18,716 results match your criteria depression mediated


Gender Matters: The Influence of Acculturation and Acculturative Stress on Latino College Student Depressive Symptomatology.

J Lat Psychol 2015 Feb;3(1):40-55

University of South Dakota.

The purpose of the study was to examine the relationship between acculturation-related variables with depressive symptomatology among Latino college students and the extent to which acculturative stress mediates the association. The extent to which gender moderates these relationships was also examined. Participants were 758 Latina and 264 Latino college students from 30 colleges and universities around the United States. Read More

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February 2015

Relatedness Need Satisfaction and the Dark Triad: The Role of Depression and Prevention Focus.

Front Psychol 2021 13;12:677906. Epub 2021 Jul 13.

Department of Psychology, Tsinghua University, Beijing, China.

Dark triad traits are often associated with maladaptive social and interpersonal interactions, such as dishonesty and self-centeredness; thus, it is important to explore predictors of the dark triad in order to better facilitate the reduction of such behaviors. The present study adopted a self-report approach with a total of 5,207 Chinese undergraduate students participated in the study. We found that relatedness need dissatisfaction significantly predicted the presence of dark personalities, which was mediated by prevention focus. Read More

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Catalpol enhanced physical exercise-mediated brain functional improvement in post-traumatic stress disorder model via promoting adult hippocampal neurogenesis.

Aging (Albany NY) 2021 Jul 29;13(undefined). Epub 2021 Jul 29.

School of Life Science, Beijing Normal University, Beijing, China.

Post-traumatic stress disorder (PTSD) is a serious psychiatric disorder characterized by hyper-response to environmental cues as well as the associated depressive and cognitive dysfunctions. According to the key roles of hippocampus for cognitive and emotional regulation, improving hippocampal functions, particularly hippocampal neural plasticity, is the necessary pathway to attenuate the core symptoms of PTSD. The effects of the alternative therapies such as exercise and natural compounds to reduce PTSD symptoms and promote adult hippocampal neurogenesis have been widely demonstrated. Read More

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Interplay of Val66Met and BDNF methylation: effect on reward learning and cognitive performance in major depression.

Clin Epigenetics 2021 Jul 29;13(1):149. Epub 2021 Jul 29.

Centre for Environment and Health, Department of Public Health and Primary Care, KU Leuven (University of Leuven), Kapucijnenvoer 35, 3000, Leuven, Belgium.

Background: There is a growing interest in the role of brain-derived neurotrophic factor (BDNF) in major depressive disorder (MDD). BDNF potentially exhibits opposite effects in the pathways linked to anhedonia and reward learning on the one hand and cognitive performance, on the other hand. However, the epigenetic mechanisms behind this remain unknown. Read More

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The role of depression and anxiety in the relationship between poor sleep quality and subjective cognitive decline in Chinese elderly: Exploring parallel, serial, and moderated mediation.

J Affect Disord 2021 Jul 19;294:464-471. Epub 2021 Jul 19.

Guangdong Mental Health Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong Province, China. Electronic address:

Background: Poor sleep quality exacerbates subjective cognitive decline (SCD). Mental health may play an important role in the relationship, but the potential underlying mechanisms remain unknown.

Methods: A cross-sectional study was conducted on older adult residents in Guangdong province, south China from November 2020 to March 2021. Read More

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Insulin-like growth factor 1 gene transfer for sporadic Alzheimer's disease: New evidence for trophic factor mediated hippocampal neuronal and synaptic recovery-based behavior improvement.

Hippocampus 2021 Jul 29. Epub 2021 Jul 29.

Institute for Biochemical Research (INIBIOLP)-National Scientific and Technical Research Council (CONICET)-School of Medical Sciences, National University of La Plata (UNLP), La Plata, Argentina.

Sporadic Alzheimer's disease (sAD) is the most prevalent neurodegenerative disorder with no cure. Patients typically suffer from cognitive impairment imprinted by irreversible neocortex and hippocampal degeneration with overt synaptic and neuron dysfunction. Insulin-like growth factor 1 (IGF1) has proven to be a potent neuroprotective molecule in animal models of age-related neurodegeneration. Read More

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Legal Status, Worries About Deportation, and Depression Among Asian Immigrants.

J Immigr Minor Health 2021 Jul 29. Epub 2021 Jul 29.

School of Transborder Studies, Arizona State University, Tempe, AZ, USA.

