9,544 results match your criteria der determined

Prediction of beryllium clusters (Be; = 3-25) from first principles.

Phys Chem Chem Phys 2021 Sep 15;23(35):19716-19728. Epub 2021 Sep 15.

Department of Chemistry, University of Manitoba, Winnipeg, Manitoba, R3T 2N2, Canada.

Evolutionary searches using the USPEX method (Universal Structure Predictor: Evolutionary Xtallography) combined with density functional theory (DFT) calculations were performed to obtain the global minimum structures of beryllium (Be, = 3-25) clusters. The thermodynamic stability, optoelectronic and photocatalytic properties as well as the nature of bonding are considered for the most stable clusters. It is found that the cluster with = 15 is the transition point at which the configurations change from 3D hollow cages to filled cage structures (with an interior atom appearing in the structure). Read More

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September 2021

First-principles prediction of infrared phonon and dielectric function in biaxial hyperbolic van der Waals crystal α-MoO.

Phys Chem Chem Phys 2021 Sep 15;23(35):19627-19635. Epub 2021 Sep 15.

Shenzhen JL Computational Science and Applied Research Institute, Shenzhen 518131, China.

Layered biaxial hyperbolic molybdenum trioxide (α-MoO) with weak van der Waals (vdW) interlayer bonding recently received extensive attention due to its anisotropic dielectric response to infrared (IR) radiation, which couples to the lattice vibrations and allows for manipulating the radiative energy transport. However, the understanding of IR-active phonon modes and dielectric function of it has not yet been fully achieved. Here, by utilizing mode-level first-principles analysis based on density functional theory (DFT), the phonon modes contributing to the IR dielectric response of α-MoO are fully determined. Read More

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September 2021

SUV39 SET domains mediate crosstalk of heterochromatic histone marks.

Elife 2021 Sep 15;10. Epub 2021 Sep 15.

Department of Molecular Biology, Faculty of Science, University of Geneva, Geneva, Switzerland.

The SUV39 class of methyltransferase enzymes deposits histone H3 lysine 9 di- and trimethylation (H3K9me2/3), the hallmark of constitutive heterochromatin. How these enzymes are regulated to mark specific genomic regions as heterochromatic is poorly understood. Clr4 is the sole H3K9me2/3 methyltransferase in the fission yeast and recent evidence suggests that ubiquitination of lysine 14 on histone H3 (H3K14ub) plays a key role in H3K9 methylation. Read More

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September 2021

Endograft apposition and infrarenal neck enlargement after endovascular aortic aneurysm repair.

J Cardiovasc Surg (Torino) 2021 Sep 14. Epub 2021 Sep 14.

Department of Surgery, Division of Vascular Surgery, University Medical Center Groningen, Groningen, The Netherlands.

Background: Sufficient apposition and oversizing of the endograft in the aortic neck are both essential for durable endovascular aneurysm repair (EVAR). These measures are however not regularly stated on post-EVAR computed tomography angiography (CTA) scan reports. In this study endograft apposition and neck enlargement (NE) after EVAR with an Endurant II(s) endograft were analyzed and associated with supra- and infrarenal aortic neck morphology. Read More

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September 2021

House dust mite-derived serine protease upregulates gene expression of interleukin-33 in canine keratinocytes via protease-activated receptor-2.

Vet Dermatol 2021 Sep 14. Epub 2021 Sep 14.

Cooperative Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai-cho, Fuchu, Tokyo, 183-8509, Japan.

Background: The involvement of interleukin (IL)-33 produced by keratinocytes has been suggested in the pathogenesis of canine atopic dermatitis (cAD). House dust mite (HDM)-derived proteases induce the production of various cytokines and chemokines in keratinocytes via protease-activated receptor-2 (PAR-2); however, their effects on IL-33 mRNA expression in canine keratinocytes have not been determined.

