Biosci Biotechnol Biochem 2021 Apr 17. Epub 2021 Apr 17.
Key Laboratory of Modern Preparation of Traditional Chinese Medicine of Ministry of Education & Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine, 330004, Nanchang, Jiangxi, China.
Six lignans (1-6) were isolated from salted Aconiti lateralis Radix Praeparata for the first time. These isolates were elucidated as hedyotisol-A (1), (7"R,8"R)-8"-syringaresinol-4"-hydroxy-3",5"-dimethoxyphenyl-7",9"-propanediol (2), lariciresinol-4-O-β-D-glucopyranoside (3), (7S,8S)-4-hydroxy-3-methoxy-7,8-(2',1'-O-β-D-glucopyranosyl)phenyl-propanetriol (4), (+)-isolariciresinol (5), and (+)-lyoniresinol (6) by analyzing extensive and comprehensive spectral data and compared with the data described in the literature, respectively. Compounds (1-6) were evaluated for their neuroprotective activities against corticosterone-induced cell death in PC12 cells with desipramine as the positive control drug. Read More