Although legal status and worries of deportation have been identified as key factors in immigrant health inequities for Latinx immigrants, how they impact health of Asian immigrants is largely unknown. Using 2016 Collaborative Multiracial Post-Election Survey, we used sets of logistic regressions to examine the relationships among legal statuses, worries about deportation, and depression for Asian immigrants (n = 1371). Asian immigrants who are in the process of applying for citizenship, those with visas, and those who are ineligible to apply for citizenship were significantly more likely to be depressed compared with naturalized citizens. Read More

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Testing whether implicit emotion regulation mediates the association between discrimination and symptoms of psychopathology in late childhood: An RDoC perspective.

Dev Psychopathol 2021 Jul 29:1-14. Epub 2021 Jul 29.

Northwestern University Department of Psychology, Northwestern University Department of Psychiatry, Northwestern University Department of Medical Social Sciences, Northwestern University Institute for Innovations in Developmental Sciences, Northwestern University Institute for Policy Research, Evanston, IL, USA.

Discrimination has been associated with adverse mental health outcomes, though it is unclear how early in life this association becomes apparent. Implicit emotion regulation, developing during childhood, is a foundational skill tied to a range of outcomes. Implicit emotion regulation has yet to be tested as an associated process for mental illness symptoms that can often emerge during this sensitive developmental period. Read More

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Helpful family climate moderates the relationship between perceived family support of ADHD symptoms and depression: a conditional process model.

BMC Psychol 2021 Jul 28;9(1):112. Epub 2021 Jul 28.

Department of Psychiatry, Faculty of Medicine, Chiang Mai University, 110 Intawaroros Rd., T. Sriphum, A. Muang, Chiang Mai, 50200, Thailand.

Background: Symptoms of attention deficit hyperactivity disorder (ADHD) are commonly comorbid with depression This study aimed to examine the relationship between ADHD symptoms and depression through perceived family support and to explore whether the magnitude of the relationship depended on the type of family climate of medical students.

Methods: This cross-sectional study was conducted among 124 first year medical students in Thailand. Participants completed questionnaires on ADHD symptoms, depression, perceived family support, and 9 types of family climate. Read More

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Increased nitro-oxidative toxicity in association with metabolic syndrome, atherogenicity and insulin resistance in patients with affective disorders.

J Affect Disord 2021 Jul 18;294:410-419. Epub 2021 Jul 18.

Health Sciences Graduation Program, Health Sciences Center, State University of Londrina, Londrina, Paraná, Brazil. Electronic address:

Background: There is a strong comorbidity between mood disorders and metabolic syndrome (MetS). Increased levels of reactive oxygen and nitrogen species (RONS) and nitro-oxidative stress toxicity (NOSTOX) partially underpin this comorbidity.

Aims: To examine the associations of RONS/NOSTOX biomarkers with MetS after adjusting for the significant effects of mood disorders (major depression, and bipolar type 1 and 2), generalized anxiety disorder (GAD), tobacco use disorder (TUD), and male sex. Read More

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Acyloxyacyl hydrolase is a host determinant of gut microbiome-mediated pelvic pain.

Am J Physiol Regul Integr Comp Physiol 2021 07 28. Epub 2021 Jul 28.

Department of Urology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States.

Dysbiosis of gut microbiota is associated with many pathologies, yet host factors modulating microbiota remain unclear. Interstitial cystitis/bladder pain syndrome (IC/BPS) is a debilitating condition of chronic pelvic pain often with co-morbid urinary dysfunction and anxiety/depression, and recent studies find fecal dysbiosis in IC/BPS patients. We identified the locus encoding acyloxyacyl hydrolase, Aoah, as a modulator of pelvic pain severity in a murine IC/BPS model. Read More

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The comorbidity between autism spectrum disorder and post-traumatic stress disorder is mediated by brooding rumination.

Autism 2021 Jul 28:13623613211035240. Epub 2021 Jul 28.

Bar-Ilan University, Israel.

Lay Abstract: Autism spectrum disorder is a neurodevelopmental condition characterized by social communication difficulties and restricted repetitive behaviors. Individuals with autism spectrum disorder are often diagnosed with other psychiatric conditions, including attention deficit hyperactivity disorder, anxiety, and depression. However, research on post-traumatic stress disorder among individuals with autism spectrum disorder is scarce. Read More

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Evidence and theory for lower rates of depression in larger US urban areas.

Proc Natl Acad Sci U S A 2021 Aug;118(31)

The University of Chicago Neuroscience Institute, University of Chicago, Chicago, IL 60637

It is commonly assumed that cities are detrimental to mental health. However, the evidence remains inconsistent and at most, makes the case for differences between rural and urban environments as a whole. Here, we propose a model of depression driven by an individual's accumulated experience mediated by social networks. Read More

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The reification of the clinical diagnosis of myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) as an immune and oxidative stress disorder: construction of a data-driven nomothethic network and exposure of ME/CFS subgroups.

