95,908 results match your criteria described literature

Combined Anterolateral and Anterior Cruciate Ligament Reconstruction Improves Pivot Shift Compared to Isolated Anterior Cruciate Ligament Reconstruction: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Arthroscopy 2021 Apr 14. Epub 2021 Apr 14.

Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL, USA.

Purpose: The purpose of the current study was to perform a systematic review and meta-analysis of the literature on anterolateral ligament (ALL) reconstruction as it related to techniques, biomechanical properties, and clinical outcomes.

Methods: PubMed, OVID/Medline, and Embase were queried in July 2020. Data pertaining to (1)techniques, (2)biomechanical properties, and (3)clinical outcomes of ALL reconstruction were recorded. Read More

View Article and Full-Text PDF

Three-Dimensional Bioprinting Scaffolding for Nasal Cartilage Defects: A Systematic Review.

Tissue Eng Regen Med 2021 Apr 17. Epub 2021 Apr 17.

Multidisciplinary 3D Printing Platform (3DPP), Biodonostia Health Research Institute, 20014, San Sebastian, Spain.

Background: In recent years, three-dimensional (3D)-printing of tissue-engineered cartilaginous scaffolds is intended to close the surgical gap and provide bio-printed tissue designed to fit the specific geometric and functional requirements of each cartilage defect, avoiding donor site morbidity and offering a personalizing therapy.

Methods: To investigate the role of 3D-bioprinting scaffolding for nasal cartilage defects repair a systematic review of the electronic databases for 3D-Bioprinting articles pertaining to nasal cartilage bio-modelling was performed. The primary focus was to investigate cellular source, type of scaffold utilization, biochemical evaluation, histological analysis, in-vitro study, in-vivo study, animal model used, length of research, and placement of experimental construct and translational investigation. Read More

View Article and Full-Text PDF

Isolation and characterization of neuroprotective lignans from salted Aconiti lateralis Radix Praeparata.

Biosci Biotechnol Biochem 2021 Apr 17. Epub 2021 Apr 17.

Key Laboratory of Modern Preparation of Traditional Chinese Medicine of Ministry of Education & Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine, 330004, Nanchang, Jiangxi, China.

Six lignans (1-6) were isolated from salted Aconiti lateralis Radix Praeparata for the first time. These isolates were elucidated as hedyotisol-A (1), (7"R,8"R)-8"-syringaresinol-4"-hydroxy-3",5"-dimethoxyphenyl-7",9"-propanediol (2), lariciresinol-4-O-β-D-glucopyranoside (3), (7S,8S)-4-hydroxy-3-methoxy-7,8-(2',1'-O-β-D-glucopyranosyl)phenyl-propanetriol (4), (+)-isolariciresinol (5), and (+)-lyoniresinol (6) by analyzing extensive and comprehensive spectral data and compared with the data described in the literature, respectively. Compounds (1-6) were evaluated for their neuroprotective activities against corticosterone-induced cell death in PC12 cells with desipramine as the positive control drug. Read More

View Article and Full-Text PDF

A scoping review of workplace wellness audit tools assessing physical activity and sedentary behavior.

Health Promot J Austr 2021 Apr 16. Epub 2021 Apr 16.

Knowledge Resource Service, Alberta Health Services, Tom Baker Cancer Centre, Canada.

Background: Regular physical inactivity and excessive sedentary behaviour are public and population health concerns. The workplace is an ideal health promotion intervention setting to support employees, particularly office workers. Workplace assessments are a critical component of workplace health promotion programming. Read More

View Article and Full-Text PDF

Safety and Efficacy of Ivermectin and Doxycycline Monotherapy and in Combination in the Treatment of COVID-19: A Scoping Review.

Drug Saf 2021 Apr 16. Epub 2021 Apr 16.

Department of Pediatrics, University of Kentucky, Lexington, KY, USA.

Introduction And Objective: Ivermectin (IVM) and doxycycline (DOXY) have demonstrated in-vitro activity against SARS-CoV-2, and have a reasonable safety profile. The objective of this systematic review was to explore the evidence in the literature on the safety and efficacy of their use as monotherapy and combination therapy in COVID-19 management.

Methods: After prospectively registering the study protocol with the Open Science Framework, we searched PubMed, Google Scholar, clinicaltrials. Read More

View Article and Full-Text PDF

Fully-automated synthesis of Lu labelled FAPI derivatives on the module modular lab-Eazy.

EJNMMI Radiopharm Chem 2021 Apr 16;6(1):16. Epub 2021 Apr 16.

Moltek A. S. Gebze Organize Sanayi, 41400 Gebze, Kocaeli, Turkey.

