251,342 results match your criteria des


Synthesis and biological assessment of new pyrimidopyrimidines as inhibitors of breast cancer resistance protein (ABCG2).

Bioorg Chem 2021 Sep 6;116:105326. Epub 2021 Sep 6.

Laboratoire de Chimie Organique et Thérapeutique, Neurosciences intégratives et cliniques EA 481, Univ. Bourgogne Franche-Comté, UFR Santé, 19, rue Ambroise Paré, F-25000 Besançon, France. Electronic address:

Multidrug resistance constitutes a serious obstacle of the treatment success of cancer by chemotherapy. Mostly it is driven by expression of ABC transport proteins that actively efflux the anticancer agents out of the cell. This work describes the design and synthesis of 12 new pyrimidopyrimidines, as well as their inhibition of ABCG2 a transporter referred also to as breast cancer resistance protein, the selectivity versus ABCB1 (P-glycoprotein/P-gp) and ABCC1 as well as the investigation of their accumulation in single cells. Read More

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September 2021

Reduction of pulse "antinutritional" content by optimizing pulse canning process is insufficient to improve fat-soluble vitamin bioavailability.

Food Chem 2021 Sep 2;370:131021. Epub 2021 Sep 2.

Aix Marseille Univ, INRAE, INSERM, C2VN, Marseille, France. Electronic address:

Some bioactive compounds found in pulses (phytates, saponins, tannins) display antinutritional properties and interfere with fat-soluble vitamin bioavailability (i.e., bioaccessibility and intestinal uptake). Read More

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September 2021

The bioavailability of nitrogen associated with sediment in riverine plumes of the Great Barrier Reef.

Mar Pollut Bull 2021 Sep 15;173(Pt A):112910. Epub 2021 Sep 15.

ARC Centre of Excellence for Coral Reef Studies, James Cook University, Townsville Q 4811, Australia.

This study quantified the bioavailable nitrogen contribution from riverine plumes to Great Barrier Reef (GBR) coastal environments. The potential bioavailable nitrogen from two Dry Tropics riverine plumes was considerable [9 - 30% added to the end-of-catchment dissolved inorganic nitrogen (DIN) load]. Particulate inorganic nitrogen conversion to DIN was an important process in short timeframes (25% to 100% of the generated load). Read More

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September 2021

Surgical treatment of terrible triad of the elbow: retrospective continuous 50-patient series at 2 years' follow-up.

Orthop Traumatol Surg Res 2021 Sep 15:103057. Epub 2021 Sep 15.

Service Orthopédie et Traumatologie, CHU Grenoble Alpes, Boulevard de la Chantourne, 38700 La Tronche, France.

Introduction: Terrible triad (TT) of the elbow is an association at high risk of instability. Treatment aims to restore joint stability. Lateral collateral ligament (LCL) repair is systematic, whereas medial collateral ligament (MCL) repair is only exceptionally necessary. Read More

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September 2021

Postoperative Pain after Clitoral Reconstruction in Women with Female Genital Mutilation: an evaluation of practices.

J Gynecol Obstet Hum Reprod 2021 Sep 15:102230. Epub 2021 Sep 15.

Service de Gynécologie-Obstétrique, Hôpital Lariboisière, 2 Rue Ambroise Paré, 75010 Paris.

Introduction: More than 200 million women and girls have undergone genital mutilation. Clitoral reconstruction (CR) can improve the quality of life of some of them, but is accompanied by significant postoperative pain.

Objective: Assess and describe the management of postoperative pain after CR, and the practices among specialists in different countries. Read More

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September 2021

Vasomotor effects of noradrenaline, 5-hydroxytryptamine, angiotensin II, bradykinin, histamine, and acetylcholine on the bat (Rhinolophus ferrumequinum) basilar artery.

Comp Biochem Physiol C Toxicol Pharmacol 2021 Sep 15:109190. Epub 2021 Sep 15.

Department of Veterinary Pharmacology, Joint Faculty of Veterinary Medicine, Kagoshima University, 1-21-24 Korimoto, Kagoshima 890-0065, Japan. Electronic address:

The responsiveness of the basilar artery to intrinsic vasoactive substances is species-specific and can be a unique characteristic. We investigated the responsiveness of the bat (Rhinolophus ferrumequinum) basilar artery to noradrenaline (NA), 5-hydroxytryptamine (5-HT), angiotensin (Ang) II, bradykinin (BK), histamine (His), and acetylcholine (ACh). NA, 5-HT, Ang II, and BK induced contraction, whereas His and ACh induced relaxation, in a concentration-dependent manner. Read More

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September 2021

Rare flavonoids and sesquiterpenoids isolated from the leaves of Goniothalamus gracilipes.

