468,578 results match your criteria depression depression


Immediate effects of the practise of on heart rate and blood pressure parameters in healthy volunteers.

J Complement Integr Med 2021 May 6. Epub 2021 May 6.

Department of Physiology and Biochemistry, Government Yoga and Naturopathy Medical College and Hospital, Chennai, Tamilnadu, India.

Objectives: , a cooling pranayama is best known for its calming and relaxing nature, widely used for many conditions like depression, anxiety and hypertension. The aim of the study was to evaluate the immediate effect of the practice of on heart rate and blood pressure parameters in healthy volunteers.

Methods: Apparently, 60 healthy volunteers were involved, from both sexes. Read More

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How to Change Your Mind: What the New Science of Psychedelics Teaches Us About Consciousness, Dying, Addiction, Depression, and Transcendence.

Authors:
Peter G Brindley

Anesth Analg 2021 Mar;132(3):e37-e38

Departments of Critical Care Medicine and Anesthesiology and Pain Medicine, Dosseter Ethics Centre, University of Alberta, Edmonton, Alberta, Canada,

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Disparities in outcomes after spine surgery: a Michigan Spine Surgery Improvement Collaborative study.

J Neurosurg Spine 2021 May 7:1-9. Epub 2021 May 7.

1Department of Neurosurgery, Henry Ford Hospital, Detroit.

Objective: Most studies on racial disparities in spine surgery lack data granularity to control for both comorbidities and self-assessment metrics. Analyses from large, multicenter surgical registries can provide an enhanced platform for understanding different factors that influence outcome. In this study, the authors aimed to determine the effects of race on outcomes after lumbar surgery, using patient-reported outcomes (PROs) in 3 areas: the North American Spine Society patient satisfaction index, the minimal clinically important difference (MCID) on the Oswestry Disability Index (ODI) for low-back pain, and return to work. Read More

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Incidence of concussion and recovery of neurocognitive dysfunction on ImPACT assessment among youth athletes with premorbid depression or anxiety taking antidepressants.

J Neurosurg Pediatr 2021 May 7:1-7. Epub 2021 May 7.

1Neurosurgery Department, Icahn School of Medicine at Mount Sinai, New York.

Objective: Concussions in youth sports comprise an estimated 1.6-3.8 million annual injuries in the US. Read More

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Symptom centrality and infrequency of endorsement identify adolescent depression symptoms more strongly associated with life satisfaction.

J Affect Disord 2021 Mar 5;289:90-97. Epub 2021 Mar 5.

University of Texas at Austin.

Although depression symptoms are often treated as interchangeable, some symptoms may relate to adolescent life satisfaction more strongly than others. To assess this premise, we first conducted a network analysis on the Mood and Feelings Questionnaire (MFQ) in a large (N = 1,059), cross-sectional sample of community adolescents (age M = 14.72 ± 1. Read More

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Trends in depression & anxiety symptom severity among mental health service attendees during the COVID-19 pandemic.

J Affect Disord 2021 Apr 24;289:105-109. Epub 2021 Apr 24.

Centre for Outcomes and Research Effectiveness, Research Department of Clinical, Educational and Health Psychology, University College London, Gower Street, London, UK; Camden & Islington NHS Foundation Trust, St Pancras Hospital, 4 St Pancras Way, London, UK.

Background: General population surveys have shown that some groups, particularly young women, experienced increased distress during nationally mandated restrictions to control the spread of COVID-19. However, there has been limited research on such trends among people with pre-existing mental health conditions, leaving mental health services ill equipped to plan for current and future lockdowns.

Methods: Mean weekly scores on the GAD-7 and PHQ-9 between 01/01/2020-22/06/2020 (n=9,538 individuals) for all patients of two psychological treatment services (Improving Access to Psychological Therapies) in London, were compared to mean weekly scores from the same time periods in 2017-2019 (n=37,849). Read More

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Gender differences in seizure recurrence and antiepileptic drug polytherapy predicting health-related quality of life of persons 1 year after diagnosis of epilepsy.

Epilepsy Behav 2021 May 4;120:107984. Epub 2021 May 4.

Department of Neurology, CHA University, Seongnam, Republic of Korea.

Purpose: The aim of this study was to determine whether gender influences the prediction of health-related quality of life (HRQoL) in persons with newly diagnosed epilepsy (NDE).

