48 results match your criteria depths propofol

Generalized Prediction of Unconsciousness during Propofol Anesthesia using 3D Convolutional Neural Networks.

Annu Int Conf IEEE Eng Med Biol Soc 2020 07;2020:134-137

Neuroscience has generated a number of recent advances in the search for the neural correlates of consciousness, but these have yet to find valuable real-world applications. Electroencephalography under anesthesia provides a powerful experimental setup to identify electrophysiological signatures of altered states of consciousness, as well as a testbed for developing systems for automatic diagnosis and prognosis of awareness in clinical settings. In this work, we use deep convolutional neural networks to automatically differentiate sub-anesthetic states and depths of anesthesia, solely from one second of raw EEG signal. Read More

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In response to Dexmedetomidine versus propofol at different sedation depths during drug-induced sleep endoscopy: A randomized trial.

Laryngoscope 2020 07 25;130(7):E453. Epub 2019 Oct 25.

Department of Otolaryngology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

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Propofol inhibits the local activity and connectivity of nuclei in the cortico-reticulo-thalamic loop in rats.

J Anesth 2019 10 30;33(5):572-578. Epub 2019 Jul 30.

Department of Anesthesiology, Chinese People's Liberation Army (PLA) General Hospital, No. 28 Fuxing Road, Beijing, 100853, China.

Purpose: The present study aimed to investigate the effects of different dosages of propofol, that induced different depths of anesthesia, on the local activity and connectivity of nuclei within the cortico-reticulo-thalamic loops, as well as the release of amino acids in those nuclei.

Methods: The nonlinear dynamics analysis of electroencephalogram, including approximate entropy (ApEn) and cross-ApEn (C-ApEn), was used to analyze the effects of different dosages of propofol on the local activity and connectivity of the important nuclei, including the primary somatosensory cortex (S1), ventroposteromedial thalamic nucleus (VPM), reticular thalamic nucleus (RTN), and oral part of the pontine reticular nucleus (PnO). The levels of glutamate (Glu), γ-aminobutyric acid (GABA), and glycine (Gly) in the S1, VPM, and RTN were detected using cerebral microdialysis. Read More

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October 2019

Alteration of coupling between brain and heart induced by sedation with propofol and midazolam.

PLoS One 2019 17;14(7):e0219238. Epub 2019 Jul 17.

Department of Brain and Cognitive Engineering, Korea University, Seoul 02841, Republic of Korea.

For a comprehensive understanding of the nervous system, several previous studies have examined the network connections between the brain and the heart in diverse conditions. In this study, we identified coupling between the brain and the heart along the continuum of sedation levels, but not in discrete sedation levels (e. g. Read More

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Dexmedetomidine versus propofol at different sedation depths during drug-induced sleep endoscopy: A randomized trial.

Laryngoscope 2020 01 1;130(1):257-262. Epub 2019 Mar 1.

Department of Anesthesia and Intensive Care, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Objectives/hypothesis: The aim of this study was to compare the effect of dexmedetomidine and propofol on airway dynamics, cardiorespiratory system, and emergence following drug-induced sleep endoscopy (DISE).

Study Design: Prospective, randomized, single-blinded study.

Methods: Sixty patients age 18 to 65 years in American Society of Anesthesiologists physical status groups 1 and 2 scheduled to undergo DISE were randomly allocated to either Group P (N = 30; receiving propofol infusion at 50-150 μg/kg/min) or Group D (N = 30; receiving dexmedetomidine bolus of 1 μg/kg followed by infusion at 0. Read More

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January 2020

Transversus abdominis plane block reduces remifentanil and propofol consumption, evaluated by closed-loop titration guided by bispectral index.

Exp Ther Med 2018 Nov 7;16(5):3897-3902. Epub 2018 Sep 7.

Department of Anesthesiology and Pain Medicine, University of California Davis Health, Sacramento, CA 95817, USA.

The present prospective, randomized, double-blind study aimed to determine the impact of transversus abdominis plane (TAP) block on propofol and remifentanil consumption, when administered by closed-loop titration guided by processed electroencephalography, i.e., bispectral index (BIS) values. Read More

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November 2018

Different effects of propofol and dexmedetomidine sedation on electroencephalogram patterns: Wakefulness, moderate sedation, deep sedation and recovery.

