417 results match your criteria dermal template

An Alternative Dermal Template for Reconstruction of Complex Upper Extremity Wounds.

Plast Reconstr Surg Glob Open 2021 Jul 12;9(7):e3674. Epub 2021 Jul 12.

MetroHealth Medical Center, Cleveland, Ohio.

The management of upper extremity soft-tissue defects with full-thickness skin loss and denuded tendon and/or bone traditionally requires vascularized tissue reconstruction. Herein, we present patient outcomes utilizing Novosorb Bio-degradable Temporizing Matrix (PolyNovo, Wilmington, Del.), a novel bilaminar dermal regenerative template, followed by skin grafting, for reconstruction of complex upper extremity injuries with exposed tendon and/or bone. Read More

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Complex Multidisciplinary Cranial and Scalp Reconstruction for Patient Salvage.

World Neurosurg 2021 Jun 16. Epub 2021 Jun 16.

Division of Neurological Surgery, University of Missouri School of Medicine, One Hospital Drive, Columbia, Missouri, USA. Electronic address:

Objective/background: Patients can develop scalp and cranial defects as a result of neoplasm, trauma, or infection. Reconstruction of these defects can be difficult in some patients and may require a multidisciplinary approach using creative solutions usually used for disease processes in other areas of the body, such as severe burns.

Methods: A series of 9 patients were treated using multidisciplinary techniques for reconstruction of complex cranial and scalp defects. Read More

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Reply: Outcomes and Predictors of Wound Healing among Patients with Complex Diabetic Foot Wounds Treated with a Dermal Regeneration Template (Integra).

Plast Reconstr Surg 2021 Jul;148(1):149e

Diabetic Foot and Wound Service and Division of Vascular Surgery and Endovascular Therapy, Department of Surgery, The Johns Hopkins Hospital, Baltimore, Md.

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Outcomes and Predictors of Wound Healing among Patients with Complex Diabetic Foot Wounds Treated with a Dermal Regeneration Template (Integra).

Li-Ming Sun

Plast Reconstr Surg 2021 Jul;148(1):148e-149e

Department of Plastic Surgery, Jinling Hospital, Nanjing School of Clinical Medicine, Bengbu Medical College, Nanjing, Jiangsu 210002, China,

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Innovative Indigenous Cost-effective Bilaminar Dermal Regeneration Template.

J Cutan Aesthet Surg 2021 Jan-Mar;14(1):110-113

Department of Plastic Surgery, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Pondicherry, India.

Context: In today's era of medical advancement, various modalities of treatment options and dressing materials are available for burn wound management. Bilaminar dermal regeneration template is doubtful in developing countries because of its high cost availability and affordability.

Aims And Objectives: The aim of this research was to study the use of innovative indigenous cost-effective bilaminar dermal regeneration template in burn raw area. Read More

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Malignant Skin Cancer Excision in Combined Therapy with Electro-Chemotherapy and Dermal Substitute.

Curr Oncol 2021 May 5;28(3):1718-1727. Epub 2021 May 5.

Surgical Science Department, Medical School, University "Tor Vergata", 00133 Rome, Italy.

Squamous cell carcinoma (SCC) is the second most common malignancy skin cancer. It is characterized by abnormal, accelerated growth of squamous cells (SCs). SCC occurs when DNA damage from exposure to ultraviolet radiation or other damaging agents trigger abnormal changes in the SCs, presenting as painless lesions on areas of high sun exposure, such as the dorsum of the hand and upper extremity. Read More

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Synergic effect of buccal fat pad pedicled flap and dermal acellular matrix for large cheek defect.

Ital J Dermatol Venerol 2021 Apr;156(2):244-247

Dermatology Unit, Surgical, Medical and Dental Department of Morphological Sciences related to Transplant, Oncology and Regenerative Medicine, University of Modena and Reggio Emilia, Modena, Italy.

Reconstruction of large defects of the upper cheek defects still remains a challenge for the surgeon, who can apply different techniques. We present a new method involving the use of a dermal regeneration template to achieve an improved, faster healing of pedicled buccal fat flap in a 75-year-old woman affected by melanoma of the upper-middle cheek. The tumor involved soft tissue, zygomatic arch and periocular fact. Read More

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Association of Systemic or Intravitreal Antivascular Endothelial Growth Factor (Anti-VEGF) and Impaired Wound Healing in Pediatric Patients: Collagen to the Rescue.