Methods: This was a 1-year longitudinal study. Persons with NDE were assessed with the Quality of Life in Epilepsy Inventory-31 (QOLIE-31), the Hospital Anxiety Depression Scale (HADS), the Stigma Scale, and the Rosenberg Self-esteem Scale. Read More

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A comparative study of perceived burden in parent caregivers of adolescents with epilepsy in a resource-restricted setting: Investigating the explanatory factors of perceived burden.

Epilepsy Behav 2021 May 4;120:107992. Epub 2021 May 4.

Department of Psychiatry and Behavioral Neurosciences, McMaster University/St Joseph's Healthcare Hamilton, Hamilton, ON, Canada.

Objective: Parent caregivers often play vital roles in the care of adolescents with epilepsy (AWE) in resource-restricted settings; however, little is known about the burden borne by these parents. This study investigated the burden perceived by parents of AWE and described the explanatory factors.

Methods: An equal number (n = 121) of age- and gender-matched parent caregivers of AWE (cases) and parents of adolescents with sickle cell disease (comparison group) were interviewed with the Parent Illness Intrusiveness Rating Scale to assess disruptions in their relationships and lifestyle. Read More

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Acceptance of disability predicts quality of life in patients with epilepsy.

Epilepsy Behav 2021 May 4;120:107979. Epub 2021 May 4.

Department of Epileptology, Tohoku University Graduate School of Medicine, Sendai, Japan.

Background: Acceptance of disability (AOD) is a key concept in rehabilitation psychology that enhances psychosocial adjustment of individuals with disability. However, the impact of AOD on well-being has never been examined for patients with epilepsy. The present study investigated whether AOD affects quality of life (QOL) in patients with epilepsy in the presence of other multiple aspects of epilepsy based on the biopsychosocial model. Read More

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Biomechanical impact of the porous-fibrous tissue behaviour in the temporomandibular joint movements. An in silico approach.

J Mech Behav Biomed Mater 2021 Apr 27;120:104542. Epub 2021 Apr 27.

Group of Biomaterials, Aragon Institute of Engineering Research (I3A), University of Zaragoza, Zaragoza, Spain.

The movement of the temporomandibular joint (TMJ) is a function of its complex geometry and its interaction with the surrounding soft tissues. Owing to an increase in the prevalence of temporomandibular joint disorders (TMDs), many computational studies have attempted to characterize its biomechanical behaviour in the last 2 decades. However, most such studies are based on a single computational model that markedly simplifies the complex geometry and mechanical properties of the TMJ's soft tissues. Read More

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Ciprofloxacin and dexamethasone in combination attenuate S. aureus induced brain abscess via neuroendocrine-immune interaction of TLR-2 and glucocorticoid receptor leading to behavioral improvement.

Int Immunopharmacol 2021 May 4;97:107695. Epub 2021 May 4.

Department of Physiology, Immunology Laboratory, University of Calcutta, University Colleges of Science and Technology, Calcutta, West Bengal, India. Electronic address:

Staphylococcus aureus induced brain abscess is a critical health concern throughout the developing world. The conventional surgical intervention could not regulate the abscess-induced brain inflammation. Thus further study over the alternative therapeutic strategy for treating a brain abscess is of high priority. Read More

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Electrochemical aptasensor for 17β-estradiol using disposable laser scribed graphene electrodes.

Biosens Bioelectron 2021 Apr 28;185:113247. Epub 2021 Apr 28.

Polymer Biointerface Centre, School of Chemical Sciences, The University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand; MacDiarmid Institute for Advanced Materials and Nanotechnology, Victoria University of Wellington, PO Box 600, Wellington, New Zealand. Electronic address:

17β-Estradiol (E2), the strongest of the three major physiological estrogens in females, is an important factor in the female reproductive system. The abnormal level of E2 causes health issues, such as weak bones, urinary tract infections and even depression. Here, we present a novel, sensitive and selective, electrochemical aptasensor for detection of 17β-estradiol (E2). Read More

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Subtypes of depression characterized by different cognitive decline and brain activity alterations.

J Psychiatr Res 2021 Apr 29;138:413-419. Epub 2021 Apr 29.

Psychiatric Laboratory and Mental Health Center, The State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China; West China Brain Research Center, West China Hospital of Sichuan University, Chengdu, Sichuan, China. Electronic address:

Depression is characterized by the heterogeneity in anti-depressant treatment response and clinical outcomes. Cognitive impairment may be one of the more practically important aspects of depression. A new approach was to identify neuropsychologically derived depression subtypes based on the trajectory of neuro-cognition such as intelligence quotient (IQ) change. Read More

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Translational evidence for the Inflammatory Response System (IRS)/Compensatory Immune Response System (CIRS) and neuroprogression theory of major depression.