PLoS One 2018 19;13(6):e0199120. Epub 2018 Jun 19.

Department of Anesthesiology, Beijing Shijitan Hospital affiliated to Capital Medical University, Beijing, China.

Sedation induces changes in electroencephalography (EEG) dynamics. However, the distinct EEG dynamic characteristics at comparable sedation levels have not been well studied, resulting in potential interpretation errors in EEG monitoring during sedation. We aimed to analyze the EEG dynamics of dexmedetomidine and propofol at comparable sedation levels and to explore EEG changes with increased sedation levels for each agent. Read More

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December 2018

Impact of different analgesic depths and abdominal trauma of different severities on stress and recovery of rats undergoing total intravenous anesthesia.

J Pain Res 2017 12;10:1143-1153. Epub 2017 May 12.

Department of Anesthesiology, Xiangya Hospital, Central South University, Changsha.

A number of animal models have been developed to examine the pathophysiological consequences of surgical procedures, but anesthetic methods, monitoring, and management measures in these models are very different from those used in humans. This study was designed to create a rat model of abdominal surgery using anesthetic methods and perioperative treatment similar to those used in the clinic and to investigate the effects of different injury severities and depths of anesthesia and analgesia on surgical stress and postoperative recovery. Abdominal skin/muscle incision was compared with exploratory laparotomy in rats under propofol intravenous anesthesia, accompanied by perioperative measures such as oxygen inhalation, fluid infusion, warmth, blood gas analysis, and infection prevention. Read More

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Effects of Propofol on Respiratory Drive and Patient-ventilator Synchrony during Pressure Support Ventilation in Postoperative Patients: A Prospective Study.

Chin Med J (Engl) 2017 May;130(10):1155-1160

Department of Critical Care Medicine, School of Medicine, Nanjing Zhongda Hospital, Southeast University, Nanjing, Jiangsu 210009, China.

Background: Propofol is increasingly used during partial support mechanical ventilation such as pressure support ventilation (PSV) in postoperative patients. However, breathing pattern, respiratory drive, and patient-ventilator synchrony are affected by the sedative used and the sedation depth. The present study aimed to evaluate the physiologic effects of varying depths of propofol sedation on respiratory drive and patient-ventilator synchrony during PSV in postoperative patients. Read More

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Patient satisfaction with procedural sedation in the emergency department.

Emerg Med Australas 2017 Jun 29;29(3):303-309. Epub 2017 Mar 29.

Department of Medicine, The University of Melbourne, Melbourne, Victoria, Australia.

Objective: The aim of this study was to determine patient satisfaction with procedural sedation as a function of nature of the procedure and depth of sedation.

Method: We undertook a prospective observational study of adult patients who received procedural sedation in two EDs (20 month period). The level of sedation was determined by an investigator, using the Observers Assessment of Anaesthesia/Sedation Scale (1 = awake to 6 = no response to noxious stimuli). Read More

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Electrocorticographic delineation of human auditory cortical fields based on effects of propofol anesthesia.

Neuroimage 2017 05 27;152:78-93. Epub 2017 Feb 27.

Department of Neurosurgery, The University of Iowa, Iowa City, IA, USA; Pappajohn Biomedical Institute, The University of Iowa, Iowa City, IA, USA; Iowa Neuroscience Institute, The University of Iowa, Iowa City, IA, USA.

The functional organization of human auditory cortex remains incompletely characterized. While the posteromedial two thirds of Heschl's gyrus (HG) is generally considered to be part of core auditory cortex, additional subdivisions of HG remain speculative. To further delineate the hierarchical organization of human auditory cortex, we investigated regional heterogeneity in the modulation of auditory cortical responses under varying depths of anesthesia induced by propofol. Read More

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Pharmacodynamic analysis of target-controlled infusion of propofol in patients with hepatic insufficiency.

Biomed Rep 2016 Dec 19;5(6):693-698. Epub 2016 Oct 19.

Department of Anesthesiology, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510630, P.R. China.

