2,670 results match your criteria des costs

[Pre-hospital red blood cells transfusions : Logistical aspects].

Rev Med Suisse 2021 Sep;17(751):1619-1623

Service d'anesthésiologie, Département de médecine aiguë, HUG, 1211 Genève 14.

Pre-hospital red blood cell transfusion is already used in many countries, both in military and civilian settings, and provides a better chance of survival for patients suffering from massive bleeding. However, this is not a current practice in Switzerland. This article aims to study Swiss specificities and provide a turnkey concept for the implementation of red blood cell transfusion in an emergency pre-hospital setting, by road or by air. Read More

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September 2021

[Molecular diagnostics of bladder cancer-practical ramifications].

Urologe A 2021 Sep 22. Epub 2021 Sep 22.

Institut für Pathologie, Uniklinik RWTH Aachen, Aachen, Deutschland.

In the future, precision medicine with agents targeting specific genetic alterations will play an important role in bladder cancer. This includes both single genetic alterations (e.g. Read More

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September 2021

In-house 3D Model Printing for Acute Cranio-maxillo-facial Trauma Surgery: Process, Time, and Costs.

Plast Reconstr Surg Glob Open 2021 Sep 17;9(9):e3804. Epub 2021 Sep 17.

École des sciences de l'administration, Université TÉLUQ, Québec, Québec, Canada.

Three-dimensional (3D) printing is used extensively in cranio-maxillo-facial (CMF) surgery, but its usage is limited in the setting of acute trauma specifically, as delays in outsourcing are too great. Therefore, we developed an in-house printing solution. The purpose of this study was to describe this process for surgeons treating acute CMF trauma. Read More

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September 2021

Targeted strategies for the management of wildlife diseases: the case of brucellosis in Alpine ibex.

Vet Res 2021 Sep 14;52(1):116. Epub 2021 Sep 14.

Laboratoire de Biométrie et Biologie Évolutive UMR 5558, CNRS, VetAgro Sup, Université de Lyon, Villeurbanne, France.

The management of infectious diseases in wildlife reservoirs is challenging and faces several limitations. However, detailed knowledge of host-pathogen systems often reveal heterogeneity among the hosts' contribution to transmission. Management strategies targeting specific classes of individuals and/or areas, having a particular role in transmission, could be more effective and more acceptable than population-wide interventions. Read More

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September 2021

Essential oils as alternative promising anti-Candidal agents: progress and prospects.

Curr Pharm Des 2021 Sep 14. Epub 2021 Sep 14.

Amity Institute of Biotechnology, Amity University Haryana, Manesar, Gurugram- 122413. India.

Candida albicans is one of the main agents responsible for opportunistic pathogenic infections. The progressive emergence of fungal resistance to conventional antibiotics and its side effects as well as treatment costs are considered as major limitations for antifungal drugs. It has drawn scientists' attention to search for potential substitution and therapeutic reliable alternatives for the antifungal compounds from sources like medicinal plants, which contain numerous bioactive compounds such as essential oils. Read More

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September 2021

[Impact de la pandémie de COVID-19 sur la charge des patients atteints d'insuffisance cardiaque chronique en France].

Ann Cardiol Angeiol (Paris) 2021 Jul 9. Epub 2021 Jul 9.

Univ. Lille, Service de CHU Lille, Institut Pasteur de Lille, Inserm U1167, F-59000 Lille, France; CHU Lille, Service de Cardiologie, F-59000 Lille, France; Inserm U1167, Institut Pasteur de Lille, F-59000 Lille, France.

Context: The COVID-19 pandemic in France has led to the implementation of containment measures, limiting medical activity to urgent care. Heart Failure (HF) patients should have particularly been concerned. During the pandemic, movement restrictions and fear of contamination could have worsened HF patients. Read More

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A randomized EPIREMED protocol study on the long-term visuo spatial effects of very preterm children with a working memory deficit.

BMC Pediatr 2021 Sep 13;21(1):402. Epub 2021 Sep 13.

CEReSS - Health Service Research and Quality of Life Center, Faculty of Medicine, Aix-Marseille University, 27 Bd Jean Moulin, 13385, Marseille, cedex 05, France.

Background: Very preterm children generally perform poorly in executive functions and particularly in working memory. Adaptive training tasks encouraging these children to work continuously on their personal working memory capacity can be very useful. Above all in preschool-age children, several cognitive training programs focused on improving working memory capacity. Read More

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September 2021

Cost of off-label antibiotic therapy for bone and joint infections: a 6-year prospective monocentric observational cohort study in a referral centre for management of complex osteo-articular infections.

J Bone Jt Infect 2021 7;6(8):337-346. Epub 2021 Sep 7.

Infectious Diseases Department, Croix-Rousse Hospital, Hospices Civils de Lyon, 69004 Lyon, France.

: Costs related to bone and joint infection (BJI) management are increasing worldwide, particularly due to the growing use of off-label antibiotics that are expensive treatments (ETs), in conjunction with increasing incidence of multi-drug-resistant pathogens. The aim of this study was to evaluate the whole costs related to these treatments during the patient route, including those attributed to the rehabilitation centre (RC) stay in one regional referral centre in France. The total annual cost of ETs for managing complex BJIs in France was then estimated. Read More

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September 2021

Water deprivation compromises maternal physiology and reproductive success in a cold and wet adapted snake .

Conserv Physiol 2021 3;9(1):coab071. Epub 2021 Sep 3.

Centre d'Études Biologiques de Chizé CNRS, UMR 7372, 79360 Villiers en Bois, France.

Droughts are becoming more intense and frequent with climate change. These extreme weather events can lead to mass mortality and reproduction failure, and therefore cause population declines. Understanding how the reproductive physiology of organisms is affected by water shortages will help clarify whether females can adjust their reproductive strategy to dry conditions or may fail to reproduce and survive. Read More

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September 2021

Analysis of ingestion admissions in a midsized pediatric intensive care unit.

J Public Health (Oxf) 2021 Sep 8. Epub 2021 Sep 8.

Blank Children's Hospital Pediatric Residency Program, Des Moines, IA 50309, USA.

Background: Pediatric ingestion of toxic substances is a complicated cause of morbidity. Currently, there is limited literature on toxic ingestions resulting in pediatric intensive care unit (PICU) admissions.

Methods: A retrospective study was conducted to quantify the number and financial costs of admissions for toxic ingestion. Read More

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September 2021

Assessment of fitness and vector competence of a New Caledonia wMel Aedes aegypti strain before field-release.

PLoS Negl Trop Dis 2021 Sep 7;15(9):e0009752. Epub 2021 Sep 7.

World Mosquito Program, Institut Pasteur of New Caledonia, Noumea, New Caledonia.

Background: Biological control programs involving Wolbachia-infected Aedes aegypti are currently deployed in different epidemiological settings. New Caledonia (NC) is an ideal location for the implementation and evaluation of such a strategy as the only proven vector for dengue virus (DENV) is Ae. aegypti and dengue outbreaks frequency and severity are increasing. Read More

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September 2021

Stochastic Assessment of the Economic Impact of -Associated Disease in German, Dutch and Spanish Swine Farms.

Front Vet Sci 2021 19;8:676002. Epub 2021 Aug 19.

Centre de Recerca en Sanitat Animal (CReSA), Institut de Recerca i Tecnologia Agroalimentàries (IRTA), Universitat Autònoma de Barcelona (UAB), Bellaterra, Spain.

The economic assessment of animal diseases is essential for decision-making, including the allocation of resources for disease control. However, that assessment is usually hampered by the lack of reliable data on disease incidence, or treatment and control measures, and that is particularly true for swine production diseases, such as infections caused by . Therefore, we deployed a questionnaire survey of clinical swine veterinarians to obtain the input data needed for a stochastic model to calculate the costs caused by , which was implemented in three of the main swine producing countries in Europe: Germany, the Netherlands and Spain. Read More

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The iSplit GFP assay detects intracellular recombinant proteins in Bacillus subtilis.

Microb Cell Fact 2021 Sep 6;20(1):174. Epub 2021 Sep 6.

Institute of Molecular Enzyme Technology, Heinrich Heine University Düsseldorf, Forschungszentrum Jülich, 52425, Jülich, Germany.

Background: Bacillus subtilis is one of the most important microorganisms for recombinant protein production. It possesses the GRAS (generally recognized as safe) status and a potent protein secretion capacity. Secretory protein production greatly facilitates downstream processing and thus significantly reduces costs. Read More

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September 2021

Economic Considerations for Advancement Through the Progressive Control Pathway: Cost-Benefit Analysis of an FMD Disease-Free Zone in Punjab Province, Pakistan.

Front Vet Sci 2021 18;8:703473. Epub 2021 Aug 18.

Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, United Kingdom.

Foot-and-mouth disease (FMD) is a priority disease of livestock in Pakistan, which was classified in stage 2 of the Progressive Control Pathway (PCP-FMD) in 2015, aiming to reduce disease impact. Further progression requires efforts to reduce viral circulation that may ultimately result in being awarded official disease-free status by the World Organisation for Animal Health [Office International des Epizooties (OIE)]. Typically, FMD control is reliant on the extensive use of vaccines, requiring careful consideration of the costs and benefits to ensure investment is likely to provide a positive return. Read More

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Knowledge gaps in economic costs of invasive alien fish worldwide.

Sci Total Environ 2021 Aug 28;803:149875. Epub 2021 Aug 28.

ISEM, Univ Montpellier, CNRS, EPHE, IRD, Montpellier, France.

Invasive alien fishes have had pernicious ecological and economic impacts on both aquatic ecosystems and human societies. However, a comprehensive and collective assessment of their monetary costs is still lacking. In this study, we collected and reviewed reported data on the economic impacts of invasive alien fishes using InvaCost, the most comprehensive global database of invasion costs. Read More

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Nanoscaffold effects on the performance of air-cathodes for microbial fuel cells: Sustainable Fe/N-carbon electrocatalysts for the oxygen reduction reaction under neutral pH conditions.

Bioelectrochemistry 2021 Aug 21;142:107937. Epub 2021 Aug 21.

School of Chemistry, CRANN and AMBER Research Centres, Trinity College Dublin, College Green, Dublin 2, Ireland. Electronic address:

Nanostructured electrocatalysts for microbial fuel cell air-cathodes were obtained via use of conductive carbon blacks for the synthesis of high performing 3D conductive networks. We used two commercially available nanocarbons, Black Pearls 2000 and multiwalled carbon nanotubes, as conductive scaffolds for the synthesis of nanocomposite electrodes by combining: a hydrothermally carbonized resin, a sacrificial polymeric template, a nitrogenated organic precursor and iron centers. The resulting materials are micro-mesoporous, possess high specific surface area and display N-sites (N/C of 3-5 at%) and Fe-centers (Fe/C < 1. Read More

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Evaluation of financial outcomes under a value-based payment program for community pharmacies.

J Manag Care Spec Pharm 2021 Sep;27(9):1198-1208

Wellmark Blue Cross Blue Shield, Des Moines, IA.

Value-based payment models have been shown to limit health care spending and waste while improving quality of care. Evidence from value-based pharmacy programs (VBPPs) is needed to guide the use of these mechanisms in health care. To evaluate financial outcomes of a VBPP implemented in 73 community pharmacies for about 40,000 commercial beneficiaries of Wellmark, Inc. Read More

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September 2021

The Socioeconomic Impact of Surgical Site Infections.

Front Public Health 2021 4;9:712461. Epub 2021 Aug 4.

General Surgery Department, University Hospitals Birmingham NHS Foundation Trust, Birmingham, United Kingdom.

Surgical site infections are an ever-increasing phenomenon worldwide due to different factors. This brief report aimeds to highlight at a glance, for both physicians and political and institutional leaders, the economic burden of surgical site infections. This brief report aimed to highlight the economic burden of surgical site infections (SSIs). Read More

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Utilization of brachytherapy in Quebec, Canada.

Brachytherapy 2021 Aug 19. Epub 2021 Aug 19.

Department of Oncology, Faculty of Medicine, McGill University, Montreal, Quebec, Canada; Department of Medical Physics, Jewish General Hospital, McGill University, Montreal, Québec, Canada.; Lady Davis Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada.

Background And Purpose: Despite the excellent clinical outcomes from brachytherapy treatments compared with other modalities and the low associated costs, there have been reports of a decline in utilization of brachytherapy. The aim of this study was to investigate in detail the trend in utilization of brachytherapy in the province of Québec, Canada, from 2011 to 2019.

Materials And Methods: All radiotherapy clinics in the province of Quebec, and among these the clinics that provide brachytherapy treatments, were identified. Read More

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Effectiveness of clinical exome sequencing in adult patients with difficult-to-diagnose neurological disorders.

Acta Neurol Scand 2021 Aug 21. Epub 2021 Aug 21.

Stem Cells and Metabolism Research Program, Faculty of Medicine, University of Helsinki, Helsinki, Finland.

Objectives: Clinical diagnostics in adults with hereditary neurological diseases is complicated by clinical and genetic heterogeneity, as well as lifestyle effects. Here, we evaluate the effectiveness of exome sequencing and clinical costs in our difficult-to-diagnose adult patient cohort. Additionally, we expand the phenotypic and genetic spectrum of hereditary neurological disorders in Finland. Read More

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Assessing the impact of exposome on the course of chronic obstructive pulmonary disease and cystc fibrosis: The REMEDIA European Project Approach.

Environ Epidemiol 2021 Aug 6;5(4):e165. Epub 2021 Aug 6.

University Paris-Est Créteil, INSERM, IMRB, Creteil, France.

Because of the direct interaction of lungs with the environment, respiratory diseases are among the leading causes of environment-related deaths in the world. Chronic obstructive pulmonary disease (COPD) and cystic fibrosis (CF) are two highly debilitating diseases that are of particular interest in the context of environmental studies; they both are characterized by a similar progressive loss of lung function with small bronchi alterations, and a high phenotypic variability of unknown origin, which prevents a good therapeutic efficacy. In the last years, there has been an evolution in the apprehension of the study of diseases going from a restricted "one exposure, one disease" approach to a broader concept with other associating factors, the exposome. Read More

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Bio-Fabrication of Human Amniotic Membrane Zinc Oxide Nanoparticles and the Wet/Dry HAM Dressing Membrane for Wound Healing.

Front Bioeng Biotechnol 2021 28;9:695710. Epub 2021 Jul 28.

Marine College, Shandong University, Weihai, China.

The preparation of unique wet and dry wound dressing products derived from unprocessed human amniotic membrane (UP-HAM) is described. The UP-HAM was decellularized, and the constituent proteins were cross-linked and stabilized before being trimmed and packed in sterile Nucril-coated laminated aluminium foil pouches with isopropyl alcohol to manufacture processed wet human amniotic membrane (PW-HAM). The dry type of PD-HAM was prepared by decellularizing the membrane, UV irradiating it, lyophilizing/freeze-drying it, sterilizing it, and storing it at room temperature. Read More

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The association between hospital financial performance and the quality of care-a scoping review protocol.

Syst Rev 2021 08 10;10(1):221. Epub 2021 Aug 10.

Department of Health Care Management, Technische Universität Berlin, Strasse des 17. Juni, 135 10623, Berlin, Germany.

Background: Hospitals operate under constant pressure to contain costs and improve the quality of care. The literature suggests that there is an association between health care providers' financial performance and the quality of care. On the one hand, providers that are financially more stable might have better capacity to maintain reliable systems and resources for quality improvement. Read More

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Development and Validation of an Instrument to Measure Health-Related Out-of-Pocket Costs: The Cost for Patients Questionnaire.

Value Health 2021 Aug;24(8):1172-1181

Département de gestion, d'évaluation et de politique de santé, École de santé publique de l'Université de Montréal, Montréal, Canada; Centre de recherche de l'Institut universitaire en santé mentale de Montréal, Montréal, Canada.

Objective: The growth of healthcare spending is a major concern for insurers and governments but also for patients whose health problems may result in costs going beyond direct medical costs. To develop a comprehensive tool to measure direct and indirect costs of a health condition for patients and their families to various outpatient contexts.

Methods: We conducted a content and face validation including results of a systematic review to identify the items related to direct and indirect costs for patients or their families and an online Delphi to determine the cost items to retain. Read More

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Characterizing hospital pathways for the care of acquired hemophilia in France using comprehensive national health data.

Rev Med Interne 2021 Jul 31. Epub 2021 Jul 31.

Service de médecine interne, Normandie Université, UNIROUEN, 76031 Rouen, France.

Purpose: Acquired hemophilia (AH) is a rare, serious bleeding disorder most often associated with older age and life-threatening complications. The patient care pathway for AH is complex because of the different types of bleeding, the presence of comorbidities, and the heterogeneity of medical specialists who care for these patients.

Methods: This observational study used the French national PMSI (Programme de médicalisation des systèmes d'information) database to characterize patients with AH in real-life practice and analyze their hospital pathway. Read More

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Cost-effectiveness of infant respiratory syncytial virus preventive interventions in Mali: A modeling study to inform policy and investment decisions.

Vaccine 2021 08 26;39(35):5037-5045. Epub 2021 Jul 26.

Center for Vaccine Development & Global Health, 685 W. Baltimore St., University of Maryland School of Medicine, Baltimore, Maryland 21201, USA. Electronic address:

Importance: Low- and middle-income countries have a high burden of respiratory syncytial virus lower respiratory tract infections. A monoclonal antibody administered monthly is licensed to prevent these infections, but it is cost-prohibitive for most low- and middle-income countries. Long-acting monoclonal antibodies and maternal vaccines against respiratory syncytial virus are under development. Read More

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Economic Analysis of the Prevention and Control of Nosocomial Infections: Research Protocol.

Front Public Health 2021 7;9:531624. Epub 2021 Jul 7.

School of Public Health, University of Montréal, Montreal, QC, Canada.

Nosocomial infections (NIs) are among the main preventable healthcare adverse events. Like all countries, Canada and its provinces are affected by NIs. In 2004, Ministry of Health and Social Services (MSSS) of Quebec instituted a mandatory surveillance NI program for the prevention and control (NIPC) in the hospitals of the province. Read More

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Economic evaluation of process utility: elucidating preferences for a non-invasive procedure to treat restenosis.

Health Econ Rev 2021 Jul 23;11(1):27. Epub 2021 Jul 23.

Department of Financial Economics and Operations Management, Faculty of Economics and Business Administration, University of Sevilla, Avda. Ramón y Cajal,1, 41018, Sevilla, Spain.

Background: In health economic evaluation, utility associated with a health state is outcome-oriented and usually measured using the QALY methodology. Even though there is consistent evidence of utility not only being derived from outcomes but also from procedures, process utility has not been fully integrated in QALY calculations. The aim of this paper is twofold: first, to provide evidence of process utility associated with an alternative treatment to angioplasty, and second, to estimate a monetary value of such process utility using the willingness to pay (WTP) approach. Read More

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Bioenergy Crops for Low Warming Targets Require Half of the Present Agricultural Fertilizer Use.

Environ Sci Technol 2021 08 21;55(15):10654-10661. Epub 2021 Jul 21.

Ministry of Education Key Laboratory for Earth System Modeling, Department of Earth System Science, Tsinghua University, Beijing 100084, China.

Bioenergy with carbon capture and storage (BECCS) is a key option for removing CO from the atmosphere over time to achieve climate mitigation. However, an overlooked impact of BECCS is the amount of nutrients required to sustain the production. Here, we use an observation-driven approach to estimate the future bioenergy biomass production for land-use scenarios maximizing BECCS and the pertaining nutrient requirements. Read More

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Action Costs Rapidly and Automatically Interfere with Reward-Based Decision-Making in a Reaching Task.

eNeuro 2021 Jul-Aug;8(4). Epub 2021 Aug 5.

Département de Kinanthropologie, Faculté des Sciences de l'Activité Physique, Université de Sherbrooke, Sherbrooke, Québec J1K 2R1, Canada.

It is widely assumed that we select actions we value the most. While the influence of rewards on decision-making has been extensively studied, evidence regarding the influence of motor costs is scarce. Specifically, how and when motor costs are integrated in the decision process is unclear. Read More

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