466,713 results match your criteria depression


The changes in kynurenine metabolites induced by rTMS in treatment-resistant depression: A pilot study.

J Psychiatr Res 2021 Apr 9;138:194-199. Epub 2021 Apr 9.

Department of Psychiatry, Faculty of Medicine, Saga University, Nabeshima 5-1-1, Saga, 849-8501, Japan.

Background: Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive brain stimulation technique that is considered a valuable and promising technique for improving depressive symptoms in treatment-resistant depression (TRD). However, the exact mechanism by which rTMS ameliorates depressive symptoms remains to be clarified.

Objective: The aim of the present study was to analyzed the changes in metabolites of patients with TRD in the rTMS treatment, especially focusing on the kynurenine (KYN) pathway. Read More

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Decreased quality of life and spirometric alterations even after mild-moderate COVID-19.

Respir Med 2021 Apr 14;181:106391. Epub 2021 Apr 14.

Department of Internal Medicine, Hospital General de Zona No.27 Del Instituto Mexicano Del Seguro Social, Mexico City, Mexico. Electronic address:

Background: The follow-up of recovered COVID-19 patients is still limited. We aimed to evaluate the changes in quality-of-life (QOL) and spirometric alterations in the convalescent phase of 115 patients with at least 30 days post-COVID-19.

Methods: We included patients with confirmed COVID-19 infection, available past medical records and at least 30 days after the onset of symptoms. Read More

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Determinants of health-related quality of life among homeless individuals during the COVID-19 pandemic.

Public Health 2021 Mar 6;194:60-66. Epub 2021 Mar 6.

Department of Health Economics and Health Services Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Objective: To clarify which variables are associated with the health-related quality of life (HRQoL) among homeless individuals during the COVID-19 pandemic.

Study Design: Cross-sectional research.

Methods: Data were taken from the Hamburg survey of homeless individuals (n = 151). Read More

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Physical activity status and quality of life in patients with epilepsy - Survey from level four epilepsy monitoring units.

Epilepsy Res 2021 Apr 9;173:106639. Epub 2021 Apr 9.

Department of Neurology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, TX, 75390, USA. Electronic address:

Purpose: People with epilepsy (PWE) tend to have sedentary lifestyles which may predispose them to a lower perceived quality of life (QOL). Moreover, the relationship between physical activity (PA) and QOL in populations of PWE with high disease burden has been under-studied. The goal of this study was to evaluate PA level and its impact on health-related QOL in PWE who were admitted to Level-4 epilepsy monitoring units (EMU). Read More

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[Long-term effect analysis of a cognitive stimulation program in mild cognitive impairment elderly in Primary Care: A randomized controlled trial].

Aten Primaria 2021 Apr 14;53(7):102053. Epub 2021 Apr 14.

Residencia Reyes de Aragón/Orpea, Zaragoza, España. Electronic address:

Objective: To provide evidence about the efficacy of a community health intervention through a cognitive stimulation program at long term in older people with mild cognitive impairment.

Design: Randomized controlled trial (CONSORT group norms).

Location: San José Norte-Centro Primary Care Center and La Caridad Foundation (Zaragoza, Spain). Read More

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An examination of reciprocal effects between cardiovascular morbidity, depressive symptoms and loneliness over time in a longitudinal cohort of Dutch older adults.

J Affect Disord 2021 Mar 31;288:122-128. Epub 2021 Mar 31.

Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands; GGZ inGeest Specialized Mental Health Care, Amsterdam, The Netherlands.

Background: Unidirectional studies suggest that the effects between cardiovascular disease, depressive symptoms and loneliness are reciprocal, but this has not been tested empirically. The aim was to study how cardiovascular morbidity, depressive symptoms and loneliness influence each other longitudinally.

Methods: Data from 2979 older adults from the Longitudinal Aging Study Amsterdam were analysed. Read More

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Assessing recurrence of depression using a zero-inflated negative binomial model: A secondary analysis of lifelog data.

Psychiatry Res 2021 Apr 1;300:113919. Epub 2021 Apr 1.