Vita Boyar

J Wound Ostomy Continence Nurs 2021 May-Jun 01;48(3):256-261

Vita Boyar, MD, Steven & Alexandra Cohen Children's Medical Center, New Hyde Park, New York; and Zucker School of Medicine at Hofstra/Northwell, New Hyde Park, New York.

Background: Bevacizumab is a humanized monoclonal antibody to vascular endothelial growth factor (VEGF) that has been used as a systemic chemotherapy treatment of various malignancies in adults since 2000. It has been used for pediatric patients over the last decade. In addition, bevacizumab is used for neonatal intravitreal administration for retinopathy of prematurity, a major complication of preterm birth, characterized by incomplete and abnormal vascularization of the retina that can lead to retinal detachment and blindness without treatment. Read More

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Role of a new acellular dermal matrix in a multistep combined treatment of dermatofibrosarcoma protuberans of the lumbar region: a case report.

J Med Case Rep 2021 Apr 20;15(1):180. Epub 2021 Apr 20.

Unit of Reconstructive and Plastic Surgery, Azienda Ospedaliero Universitaria Ospedali Riuniti di Foggia, 71122, Foggia, Italy.

Background: Dermatofibrosarcoma protuberans (DFSP) is a rare skin fibroblastic tumor, with a high rate of recurrence. The treatment of DFSP is generally surgical, and wide local excision is the mainstay of surgical treatment. Therefore, complete assessment of all surgical margins is fundamental before definitive reconstruction. Read More

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A Case of Large Aplasia Cutis Congenita with Underlying Skull Defect: Effective Surgical Treatment with Integra® Dermal Regeneration Template.

Pediatr Neurosurg 2021 7;56(3):268-273. Epub 2021 Apr 7.

Department of Plastic Surgery, Niguarda Ca' Granda Hospital, Milan, Italy.

Introduction: Aplasia cutis congenita (ACC) is a rare congenital abnormality characterized by the absence of a portion of skin at birth which most commonly involves the scalp and can affect the galea, the pericranium, the bone, and the dura mater. It can be an isolated condition or associated with other disorders.

Case Report: We present a case of ACC with a large defect of the scalp and the underlying bone treated with the use of Integra® Dermal regeneration template. Read More

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Efficacy and safety of an artificial dermal graft for the reconstruction of exenterated sockets: a preliminary report.

Graefes Arch Clin Exp Ophthalmol 2021 Mar 26. Epub 2021 Mar 26.

Ophthalmology Department, University Hospital of Nice, Nice, France.

Purpose: The purpose of this study is to report our experience with the use of artificial dermis grafts for orbital socket reconstruction following orbital exenteration (OE).

Method: A retrospective study was conducted in our ocular oncology centre from May 2018 to June 2020 in patients undergoing OE for orbital malignancies in whom an artificial dermis device (Integra® template, 2 layers) was used for reconstruction. Data recorded included demographics, previous and adjuvant treatments, aetiologies, surgical procedure, surgical reconstruction, complications and follow-up. Read More

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The Use of Integra Dermal Regeneration Templates and Cortical Bone Fenestrations over Exposed Tibia.

Plast Reconstr Surg Glob Open 2021 Feb 1;9(2):e3340. Epub 2021 Feb 1.

Department of Surgery, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, Pa.

We present the case of an 86-year-old woman who suffered full-thickness soft tissue loss secondary to degloving injury to the lower left limb, resulting in an exposed tibia. This patient underwent drilling to create artificial fenestrations in the cortical bone followed by placement of Integra dermal regeneration template. The technique of drilling fenestrations to expose underlying vasculature of cortical bone has not previously been described in its relationship with Integra dermal regeneration templates in large degloving injuries of the lower limb. Read More

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February 2021

Polydopamine-modified collagen sponge scaffold as a novel dermal regeneration template with sustained release of platelet-rich plasma to accelerate skin repair: A one-step strategy.