Background: To the best of our knowledge, manually production of [Lu]Lu-FAPI radiopharmaceutical derivatives has been only described in literature. In this work, a fully-automated [Lu]Lu-FAPI synthesis has been well designed for the first time using commercially available synthesis module. In addition to the development of an automated system with disposable cassette, quality control (QC) and stability studies were comprehensively presented. Read More

View Article and Full-Text PDF

Phylogenomic and morphological relationships among the botryllid ascidians (Subphylum Tunicata, Class Ascidiacea, Family Styelidae).

Sci Rep 2021 Apr 16;11(1):8351. Epub 2021 Apr 16.

Biology Department and Estuarine and Ocean Science Center, San Francisco State University, 3150 Paradise Drive, Tiburon, CA, 94920, USA.

Ascidians (Phylum Chordata, Class Ascidiacea) are a large group of invertebrates which occupy a central role in the ecology of marine benthic communities. Many ascidian species have become successfully introduced around the world via anthropogenic vectors. The botryllid ascidians (Order Stolidobranchia, Family Styelidae) are a group of 53 colonial species, several of which are widespread throughout temperate or tropical and subtropical waters. Read More

View Article and Full-Text PDF

The arthritis connection to inflammatory bowel disease (IBD): why has it taken so long to understand it?

RMD Open 2021 Apr;7(1)

Internal Medicine, Stanford University School of Medicine, Stanford, California, USA

Inflammatory bowel disease (IBD) associated arthritis is a subgroup of spondyloarthritis (SpA) that has suffered from lack of recognition in rheumatology clinical and research circles for over 100 years. Although clinically distinguishable from rheumatoid arthritis and ankylosing spondylitis, it took advances in detection systems in the middle of the last century (rheumatoid factor, HLA-B27) to convincingly make the final separations. We now know that significant numbers of patients with SpA have associated clinical IBD and almost half of them show subclinical gut inflammation, yet the connection between the gut and the musculoskeletal system has remained a vexing problem. Read More

View Article and Full-Text PDF

De Garengeot hernia: a rare case in an elderly woman and a review of operative approaches.

BMJ Case Rep 2021 Apr 16;14(4). Epub 2021 Apr 16.

Department of Surgery, Duchess of Kent Hospital, Sandakan, Malaysia.

De Garengeot hernia is a rare finding of the vermiform appendix inside a femoral hernia sac. We report this occurrence in a 73-year-old woman who presented in the acute setting. There are no standardised surgical approaches and many different techniques have been described in case reports in the literature. Read More

View Article and Full-Text PDF

Eyelid closing and opening disorders in patients with unilateral brain lesions: A case report with video neuroimage and a systematic review of the literature.

J Clin Neurosci 2021 May 12;87:69-73. Epub 2021 Mar 12.

Department of Neurosciences, Università Cattolica del Sacro Cuore, Rome, Italy.

Eyelid closing or opening disorders have been only sporadically described in patients with focal brain lesions over the last decades. Furthermore, the restricted number of reports and the lack of uniform clinical assessment of affected individuals did not allow to define more in depth the clinical features and the underlying neural correlates of these uncommon clinical disorders. Here we report an 89-years old woman with a right hemispheric lesion who showed a contralesional defect of eyelid closure. Read More

View Article and Full-Text PDF

Management of syringomyelia associated with tuberculous meningitis: A case report and systematic review of the literature.

J Clin Neurosci 2021 May 5;87:20-25. Epub 2021 Mar 5.

Division of Neurosciences Critical Care, Department of Neurology, Neurosurgery, Anesthesiology and Critical Care Medicine and Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States. Electronic address:

Determinants of tuberculosis (TB) syringomyelia, its management options and outcomes are still under investigation. The aim of this study is to present a case of TB syringomyelia with markedly improved symptoms status-post surgery and to understand the clinical characteristics and outcomes of 33 TB syringomyelia cases reported in the literature. Specifically, we examined the differences between patients who were managed medically and those who underwent surgical intervention. Read More

View Article and Full-Text PDF

A rare case of spontaneous otogenic pneumocephalus with pictorial illustration of temporal evolution.

J Clin Neurosci 2021 May 20;87:132-136. Epub 2021 Mar 20.

Department of Diagnostic Imaging, National University Hospital, National University Health System, Singapore. Electronic address:

Pneumocephalus is commonly seen on imaging in the setting of craniofacial trauma, skull base tumours, intracranial infection and after neurological intervention. Spontaneous pneumocephalus in the absence of these conditions is exceedingly rare, with only approximately 30 cases reported in the literature to date. Spontaneous otogenic pneumocephalus (SOP) is believed to occur as a result of anomalous communication between the intracranial space and a hyper-pneumatised temporal bone, with either positive extra-to-intracranial pressure or negative intracranial pressure gradient. Read More

View Article and Full-Text PDF

Fire in operating room: The adverse "never" event. Case report, mini-review and medico-legal considerations.

Leg Med (Tokyo) 2021 Apr 9;51:101879. Epub 2021 Apr 9.

Section of Legal Medicine, Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Italy.

The patient's security and safety represent a topic of great importance for public health that led several healthcare organizations in many Countries to share documents to promote risk management and preventing adverse events. Surgical Fire (SF) is an infrequent adverse event generally occurring in the operating room (OR) and consisting of a fire that occurs in, on, or around a patient undergoing a medical or surgical procedure. Here a medico-legal case involving a 65-year-old woman reporting burns to the neck due to an SF during a thyroidectomy was described. Read More

View Article and Full-Text PDF

A Case of Rapidly Progressive Upper Limb Ischemic Necrosis in a Patient with COVID-19.

Int J Infect Dis 2021 Apr 13. Epub 2021 Apr 13.

Departments of Keter B and Internal medicine E, Rabmbam health care campus, Haifa, Israel; Rappaort faculty of medicine, Technion, Israel institute of technology, Haifa, Israel. Electronic address:

Aim: For more than one year the health systems all over the world are combating the global Corona virus disease 2019 (COVID-19) pandemic, cased by a novel Corona virus (N-COV) which was first described in Wuhan city, China, presenting as an atypical infection of the lower respiratory tract.

Methods: COVID-19 is characterized by multisystemic involvement, and mortality is attributed mainly to the respiratory system involvement, which may lead to severe acute respiratory distress syndrome and respiratory failure. Several COVID-19 associated complications are being increasingly reported, among which arterial and venous thromboembolic events, that may lead to amputation of affected limbs. Read More

View Article and Full-Text PDF

The Utility of Chest CT imaging in suspected or diagnosed COVID-19 Patients - a review of literature.

Chest 2021 Apr 13. Epub 2021 Apr 13.

Lenox Hill Hospital, Pulmonary Medicine. Electronic address:

The COVID-19 pandemic has had devastating medical and economic consequences globally. The severity of COVID-19 is related, in a large measure, to the extent of pulmonary involvement. The role of chest CT in the management of patients with COVID-19 has evolved since the onset of the pandemic. Read More

View Article and Full-Text PDF

Magnetic Anisotropy in a Cubane-like Ni Complex: An Ab Initio Perspective.

Rémi Maurice

Inorg Chem 2021 Apr 16. Epub 2021 Apr 16.

SUBATECH, UMR CNRS 6457, IN2P3/IMT Atlantique/Université de Nantes, 4 rue A. Kastler, 44307 Nantes Cedex 3, France.

Magnetic anisotropy, in the absence of an external magnetic field, relates to the degeneracy lift of energy levels. In the standard case of transition metal complexes, this property is usually modeled by an anisotropic spin Hamiltonian and one speaks of "zero-field splitting" (ZFS) of spin states. While the case of mononuclear complexes has been extensively described by means of ab initio quantum mechanical calculations, the literature on polynuclear complexes studied with these methodologies is rather scarce. Read More

View Article and Full-Text PDF

Os acromiale : literature review and treatment options.

Acta Orthop Belg 2020 Dec;86(4):702-705

Os acromiale is due to a defect of fusion of the different ossification centers of the acromion. It is a common cause of shoulder pain that should be evoked in the differential diagnosis of the sub-acromial conflict. CT scan or magnetic resonance are therefore often helpful to confirm the diagnosis. Read More

View Article and Full-Text PDF
December 2020

[Recommendation for the recognition, management and follow up of cardiovascular compromise in patients with Pediatric Multisystemic Inflammatory Syndrome associated with COVID-19 (PIMS-CT). Position statement of Chilean Scientific Societies].

Rev Chil Pediatr 2020 Dec 8;91(6):982-990. Epub 2020 Oct 8.

Clínica Santa María, Santiago, Chile.

Since the onset of the SARS-CoV-2 pandemic, the pediatric population has been less affected by the disease both in frequency and severity. However, since April cases of variable presentation and severity characterized by inflammatory phenomena that affect multiple organs have been reported, a condition called Multisystem Inflammatory Syndrome in Children (MIS-C). The literature has reported frequent cardiac involvement, up to 80%. Read More

View Article and Full-Text PDF
December 2020

Developmental Functional Modules in Infant Vocalizations.

Ray D Kent

J Speech Lang Hear Res 2021 Apr 16:1-24. Epub 2021 Apr 16.

Department of Communication Sciences & Disorders, University of Wisconsin-Madison.

Purpose Developmental functional modules (DFMs) are biological modules that are defined by their structural (morphological), functional, or developmental elements, and, in some cases, all three of these. This review article considers the hypothesis that vocal development in the first year of life can be understood in large part with respect to DFMs that characterize the speech production system. Method Literature is reviewed on relevant embryology, orofacial reflexes, craniofacial muscle properties, stages of vocal development, and related topics to identity candidates for DFMs. Read More

View Article and Full-Text PDF

Effect of anticoagulant therapy in COVID-19 patients.

Neth Heart J 2021 Apr 16. Epub 2021 Apr 16.

Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands.

Background: In patients hospitalised with COVID-19, an increased incidence of thromboembolic events, such as pulmonary embolism, deep vein thrombosis and stroke, has been reported. It is unknown whether anticoagulation can prevent these complications and improve outcome.

Methods: A systematic literature search was performed to answer the question: What is the effect of (prophylactic and therapeutic dose) anticoagulation therapy in COVID-19 patients on cardiovascular and thromboembolic complications and clinical outcome? Relevant outcome measures were mortality (crucial), hospital admission, length of stay, thromboembolic complications (pulmonary embolism, stroke, transient ischaemic attack), need for mechanical ventilation, acute kidney injury and use of renal replacement therapy. Read More

View Article and Full-Text PDF

Making sense of senseless murders: The who, what, when, and where?

Behav Sci Law 2021 Apr 16. Epub 2021 Apr 16.

Royal Canadian Mounted Police, Burnaby, British Columbia, Canada.

The phenomenon of "senseless" or "motiveless" homicide refers to homicides that lack an objective external motivation. Despite the unique challenges these homicides pose to police, few empirical studies have been conducted on the topic and existing studies are limited to clinical studies using small samples. To overcome existing empirical shortcomings, the current study used a sample of 319 homicide cases where no motive was established during the investigation to describe the "who" (offender and victim characteristics), "what" (modus operandi, crime characteristics), "where" (encounter, crime, and body recovery associated locations), and "when" (time of the crime) of the entire criminal event. Read More

View Article and Full-Text PDF

The effects of ACE2 expression mediating pharmacotherapy in COVID-19 patients.

Neth Heart J 2021 Apr 16. Epub 2021 Apr 16.

Department of Experimental Cardiology, Amsterdam University Medical Center, Amsterdam, The Netherlands.

Background: There has been debate on the use of angiotensin-converting enzyme‑2 (ACE2) expression mediating pharmacotherapy in COVID-19 infected patients. Although it has been suggested that these drugs might lead to a higher susceptibility and severity of COVID-19 infection, experimental data suggest these agents may reduce acute lung injury via blocking angiotensin-II-mediated pulmonary permeability, inflammation and fibrosis.

Methods: A systematic literature search was performed to answer the question: What is the effect of medications that influence ACE2 expression (ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), nonsteroidal anti-inflammatory drugs (NSAIDs) and thiazolidinediones) on the outcomes of COVID-19? Relevant outcome measures were mortality (crucial), hospital admission, length of stay, thromboembolic complications (pulmonary embolism, stroke, transient ischaemic attack), need for mechanical ventilation, acute kidney injury and use of renal replacement therapy. Read More

View Article and Full-Text PDF

Radiologic evaluation of the fossa navicularis: incidence, morphometric features, and clinical implications.

Surg Radiol Anat 2021 Apr 16. Epub 2021 Apr 16.

Department of Dentomaxillofacial Radiology, Faculty of Dentistry, Gaziantep University, Gaziantep, Turkey.

Introduction: The aim of this study was to determine the incidence and morphometric and morphological characteristics of fossa navicularis (FN) on cone beam computed tomography (CBCT) images of healthy adults MATERIALS AND METHODS: CBCT images of 900 individuals (450 males, 450 females, over the age of 18) admitted to Gaziantep University, Dentistry Faculty were retrospectively examined. The incidence and shape of FN were determined. Transverse diameter (TDFN), sagittal diameter (SDFN), depth in transverse section (DFNT), depth in sagittal section (DFNS), and the shortest distance between the deepest point of FN and intracranial cavity (FNI) were measured. Read More

View Article and Full-Text PDF

What constitutes a palliative care need in people with serious illnesses across Africa? A mixed-methods systematic review of the concept and evidence.

Palliat Med 2021 Apr 16:2692163211008784. Epub 2021 Apr 16.