Hypothesis/objective: To clarify whether HDM-derived proteases induce IL-33 mRNA expression in canine keratinocytes via PAR-2. Read More

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September 2021

An expression for the angle of repose of dry cohesive granular materials on Earth and in planetary environments.

Proc Natl Acad Sci U S A 2021 Sep;118(38)

Faculty of Physics, University of Duisburg-Essen, 47057 Duisburg, Germany

The angle of repose-i.e., the angle [Formula: see text] between the sloping side of a heap of particles and the horizontal-provides one of the most important observables characterizing the packing and flowability of a granular material. Read More

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September 2021

A Joint Venture of Ab Initio Molecular Dynamics, Coupled Cluster Electronic Structure Methods, and Liquid-State Theory to Compute Accurate Isotropic Hyperfine Constants of Nitroxide Probes in Water.

J Chem Theory Comput 2021 Sep 13. Epub 2021 Sep 13.

Lehrstuhl für Theoretische Chemie, Ruhr-Universität Bochum, 44780 Bochum, Germany.

The isotropic hyperfine coupling constant (HFCC, ) of a pH-sensitive spin probe in a solution, HMI (2,2,3,4,5,5-hexamethylimidazolidin-1-oxyl, CHNO) in water, is computed using an ensemble of state-of-the-art computational techniques and is gauged against X-band continuous wave electron paramagnetic resonance (EPR) measurement spectra at room temperature. Fundamentally, the investigation aims to delineate the cutting edge of current first-principles-based calculations of EPR parameters in aqueous solutions based on using rigorous statistical mechanics combined with correlated electronic structure techniques. In particular, the impact of solvation is described by exploiting fully atomistic, RISM integral equation, and implicit solvation approaches as offered by ab initio molecular dynamics (AIMD) of the periodic bulk solution (using the spin-polarized revPBE0-D3 hybrid functional), embedded cluster reference interaction site model integral equation theory (EC-RISM), and polarizable continuum embedding (using CPCM) of microsolvated complexes, respectively. Read More

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September 2021

The Expression Profile of Protease Inhibitors in the Airway Epithelial Cells after Allergen (Der p 1) Stimulation.

Int Arch Allergy Immunol 2021 Aug 20:1-9. Epub 2021 Aug 20.

Department of Pediatric Allergy, Faculty of Medicine, Hacettepe University, Ankara, Turkey.

Background: Airway epithelial cells are constantly exposed to intracellular and extracellular proteases that play a pivotal role in several airway diseases. Dermatophagoides pteronyssinus (Der p) 1 derived from house dust mite has protease activity that causes epithelial barrier defect and inflammatory response. Protease inhibitors released against proteases are involved in the maintenance of homeostasis. Read More

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Bone Mineral Density in Adult Survivors of Pediatric Differentiated Thyroid Carcinoma: a longitudinal follow-up study.

Thyroid 2021 Sep 13. Epub 2021 Sep 13.

University of Groningen, University Medical Center Groningen, Internal Medicine, Department of Endocrinology, Groningen, Netherlands;

Background: Survivors of pediatric differentiated thyroid carcinoma (DTC) receive thyrotropin (TSH) suppressive therapy to minimize disease recurrence. However, knowledge about long-term effects of subclinical hyperthyroidism on bone mineral density (BMD) in pediatric DTC survivors is scarce, as is the information regarding long-term consequences of permanent hypoparathyroidism on BMD. We evaluated BMD in pediatric DTC survivors and investigated if BMD was affected by subclinical hyperthyroidism and/or permanent hypoparathyroidism during long-term follow-up. Read More

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September 2021

Crystal structure, Hirshfeld surface analysis, inter-action energy, and DFT studies of cholesteryl hepta-noate.

Acta Crystallogr E Crystallogr Commun 2021 Jul 4;77(Pt 7):686-691. Epub 2021 Jun 4.

Department of Physics, Hacettepe University, 06800 Beytepe, Ankara, Turkey.