Bioact Mater 2021 Aug 10;6(8):2613-2628. Epub 2021 Feb 10.

Department of Burns, Nanfang Hospital, Southern Medical University, Jingxi Street, Baiyun District, Guangzhou, 510515, PR China.

Although employed to release growth factors (GFs) for regenerative medicine, platelet-rich plasma (PRP) has been hindered by issues like burst effect. Based on collagen sponge scaffolds (CSSs) modified with polydopamine (pDA), a novel dermal regeneration template (DRT) was designed. However, whether it could efficiently deliver PRP and even foster wound healing remained unclear. Read More

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Dermal Regeneration Template and Staged Skin Grafting for Extirpative Scalp Wound Reconstruction: A 14-Year Experience.

Otolaryngol Head Neck Surg 2021 Feb 16:194599820986582. Epub 2021 Feb 16.

Department of Plastic and Reconstructive Surgery, Wake Forest Baptist Medical Center, Winston-Salem, North Carolina, USA.

Objective: Dermal regeneration template and staged split-thickness skin grafting may mitigate the need for flap coverage of postoncologic scalp defects. This technique has been studied previously in small case series. We examine the effect of risk factors, surgical technique, irradiation, and dressing modalities on reconstructive outcomes in a highly comorbid patient cohort. Read More

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February 2021

Coffee Bean Polyphenols Can Form Biocompatible Template-free Antioxidant Nanoparticles with Various Sizes and Distinct Colors.

ACS Omega 2021 Feb 18;6(4):2767-2776. Epub 2021 Jan 18.

Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Amman 11733, Jordan.

Plant polyphenols have attracted attention in recent years due to their ability to undergo oxidative coupling reactions enabled by the presence of multiple phenolic hydroxyl groups, forming chemically versatile coatings and biocompatible nanoparticles (NPs) for various applications. The aim of this study was to investigate whether coffee bean aqueous extracts, which are known to be rich in polyphenols, could serve as a natural source of NP building blocks. Extracts were prepared by heating ground Arabica beans of varying roasting degrees in water with or without the addition of sodium metaperiodate or copper sulfate as an oxidizing agent, followed by filtration. Read More

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February 2021

Release of pseudosyndactyly in recessive dystrophic epidermolysis bullosa using a dermal regeneration template glove: the Foggia experience.

Orphanet J Rare Dis 2021 01 28;16(1):52. Epub 2021 Jan 28.

Department of Plastic and Reconstructive Surgery, Ospedali Riuniti University of Foggia, Viale Pinto1, 71100, Foggia, Italy.

Background: Epidermolysis bullosa (EB) comprises a heterogeneous group of rare genetic diseases associated with skin blistering caused by minimal trauma. A major and common EB subtype, recessive dystrophic EB (RDEB), is characterized by altered wound healing, inflammatory dysbalance and fibrotic changes associated with reduced to absent collagen VII. Because of its exposed position and its continued use in daily activities, the hand is constantly at risk of microtrauma and is therefore one of the organs most affected by the disease with highly disabling deformities that represent a challenging field in hand surgery practice. Read More

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January 2021

Skin regeneration is accelerated by a lower dose of multipotent mesenchymal stromal/stem cells-a paradigm change.

Stem Cell Res Ther 2021 01 25;12(1):82. Epub 2021 Jan 25.

Sunnybrook Research Institute, Sunnybrook Health Sciences Centre, Toronto, Canada.

Background: Multipotent mesenchymal stromal/stem cell (MSC) therapy is under investigation in promising (pre-)clinical trials for wound healing, which is crucial for survival; however, the optimal cell dosage remains unknown. The aim was to investigate the efficacy of different low-to-high MSC dosages incorporated in a biodegradable collagen-based dermal regeneration template (DRT) Integra®.

Methods: We conducted a porcine study (N = 8 Yorkshire pigs) and seeded between 200 and 2,000,000 cells/cm of umbilical cord mesenchymal stromal/stem cells on the DRT and grafted it onto full-thickness burn excised wounds. Read More

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January 2021

Dermal Regeneration Templates in Maxillo-Facial District: A Multipurpose Aid.

J Craniofac Surg 2021 Jan 20. Epub 2021 Jan 20.