Department of Health Promotion and Human Behavior, Kyoto University Graduate School of Medicine / School of Public Health, Kyoto, Japan.

When studying recurrence of depression, researchers should pay attention to cases where physicians' assessment corresponds to the patients' perception. However, they should also focus on potential signs of recurrence when the recurrence is suspected by the physicians but not the patients (false-negative zeros). Because false negatives can delay diagnosis and treatment, we aimed to investigate "sitting idly" as a predictor influencing no alert sign of recurrence and estimated the counts of recurrence of depression. Read More

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Long-term functional alterations following prenatal GLP-1R activation.

Neurotoxicol Teratol 2021 Apr 14:106984. Epub 2021 Apr 14.

Department of Biomedical Sciences and Center for Brain Repair, Florida State University College of Medicine, Tallahassee, FL 32306, United States of America. Electronic address:

Evidence supporting the use of glucagon-like peptide-1 (GLP-1) analogues to pharmacologically treat disorders beyond type 2 diabetes and obesity is increasing. However, little is known about how activation of the GLP-1 receptor (GLP-1R) during pregnancy affects maternal and offspring outcomes. We treated female C57Bl/6 J mice prior to conception and throughout gestation with a long-lasting GLP-1R agonist, Exendin-4. Read More

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Sleep disturbance in adult dermatological patients: A cross-sectional study on prevalence, burden and associated factors.

J Am Acad Dermatol 2021 Apr 13. Epub 2021 Apr 13.

Dermatological Allergology, Department of Dermatology and Allergy, Charité - Universitätsmedizin Berlin, Germany. Electronic address:

Background: Sleep disturbance remains insufficiently characterized in many dermatoses.

Objective: To investigate the prevalence, burden and factors associated with sleep disturbance in dermatological patients.

Methods: We recruited 800 patients and recorded pruritus characteristics, sociodemographic and clinical parameters. Read More

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Reduced anterior cingulate cortex volume induced by chronic stress correlates with increased behavioral emotionality and decreased synaptic puncta density.

Neuropharmacology 2021 Apr 14:108562. Epub 2021 Apr 14.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health (CAMH), Toronto, Canada; Departments of Pharmacology and Toxicology, University of Toronto, Toronto, Canada; Department of Psychiatry, University of Toronto, Toronto, Canada. Electronic address:

Clinical and preclinical studies report that chronic stress induces behavioral deficits as well as volumetric and synaptic alterations in corticolimbic brain regions including the anterior cingulate cortex (ACC), amygdala (AMY), nucleus accumbens (NAc) and hippocampus (HPC). Here, we aimed to investigate the volumetric changes associated with chronic restraint stress (CRS) and link these changes to the CRS-induced behavioral and synaptic deficits. We first confirmed that CRS increases behavioral emotionality, defined as collective scoring of anxiety- and anhedonia-like behaviors. Read More

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Allopurinol for fibromyalgia pain in adults: a randomized controlled trial.

Pain Pract 2021 Apr 17. Epub 2021 Apr 17.

Department of Biochemistry, Instituto de Ciências Básicas da Saúde (ICBS), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.

Background: Allopurinol is a potent inhibitor of the enzyme xanthine oxidase used in the treatment of hyperuricemia and gout. Since it is well known that purines exert multiple effects on pain transmission, we hypothesized that the inhibition of xanthine oxidase by allopurinol could be a valid strategy to treat pain in humans. This study aimed to compare the analgesic efficacy of oral allopurinol versus placebo as an adjuvant therapy in patients displaying fibromyalgia. Read More

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Dynamic insulin-stimulated mTOR/GSK3 signaling in peripheral immune cells: Preliminary evidence for an association with lithium response in bipolar disorder.

Bipolar Disord 2021 Apr 17. Epub 2021 Apr 17.

Mayo Clinic Depression Center, Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, 55905, United States.

Introduction: A key mechanism of lithium is the inhibition of glycogen synthase kinase-3β (GSK3β) and activation of mammalian target of rapamycin (mTOR), two contributors to insulin signaling. We explored the relationship between these markers and clinical response to lithium in bipolar disorder (BD).