The effect of liver dysfunction on target-controlled infusion (TCI) of propofol remains poorly documented. The pharmacodynamic performance of propofol TCI was evaluated in a cohort of Chinese patients with hepatic insufficiency. Fifty-three patients with hepatic insufficiency were enrolled in the current prospective, observational study. Read More

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December 2016

Recovery Profile and Patient Satisfaction After Ambulatory Anesthesia for Dental Treatment-A Crossover Comparison Between Propofol and Sevoflurane.

Anesth Prog 2016 ;63(4):175-180

Professor and Chairman, Department of Dental Anesthesiology, Tokyo Dental College, Tokyo, Japan.

The purpose of this study was to determine which anesthetic was preferable for ambulatory anesthesia: propofol alone or sevoflurane alone. A crossover study was performed to compare the recovery profile and patient satisfaction after 2 anesthesia methods. Twenty healthy patients with severe anxiety toward dental treatment undergoing 2 sessions of day-case dental treatment received either propofol or sevoflurane anesthesia. Read More

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Assessment of different anesthesia depth under total intravenous anesthesia on postoperative cognitive function in laparoscopic patients.

J Res Med Sci 2016 1;21:73. Epub 2016 Sep 1.

Department of Psychology and Behavior Science, Zhejiang University, Hangzhou, China.

Background: This study aimed to compare the effects of different depths of sedation during total intravenous anesthesia (TIVA) with remifentanil and propofol given by target-controlled infusion (TCI) on postoperative cognitive function in young and middle-aged patients undergoing gynecological laparoscopic surgery.

Materials And Methods: A total of 150 American Society of Anesthesiologists physical Status I/II patients scheduled for gynecological laparoscopic operation were randomly divided into three groups. Anesthesia was maintained with intravenous infusion of TCI propofol and remifentanil, intermittent injected intravenously with rocuronium. Read More

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September 2016

The Patient State Index is well balanced for propofol sedation.

Hippokratia 2015 Jul-Sep;19(3):235-8

Clinical Trial Center of Busan Paik Hospital, Busan, Korea.

Background: The SEDLine™ monitor derived patient state index (PSI) is used to follow the depth of sedation. The demand for propofol sedation by anesthesiologists or non-anesthesiologists is increasing, and there are only a few studies addressing the relationship between PSI and propofol sedation. We aimed to investigate the ability of PSI index to identify the correct level of sedation of our patients during induction to anesthesia with target-controlled infusions of propofol. Read More

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Propofol target-controlled infusion modeling in rabbits: Pharmacokinetic and pharmacodynamic analysis.

J Huazhong Univ Sci Technolog Med Sci 2016 Jun 5;36(3):428-433. Epub 2016 Jul 5.

Department of Anesthesiology, Shenzhen People's Hospital, Shenzhen, 518020, China.

This study aimed to establish a new propofol target-controlled infusion (TCI) model in animals so as to study the general anesthetic mechanism at multi-levels in vivo. Twenty Japanese white rabbits were enrolled and propofol (10 mg/kg) was administrated intravenously. Artery blood samples were collected at various time points after injection, and plasma concentrations of propofol were measured. Read More

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Modelling of the Sedative Effects of Propofol in Patients undergoing Spinal Anaesthesia: A Pharmacodynamic Analysis.

Basic Clin Pharmacol Toxicol 2016 Jun 14;118(6):480-6. Epub 2016 Jan 14.

Department of Anaesthesiology and Pain Medicine, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul, Korea.

Sedation can increase patient comfort during spinal anaesthesia. Understanding the relationship between the propofol effect-site concentration (Ce) and patient sedation level could help clinicians achieve the desired sedation level with minimal side effects. We aimed to model the relationship between the propofol Ce and adequate and deep sedation and also incorporate covariates. Read More

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Propofol differentially inhibits the release of glutamate, γ-aminobutyric acid and glycine in the spinal dorsal horn of rats.

Iran J Basic Med Sci 2015 Aug;18(8):822-6

Department of Anesthesiology, Chinese People Liberation Army (PLA) General Hospital, Beijing 100853, China.