Fitoterapia 2021 Sep 15:105034. Epub 2021 Sep 15.

Institute of Marine Biochemistry of the Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam; Graduate University of Science and Technology, VAST, 18 Hoang Quoc Viet, Caugiay, Hanoi, Viet Nam. Electronic address:

Three previously undescribed benzopyranyl sesquiterpenes gracilipins BD (1-3) and two flavonoids 5,4'-dihydroxy-6-(2-hydroxybenzyl)-3,7,3'-trimethoxyflavone (4), and 5,4'-dihydroxy-8-(2-hydroxybenzyl)-3,7-dimethoxyflavone (5) were isolated from the leaves of Goniothalamus gracilipes (Annonaceae). Their structures were determined by analyses of MS and 2D NMR data. The absolute configurations of 1 were established by analysis of X-ray diffraction data. Read More

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September 2021

Preparation of sodium hyaluronate/dopamine/AgNPs hydrogel based on the natural eutetic solvent as an antibaterial wound dressing.

Int J Biol Macromol 2021 Sep 15. Epub 2021 Sep 15.

College of Chemistry & Pharmacy and Life Science, Northwest A&F University, Yangling, Shaanxi 712100, PR China. Electronic address:

Baesd on previous researches, the natural deep eutectic solvent (DES) has enormous potential to be used in the fabrication of hydrogel wound dressing due to its outstanding properties including cytocompatibility, degradability and solubility. In order to further improve the antibaterial capacity of hydrogel, in the present study sodium hyaluronate (SH) and the natural DES were utilized to develop a novel hydrogel wound dressing by dopamine (DA) coated SH with in situ reduction of silver nanoparticles ([email protected]). Furthermore, during the preparation process, we discovered for the first time that the DES can be used to fill the freeze-dried DASH to prepare a hydrogel (DES-DASH), which was promising to utilized in the fabrication of other hydrogels. Read More

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September 2021

Onasemnogene abeparvovec gene therapy for symptomatic infantile-onset spinal muscular atrophy type 1 (STR1VE-EU): an open-label, single-arm, multicentre, phase 3 trial.

Lancet Neurol 2021 Oct;20(10):832-841

Novartis Gene Therapies, Cambridge, UK.

Background: Spinal muscular atrophy is a rare, autosomal recessive, neuromuscular disease caused by biallelic loss of the survival motor neuron 1 (SMN1) gene, resulting in motor neuron dysfunction. In this STR1VE-EU study, we aimed to evaluate the safety and efficacy of onasemnogene abeparvovec gene replacement therapy in infants with spinal muscular atrophy type 1, using broader eligibility criteria than those used in STR1VE-US.

Methods: STR1VE-EU was a multicentre, single-arm, single-dose, open-label phase 3 trial done at nine sites (hospitals and universities) in Italy (n=4), the UK (n=2), Belgium (n=2), and France (n=1). Read More

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October 2021

Using Bayesian networks for environmental health risk assessment.

Environ Res 2021 Sep 15:112059. Epub 2021 Sep 15.

Institut Ecocitoyen pour la Connaissance des Pollutions, Centre de vie, La Fossette, Fos-sur-Mer, France.

The study investigated the potential relationships between air pollution, socio-economy, and proven pathologies (e.g., respiratory, cardiovascular) within an industrial area in Southern France (Etang de Berre), gathering steel industries, oil refineries, shipping, road traffic and experiencing a Mediterranean climate. Read More

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September 2021

Cross-sectional study on exhaled nitric oxide in relation to upper airway inflammatory disorders with regard to asthma and perennial sensitisation.

Clin Exp Allergy 2021 Sep 18. Epub 2021 Sep 18.

Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden.

Background: Fractional exhaled nitric oxide (FeNO) is a well-known marker of type-2 inflammation. FeNO is elevated in asthma and allergic rhinitis, with IgE sensitisation as a major determinant.

Objective: We aimed to see if there was an independent association between upper airway inflammatory disorders (UAID) and FeNO, after adjustment for asthma and sensitisation, in a multi-centre population-based study. Read More

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September 2021

Natalizumab Versus Fingolimod in Patients with Relapsing-Remitting Multiple Sclerosis: A Subgroup Analysis From Three International Cohorts.

CNS Drugs 2021 Sep 18. Epub 2021 Sep 18.

Neurology Unit, Garibaldi Hospital, Catania, Italy.

Introduction: Natalizumab has proved to be more effective than fingolimod in reducing disease activity in relapsing-remitting multiple sclerosis (RRMS). Whether this association is universal for all patient groups remains to be determined.

Objective: The aim of this study was to compare the relative effectiveness of natalizumab and fingolimod in RRMS subgroups defined by the baseline demographic and clinical characteristics of interest. Read More

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September 2021

Evaluating the Apoptotic Cell Death Modulatory Activity of Nanoparticles in Men and Women Neutrophils and Eosinophils.

Inflammation 2021 Sep 18. Epub 2021 Sep 18.

Laboratoire de Recherche en Inflammation Et Physiologie Des Granulocytes, Université du Québec, INRS-Centre Armand-Frappier Santé Biotechnologie, 531 Boul. des Prairies, Laval, QC, H7V 1B7, Canada.

Apoptosis is an important cell death mechanism for the resolution of inflammation. Neutrophil spontaneous apoptosis rates were reported to be slightly different in men and women and to be modulated by female sex hormones. The aim of this study was to determine whether different nanoparticles (NPs) will alter the neutrophil and eosinophil apoptotic rates differently in men and women. Read More

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September 2021

Design of a multifaceted strategy based on automated text messaging in patients with recent heart failure admission.

ESC Heart Fail 2021 Sep 18. Epub 2021 Sep 18.

HCor Research Institute, R. Des. Eliseu Guilherme, 147 - Paraíso, São Paulo, 04004-030, Brazil.

Aims: To evaluate a telemonitoring strategy based on automated text messaging and telephone support after heart failure (HF) hospitalization.

Methods And Results: The MESSAGE-HF study is a prospective multicentre, randomized, nationwide trial enrolling patients from 30 clinics in all regions of Brazil. HF patients with reduced left ventricular ejection fraction (<40%) and access to mobile phones are eligible after an acute decompensated HF hospitalization. Read More

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September 2021

Smartphone-based virtual agents and insomnia management: A proof-of-concept study for new methods of autonomous screening and management of insomnia symptoms in the general population.

J Sleep Res 2021 Sep 18:e13489. Epub 2021 Sep 18.

Université de Bordeaux, SANPSY USR 3413, Bordeaux, France.

Insomnia is the most frequent sleep disorder, and the COVID-19 crisis has massively increased its prevalence in the population, due to psychosocial stress or direct viral contamination. KANOPEE_2 is a smartphone-based application that provides interactions with a virtual agent to autonomously screen and alleviate insomnia symptoms through an intervention programme giving personalized advices regarding sleep hygiene, relaxation techniques and stimulus-control. In this proof-of-concept study, we tested the effects of KANOPEE_2 among users from all over the country (France) who downloaded the app between 1 June and 26 October 2020 (to focus on effects after the end of COVID-19 confinement). Read More

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September 2021

Are Cutibacterium acnes present at the end of primary shoulder prosthetic surgeries responsible for infection? Prospective study.

Eur J Clin Microbiol Infect Dis 2021 Sep 17. Epub 2021 Sep 17.

Service de Bactériologie Et Des Contrôles Microbiologiques, Université de Nantes, CHU Nantes, CRCINA U1232, 44000, Nantes, France.

The purpose of this study was to investigate if the C. acnes present at the end of a primary shoulder arthroplasty could be responsible for shoulder arthroplasty infection. Prospective study includes patients undergoing primary shoulder arthroplasty from January 2015 until December 2018. Read More

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September 2021

Impacts of environmental conditions, and allelic variation of cytosolic glutamine synthetase on maize hybrid kernel production.

Commun Biol 2021 Sep 17;4(1):1095. Epub 2021 Sep 17.

Institut Jean-Pierre Bourgin, Institut national de la Recherche Agronomique et de l'Environnement (INRAE), Centre de Versailles-Grignon, Unité Mixte de Recherche 1318, RD10, Versailles, Cedex, France.

Cytosolic glutamine synthetase (GS1) is the enzyme mainly responsible of ammonium assimilation and reassimilation in maize leaves. The agronomic potential of GS1 in maize kernel production was investigated by examining the impact of an overexpression of the enzyme in the leaf cells. Transgenic hybrids exhibiting a three-fold increase in leaf GS activity were produced and characterized using plants grown in the field. Read More

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September 2021

Digital intervention increases influenza vaccination rates for people with diabetes in a decentralized randomized trial.

NPJ Digit Med 2021 Sep 17;4(1):138. Epub 2021 Sep 17.

Sanofi Pasteur, Lyon, France.