Methods: Thirty-four subjects with BD who had been taking lithium for ≥ 2 years and had a maintenance lithium Alda score defined as either high (≥7; n=20) or low (≤2; n=14) were included in the study. Read More

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Spread of self-compatibility constrained by an intrapopulation crossing barrier.

New Phytol 2021 Apr 17. Epub 2021 Apr 17.

Department of Biology, Colorado State University, Fort Collins, CO, 80523-1878, USA.

Mating system transitions from self-incompatibility (SI) to self-compatibility (SC) are common in plants. In the absence of high levels of inbreeding depression, SC alleles are predicted to spread due to transmission advantage and reproductive assurance. We characterized mating system and pistil-expressed SI factors in 20 populations of the wild tomato species Solanum habrochaites from the southern half of the species range. Read More

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Molecular mechanisms of physical exercise on depression in the elderly: a systematic review.

Mol Biol Rep 2021 Apr 17. Epub 2021 Apr 17.

Physical Education Department, Federal University of the Valleys of Jequitinhonha and Mucuri (UFVJM), Diamantina, MG, Brazil.

Depressive disorders are common among the elderly. Major depressive disorder will be one of the highest healthcare costs in middle and higher income countries by 2030. It is known that physical inactivity leads to negative effects on mental health in the elderly. Read More

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The vicious circle between physical, psychological, and physiological characteristics of shift work in nurses: a multidimensional approach.

Sleep Breath 2021 Apr 17. Epub 2021 Apr 17.

Department of Physical Education and Sport Science, University of Thessaly, Karies, 42100, Trikala, Thessaly, Greece.

Purpose: To compare physical, psychological, and physiological adaptations between rotating and morning shift health workers using objective and subjective approaches.

Methods: Forty nurses [n = 20 morning shift (MS) group; n = 20 rotating shift (RS) group] were evaluated for anthropometry, body composition, and handgrip strength. Quality of life, depression, fatigue, daytime sleepiness, and sleep quality were assessed with SF-36, Zung Self-Rating Depression Scale (SDS), Fatigue Severity Scale (FSS), Epworth Sleepiness Scale (ESS), and Pittsburgh Sleep Quality Index (PSQI), respectively. Read More

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Community-Based Multi-Site Randomized Controlled Trial of Behavioral Activation for Patients with Depressive Disorders.

Community Ment Health J 2021 Apr 17. Epub 2021 Apr 17.

Department of Psychology, Korea University, 145, Anam-ro, Seongbuk-gu, Seoul, 02841, Republic of Korea.

Behavioral activation (BA) is a beneficial and relatively cost-effective treatment option for depression. This study utilized a pragmatic randomized controlled research design to investigate whether BA, as compared with treatment as usual (TAU), led to superior treatment effects, when delivered in community mental health settings by retrained community mental health professionals. Patients with depressive disorders (n = 64) were randomly assigned to a 10-session BA (n = 31) or TAU (n = 33) group. Read More

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Beyond the Cuckoo's Nest: Patient and Public Attitudes about Psychiatric Electroceutical Interventions.

Psychiatr Q 2021 Apr 17. Epub 2021 Apr 17.

Department of Philosophy, College of Arts and Letters, Michigan State University, East Lansing, MI, USA.

Recent research emphasizes the role of psychiatric electroceutical interventions (PEIs), bioelectronic treatments that employ electrical stimulation to affect and modify brain function, to effectively treat psychiatric disorders. We sought to examine attitudes about three PEIs-electroconvulsive therapy, transcranial magnetic stimulation, and deep brain stimulation-among patients with depression and members of the general public. As part of a larger study to assess different stakeholders' attitudes about PEIs, we conducted semi-structured key informant interviews with 16 individuals living with depression and 16 non-depressive members of the general public. Read More

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"Comparison of QR 678 & QR678 Neo as monotherapy and as combination therapy with 5% Minoxidil solution and oral Finasteride in the treatment of male androgenetic alopecia - Which is better?"

J Cosmet Dermatol 2021 Apr 17. Epub 2021 Apr 17.

Clinical Research Coordinator, The Esthetic Clinics, Mumbai, India.

Hair is an essential aspect of image and is correlated with youth, elegance, fitness and achievement. Hair loss leads to lowered self-esteem, lack of confidence and depression amongst affected individuals. The US Food and Drug Administration (FDA) permitted management options for male Androgenetic Alopecia (AGA) are topical Minoxidil and oral Finasteride. Read More

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Effect of magnesium and vitamin B6 supplementation on mental health and quality of life in stressed healthy adults: Post-hoc analysis of a randomised controlled trial.

Stress Health 2021 Apr 16. Epub 2021 Apr 16.

Global Medical Nutritionals, Consumer Healthcare, Sanofi-Aventis, Paris, France.

Magnesium status and vitamin B6 intake have been linked to mental health and/or quality of life (QoL). In an 8-week Phase IV randomised controlled study in individuals with low magnesemia and severe/extremely severe stress but who were otherwise healthy, greater stress reduction was achieved with magnesium combined with vitamin B6 than with magnesium alone. Here, we present a previously unreported secondary analysis of the effect of magnesium, with and without vitamin B6, on depression, anxiety, and QoL. Read More

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The impact of manic symptoms in first-episode psychosis: findings from the UK National EDEN study.

Acta Psychiatr Scand 2021 Apr 16. Epub 2021 Apr 16.

Mental Health and Well-being, University of Warwick Medical School, Warwick University, Coventry, UK.

Objective: The extant literature is inconsistent over whether manic symptoms in First Episode Psychosis (FEP) impact on its development and trajectory. This study addressed: 1) Does Duration of Untreated Illness (DUI) and Duration of Untreated Psychosis (DUP) differ between FEP patients with and without manic symptoms? 2) Do manic symptoms in FEP have an impact on time to remission over 1 year?

Methods: We used data from the National EDEN study, a longitudinal cohort of patients with FEP accessing early intervention services (EIS) in England, which measured manic, positive and negative psychotic symptoms, depression and functioning at service entry and 1 year. Data from 913 patients with FEP (639 without manic symptoms, 237 with manic symptoms) were analysed using both general linear modelling and survival analysis. Read More

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Effects of Gocovri (Amantadine) Extended Release Capsules on Non-Motor Symptoms in Patients with Parkinson's Disease and Dyskinesia.

Neurol Ther 2021 Apr 17. Epub 2021 Apr 17.

Adamas Pharmaceuticals, Inc., Emeryville, CA, USA.

Introduction: Gocovri (amantadine) extended release capsules are approved for treatment of dyskinesia and as a levodopa adjunct for OFF episodes in patients with Parkinson's disease (PD). We report treatment-related effects on non-motor symptoms (NMS) assessed as secondary outcomes in two trials using the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part I.

Methods: EASE LID and EASE LID 3 enrolled levodopa-treated patients with PD and ≥ 1 h/day ON time with troublesome dyskinesia. Read More

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Emotion Regulation as a Mediator in the Relationship Between Cognitive Biases and Depressive Symptoms in Depressed, At-risk and Healthy Children and Adolescents.

Res Child Adolesc Psychopathol 2021 Apr 16. Epub 2021 Apr 16.

Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University Hospital, LMU Munich, Munich, Germany.

Contemporary cognitive models of depression propose that cognitive biases for negative information at the level of attention (attention biases; AB) and interpretation (interpretation biases; IB) increase depression risk by promoting maladaptive emotion regulation (ER). So far, empirical support testing interactions between these variables is restricted to non-clinical and clinical adult samples. The aim of the current study was to extend these findings to a sample of children and adolescents. Read More

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Reduction of higher-order occipital GABA and impaired visual perception in acute major depressive disorder.

Mol Psychiatry 2021 Apr 16. Epub 2021 Apr 16.

Affilianted Mental Health Center & Hangzhou Seventh People's Hospital, Interdisciplinary Institute of Neuroscience and Technology, Zhejiang University School of Medicine, Hangzhou, China.

Major depressive disorder (MDD) is a complex state-dependent psychiatric illness for which biomarkers linking psychophysical, biochemical, and psychopathological changes remain yet elusive, though. