utrecht, Netherlands.

Introduction: Besides recurrent infections, a proportion of patients with Common Variable Immunodeficiency Disorders (CVID) may suffer from immune dysregulation such as granulomatous-lymphocytic interstitial lung disease (GLILD). The optimal treatment of this complication is currently unknown. Experienced-based expert opinions have been produced, but a systematic review of published treatment studies is lacking. Read More

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Distribution of pathogens and antimicrobial resistance in bacteremia according to hospitalization duration: A nationwide surveillance study in Switzerland.

Clin Microbiol Infect 2021 Apr 29. Epub 2021 Apr 29.

Department of Infectious Diseases, Bern University Hospital and University of Bern, Switzerland; Infectious Diseases and Hospital Epidemiology, Hirslanden Central Switzerland, Lucerne, Switzerland.

Objectives: Changing microorganism distributions and decreasing antibiotic susceptibility with increasing length of hospital stay have been demonstrated for the colonization or infection of selected organ systems. We wanted to describe microorganism distribution or antibiotic resistance in bacteremia according to duration of the hospitalization using a large national epidemiological/microbiological database (ANRESIS) in Switzerland.

Methods: We conducted a nationwide, observational study on bacteremia using ANRESIS data from 1 January 2008 to 31 December 2017. Read More

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Dynamic changes and prevalence of SARS-CoV-2 IgG/IgM antibodies: multiple factors-based analysis.

Int J Infect Dis 2021 Apr 28. Epub 2021 Apr 28.

The First College of Clinical Medical Science, China Three Gorges University, Yichang, China; Yichang Central People's Hospital, China. Electronic address:

Objective: Investigating the dynamic characteristics of serologic antibodies against SARS-CoV-2 is of significance.

Method: Here, the dynamic changes and prevalence of IgM and IgG antibodies against SARS-CoV-2 from symptoms onset to 210 days were described. Antibodies were detected by a chemiluminescence immunoassay. Read More

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Deaths from hepatocellular carcinoma are more likely to occur in medical facilities than deaths from other cancers: 2003-2018.

Liver Int 2021 May 1. Epub 2021 May 1.

Department of Medicine, Division of Gastroenterology and Hepatology and Department of Preventive Medicine-Epidemiology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.

Place of death is a key indicator of quality of end-of-life care, and most people with a terminal diagnosis prefer to die at home. Home has surpassed the hospital as the most common location of all-cause and total cancer-related deaths in the United States. However, trends in place of death due to hepatocellular carcinoma (HCC), which is uniquely comanaged by hepatologists and oncologists, have not been described. Read More

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The metastasis suppressor protein NM23-H1 modulates the PI3K-AKT axis through interaction with the p110α catalytic subunit.

Oncogenesis 2021 Apr 30;10(4):34. Epub 2021 Apr 30.

Department of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine, Tumor Virology Program, Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA.

The PI3K pathway is one of the most deregulated pathways in cancer, which is predominantly due to gain of function mutations or altered expression of the PI3KCA gene. This is codified by what is seen for the class I PI3K catalytic subunit p110α, a common feature of many cancers. The metastasis suppressor protein NM23-H1 (NME1), whose ability to suppress the metastasis activities of different tumors has been widely described and was previously reported to alter phosphatidylinositol signaling. Read More

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Trends in the Mortality of Biliary Tract Cancers Based on Their Anatomical Site in the United States From 2009 to 2018.

Am J Gastroenterol 2021 May;116(5):1053-1062

Division of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, California, USA.

Introduction: Recent trends in the incidence and mortality of biliary tract cancers are unknown. We estimated the trends in biliary tract cancers-related incidence and mortality stratified by anatomical site, age, sex, and race/ethnicity in the US adults.

Methods: We performed a population-based trend analysis using the US national incidence (2009-2017) and mortality records (2009-2018). Read More

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Impact of China's zero mark-up drug policy on drug cost of NCDs' outpatients: an interrupted time series analysis.

BMC Health Serv Res 2021 Apr 29;21(1):404. Epub 2021 Apr 29.

School of Public Health and Management, Chongqing Medical University, Chongqing, China.

Background: China proposed the Zero Markup Drug Policy (ZMDP), which popularized in tertiary hospitals across the country in 2017, to control drug expenditures' rapid growth further and reduce the public's medical burden. This study aims to evaluate the impact of ZMDP on the drug cost of chronic disease outpatients in the tertiary hospital in Chongqing.

Methods: We collected and described the drug-cost data for outpatients with chronic diseases in a Chongqing's tertiary hospital from 2015 to 2019. Read More

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Enzyme Immobilization on Gold Nanoparticles for Electrochemical Glucose Biosensors.

Nanomaterials (Basel) 2021 Apr 28;11(5). Epub 2021 Apr 28.

Centre for Plasma and Laser Engineering, The Szewalski Institute of Fluid-Flow Machinery, Polish Academy of Sciences, Fiszera 14 St., 80-231 Gdańsk, Poland.

More than 50 years have passed since Clark and Lyon developed the concept of glucose biosensors. Extensive research about biosensors has been carried out up to this day, and an exponential trend in this topic can be observed. The scope of this review is to present various enzyme immobilization methods on gold nanoparticles used for glucose sensing over the past five years. Read More

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Liver Fibrosis and Steatosis in Alström Syndrome: A Genetic Model for Metabolic Syndrome.

Diagnostics (Basel) 2021 Apr 28;11(5). Epub 2021 Apr 28.

Internal Medicine 3, Department of Medicine, DIMED, University of Padua, 35128 Padua, Italy.

Alström syndrome (ALMS) is an ultra-rare monogenic disease characterized by insulin resistance, multi-organ fibrosis, obesity, type 2 diabetes mellitus (T2DM), and hypertriglyceridemia with high and early incidence of non-alcoholic fatty liver disease (NAFLD). We evaluated liver fibrosis quantifying liver stiffness (LS) by shear wave elastography (SWE) and steatosis using ultrasound sonographic (US) liver/kidney ratios (L/K) in 18 patients with ALMS and 25 controls, and analyzed the contribution of metabolic and genetic alterations in NAFLD progression. We also genetically characterized patients. Read More

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Fabrication of Submicrometer-Sized Meloxicam Particles Using Femtosecond Laser Ablation in Gas and Liquid Environments.

Nanomaterials (Basel) 2021 Apr 13;11(4). Epub 2021 Apr 13.

Department of Optics and Quantum Electronics, University of Szeged, Dóm tér 9, 6720 Szeged, Hungary.

In pharmaceutical development, more and more drugs are classified as poorly water-soluble or insoluble. Particle size reduction is a common way to fight this trend by improving dissolution rate, transport characteristics and bioavailability. Pulsed laser ablation is a ground-breaking technique of drug particle generation in the nano- and micrometer size range. Read More

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Supervised Learning Methods for Modeling Concrete Compressive Strength Prediction at High Temperature.

Materials (Basel) 2021 Apr 15;14(8). Epub 2021 Apr 15.

Department of Transportation Engineering, Pak-Austria Fachhochschule: Institute of Applied Sciences and Technology, Haripur 22620, Pakistan.

Supervised learning algorithms are a recent trend for the prediction of mechanical properties of concrete. This paper presents AdaBoost, random forest (RF), and decision tree (DT) models for predicting the compressive strength of concrete at high temperature, based on the experimental data of 207 tests. The cement content, water, fine and coarse aggregates, silica fume, nano silica, fly ash, super plasticizer, and temperature were used as inputs for the models' development. Read More

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Diversification of Morphological Features of the Dark European Honey Bee of the 'Augustow M' Line.

Animals (Basel) 2021 Apr 17;11(4). Epub 2021 Apr 17.

Owner of the Breeding Apiary Sawa, Helenowska 22/28, 05-804 Pruszkow, Poland.

The aim of this study was to investigate the diversification of morphological features of the Dark European honey bee of the Augustow M line. The authors studied the proboscis length and cubital index, as features determining the affiliation to the species; the width of tergite 4 and the sum of widths of tergites 3 + 4, as indicators of the bee body size; and the length and width of the right forewing. They compared bees sampled from (1) the "lead apiary", (2) "associate apiaries" and (3) "conservation area apiaries"-apiaries situated in the conservation area established by the national program for the conservation of genetic resources of this bee line. Read More

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When an obscurity becomes trend: social-media descriptions of tianeptine use and associated atypical drug use.

Am J Drug Alcohol Abuse 2021 Apr 28:1-12. Epub 2021 Apr 28.

National Institute on Drug Abuse Intramural Research Program, Translational Addiction Medicine Branch, Baltimore, MD, USA.

: Originally believed to be an atypical antidepressant acting at serotonin transporters, tianeptine is now known to also be an atypical agonist at mu-opioid receptors. Its nonmedical use may be increasing amidst the broader context of novel drug and supplement use.: To analyze social-media text from current, former, and prospective tianeptine users for better understanding of their conceptualizations of tianeptine, motives for and patterns of use, and reported benefits and harms. Read More

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Pachydrusen, choroidal vascular hyperpermeability, and punctate hyperfluorescent spots.

Graefes Arch Clin Exp Ophthalmol 2021 Apr 27. Epub 2021 Apr 27.

Department of Ophthalmology, Institute of Vision Research, Severance Eye Hospital, Yonsei University College of Medicine, 50-1 Yonse-iro, Seodaemun-gu, Seoul, Republic of Korea, 03722.

Purpose: To investigate the relationship between pachydrusen and features of choroidal vascular hyperpermeability (CVH) and punctate hyperfluorescent spots (PHS) on serial imaging in patients with polypoidal choroidal vasculopathy (PCV) or pachychoroid neovasculopathy (PNV).

Methods: Patients diagnosed between January 2007 and June 2016 at 2 high-volume, tertiary hospitals were retrospectively reviewed with serial multimodal imaging assessment. The primary outcome was the association between drusen subtypes (hard/soft drusen, subretinal drusenoid droplets, or pachydrusen) with CVH and PHS, previously described in central serous chorioretinopathy. Read More

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Post-vaccination SARS-CoV-2 infections and incidence of the B.1.427/B.1.429 variant among healthcare personnel at a northern California academic medical center.

medRxiv 2021 Apr 24. Epub 2021 Apr 24.

Background: Distribution of mRNA-based SARS-CoV-2 vaccines to healthcare personnel (HCP) in the United States began in December 2020, with efficacy > 90%. However, breakthrough infections in fully vaccinated individuals have been reported. Meanwhile, multiple SARS-CoV-2 variants of concern have emerged worldwide, including the B. Read More

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Social Media Data Analytics for Outbreak Risk Communication: Public Attention on the "New Normal" During the COVID-19 Pandemic in Indonesia.

Comput Methods Programs Biomed 2021 Apr 6;205:106083. Epub 2021 Apr 6.

Graduate Institute of Biomedical Informatics, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan; International Center for Health Information Technology (ICHIT), Taipei Medical University, Taipei, Taiwan; Research Center of Big Data and Meta-analysis, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan; Department of Dermatology, Wan Fang Hospital, Taipei, Taiwan; TMU Research Center of Cancer Translational Medicine, Taipei Medical University, Taiwan. Electronic address:

Background: After two months of implementing a partial lockdown, the Indonesian government had announced the "New Normal" policy to prevent a further economic crash in the country. This policy received many critics, as Indonesia still experiencing a fluctuated number of infected cases. Understanding public perception through effective risk communication can assist the government in relaying an appropriate message to improve people's compliance and to avoid further disease spread. Read More

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On-the-Fly Second Virial Coefficients.

J Phys Chem B 2021 May 27;125(17):4494-4500. Epub 2021 Apr 27.

Department of Chemical, Biomolecular, and Corrosion Engineering, The University of Akron, Akron, Ohio 44325-3906, United States.

A simple but approximate algorithm is described for computing second virial coefficients based on equilibrated molecular configurations that may be generated during any Monte Carlo or molecular dynamics simulation. The algorithm uses simple quadrature based on sampling every binary pair in the configuration and moving their center-center distances from zero to infinity. Comparisons are made in the literature results using more sophisticated sampling and integration for -alkanes of ethane through -dodecane. Read More

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[The dynamics of life-span of citizen of the Russian Federation: the sociological aspect].

Authors:
T V Fomicheva

Probl Sotsialnoi Gig Zdravookhranenniiai Istor Med 2021 Mar;29(2):260-264

Russian State Social University, 129226, Moscow, Russia,

The article considers the results of sociological study that was carried out to determine vector of dynamics of indices regulating duration of life of the Russian population, including the expected one. The method of secondary analysis of statistical and sociological information data was applied. Results. Read More

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