The title compound, CHO, consists of cholesteryl and hepta-noate units, in which the six-membered rings adopt chair and twisted-boat conformations while the five-membered ring adopts an envelope conformation. In the crystal, the mol-ecules are aligned along the -axis direction and stacked along the -axis direction. The Hirshfeld surface analysis of the crystal structure indicates that the most important contributions for the crystal packing are from H⋯H (92. Read More

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Boundary values of binding constants determined by affinity capillary electrophoresis.

J Sep Sci 2021 Sep 12. Epub 2021 Sep 12.

Institute of Chemistry and Chemical Technology SB RAS, Federal Research Center "Krasnoyarsk Science Center SB RAS", Akademgorodok 50/24, Krasnoyarsk, 660036, Russia.

This study shows that the upper limit of binding (stability) constants determined by mobility shift affinity capillary electrophoresis can be increased from 10 to 10 -10 L/mol if the lowest possible analyte concentration in samples is used (for example, the concentration that gives electrophoretic peaks with a signal-to-noise ratio of 10) and the effective electrophoretic mobility of the analyte is calculated via the parameter a of the Haarhoff-Van der Linde function. The equation to calculate the boundary values of binding constants for 1:1 complexes was derived for the case when the constants cannot be calculated in the usual way. These values are obtained from the inequality: the difference between the ionic mobility of the analyte-ligand complex and the effective electrophoretic mobility of the analyte determined at the lowest ligand concentration in the background electrolyte at which the analyte appears as an undistorted peak in electropherograms is less than or equal to the absolute error in mobility measurements. Read More

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September 2021

Copper(II)-N-hydroxy-N,N'-diarylformamidine complexes: Synthesis, crystal structures, antibacterial and molecular docking studies.

J Inorg Biochem 2021 Sep 3;225:111600. Epub 2021 Sep 3.

School of Chemistry and Physics, Pietermaritzburg Campus, University of Kwazulu-Natal, Private Bag X01, Scottsville 3209, South Africa. Electronic address:

A series of Cu(II) complexes were synthesized by using N-hydroxy-N,N'-diarylformamidine ligands: N-hydroxy-N,N'-(phenyl)formamidine (L1), N-hydroxy-N'-(4-methylphenyl)formamidine (L2), N-hydroxy-N,N'-(2,6-dimethylphenyl)formamidine (L3), N-hydroxy-N,N'-(2,6-diisopropylphenyl)formamidine (L4). Reaction of ligands L1-L4 with hydrated copper acetate furnished mononuclear Cu(II) complexes 1-4 with general formula [Cu-(L)]. The molecular structures of complexes 3 and 4, as determined by single crystal X-ray diffraction, showed both to have square planar geometry with a near C symmetry. Read More

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September 2021

Involvement of the extracellular matrix proteins periostin and tenascin C in nasal polyp remodeling by regulating the expression of MMPs.

Clin Transl Allergy 2021 Aug 6;11(7):e12059. Epub 2021 Sep 6.

Department of Oto-Rhino-Laryngology Upper Airways Research Laboratory Ghent University Hospital Ghent Belgium.

Background: Tissue remodeling caused by increased MMPs is involved in the pathogenesis of chronic rhinosinusitis with nasal polyposis (CRSwNP). We previously found higher levels of periostin and tenascin C in CRSwNPs, but whether they are associated with the dysregulation of MMPs is unknown. Therefore, the present study aimed to investigate the regulatory roles of these two ECM proteins in the expression of MMPs in nasal polyps. Read More

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MRI-Determined Psoas Muscle Fat Infiltration Correlates with Severity of Weight Loss during Cancer Cachexia.

Cancers (Basel) 2021 Sep 2;13(17). Epub 2021 Sep 2.

Department of Diagnostic and Interventional Radiology, Klinikum Rechts der Isar, Technical University of Munich, 81675 Munich, Germany.

Purpose: To evaluate the suitability of psoas and erector spinae muscle proton density fat fraction (PDFF) and fat volume as biomarkers for monitoring cachexia severity in an oncological cohort, and to evaluate regional variances in muscle parameters over time.