Cicely Saunders Institute of Palliative Care, Policy and Rehabilitation, Florence Nightingale Faculty of Nursing, Midwifery and Palliative Care, King's College London, London, UK.

Background: Clarity on what constitutes a palliative care need is essential to ensure that health systems and clinical services deliver an appropriate response within Universal Health Coverage.

Aim: To synthesise primary evidence from Africa for palliative care needs among patients and families with serious illness.

Design: We conducted a mixed methods systematic review with sequential synthesis design. Read More

View Article and Full-Text PDF

A prospective sonographic evaluation of peripheral intravenous catheter associated thrombophlebitis.

J Vasc Access 2021 Apr 16:11297298211009019. Epub 2021 Apr 16.

Beaumont Hospital, Royal Oak, MI, USA.

Objective: Thrombophlebitis associated with peripheral intravenous catheters (PIVCs) is a poorly described complication in the literature. Given limited accuracy of current assessment tools and poor documentation in the medical record, the true incidence and relevance of this complication is misrepresented. We aimed to identify risk factors in the development of thrombophlebitis using an objective methodology coupling serial diagnostic ultrasound and clinical assessment. Read More

View Article and Full-Text PDF

Pyruvate carboxylase deficiency type C as a differential diagnosis of diabetic ketoacidosis.

J Pediatr Endocrinol Metab 2021 Apr 15. Epub 2021 Apr 15.

Department of Pediatric Metabolism, Ankara University Faculty of Medicine, Ankara, Turkey.

Objectives: Type C pyruvate carboxylase (PC) deficiency is extremely rare, and has been described in only a few patients in literature to date. Herein, we present the case of a four-year-old patient admitted with diabetic ketoacidosis and diagnosed with type C PC deficiency based on clinical and biochemical findings.

Case Presentation: A Turkish girl was referred to the intensive care unit at the age of three-years with a three-day history of vomiting and abdominal pain. Read More

View Article and Full-Text PDF

Posterior cruciate ligament repair with suture tape augmentation: a case series with minimum 2-year follow-up.

J Exp Orthop 2021 Apr 15;8(1):28. Epub 2021 Apr 15.

University of Stirling, Stirling, UK.

Purpose: The posterior cruciate ligament (PCL) is an important stabilizer of the knee and can be damaged in up to 20% of ligamentous injuries. Numerous techniques for surgical treatment have been described in the literature with none shown to be clearly superior. The aim of this study was to assess the 2-year outcomes of PCL repair with suture tape augmentation. Read More

View Article and Full-Text PDF

Multimodal Analysis of the Tissue Response to a Bone-Anchored Hearing Implant: Presentation of a Two-Year Case Report of a Patient With Recurrent Pain, Inflammation, and Infection, Including a Systematic Literature Review.

Front Cell Infect Microbiol 2021 30;11:640899. Epub 2021 Mar 30.

Department of Biomaterials, Institute of Clinical Sciences, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Osseointegration is a well-established concept used in applications including the percutaneous Bone-Anchored Hearing System (BAHS) and auricular rehabilitation. To date, few retrieved implants have been described. A systematic review including cases where percutaneous bone-anchored implants inserted in the temporal bone were retrieved and analyzed was performed. Read More

View Article and Full-Text PDF

Neurological Manifestations of COVID-19 Within the Intensive Care Unit During a Military Deployment for the Early Pandemic Surge in New York City.

Cureus 2021 Mar 12;13(3):e13858. Epub 2021 Mar 12.

Plastic and Reconstructive Surgery, Massachusetts General Hospital, Boston, USA.

Coronavirus disease 2019 (COVID-19) resulted in a worldwide pandemic that at the time of this writing has caused over 400,000 deaths within the United States. During the pandemic surge in New York City, NY, a number of military Medical Corps (MC) and Nurse Corps (NC) providers were mobilized in direct support of critical care capabilities through expansion intensive care units. In the course of the deployment, high rates of neurological-related manifestations associated with COVID-19 infection were directly observed by our military provider teams which will be described and supporting literature highlighted. Read More

View Article and Full-Text PDF

Consistency in Motion Event Encoding Across Languages.

Front Psychol 2021 30;12:625153. Epub 2021 Mar 30.

Department of Linguistics, Stockholm University, Stockholm, Sweden.

Syntactic templates serve as schemas, allowing speakers to describe complex events in a systematic fashion. Motion events have long served as a prime example of how different languages favor different syntactic frames, in turn biasing their speakers toward different event conceptualizations. However, there is also variability in how motion events are syntactically framed within languages. Read More

View Article and Full-Text PDF