Objectives: Propofol (2, 6-diisopropylphenol) is an intravenous anesthetic that is commonly used for the general anesthesia. It is well known that the spinal cord is one of the working targets of general anesthesia including propofol. However, there is a lack of investigation of the effects of propofol on spinal dorsal horn which is important for the sensory transmission of nociceptive signals. Read More

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The relationship between the Bispectral Index (BIS) and the Observer Alertness of Sedation Scale (OASS) scores during propofol sedation with and without ketamine: a randomized, double blinded, placebo controlled clinical trial.

J Clin Monit Comput 2016 Aug 29;30(4):495-501. Epub 2015 Jul 29.

Department of Anesthesiology, Feinberg School of Medicine, Northwestern University, 251 E. Huron St., Chicago, IL, 60611, USA.

Prior studies have examined the static effect of intravenous ketamine on the BIS Index for sedation but it remains unknown if the BIS Index is a reliable method to track sedation levels in the presence of ketamine. The major objective of the current investigation was to compare the BIS Vista Index ability to track varying depths of sedation as determined by OASS scores in a standardized anesthetic regimen with and without ketamine. The study was a randomized, double blinded clinical trial. Read More

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The effects of deep and light propofol anesthesia on stress response in patients undergoing open lung surgery: a randomized controlled trial.

Korean J Anesthesiol 2015 Jun 28;68(3):224-31. Epub 2015 May 28.

Department of Anesthesiology and Pain Medicine, Konyang University School of Medicine, Daejeon, Korea. ; Konyang University Myunggok Medical Research Institute, Daejeon, Korea.

Background: This prospective, randomized controlled study was undertaken to compare stress hormone response to open thoracotomy for lung resection at different anesthetic depths, as determined by bispectral index (BIS) monitoring, in patients under propofol-remifentanil anesthesia.

Methods: Forty-eight adult patients scheduled for lung resection surgery using one-lung ventilation were randomly assigned to either a deep anesthesia group (BIS score of 40 ± 5, n = 24) or a light anesthesia group (BIS score of 60 ± 5, n = 24) by adjusting propofol infusion rates. Blood norepinephrine, epinephrine, adrenocorticotropic hormone, and cortisol levels were measured before the induction of anesthesia, at the end of surgery, and at 2 hours postoperatively. Read More

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[Evaluation of heart rate variability for monitoring the depth of anaesthesia in dogs. Investigations based on total intravenous anaesthesia using propofol alone or in combination with dexmedetomidine or remifentanil].

Tierarztl Prax Ausg K Kleintiere Heimtiere 2015 27;43(1):1-10. Epub 2014 Nov 27.

Carina Bergfeld, Klinik für Kleintiere, Stiftung Tierärztliche Hochschule Hannover, Bünteweg 9, 30559 Hannover, E-Mail:

Objective: Evaluation of heart-rate variability (HRV) as an indicator for autonomous activity to monitor anaesthesia in dogs during three different total intravenous anaesthetic protocols and three anaesthetic depth levels as well as before and after electrical nociceptive stimulation.

Material And Methods: Seven beagle dogs (14.3±1. Read More

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January 2016

Effects of general anesthesia with propofol on thalamocortical sensory processing in rats.

J Pharmacol Sci 2014 26;126(4):370-81. Epub 2014 Nov 26.

Department of Anesthesiology, the Affiliated Hospital of Zunyi Medical College, Guizhou Key Laboratory of Anesthesia and Organ Protection, China.

The effects of anesthetics on the transmission and processing of sensory information within the thalamocortical pathway and the underlying mechanism are not fully understood. Using the extracellular recording technique, we investigated the changes of spontaneous and stimulation-evoked activities within and between the ventral posteromedial nucleus (VPM) and primary somatosensory cortex barrel field (S1BF) of the rat in vivo during propofol anesthesia. Spontaneous local field potentials, whiskers deflection–elicited somatosensory evoked potentials, and multi-unit activities in VPM/S1BF were assessed at different depths of propofol anesthesia. Read More

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Sevoflurane versus propofol for interventional neuroradiology: a comparison of the maintenance and recovery profiles at comparable depths of anesthesia.

Korean J Anesthesiol 2014 Apr 28;66(4):290-4. Epub 2014 Apr 28.

Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.

Background: Sevoflurane and propofol are used widely for interventional neuroradiology (INR). Using the bispectral index (BIS), we compared the clinical properties of sevoflurane and propofol anesthesia in patients undergoing INR at comparable depths of anesthesia.

Methods: The patients were allocated randomly into two groups. Read More

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Effects of propofol on patient-ventilator synchrony and interaction during pressure support ventilation and neurally adjusted ventilatory assist.

Crit Care Med 2014 Jan;42(1):74-82

1Anesthesia and Intensive Care, "Maggiore Della Carità" Hospital, Novara, Italy. 2Anesthesia and Intensive Care, Department of Translational Medicine, Eastern Piedmont University "A. Avogadro," Novara, Italy. 3Anesthesia and Intensive Care, Sant'Andrea Hospital, ASL VC, Vercelli, Italy. 4CRRF Mons. L. Novarese, Moncrivello (VC), Vercelli, Italy.

Objectives: Evaluating the physiologic effects of varying depths of propofol sedation on patient-ventilator interaction and synchrony during pressure support ventilation and neurally adjusted ventilatory assist.

Design: Prospective crossover randomized controlled trial.

Setting: University hospital ICU. Read More

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January 2014

Multiphasic modification of intrinsic functional connectivity of the rat brain during increasing levels of propofol.

Neuroimage 2013 Dec 10;83:581-92. Epub 2013 Jul 10.

Department of Anesthesiology, Medical College of Wisconsin, USA.

The dose-dependent effects of anesthetics on brain functional connectivity are incompletely understood. Resting-state functional magnetic resonance imaging (rsfMRI) is widely used to assess the functional connectivity in humans and animals. Propofol is an anesthetic agent with desirable characteristics for functional neuroimaging in animals but its dose-dependent effects on rsfMRI functional connectivity have not been determined. Read More

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December 2013

Colonoscopy: Sliding into the depths of sedation--is this what we want?

Geir Hoff

Nat Rev Gastroenterol Hepatol 2013 Jun 23;10(6):325-6. Epub 2013 Apr 23.

Department of Medicine, Telemark Hospital, 3710 Skien, Norway.

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Double- vs. single-balloon enteroscopy: single center experience with emphasis on procedural performance.

Int J Colorectal Dis 2013 Sep 16;28(9):1239-46. Epub 2013 Mar 16.

Department of Medicine B, University of Muenster, Albert-Schweitzer-Campus 1, Building A1, Muenster, Germany.

Purpose: This study aims to compare double- (DBE) and single-balloon enteroscopy (SBE) in small bowel disorders with respect to procedural performance and clinical impact.

Methods: This retrospective analysis at a tertial referral center included 1,052 DBEs and 515 SBEs performed in 904 patients over 7 years. Procedural and patients' characteristics were precisely analyzed. Read More

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September 2013

Anesthetic techniques for fetal surgery: effects of maternal anesthesia on intraoperative fetal outcomes in a sheep model.

Anesthesiology 2013 Apr;118(4):796-808

Department of Anesthesiology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.

Background: Use of high-dose inhalational anesthesia during open fetal surgery may induce maternal-fetal hemodynamic instability and fetal myocardial depression. The authors' preliminary human retrospective study demonstrated less fetal bradycardia and left ventricular systolic dysfunction with lower dose desflurane supplemented with propofol and remifentanil IV anesthesia (SIVA). In this animal study, the authors compare maternal-fetal effects of high-dose desflurane anesthesia (HD-DES) and SIVA. Read More

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The influence of the severity of chronic virus-related liver disease on propofol requirements during propofol-remifentanil anesthesia.

Yonsei Med J 2013 Jan;54(1):231-7

Department of Anesthesiology, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Purpose: The purpose of this study was to investigate the influence of chronic virus- related liver disease severity on propofol requirements.

Materials And Methods: In this study, 48 male patients with chronic hepatitis B infection were divided into three groups according to Child-Turcotte-Pugh classification of liver function (groups A, B, and C with mild, moderate and severe liver disease, respectively). After intubation, propofol concentration was adjusted by ± 0. Read More

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January 2013