Methods: In this prospective study, 58 oncological patients were examined by a 3 T MRI receiving between one and five scans. Muscle volume and PDFF were measured, segmentation masks were divided into proximal, middle and distal muscle section. Read More

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September 2021

Ga-DOTATATE PET/CT and MRI with Diffusion-Weighted Imaging (DWI) in Short- and Long-Term Assessment of Tumor Response of Neuroendocrine Liver Metastases (NELM) Following Transarterial Radioembolization (TARE).

Cancers (Basel) 2021 Aug 27;13(17). Epub 2021 Aug 27.

Klinik und Poliklinik für Radiologie, Klinikum der Universität München, LMU München, Marchioninistr. 15, 81377 Munich, Germany.

The aim of this study was to evaluate the role of SUV and ADC in assessing early response in patients with NELM following TARE. Thirty-two patients with pre- and postinterventional MRI with DWI and Ga-DOTATATE PET/CT were included. ADC and SUV of three target lesions and of tumor-free spleen and liver tissue were determined on baseline and first follow-up imaging, and tumor to spleen (T/S) and tumor to liver (T/L) ratios were calculated. Read More

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Crystalline Forms of Trazodone Dihydrates.

Molecules 2021 Sep 3;26(17). Epub 2021 Sep 3.

Department of Chemistry, University of Aberdeen, Meston Walk, Aberdeen AB24 3UE, UK.

In this study, treatment of anhydrous trazodone powder with ammonium carbamate in warm water crystallised two new polymorphs or dihydrates of trazodone after 5 h, whose structures were determined by X-ray single crystal diffraction. Each dihydrate contains infinite zigzag hydrogen-bonded chains of water molecules, which are stabilised by the N4 acceptor atom of the piperazine ring and the pendant carbonyl O1 atom of the triazole ring, as well as other water molecules. The strong dipole moment expected for the O1 atom makes it a good hydrogen bond acceptor for stabilising the chains of water molecules. Read More

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September 2021

Ratio between Lactobacillus plantarum and Acetobacter pomorum on the surface of Drosophila melanogaster adult flies depends on cuticle melanisation.

BMC Res Notes 2021 Sep 8;14(1):351. Epub 2021 Sep 8.

University of Tübingen, Interfaculty Institute of Cell Biology, Section Animal Genetics, Auf der Morgenstelle 15, 72076, Tübingen, Germany.

Objectives: As in most organisms, the surface of the fruit fly Drosophila melanogaster is associated with bacteria. To examine whether this association depends on cuticle quality, we isolated and quantified surface bacteria in normal and melanized flies applying a new and simple protocol.

Results: On wild flies maintained in the laboratory, we identified two persistently culturable species as Lactobacillus plantarum and Acetobacter pomorum by 16S rDNA sequencing. Read More

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September 2021

Temperature and salt controlled tuning of protein clusters.

Soft Matter 2021 Sep 7. Epub 2021 Sep 7.

Institut Max von Laue - Paul Langevin, 71 avenue des Martyrs, 38042 Grenoble, France.

The formation of molecular assemblies in protein solutions is of strong interest both from a fundamental viewpoint and for biomedical applications. While ordered and desired protein assemblies are indispensable for some biological functions, undesired protein condensation can induce serious diseases. As a common cofactor, the presence of salt ions is essential for some biological processes involving proteins, and in aqueous suspensions of proteins can also give rise to complex phase diagrams including homogeneous solutions, large aggregates, and dissolution regimes. Read More

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September 2021

Spectroscopic glimpses of the transition state of ATP hydrolysis trapped in a bacterial DnaB helicase.

Nat Commun 2021 Sep 6;12(1):5293. Epub 2021 Sep 6.

Physical Chemistry, ETH Zürich, Zürich, Switzerland.