People with diabetes (PWD) have an increased risk of developing influenza-related complications, including pneumonia, abnormal glycemic events, and hospitalization. Annual influenza vaccination is recommended for PWD, but vaccination rates are suboptimal. The study aimed to increase influenza vaccination rate in people with self-reported diabetes. Read More

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September 2021

MAPK-pathway inhibition mediates inflammatory reprogramming and sensitizes tumors to targeted activation of innate immunity sensor RIG-I.

Nat Commun 2021 Sep 17;12(1):5505. Epub 2021 Sep 17.

Department of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, 50931, Cologne, Germany.

Kinase inhibitors suppress the growth of oncogene driven cancer but also enforce the selection of treatment resistant cells that are thought to promote tumor relapse in patients. Here, we report transcriptomic and functional genomics analyses of cells and tumors within their microenvironment across different genotypes that persist during kinase inhibitor treatment. We uncover a conserved, MAPK/IRF1-mediated inflammatory response in tumors that undergo stemness- and senescence-associated reprogramming. Read More

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September 2021

Transverse barrier formation by electrical triggering of a metal-to-insulator transition.

Nat Commun 2021 Sep 17;12(1):5499. Epub 2021 Sep 17.

Department of Physics and Center for Advanced Nanoscience, University of California San Diego, La Jolla, CA, USA.

Application of an electric stimulus to a material with a metal-insulator transition can trigger a large resistance change. Resistive switching from an insulating into a metallic phase, which typically occurs by the formation of a conducting filament parallel to the current flow, is a highly active research topic. Using the magneto-optical Kerr imaging, we found that the opposite type of resistive switching, from a metal into an insulator, occurs in a reciprocal characteristic spatial pattern: the formation of an insulating barrier perpendicular to the driving current. Read More

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September 2021

Ignored Papers, Invented Quotations: A History of Fetal Alcohol Syndrome.

Authors:
Michael Obladen

Neonatology 2021 Sep 14:1-7. Epub 2021 Sep 14.

Department of Neonatology, Charité University Medicine, Berlin, Germany.

Given the high rate of alcoholism throughout history, its effects on the fetus may have existed for millennia. But, the claim that Greeks and Romans were aware of fetal alcohol syndrome rests on incorrect citations. From 1725, maternal alcohol consumption was associated with retarded fetal growth and neurological anomalies. Read More

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September 2021

Haplotype divergence supports long-term asexuality in the oribatid mite .

Proc Natl Acad Sci U S A 2021 Sep;118(38)

Department of Ecology and Evolution, University of Lausanne, 1015 Lausanne, Switzerland.

Sex strongly impacts genome evolution via recombination and segregation. In the absence of these processes, haplotypes within lineages of diploid organisms are predicted to accumulate mutations independently of each other and diverge over time. This so-called "Meselson effect" is regarded as a strong indicator of the long-term evolution under obligate asexuality. Read More

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September 2021

Alternative splicing of viral transcripts: the dark side of the HBV.

Gut 2021 Sep 17. Epub 2021 Sep 17.

Institut National de la Santé et de la Recherche Médicale U938, Centre de Recherche de Saint Antoine, Sorbonne Université-Faculté Saint Antoine, Paris, France

Regulation of alternative splicing is one of the most efficient mechanisms to enlarge the proteomic diversity in eukaryotic organisms. Many viruses hijack the splicing machinery following infection to accomplish their replication cycle. Regarding the HBV, numerous reports have described alternative splicing events of the long viral transcript (pregenomic RNA), which also acts as a template for viral genome replication. Read More

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September 2021

Coronary artery disease in adults with Noonan syndrome: Case series and literature review.

Arch Cardiovasc Dis 2021 Sep 14. Epub 2021 Sep 14.

Université de Paris, hôpital européen Georges-Pompidou, 75015 Paris, France; Adult congenital heart disease unit, centre de référence des malformations cardiaques congénitales complexes, 75015 Paris, France; INSERM U970, Paris centre de recherche cardiovasculaire, 75015 Paris, France.

Noonan syndrome (NS) is a genetic disorder characterized by facial dysmorphism, congenital heart disease, and short stature. In very rare cases, patients with this syndrome have coronary disease. Their management and prognosis are currently unclear. Read More

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September 2021

[Reverse abdominoplasty in the presence of bi-subcostal scar: Technical note].

Ann Chir Plast Esthet 2021 Sep 14. Epub 2021 Sep 14.

Service de Chirurgie plastique, Hôpitaux universitaires de Strasbourg, 1, avenue Molière, 67200 Strasbourg, France.

Introduction: The presence of horizontal supraumbilical scars increases the risk of vascular complications after a large abdominoplasty. We present here a technique of abdominal dermolipectomy with umbilical transposition called « reverse », in the presence of a bi-subcostal scar.

Technical Note: The reverse abdominoplasty technique consists in uninserting the umbilicus, detaching the supra-umbilical and sub-umbilical soft tissues by assessing the existing bi-subcostal scar in order to pull the skin upwards, and to remove the supra-umbilical excess skin, before bringing the umbilicus back to its proper position. Read More

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September 2021

Comparison of Hyperangulated and Standard Geometry Video Laryngoscopy Tracheal Intubation for Prehospital Care in a Manikin: A Randomized Controlled Crossover Trial.

Air Med J 2021 Sep-Oct;40(5):317-321. Epub 2021 Jun 18.

BerbeeWalsh Department of Emergency Medicine, University of Wisconsin-Madison, Madison, WI.

Objective: The purpose of this study was to investigate the efficacy of hyperangulated video laryngoscopy (HAVL) versus standard geometry video laryngoscopy (SGVL) in the simulated prehospital environment using a manikin. There is consensus that video laryngoscopy (VL) can be very useful in the emergency department when difficult intubations are predicted. Emergency medical service (EMS) providers are also often faced with difficult, rapidly deteriorating airway management situations that not only involve patient and operator factors but also include challenging unique environmental factors, such as nonoptimized positions in transport vehicles (eg, helicopters and ambulances) or at ground level or entrapped positions. Read More

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Spatiotemporal AMPKα2 deletion in mice induces cardiac dysfunction, fibrosis and cardiolipin remodeling associated with mitochondrial dysfunction in males only.

Biol Sex Differ 2021 Sep 17;12(1):52. Epub 2021 Sep 17.

Faculté de Pharmacie, UMR-S1180, INSERM, Université Paris-Saclay, 5 rue J-B Clément, 92296, Châtenay-Malabry, France.

Background: The AMP-activated protein kinase (AMPK) is a major regulator of cellular energetics which plays key role in acute metabolic response and in long-term adaptation to stress. Recent works have also suggested non-metabolic effects.

Methods: To decipher AMPK roles in the heart, we generated a cardio-specific inducible model of gene deletion of the main cardiac catalytic subunit of AMPK (Ampkα2) in mice. Read More

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September 2021

A recurrent RYR1 mutation associated with early-onset hypotonia and benign disease course.

Acta Neuropathol Commun 2021 Sep 17;9(1):155. Epub 2021 Sep 17.

Laboratoire de Biochimie et Génétique Moléculaire, Pôle de Biologie, CHU Grenoble Alpes, Grenoble, France.

The ryanodine receptor RyR1 is the main sarcoplasmic reticulum Ca channel in skeletal muscle and acts as a connecting link between electrical stimulation and Ca-dependent muscle contraction. Abnormal RyR1 activity compromises normal muscle function and results in various human disorders including malignant hyperthermia, central core disease, and centronuclear myopathy. However, RYR1 is one of the largest genes of the human genome and accumulates numerous missense variants of uncertain significance (VUS), precluding an efficient molecular diagnosis for many patients and families. Read More

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September 2021

Early versus late awake prone positioning in non-intubated patients with COVID-19.

Crit Care 2021 Sep 17;25(1):340. Epub 2021 Sep 17.

Division of Respiratory Care, Department of Cardiopulmonary Sciences, Rush University Medical Center, 600 S Paulina St, Suite 765, Chicago, IL, USA.

Background: Awake prone positioning (APP) is widely used in the management of patients with coronavirus disease (COVID-19). The primary objective of this study was to compare the outcome of COVID-19 patients who received early versus late APP.

Methods: Post hoc analysis of data collected for a randomized controlled trial (ClinicalTrials. Read More

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September 2021

Risk factors for revascularization and in-stent restenosis in patients with triple-vessel disease after second-generation drug-eluting stent implantation: a retrospective analysis.

BMC Cardiovasc Disord 2021 Sep 17;21(1):446. Epub 2021 Sep 17.

Department of Cardiology, Peking Union Medical College Hospital (Dongdan Campus), Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Shuaifuyuan Wangfujing Dongcheng District, Beijing, 100730, China.

Objectives: Coronary artery disease (CAD) is a common cardiac disease with high morbidity and mortality, and triple-vessel disease (TVD) is a severe type of CAD. This study investigated risk factors for revascularization and in-stent restenosis (ISR) in TVD patients who underwent second-generation drug-eluting stent implantation.

Methods: A retrospective clinical study was conducted, and 246 triple-vessel disease (TVD) patients with 373 vessels after second-generation drug-eluting stent (DES) implantation who received follow-up coronary angiography (CAG) were consequently enrolled. Read More

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September 2021