Prog Neuropsychopharmacol Biol Psychiatry 2021 May 4:110343. Epub 2021 May 4.

Deakin University, School of Medicine, IMPACT Strategic Research Centre, Barwon Health, Geelong, Victoria, Australia; Department of Psychiatry, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Department of Psychiatry, Medical University of Plovdiv, Plovdiv, Bulgaria.

Major depressive disorder (MDD) is a common, severe and disabling neuropsychiatric disorder with a heterogenous aetiology. Among the most widely recognized etiological models, immunopathogenesis is a predominant one. Numerous studies have demonstrated aberrant levels of inflammatory markers in the peripheral blood, cerebrospinal fluid (CSF) and brain of patients with MDD. Read More

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Characterization of brain functional connectivity in treatment-resistant depression.

Prog Neuropsychopharmacol Biol Psychiatry 2021 May 4:110346. Epub 2021 May 4.

Medical Physics and Biomedical Engineering Department, Faculty of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran; Physical Medicine and Rehabilitation Department, Northwestern University, USA. Electronic address:

Objective: To characterize the functional connectivity (FC) of target brain regions for deep brain stimulation (DBS) in patients with treatment-resistant depression (TRD), and to evaluate its gender and brain lateralization dependence.

Methods: Thirty-one TRD patients and twenty-nine healthy control (HC) subjects participated. FC of subcallosal cingulate gyrus (SCG), ventral caudate (VCa), nucleus accumbens (NAc), lateral habenula (LHb), and inferior thalamic peduncle (ITP) were evaluated using resting-state fMRI. Read More

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Stimulation of astrocytic sigma-1 receptor is sufficient to ameliorate inflammation- induced depression.

Behav Brain Res 2021 May 4:113344. Epub 2021 May 4.

Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Jiangsu, China. Electronic address:

Astrocytes play important roles in the development of depression. As a promising target for antidepressant development, sigma-1 receptor (Sig-1R) is reported to promote activation of astrocyte in chronic stress-induced depression in our previous study. However, astrocytes are hyper-activated in inflammation-induced depression, raising concerns of whether stimulation of astrocytic Sig-1R would exert antidepressant-like effect in inflammation-induced depression. Read More

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Prevalence and variability of current depressive disorder in 27 European countries: a population-based study.

Lancet Public Health 2021 May 4. Epub 2021 May 4.

CIBER Epidemiology and Public Health, Madrid, Spain; Health Services Research Group, Hospital del Mar Medical Research Institute, Barcelona, Spain; Department of Experimental and Health Sciences, Pompeu Fabra University, Barcelona, Spain.

Background: We aimed to estimate the prevalence of current depressive disorder in 27 European countries, and to explore differences in prevalence between European countries and by gender.

Methods: In this population-based study, we analysed data from respondents living in 27 European countries who were included in the second wave of the European Health Interview Survey, collected between 2013 and 2015. We assessed the prevalence of current depressive disorder using the eight-item Patient Health Questionnaire (PHQ-8), with depressive disorder defined as a PHQ-8 score of 10 or higher. Read More

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Antidepressant and antipsychotic treatment of Psychotic Major Depression in a British mental healthcare setting.

J Ment Health 2021 May 7:1-7. Epub 2021 May 7.

Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

Background: Evidence from treatment trials shows that the most effective pharmacological treatment for Psychotic Major Depression (PMD) is combined antidepressant and antipsychotic pharmacotherapy.

Aim: This study investigates the use of antidepressant and antipsychotic treatment for PMD in clinical practice and examines how treatment profiles correlate with demographic and clinical symptoms.

Method: Anonymised electronic health records of 2,837 individuals with PMD were followed up for 12-months post-diagnosis in a historic open cohort design. Read More

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Discovery of Non-racemic Amisulpride to Maximize Benefit/Risk of 5-HT7 and D2 Receptor Antagonism for the Treatment of Mood Disorders.

Clin Pharmacol Ther 2021 May 7. Epub 2021 May 7.

Sunovion Pharmaceuticals Inc, Marlborough, MA, USA.

In contrast to the dose-occupancy relationship in the treatment of schizophrenia, the minimal effective level of dopamine receptor 2 (D2R) blockade for antipsychotics in the treatment of bipolar depression is unknown. Lower doses aimed at relieving extrapyramidal side effects are balanced against retaining D2R benefit on emergent cycling, mixed, manic, anxiety and/or psychotic symptoms. Dose-reductions intended to lower D2R blockade however could also decrease concomitant serotonin receptor antagonism and its potential benefit on depressive symptoms. Read More

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People with epilepsy still feel stigmatized.

Acta Neurol Scand 2021 May 7. Epub 2021 May 7.

National Centre for Epilepsy, Division of Clinical Neuroscience, Oslo University Hospital, Oslo, Norway.

Objectives: Those affected with epilepsy have long been subject to stigmatization. This may have manifold negative effects, for example social isolation, low self-esteem, reduced quality of life and worsening of seizures. In Norway educational programs have been arranged at the National Centre for Epilepsy, aiming at reducing stigma and shame associated with epilepsy, and thereby increase the quality of life for those affected and their families. Read More

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Loneliness and Risk for Cardiovascular Disease: Mechanisms and Future Directions.

Curr Cardiol Rep 2021 May 7;23(6):68. Epub 2021 May 7.

Department of Behavioural Science and Health, University College London, 1-19 Torrington Place, London, WC1E 7HB, UK.

Purpose Of Review: In this review, we synthesise recent research on the association between loneliness and cardiovascular disease (CVD). We present evidence for mechanisms underlying this association and propose directions for future research.

Recent Findings: Loneliness is related to increased risk of early mortality and CVD comparable to other well-established risk factors such as obesity or smoking. Read More

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Na leak-current channel (NALCN) at the junction of motor and neuropsychiatric symptoms in Parkinson's disease.

J Neural Transm (Vienna) 2021 May 7. Epub 2021 May 7.

Departments of Psychiatry and Pharmacology, Toxicology and Neuroscience, LSU Health Shreveport, 1501 Kings Highway, Shreveport, LA, 71130, USA.

Parkinson's disease (PD) is a debilitating movement disorder often accompanied by neuropsychiatric symptoms that stem from the loss of dopaminergic function in the basal ganglia and altered neurotransmission more generally. Akinesia, postural instability, tremors and frozen gait constitute the major motor disturbances, whereas neuropsychiatric symptoms include altered circadian rhythms, disordered sleep, depression, psychosis and cognitive impairment. Evidence is emerging that the motor and neuropsychiatric symptoms may share etiologic factors. Read More

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Perceived colorism and lifetime psychiatric disorders among Black American adults: findings from the National Survey of American Life.

Soc Psychiatry Psychiatr Epidemiol 2021 May 7. Epub 2021 May 7.

Harvard University, Cambridge, MA, USA.

Colorism has been propagated across the globe, and skin tone discrimination may partly explain social stratification and health disparities within the Black American population. Using data from a large probability sample of Black American adults (National Survey of American Life; 2001-2003), we examined the relations between perceived colorism and psychiatric disorders. In multivariable logistic regression models, in-group colorism was associated with greater odds of having any lifetime psychiatric disorder (aOR: 1. Read More

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Estimating the cumulative risk of postnatal depressive symptoms: the role of insomnia symptoms across pregnancy.

Soc Psychiatry Psychiatr Epidemiol 2021 May 7. Epub 2021 May 7.

Department of Public Health and Welfare, Finnish Institute for Health and Welfare, Mannerheimintie 166, P. O. Box 30, 00271, Helsinki, Finland.

Purpose: Insomnia symptoms during late pregnancy are a known risk for postnatal depressive symptoms (PDS). However, the cumulative effect of various risk factors throughout pregnancy has not been explored. Our aim was to test how various insomnia symptoms (sleep latency, duration, quality, frequent night awakenings, early morning awakenings) and other risk factors (e. Read More

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Associations between diet quality and DSM-IV mood disorders during young- to mid-adulthood among an Australian cohort.

Soc Psychiatry Psychiatr Epidemiol 2021 May 7. Epub 2021 May 7.

Menzies Institute for Medical Research, University of Tasmania, Private Bag 23, Hobart, TAS, 7001, Australia.

Purpose: Many studies have reported associations between diet and depression, but few have used formal diagnoses of mood disorder as the outcome measure. We examined if overall diet quality was associated cross-sectionally or longitudinally with DSM-IV mood disorders among an adult cohort.

Methods: Participants from the Australian Childhood Determinants of Adult Health study were followed up during 2004-06 (n = 1974, age 26-36 years), 2009-11 (n = 1480, 31-41 years), and 2014-19 (n = 1191, 36-49 years). Read More

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