Curr Top Med Chem 2021 Jul 27. Epub 2021 Jul 27.

Monnet Research Center, Louvain-La-Neuve. Belgium.

The approach towards myalgic encephalomyelitis / chronic fatigue syndrome (ME/CFS) remains in a permanent state of crisis with fierce competition between the psychosocial school, which attributes ME/CFS to the perception of effort, and the medical approach (Maes and Twisk, BMC Med, 2010,8,35). The aim of this paper is to review how to construct a nomothetic model of ME/CFS using Partial Least Squares (PLS) path analysis and ensembling causome (bacterial translocation as assessed with IgM/IgA responses to LPS), protectome (lowered coenzyme Q10), adverse outcome pathways (AOP) including increased lysozyme, CD38+ T cell activation, cell-mediated immune activation (CMI), and IgM responses to oxidative specific epitopes and NO-adducts (IgM OSENO). Using PLS, we trained, tested and validated this knowledge- and data-driven causal ME/CFS model, which showed adequate convergence, construct and replicability validity. Read More

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Victimization and depressive symptoms among Chinese adolescents: A moderated mediation model.

J Affect Disord 2021 Jul 20;294:375-381. Epub 2021 Jul 20.

School of Humanities and Social Sciences, University of Science and Technology of China, No. 96 Jinzhai Road, Baohe District, Hefei 230022, PR China. Electronic address:

Background: Victimization as an inducing factor of depressive symptoms has been confirmed in previous studies. However, little is known about how and when it induces depressive symptoms in adolescents.

Methods: In total, 1174 Chinese adolescents were recruited to complete the Juvenile Victimization Questionnaire, Security Questionnaire, Positive Psychological Capital Questionnaire, and the Chinese version of the Center for Epidemiologic Studies Depression Scale. Read More

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Do depressive symptoms link chronic diseases to cognition among older adults? Evidence from the Health and Retirement Study in the United States.

J Affect Disord 2021 Jul 19;294:357-365. Epub 2021 Jul 19.

Research Department of Epidemiology and Public Health, University College London, London, United Kingdom.

Background: Few studies have assessed psychological pathways that connect the association between non-psychotropic chronic disease and cognition. We assessed the extent to which the association between the two was mediated by depressive symptoms in older adults.

Methods: Data came from waves 10-13 (2010-2016) of the Health and Retirement Study in the United States (7,651 men and 10,248 women). Read More

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Posttraumatic stress disorder predicts poor health-related quality of life in cardiac patients in Palestine.

PLoS One 2021 27;16(7):e0255077. Epub 2021 Jul 27.

Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland.

Background: The longitudinal association of posttraumatic stress disorder (PTSD) with health-related quality of life (HRQL) in cardiac patients' remains poorly studied, particularly in conflict-affected settings.

Materials And Methods: For this cohort study, we used baseline and one-year follow-up data collected from patients 30 to 80 years old consecutively admitted with a cardiac diagnosis to four major hospitals in Nablus, Palestine. All subjects were screened for PTSD and HRQL using the PTSD Checklist Specific and the HeartQoL questionnaire. Read More

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Examining the Associations Between Childhood Trauma, Resilience, and Depression: A Multivariate Meta-Analysis.

Trauma Violence Abuse 2021 Jul 27:15248380211029397. Epub 2021 Jul 27.

Department of Family Social Sciences, University of Minnesota, MN, USA.

Topic Of Review: Childhood trauma has been associated with increased depression; however, resilience has been found to reduce this association.

Method Of Review: Present analyses were based on multivariate meta-analytical techniques, an extension of univariate meta-analysis. All computations were performed using the metafor package and the metaRmat package from R. Read More

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2-Phenyl-3-(phenylselanyl)benzofuran elicits acute antidepressant-like action in male Swiss mice mediated by modulation of the dopaminergic system and reveals therapeutic efficacy in both sexes.

Psychopharmacology (Berl) 2021 Jul 27. Epub 2021 Jul 27.

Programa de Pós-Graduação em Bioquímica e Bioprospecção (PPGBBio), Laboratório de Bioquímica e Neurofarmacologia Molecular (LABIONEM), Grupo de Pesquisa em Neurobiotecnologia (GPN), Centro de Ciências Químicas, Farmacêuticas e de Alimentos (CCQFA), Universidade Federal de Pelotas (UFPel), Pelotas, RS, CEP 96010-900, Brasil.

Rationale: Depression is a psychiatric disorder that constitutes one of the leading causes of disability worldwide. 2-Phenyl-3-(phenylselanyl)benzofuran (SeBZF1) has been studied as a potential antidepressant drug, but its pharmacological action needs more investigation.

Objectives And Methods: Our aim was to extend information about the antidepressant-like action of SeBZF1 using the mouse tail suspension test (TST). Read More

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Pain Appraisals in Patients with Physical Injury: Assessing the Role of Distress Tolerance in the Relationship between Depression and Pain Catastrophizing.

Health Soc Work 2021 Jul 27. Epub 2021 Jul 27.

Internal Medicine, Epidemiology, University of Utah, Salt Lake City.

Pain is a complex construct contributing to significant impairment, particularly among physically injured patients seeking treatment in trauma and orthopedic surgery settings in which social workers are an integral component of care. The biopsychosocial theory, fear-avoidance, and cognitive mediation models of pain suggest that psychological factors (for example, depression) affect one's ability to tolerate distress, leading to negative pain appraisals, such as catastrophizing. This study examined whether distress tolerance serves as a mechanism by which depression is associated with pain catastrophizing. Read More

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Resolvins as potential candidates for the treatment of major depressive disorder.

J Pharmacol Sci 2021 Sep 24;147(1):33-39. Epub 2021 May 24.

Laboratory of Molecular Pharmacology, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, 920-1192, Japan.

In contrast with the delayed onset of therapeutic responses and relatively low efficacy of currently available monoamine-based antidepressants, a single subanesthetic dose of ketamine, an N-methyl-D-aspartate receptor antagonist, produces rapid and sustained antidepressant actions even in patients with treatment-resistant depression. However, since the clinical use of ketamine as an antidepressant is limited owing to its adverse effects, such as psychotomimetic/dissociative effects and abuse potential, there is an unmet need for novel rapid-acting antidepressants with fewer side effects. Preclinical studies have revealed that the antidepressant actions of ketamine are mediated via the release of brain-derived neurotrophic factor and vascular endothelial growth factor, with the subsequent activation of mechanistic target of rapamycin complex 1 (mTORC1) in the medial prefrontal cortex. Read More

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September 2021

Yolk-shell [email protected] ternary heterostructures with conductive N-doped carbon mediated electron transfer for highly efficient water splitting.

J Colloid Interface Sci 2021 Jul 18;605:23-32. Epub 2021 Jul 18.

Ankara Yildirim Beyazit University, Faculty of Engineering and Natural Sciences, Department of Chemical Engineering, Ankara, Turkey. Electronic address:

Herein, carbon-incorporated yolk-shell [email protected] ternary heterostructures are employed as visible light responsive photocatalyst for highly efficient photoelectrochemical (PEC) water splitting. Compared to conventional ZnO/CeO semiconductors, introduction of a thin PDA shell layer assures the generation of a conductive N-doped graphitic carbon layer after a calcination post-treatment with mesoporous hollow morphologies. The evaluation of PEC water splitting performance of [email protected] photoanodes reveals the maximum photocurrent density as 7. Read More

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Adenosine A Receptor Neurons in the Olfactory Bulb Mediate Odor-Guided Behaviors in Miceg.

Brain Res 2021 Jul 23:147590. Epub 2021 Jul 23.

Department of Pharmacology, School of Basic Medical Sciences, State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, and Institutes of Brain Science, Fudan University, Shanghai, 200032, China. Electronic address:

Depression, rapid eye movement (REM) sleep behavior disorder, and altered olfaction are often present in Parkinson's disease. Our previous studies demonstrated the role of the olfactory bulb (OB) in causing REM sleep disturbances in depression. Furthermore, adenosine A receptors (AR) which are richly expressed in the OB, play an important role in the regulation of REM sleep. Read More

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Sex and brain region specific regulation of serotonin transporter activity in synaptosomes in guanine nucleotide-binding protein G(q) alpha knockout mice.

J Neurochem 2021 Jul 26. Epub 2021 Jul 26.

Institute of Integrative Neuroanatomy, Charité University Medicine Berlin and Max-Planck-Institute for Biophysical Chemistry Göttingen, Germany.

The regulation of the serotonin transporter (SERT) by guanine nucleotide-binding protein alpha (Gα) q was investigated using Gαq knockout mice. In the absence of Gαq, SERT mediated uptake of 5-hydroxytryptamine (5HT) was enhanced in midbrain and frontal cortex synaptosomes, but only in female mice. The mechanisms underlying this sexual dimorphism were investigated using quantitative Western blot analysis revealing brain region specific differences. Read More

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The Effect of Chinese Square Dance Exercise on Cognitive Function in Older Women With Mild Cognitive Impairment: The Mediating Effect of Mood Status and Quality of Life.