The ATP hydrolysis transition state of motor proteins is a weakly populated protein state that can be stabilized and investigated by replacing ATP with chemical mimics. We present atomic-level structural and dynamic insights on a state created by ADP aluminum fluoride binding to the bacterial DnaB helicase from Helicobacter pylori. We determined the positioning of the metal ion cofactor within the active site using electron paramagnetic resonance, and identified the protein protons coordinating to the phosphate groups of ADP and DNA using proton-detected P,H solid-state nuclear magnetic resonance spectroscopy at fast magic-angle spinning > 100 kHz, as well as temperature-dependent proton chemical-shift values to prove their engagements in hydrogen bonds. Read More

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September 2021

Anthelmintic flavonoids and other compounds from Combretum glutinosum Perr. ex DC (Combretaceae) leaves.

Acta Crystallogr C Struct Chem 2021 09 6;77(Pt 9):505-512. Epub 2021 Aug 6.

Laboratoire de Pharmacognosie et des Huiles Essentielles, Facultés des Sciences et Techniques, Université d'Abomey Calavi, 01 BP: 918 ISBA Cotonou, Benin.

A chemical study of the hydro-ethanol extract of the leaves of Combretum glutinosum resulted in the isolation of nine compounds, including 5-demethylsinensetin (1), umuhengerin (2), (20S,24R)-ocotillone (3), lupeol (4), β-sitosterol (5), oleanolic acid (6), betulinic acid (7), corymbosin (8) and β-sitosterol glucoside (9). Four compounds have been isolated for the first time from the genus Combretum [viz. (1), (2), (3) and (8)]. Read More

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September 2021

Immunocontraception of male and female giraffes using the GnRH vaccine Improvac®.

Zoo Biol 2021 Sep 3. Epub 2021 Sep 3.

Zoo Odense, Odense, Denmark.

The aim of this study was to develop protocols for contraception in both sexes of giraffes (Giraffa camelopardalis) by using the GnRH vaccine Improvac®. We evaluated the success of immunization by analyzing fecal reproductive hormone metabolites in female (n = 20) and male (n = 9) giraffes. Endocrine analysis provided the basis for the successful immunization protocol, as well as for assessing long-term effects. Read More

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September 2021

An Activity-Based Probe for Cathepsin K Imaging with Excellent Potency and Selectivity.

J Med Chem 2021 Sep 2. Epub 2021 Sep 2.

Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, An der Immenburg 4, Bonn 53121, Germany.

The cysteine protease cathepsin K is a target for the treatment of diseases associated with high bone turnover. Cathepsin K is mainly expressed in osteoclasts and responsible for the destruction of the proteinaceous components of the bone matrix. We designed various fluorescent activity-based probes (ABPs) and their precursors that bind to and inactivate cathepsin K. Read More

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September 2021

On the interdependence of post-error control and memory.

J Exp Psychol Learn Mem Cogn 2021 Sep 2. Epub 2021 Sep 2.

Department of Psychology.

Post-error cognitive control processes are evident in post-error slowing (PES) and post-error increased accuracy (PIA). A recent theory (Wessel, 2018) proposes that post-error control disrupts not only ongoing motor activity but also current task-set representations, suggesting an interdependence of post-error control and memory. In 2 experiments, we directly tested this interdependence using response repeat/switch targets. Read More

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September 2021

Determining infrastructure requirements for an air taxi service at Cologne Bonn Airport.

CEAS Aeronaut J 2021 Aug 27:1-13. Epub 2021 Aug 27.

Institute of Transport Science, RWTH Aachen, Mies-van-der-Rohe-Straße 1, 52074 Aachen, Germany.

The worldwide increasing population density in major urban centres poses great challenges for transportation systems. Air taxi services could be a solution to this growing problem by bringing the existing transportation system to the three dimensional space. This paper analyzes the challenges and requirements of developing a vertiport intended for the use of air taxis at Cologne Bonn Airport. Read More

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Analytical performance of aPROMISE: automated anatomic contextualization, detection, and quantification of [F]DCFPyL (PSMA) imaging for standardized reporting.