Department of Maxillofacial Surgery, Santa Maria Hospital, Terni Department of Maxillofacial Surgery, University of Siena, Policlinico Santa Maria alle Scotte, Viale Mario Bracci, Siena Dipartimento di Scienze Odontostomatologiche e Maxillo-Facciale, "Sapienza" Università di Roma, Roma, Italy.

Abstract: Since 1980s, the use of dermal regeneration templates (DRT) for reconstructive purposes has been described in Literature.1 The authors present their experience of 13 patients treated with integra dermal regeneration template and a single-stage surgery for different indications like oncologic reconstruction, trauma injuries, and preprosthetic surgery in the maxillo-facial district.The authors retrospectively reviewed a total of 13 patients treated with DRT at Maxillo-Facial Department of S. Read More

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January 2021

The Black Locust Tree: Toxalbumin-Induced Tissue Necrosis of the Upper Extremity.

Cureus 2020 Nov 28;12(11):e11758. Epub 2020 Nov 28.

Plastic and Reconstructive Surgery, Wake Forest School of Medicine, Winston-Salem, USA.

We present the case of a 48-year-old male who developed tissue necrosis and subsequent necrotizing fasciitis in his right upper extremity after sustaining a puncture injury from a large black locust tree () splinter. Blood and intraoperative wound cultures revealed  and infection. The treatment consisted of IV antibiotics, fasciotomy, and multiple debridements, which left a 30 x 5-cm defect, requiring negative pressure wound therapy with Integra Dermal Regeneration Template (Integra Lifesciences, Plainsboro Township, NJ) and, ultimately, split-thickness skin grafts. Read More

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November 2020

[National expert consensus on the application of natural dermal matrix in wound repair (2020 version)].


Zhonghua Shao Shang Za Zhi 2020 Oct;36(10):895-900

Natural dermal matrix has good biocompatibility and can serve as " biological template" in wound repair. According to the source of material, natural dermal matrix can be divided into acellular dermal matrix (ADM), denatured dermal matrix, and scar dermal matrix. ADM is a biological material prepared by removing cellular components from the skin and retaining extracellular matrix (ECM) of the dermis. Read More

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October 2020

Indications and functional outcome of the use of integra dermal regeneration template for the management of traumatic soft tissue defects on dorsal hand, fingers and thumb.

Arch Orthop Trauma Surg 2020 Dec 12;140(12):2115-2127. Epub 2020 Oct 12.

Plastic, Burn and Hand Surgery Departement, FX. Michelet Center, Bordeaux University Hospital (Pellegrin Site), Place Amelie Raba-Leon, 33076, Bordeaux, France.

Introduction: Few studies have been conducted to explore the utility of the Integra dermal regeneration template (IDRT) combined with a delayed split-thickness skin graft (STSG) for reconstructing complex dorsal hand, digit, and thumb injuries. This study reports the indications and outcomes for 14 patients treated with this technique via a two-stage process.

Materials And Methods: We retrospectively reviewed all patients treated by IDRT combined with STSG from May 2015 to October 2018. Read More

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December 2020

Use of Integra® dermal regeneration template and flowable matrix to reconstruct an oral cavity defect involving the nasal floor.

Br J Oral Maxillofac Surg 2020 12 21;58(10):e343-e344. Epub 2020 Aug 21.

Oral and Maxillofacial Surgery Department, Bristol Royal Infirmary, Bristol, UK.

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December 2020

Surgical Reconstruction following Wide Local Excision of Malignant Melanoma of the Scalp.

Plast Reconstr Surg Glob Open 2020 Aug 26;8(8):e3059. Epub 2020 Aug 26.

Clinica di Chirurgia Plastica e Ricostruttiva, Ospedale Policlinico San Martino e Sezione di Chirurgia Plastica, Dipartimento di Scienze Chirurgiche e Diagnostiche Integrate-DISC, Università degli Studi di Genova, Genova, Italy.

Scalp reconstruction in cases of melanoma excision can be challenging due to specific functional and aesthetic outcome requirements. Reconstructive techniques reported in the literature were reviewed to establish whether a surgical algorithm for the management of melanoma of the scalp may be deduced.