Front Psychiatry 2021 9;12:711079. Epub 2021 Jul 9.

Editorial Department, the Journal of Shandong Sports University, Shandong Sports University, Jinan, China.

The present study aimed to assess the effects of square dance exercise on the cognitive function and quality of life in older women with mild cognitive impairment and to investigate the mediating role of a depressed mood and reduced quality of life in the relationship between square dance exercise and cognition. The study design was a single-blind whole-group controlled trial. A total of 136 eligible participants were divided according to their nursing home into either an experimental or control group. Read More

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Anxiety, Loneliness, Drug Craving, and Depression Among Substance Abusers in Sichuan Province, China.

Front Pharmacol 2021 7;12:623360. Epub 2021 Jul 7.

College of Physical Education, Guizhou University, Guiyang, China.

Studies have reported that anxiety had a positive effect on depression among substance abusers in males. However, little is known about the mechanism underlying this relationship in substance abusers in males. The purpose of this study was to investigate the mediating effect of loneliness and drug craving between anxiety and depression in substance abusers in males. Read More

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Lack of the Transient Receptor Potential Vanilloid 1 Shifts Cannabinoid-Dependent Excitatory Synaptic Plasticity in the Dentate Gyrus of the Mouse Brain Hippocampus.

Front Neuroanat 2021 7;15:701573. Epub 2021 Jul 7.

Department of Neurosciences, Faculty of Medicine and Nursing, University of the Basque Country UPV/EHU, Leioa, Spain.

The transient receptor potential vanilloid 1 (TRPV1) participates in synaptic functions in the brain. In the dentate gyrus, post-synaptic TRPV1 in the granule cell (GC) dendritic spines mediates a type of long-term depression (LTD) of the excitatory medial perforant path (MPP) synapses independent of pre-synaptic cannabinoid CB receptors. As CB receptors also mediate LTD at these synapses, both CB and TRPV1 might be influencing the activity of each other acting from opposite synaptic sites. Read More

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Is psychological flexibility a mediator between perceived stress and general anxiety or depression among suspected patients of the 2019 coronavirus disease (COVID-19)?

Pers Individ Dif 2021 Dec 15;183:111132. Epub 2021 Jul 15.

Department of Health Management, The Third XiangYa Hospital, Central South University, Changsha 410013, China.

This study is aimed to investigate the status of general anxiety and depression among suspected patients of COVID-19 and explore whether psychological flexibility can serve as a mediator between perceived stress and general anxiety or depression. Total of 180 participants completed the online questionnaire which comprised demographic information, the Perceived Stress Scale (PSS), the 7-item Generalized Anxiety Disorder scale (GAD-7), the 9-item Patients Health Questionnaire (PHQ-9), the Acceptance and Action Questionnaire-II (AAQ-II) and the Cognitive Fusion Questionnaire (CFQ). Statistical methods including correlation analysis, multiple linear regression analysis and structural equation model were used in this study. Read More

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December 2021

Breast Cancer Survivors' Contribution to Psychosocial Adjustment of Newly Diagnosed Breast Cancer Patients in a Computer-Mediated Social Support Group.

Journal Mass Commun Q 2017 Jun 19;94(2):486-514. Epub 2017 Jan 19.

University of Wisconsin-Madison, USA.

This study investigated the role of breast cancer survivors in a computer-mediated social support (CMSS) group for women with breast cancer. Applying a computer-aided content analytic method, the present study examined the differences in support provision between survivors and newly diagnosed patients. This study further investigated the impacts of survivor-provided social support on psychosocial adjustment of newly diagnosed patients. Read More

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Effect of qigong for sleep disturbance-related symptom clusters in cancer: a systematic review and meta-analysis.

Sleep Med 2021 Jun 29;85:108-122. Epub 2021 Jun 29.

School of Nursing, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong; School of Nursing, College of Nursing, Taipei Medical University, Taiwan; Alice Ho Miu Ling Nethersole Charity Foundation Professor in Nursing, Hong Kong. Electronic address:

Objectives: To examine the effects of qigong interventions on sleep disturbance-related symptom clusters for cancer patients and to explore the possible mediating role of fatigue and depression in affecting sleep.

Methods: In this systematic review and meta-analysis, a systematic search was conducted through October 2020 by searching multiple English and Chinese databases. Inclusion was limited to randomized controlled trials that measured the effect of qigong on sleep and fatigue/depressive symptoms in cancer patients. Read More

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