424 results match your criteria dermatologic ocular


Ocular Complications After Laser or Light-Based Therapy-Dangers Dermatologists Should Know.

Dermatol Surg 2021 Mar 9. Epub 2021 Mar 9.

Department of Dermatology, University of California, Irvine, California; AboutSkin Dermatology and DermSurgery, Greenwood Village, Colorado.

Background: Laser and light-based technologies have been used in the medical field for over 50 years. In dermatologic and cosmetic practice, cutaneous side effects are commonly discussed; however, ocular injury may also occur.

Objective: To complete a systematic review of the current literature regarding ocular complications in the dermatologic field after laser and/or light-based therapies. Read More

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FDA Approval Summary: Selumetinib for Plexiform Neurofibroma.

Clin Cancer Res 2021 Mar 12. Epub 2021 Mar 12.

Office of Oncologic Diseases, FDA, Silver Spring, Maryland.

On April 10, 2020, the FDA approved selumetinib (KOSELUGO, AstraZeneca) for the treatment of pediatric patients 2 years of age and older with neurofibromatosis type 1 who have symptomatic, inoperable plexiform neurofibromas. Approval was based on demonstration of a durable overall response rate per Response Evaluation in Neurofibromatosis and Schwannomatosis criteria and supported by observed clinical improvements in plexiform neurofibroma-related symptoms and functional impairments in 50 pediatric patients with inoperable plexiform neurofibromas in a single-arm, multicenter trial. The overall reponse rate per NCI investigator assessment was 66% (95% confidence interval, 51-79) with at least 12 months of follow-up. Read More

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Real-world comorbidities of atopic dermatitis in the pediatric ambulatory population in the United States.

J Am Acad Dermatol 2021 Mar 6. Epub 2021 Mar 6.

Department of Dermatology, Johns Hopkins University School of Medicine; Bloomberg School of Public Health, Johns Hopkins University. Electronic address:

Background: Increasing evidence points to the systemic nature of atopic dermatitis (AD), a common inflammatory skin condition in children. However, comprehensive analyses of real-world comorbidities in pediatric AD are limited.

Objective: To characterize the comorbidity burden in patients <18 years old with AD. Read More

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Less Common Respiratory Conditions: Sarcoidosis.

FP Essent 2021 Mar;502:18-22

Florida State University College of Medicine Family Medicine Residency Program at BayCare Health System, 1201 1st St S Suite 100A, Winter Haven, FL 33880.

Sarcoidosis is a systemic condition characterized by formation of granulomas that can involve many organ systems, with the lungs and intrathoracic lymph nodes involved in more than 90% of cases. Sarcoidosis also can involve the cardiac, ocular, hepatic, dermatologic, and central nervous systems. The presentation of pulmonary sarcoidosis is nonspecific. Read More

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Psychiatric side effects of chloroquine in COVID-19 patients: two case reports.

Pan Afr Med J 2020 20;35(Suppl 2):83. Epub 2020 Jun 20.

Faculty of Medicine, Mohammed VI University of Health Sciences (UM6SS), Casablanca, Morocco.

Chloroquine and hydroxy chloroquine are widely use in Africa and all over the world as anti-malarial drugs but also in the treatment of chronic inflammatory diseases. Since the outbreak of COVID-19 pandemic, Morocco have included this medication in the COVID-19 treatment guidelines in association with azithromycine. Besides dermatologic problems, ocular impairments and gastro-intestinal effects, quinolines may also cause rarely described psychiatric adverse effects. Read More

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Response to: 'Correspondence on 'A pilot study of tofacitinib for refractory Behçet's syndrome'' by Zou .

Ann Rheum Dis 2021 Jan 25. Epub 2021 Jan 25.

Department of Rheumatology and Clinical Immunology, Key Laboratory of Rheumatology and Clinical Rheumatology, Ministry of Education, National Clinical Research Center for Dermatologic and Immunologic Diseases, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China

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January 2021

Cutaneous Cell-Mediated Delayed Hypersensitivity to Intravitreal Bevacizumab.

Middle East Afr J Ophthalmol 2020 Jul-Sep;27(3):182-184. Epub 2020 Oct 30.

Department of Ocular Tumor, Orbital Disease and Ophthalmic Radiation Therapy., The New York Eye Cancer Center, New York, NY, USA.

The literature contains few reports describing autoimmune reactions to intravitreal bevacizumab and no Type-IV delayed hypersensitivity reactions. This was unexpected, as administration of intravenous bevacizumab has frequently caused dermatologic side-effects. This difference was likely attributable in part to the minimum 300-times difference between intravitreal versus intravenous dosing. Read More

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January 2021

Diagnosis and Management of the Cryopyrin-Associated Periodic Syndromes (CAPS): What Do We Know Today?

J Clin Med 2021 Jan 1;10(1). Epub 2021 Jan 1.

Pediatric Rheumatology and Autoinflammation Reference Center Tuebingen (arcT), University Children's Hospital Tuebingen, D-72076 Tuebingen, Germany.

The cryopyrin-associated periodic syndromes (CAPS) are usually caused by heterozygous gene variants, resulting in excessive inflammasome activation with subsequent overproduction of interleukin (IL)-1β. The CAPS spectrum includes mild, moderate, and severe phenotypes. The mild phenotype is called familial cold autoinflammatory syndrome (FCAS), the moderate phenotype is also known as Muckle-Wells syndrome (MWS), and the neonatal-onset multisystem inflammatory disease (NOMID)/chronic infantile neurologic cutaneous articular syndrome (CINCA) describes the severe phenotype. Read More

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January 2021

[Nystagmus secondary to albinism with ocular involvement in a female: A diagnostic challenge].

Rev Chil Pediatr 2020 Aug 23;91(4):573-578. Epub 2020 Jun 23.

Departamento de Pediatría, Facultad de Medicina, Universidad del Desarrollo, Santiago, Chile.

Introduction: Infantile nystagmus is an infrequent condition that represents a diagnostic challenge for the pediatri cian. Albinism is one of its main causes, being difficult to suspect in the absence of evident cutaneous involvement, especially in female patients, due to the inheritance type of ocular albinism. Objec tive: To describe a case of nystagmus secondary to albinism with isolated ocular involvement in a female patient, in order to provide tools for pediatric approach and diagnosis. Read More

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Clinical Pharmacokinetics and Pharmacodynamics of Selumetinib.

Clin Pharmacokinet 2021 Mar 23;60(3):283-303. Epub 2020 Dec 23.

Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN, 38105-2794, USA.

Selumetinib, a highly specific mitogen-activated protein kinase 1/2 inhibitor, is approved for children older than 2 years of age with neurofibromatosis 1 who have inoperable plexiform neurofibromas. By selectively binding to mitogen-activated protein kinase 1/2 proteins, selumetinib can arrest the mitogen-activated protein kinase/extracellular signal-regulated kinase signaling pathway that regulates critical cellular responses. Selumetinib has shown promising results as a single agent or in combination with conventional chemotherapy and other targeted therapies both preclinically and clinically, in multiple cancers including pediatric low-grade glioma, non-small cell lung cancer, and melanoma, among others. Read More

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Uveitis for Dermatologists: A Review.

J Drugs Dermatol 2020 Dec;19(12):1192-1198

Certain dermatologic conditions and drugs used for their treatment are associated with uveitis, a vision-threatening group of inflammatory eye diseases. Dermatologists may therefore be the first healthcare providers to recognize the presence of uveitis in certain patients and can help ensure morbidity is minimized. Posterior uveitis in particular, which may manifest as insidious, painless vision loss, may first be identified by a careful review of systems by a dermatologist. Read More

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December 2020

Identification of KRAS mutation in a patient with linear nevus sebaceous syndrome: a case report.

BMC Med Genomics 2020 12 12;13(1):188. Epub 2020 Dec 12.

Department of Dermatologic Surgery, Hospital for Skin Diseases (Institute of Dermatology), Chinese Academy of Medical Sciences and Peking Union Medical College, Nanjing, 210042, Jiangsu, China.

Background: Linear nevus sebaceous syndrome (LNSS) is a rare genetic disease characterized by large linear sebaceous nevus typically on the face, scalp, or neck. LNSS could be accompanied by multisystem disorders including the central nervous system. Herein, we report gene mutational profile via whole exome sequencing of both lesional and non-lesional skin samples in a LNSS patient. Read More

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December 2020

Surveillance of patients with conjunctival melanoma in German-speaking countries: A multinational survey of the German dermatologic cooperative oncology group.

Eur J Cancer 2021 Jan 3;143:43-45. Epub 2020 Dec 3.

Department of Dermatology, Universitätsklinikum Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg (FAU), Ulmenweg 18, 91054 Erlangen, Germany; Comprehensive Cancer Center Erlangen - European Metropolitan Region of Nuremberg, Erlangen, Germany.

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January 2021

Patterns of care and follow-up care of patients with uveal melanoma in German-speaking countries: a multinational survey of the German Dermatologic Cooperative Oncology Group (DeCOG).

J Cancer Res Clin Oncol 2020 Nov 21. Epub 2020 Nov 21.

Department of Dermatology, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg (FAU), Ulmenweg 18, 91054, Erlangen, Germany.

Purpose: Uveal melanoma (UM) is an orphan cancer of high unmet medical need. Current patterns of care and surveillance remain unclear as they are situated in an interdisciplinary setting.

Methods: A questionnaire addressing the patterns of care and surveillance in the management of patients with uveal melanoma was distributed to 70 skin cancer centers in Austria, Germany and Switzerland. Read More

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November 2020

Behçet's Disease: Different Systemic Manifestations at Different Ages.

Eurasian J Med 2020 Oct 2;52(3):304-306. Epub 2020 Jun 2.

Department of Pulmonary Disease, Ataturk University School of Medicine, Erzurum, Turkey.

Behçet's disease, an inflammatory condition, can involve various systems. The disease usually manifests with dermatologic and ocular signs but can also cause serious symptoms due to pulmonary or neurologic involvement. Although the onset may occur at any age, it typically emerges in the second to fourth decades of life. Read More

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October 2020

Autoantibodies in NLRP3-associated autoinflammatory disease: a case report.

Clin Exp Rheumatol 2020 Sep-Oct;38 Suppl 127(5):122-123. Epub 2020 Nov 13.

McKusick-Zhang Centre for Genetic Medicine, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing, China.

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February 2021

Multisystem Imaging Manifestations of COVID-19, Part 2: From Cardiac Complications to Pediatric Manifestations.

Radiographics 2020 Nov-Dec;40(7):1866-1892

From the Department of Radiology and Biomedical Imaging, Yale University School of Medicine, 333 Cedar St, PO Box 208042, Room TE-2, New Haven, CT 06520 (M.V.R., A.M., A.S.B.); Department of Radiology, Zucker School of Medicine at Hofstra/Northwell, Northwell Health System, Manhasset, NY (S.R., R.W., C.D., R.D.P., K.C., C.K., J.S.P.); and Department of Diagnostic Radiology, Danbury Radiological Associates, PC, Danbury, Conn (N.C.S.).

Infection with severe acute respiratory syndrome coronavirus 2 results in coronavirus disease 2019 (COVID-19), which was declared an official pandemic by the World Health Organization on March 11, 2020. COVID-19 has been reported in most countries, and as of August 15, 2020, there have been over 21 million cases of COVID-19 reported worldwide, with over 800 000 COVID-19-associated deaths. Although COVID-19 predominantly affects the respiratory system, it has become apparent that many other organ systems can also be involved. Read More

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November 2020

Acne in the first three decades of life: An update of a disorder with profound implications for all decades of life.

Dis Mon 2021 Apr 9;67(4):101103. Epub 2020 Oct 9.

Department of Pediatric and Adolescent Medicine, Western Michigan University, Homer Stryker M.D. School of Medicine, 1000 Oakland Drive, Kalamazoo, MI 49008-1284, United States.

Acne vulgaris is a chronic, inflammatory, skin condition that involves the pilosebaceous follicles and is influenced by a variety of factors including genetics, androgen-stimulation of sebaceous glands with abnormal keratinization, colonization with Cutibacterium acnes (previously called Propionibacterium acnes), and pathological immune response to inflammation. Acne can occur at all ages and this discussion focuses on the first three decades of life. Conditions that are part of the differential diagnosis and/or are co-morbid with acne vulgaris are also considered. Read More

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Multisystem Imaging Manifestations of COVID-19, Part 1: Viral Pathogenesis and Pulmonary and Vascular System Complications.

Radiographics 2020 10;40(6):1574-1599

From the Department of Radiology and Biomedical Imaging, Yale University School of Medicine, 333 Cedar St, PO Box 208042, Room TE-2, New Haven, CT 06520 (M.V.R., A.S.B., A.M.); Department of Radiology, Zucker School of Medicine at Hofstra/Northwell, Northwell Health System, Manhasset, NY (S.R., R.W., C.D., R.D.P., K.C., C.K., J.S.P.); and Department of Diagnostic Radiology, Danbury Radiological Associates, PC, Danbury, Conn (N.C.S.).

Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) results in coronavirus disease 2019 (COVID-19), which was declared an official pandemic by the World Health Organization on March 11, 2020. The infection has been reported in most countries around the world. As of August 2020, there have been over 21 million cases of COVID-19 reported worldwide, with over 800 000 COVID-19-associated deaths. Read More

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October 2020

Ocular complications of oak processionary caterpillar setae in the Netherlands; case series, literature overview, national survey and treatment advice.

Acta Ophthalmol 2020 Sep 30. Epub 2020 Sep 30.

Department of Ophthalmology, University Medical Center Utrecht, Utrecht, The Netherlands.

During early summer 2019, the Netherlands experienced an outbreak of the exotic oak processionary caterpillar. The vast number of caterpillars, which live in large nests on oak trees before they turn into moths, possess thousands of small, barbed hairs (setae) that are disseminated with the wind. The hairs cause a range of primarily dermatologic problems. Read More

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September 2020

Pulmonary and Extra-Pulmonary Clinical Manifestations of COVID-19.

Front Med (Lausanne) 2020 13;7:526. Epub 2020 Aug 13.

Department of Gastroenterology and Hepatology, University of Arkansas for Medical Sciences, Little Rock, AR, United States.

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been recently identified as the culprit of the highly infectious, outbreak named coronavirus disease 2019 (COVID-19) in China. Now declared a public health emergency, this pandemic is present in more than 200 countries with over 14 million cases and 600,000 deaths as of July 18, 2020. Primarily transmitted through the respiratory tract, the most common clinical presentations of symptomatic individuals infected with SARS-CoV-2 include fever, dyspnea, cough, fatigue, and sore throat. Read More

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Relentlessly Progressive Sweet Syndrome of the Eye with Scleritis and Choroidal Infiltration.

Ocul Immunol Inflamm 2020 Aug 19:1-5. Epub 2020 Aug 19.

Department of Ophthalmology and Visual Sciences, Faculty of Medicine, Dalhousie University , Halifax, Nova Scotia, Canada.

Purpose: To describe a case of Sweet syndrome, a dermatologic inflammatory disease, with progressive, unrelenting ocular findings.

Methods: Case report.

Results: A 73-year-old male was evaluated with a six-month history of Sweet syndrome, manifesting as cutaneous erythematous edematous papules on the dorsal arms and shins and confirmed with biopsy demonstrating neutrophil infiltration with nuclei fragmentation and lack of vasculitis. Read More

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Extrapulmonary manifestations of COVID-19.

Nat Med 2020 07 10;26(7):1017-1032. Epub 2020 Jul 10.

Division of Nephrology, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, NY, USA.

Although COVID-19 is most well known for causing substantial respiratory pathology, it can also result in several extrapulmonary manifestations. These conditions include thrombotic complications, myocardial dysfunction and arrhythmia, acute coronary syndromes, acute kidney injury, gastrointestinal symptoms, hepatocellular injury, hyperglycemia and ketosis, neurologic illnesses, ocular symptoms, and dermatologic complications. Given that ACE2, the entry receptor for the causative coronavirus SARS-CoV-2, is expressed in multiple extrapulmonary tissues, direct viral tissue damage is a plausible mechanism of injury. Read More

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Validation of the OptiSafe™ eye irritation test.

Cutan Ocul Toxicol 2020 Sep 16;39(3):180-192. Epub 2020 Jul 16.

Integrated Laboratory Systems, Inc., Research Triangle Park, NC, USA.

Purpose: OptiSafe is an test method that identifies potential eye irritants based on macromolecular damage following test chemical exposure. The OptiSafe protocol includes a prescreen assessment that identifies test chemicals that are outside the applicability domain of the test method and thus determines the optimal procedure. We assessed the usefulness and limitations of the OptiSafe test method for identifying chemicals not requiring classification for ocular irritation (i. Read More

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September 2020

Update on the pathogenesis and management of ocular rosacea: an interdisciplinary review.

Eur J Ophthalmol 2021 Jan 25;31(1):22-33. Epub 2020 Jun 25.

Department of Ophthalmology, University of Illinois at Chicago, Chicago, IL, USA.

Purpose: Rosacea is one of the most common conditions affecting the ocular surface. The purpose of this review is to provide an update on the pathogenesis and treatment of rosacea based on the dermatology and ophthalmology literatures.

Methods: Literature searches were conducted for rosacea and ocular rosacea. Read More

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January 2021

Oncologic Emergencies: Immune-Based Cancer Therapies and Complications.

West J Emerg Med 2020 Apr 13;21(3):566-580. Epub 2020 Apr 13.

The University of Texas Southwestern Medical Center, Department of Emergency Medicine, Dallas, Texas.

Cancer therapies have undergone several recent advancements. Current cancer treatments include immune-based therapies comprised of checkpoint inhibitors, and adoptive immunotherapy; each treatment has the potential for complications that differ from chemotherapy and radiation. This review evaluates immune-based therapies and their complications for emergency clinicians. Read More

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Clinical manifestations of Behçet's disease in a large cohort of Chinese patients: gender- and age-related differences.

Clin Rheumatol 2020 Nov 11;39(11):3449-3454. Epub 2020 May 11.

Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100730, China.

Objectives: To investigate the clinical characteristics of Bechet's disease (BD) with respect to gender and age in China.

Method: Clinical data of 489 BD patients admitted to Peking Union Medical College Hospital (PUMCH) and registered by the BD registry database established by PUMCH from March 2014 to January 2019 were collected and analyzed in this study. Demographics, medical histories, clinical manifestations, laboratory test results, imaging findings, assessment of disease activity, treatment regimen, as well as the outcomes were reviewed. Read More

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November 2020

Physical illnesses associated with childhood homelessness: a literature review.

Ir J Med Sci 2020 Nov 8;189(4):1331-1336. Epub 2020 May 8.

Graduate Entry Medical School (GEMS), University of Limerick, Limerick, Ireland.

Background: Childhood homelessness is a growing concern in Ireland [1] creating a paediatric subpopulation at increased risk of physical illnesses, many with life-long consequences [2].

Aim: Our aim was to identify and categorize the physical morbidities prevalent in homeless children.

Methods: A review of the English-language literature on physical morbidities affecting homeless children (defined as ≤ 18 years of age) published from 1999 to 2019 was conducted. Read More

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November 2020

Ophthalmological treatment of early-onset sarcoidosis/Blau syndrome in a Colombian child: A case report.

Am J Ophthalmol Case Rep 2020 Jun 18;18:100714. Epub 2020 Apr 18.

NeURos Research Group. Escuela de Medicina y Ciencias de La Salud, Universidad Del Rosario, Carrera 24 # 63 C 69, Bogotá, Colombia.

Purpose: To report the ophthalmological approach of a patient with Blau syndrome (BS) in Colombia.

Observations: We describe a 9-year-old Colombian boy with sporadic BS due to a nucleotide-binding oligomerization domain containing 2 (NOD2) mutation, who presented with joint and dermatologic symptoms. He was referred to the uveitis service with a single functional eye, due to retinal detachment in the other eye. Read More

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