Eur J Nucl Med Mol Imaging 2021 Aug 31. Epub 2021 Aug 31.

Department of Data Science and Machine Learning, EXINI Diagnostics AB, Lund, Sweden.

Purpose: The application of automated image analyses could improve and facilitate standardization and consistency of quantification in [F]DCFPyL (PSMA) PET/CT scans. In the current study, we analytically validated aPROMISE, a software as a medical device that segments organs in low-dose CT images with deep learning, and subsequently detects and quantifies potential pathological lesions in PSMA PET/CT.

Methods: To evaluate the deep learning algorithm, the automated segmentations of the low-dose CT component of PSMA PET/CT scans from 20 patients were compared to manual segmentations. Read More

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Cryo-EM photosystem I structure reveals adaptation mechanisms to extreme high light in Chlorella ohadii.

Nat Plants 2021 Aug 30. Epub 2021 Aug 30.

Institute of Life Science, Faculty of Science and Mathematics, The Hebrew University of Jerusalem, Jerusalem, Israel.

Photosynthesis in deserts is challenging since it requires fast adaptation to rapid night-to-day changes, that is, from dawn's low light (LL) to extreme high light (HL) intensities during the daytime. To understand these adaptation mechanisms, we purified photosystem I (PSI) from Chlorella ohadii, a green alga that was isolated from a desert soil crust, and identified the essential functional and structural changes that enable the photosystem to perform photosynthesis under extreme high light conditions. The cryo-electron microscopy structures of PSI from cells grown under low light (PSI) and high light (PSI), obtained at 2. Read More

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High-resolution structure of the amino acid transporter AdiC reveals insights into the role of water molecules and networks in oligomerization and substrate binding.

BMC Biol 2021 Aug 30;19(1):179. Epub 2021 Aug 30.

Institute of Biochemistry and Molecular Medicine, and Swiss National Centre of Competence in Research (NCCR) TransCure, University of Bern, CH-3012, Bern, Switzerland.

Background: The L-arginine/agmatine transporter AdiC is part of the arginine-dependent extreme acid resistance system of the bacterium Escherichia coli and its pathogenic varieties such as strain E. coli O157:H7. At the present time, there is a lack of knowledge concerning the role of water molecules and networks for the structure and function of AdiC, and solute transporters in general. Read More

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Effects and interaction mechanism of soybean 7S and 11S globulins on anthocyanin stability and antioxidant activity during simulated digestion.

Curr Res Food Sci 2021 13;4:543-550. Epub 2021 Aug 13.

Faculty of Agriculture and Food, Yunnan Institute of Food Safety, Kunming University of Science and Technology, Kunming, 650500, Yunnan, China.

The objective of this study was to investigate the effects of soybean 7S and 11S globulins on the stability and antioxidant capacity of cyanidin-3-O-glucoside (C3G) in the simulated gastrointestinal environment, and further to elucidate their interaction mechanism. The stability and total content of anthocyanins (ACNs) before and after simulated digestion were determined by Ultraviolet-visible (UV-Vis) spectroscopic and pH differential methods, respectively, and free radical scavenging activity of C3G after simulated digestion were measured using ABTS and DPPH assays. The interaction mechanism was further investigated using molecular docking and molecular dynamics simulation. Read More

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Edoxaban versus Vitamin K Antagonist for Atrial Fibrillation after TAVR.

N Engl J Med 2021 Aug 28. Epub 2021 Aug 28.

From the Department of Cardiology, Erasmus University Medical Center, Thoraxcenter, Rotterdam, the Netherlands (N.M.V.M., E.B.); Daiichi Sankyo, Basking Ridge, NJ (M.U., J.J., A.D., C.C.); the Department of Internal Medicine II, Division of Cardiology, Vienna General Hospital, Medical University, Vienna (C.H., I.L.); the Department of Internal Medicine, St. Johannes Hospital, Dortmund (H.M.), the Department of Internal Medicine I, University Hospital Würzburg, Würzburg (P.N.), the Department of Internal Medicine-Cardiology, Heart Center Leipzig at University of Leipzig, Leipzig (H.T.), Bremer Institute for Heart and Circulation Research at Klinikum Links der Weser, Bremen (R.H.), the Department of Cardiology, Asklepios Klinik St. Georg, Hamburg (F.M.), Daiichi Sankyo Europe, Munich (P.L., H.L.), the Department of Neurology, Alfried Krupp Krankenhaus, Essen (R.V.), and the Department of Neurology, University Hospital Heidelberg, Heidelberg (R.V.) - all in Germany; Zena and Michael A. Wiener Cardiovascular Institute, Mount Sinai Hospital, New York (R. Mehran, G.D.D.); the Department of Cardiology, Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela (D.L.-O.), the Cardiovascular Institute, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria San Carlos (L.N.-F.), the Department of Cardiology, University Hospital La Paz (R. Moreno), and the Department of Cardiology, University Hospital Ramon y Cajal (J.L.Z.), Madrid - all in Spain; the Department of Cardiology, Washington Adventist Hospital, Takoma Park, MD (F.S.); the Department of Cardiology, Toyohashi Heart Center, Toyohashi (M.Y.), the Department of Cardiology, Teikyo University School of Medicine (Y.W.), and the Department of Cardiology, Keio University School of Medicine (K.H.), Tokyo, and the Division of Cardiology and Catheterization Laboratories, Shonan Kamakura General Hospital, Kamakura (S.S.) - all in Japan; the Department of Cardiology, Jessa Hospital, Hasselt, Belgium (P.V.); Quebec Heart and Lung Institute, Laval University, Quebec, QC, Canada (J.R.-C.); the Division of Cardiovascular Medicine, University Hospital of Strasbourg, Strasbourg, France (P.O.); the Division of Cardiology, Policlinico Hospital, University of Catania, Catania, Italy (P.C.); the Department of Internal Medicine, Cardiovascular Center, Seoul National University Hospital, Seoul, South Korea (H.-S.K.); the Department of Cardiology, University of Bern, Bern (T.P.), and Cardiocentro Ticino Institute and Department of Biomedical Sciences, University of Italian Switzerland, Lugano (M.V.) - both in Switzerland; the Department of Cardiology, University Hospital of Wales, Cardiff (R.A.), and the Division of Brain Sciences, Imperial College London, London (R.V.) - both in the United Kingdom; the Cardiology Section, University of Oklahoma Health Sciences Center, Oklahoma City (U.B.); and National and Kapodistrian University of Athens, School of Medicine, Athens (G.D.D.).

Background: The role of direct oral anticoagulants as compared with vitamin K antagonists for atrial fibrillation after successful transcatheter aortic-valve replacement (TAVR) has not been well studied.

Methods: We conducted a multicenter, prospective, randomized, open-label, adjudicator-masked trial comparing edoxaban with vitamin K antagonists in patients with prevalent or incident atrial fibrillation as the indication for oral anticoagulation after successful TAVR. The primary efficacy outcome was a composite of adverse events consisting of death from any cause, myocardial infarction, ischemic stroke, systemic thromboembolism, valve thrombosis, or major bleeding. Read More

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[Influence of molecular markers on oncological surgery of colorectal cancer].

Chirurg 2021 Aug 27. Epub 2021 Aug 27.

Klinik für Allgemein‑, Viszeral- und Kinderchirurgie, Universitätsmedizin Göttingen, Göttingen, Deutschland.

Colorectal cancer (CRC) is still a very common disease and one of the best characterized malignancies on a molecular level. Interdisciplinary and multimodal treatment strategies should be preferred. In addition to surgical resection in localized stages as well as metastasectomy for oligometastatic advanced stages, neoadjuvant chemoradiotherapy for localized rectal cancer and cytostatic treatment, targeted treatment approaches should also be considered. Read More

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