Methods: A literature search was conducted to evaluate reconstructive strategies after melanoma wide local excision of the scalp according to Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Read More

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Adipose Stem Cells and Platelet-Rich Plasma Induce Vascular-Like Structures in a Dermal Regeneration Template.

Tissue Eng Part A 2021 05 12;27(9-10):631-641. Epub 2020 Oct 12.

Department of Medical and Surgical Sciences, University of Foggia, Foggia, Italy.

In the context of biointeractive dressings used for enhancing wound healing, the use of stromal vascular fraction (SVF) or adipose-derived stem cells (ASCs) hereof derived has not been fully exploited yet. Noncultured SVF, a heterogeneous mesenchymal population of cells, is attractive in the field of dermal regeneration because it can be instantaneously obtained, avoids genomic alterations, and is comparatively safer than cultured ASCs. Integra Dermal Regeneration Template (DRT) was sprinkled with ASCs in complete medium supplemented with 10% fetal bovine serum (FBS), or SVF, obtained from emulsified or nonemulsified fat, in medium supplemented with 2% platelet-rich plasma (PRP). Read More

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A human skin equivalent burn model to study the effect of a nanocrystalline silver dressing on wound healing.

Burns 2021 03 15;47(2):417-429. Epub 2020 Jul 15.

Queensland University of Technology (QUT), Tissue Repair and Translational Physiology Program, Institute of Health and Biomedical Innovation, Brisbane, Queensland, Australia; Queensland University of Technology (QUT), Faculty of Health, School of Biomedical Sciences, Brisbane, Queensland, Australia; Queensland University of Technology (QUT), Centre for Children's Burns and Trauma Research, Institute of Health and Biomedical Innovation at Centre for Children's Health Research, Brisbane, Queensland, Australia. Electronic address:

In this study, a deep burn wound model was established using a 3D human skin equivalent (HSE) model and this was compared to native skin. HSEs were constructed from dermis derived from abdominoplasty/breast surgery and this dermal template was seeded with primary keratinocytes and fibroblasts. The HSE model was structurally similar to native skin with a stratified and differentiated epidermis. Read More

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Silicone Scaffold Support Using a Bilayer Dermal Regeneration Matrix Template for Correction of Primary or Recurrent Eyelid Retraction.

Ophthalmic Plast Reconstr Surg 2021 Mar-Apr 01;37(2):183-187

Department of Ophthalmology, University of Colorado Health Science Center, Denver, CO, U.S.A.

Purpose: To evaluate the efficacy and safety of a bilayer dermal regenerative matrix for primary or complex/recurrent eyelid retraction.

Methods: Retrospective review of patients undergoing eyelid retraction repair using the bilayer dermal regenerative matrix from 2005 to 2019. Nineteen eyelid surgeries from 15 patients were identified. Read More

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Placement of Dermal Regeneration Template on Fibrotic Dura.

Cureus 2020 Jul 14;12(7):e9185. Epub 2020 Jul 14.

Plastic Surgery, Creighton University School of Medicine, Phoenix, USA.

We report the case of a male presenting with a large, fungating Marjolin ulcer over a prior craniectomy defect that had undergone several attempts at reconstruction. On presentation, he had a large area of exposed, fibrotic dura that ultimately required excision of the outer layer prior to placement of Integra (Integra LifeSciences, Plainsboro, NJ) and subsequent split-thickness skin grafting. Although there have been four other reports of dermal regeneration templates being used on exposed dura, this is the first case report of one being used on exposed dura that required dural preparation prior to placement. Read More

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Use of Porcine-Derived Dermal Substitutes for Treatment of Nonhealing Vascular Leg Ulcers: A Case Series.

Int J Low Extrem Wounds 2020 Aug 17:1534734620945561. Epub 2020 Aug 17.

Vascular Surgery Unit, Department of Transalational Medical Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy.

Nonhealing leg ulcers are a major health problem worldwide with a high economic burden since they require human and material resources. Moreover, nonhealing ulcers are a major nontraumatic cause of lower limb amputations. Dermal substitutes have emerged as an effective therapeutic option for treatment of skin lesions, but data on leg ulcers are scarce. Read More

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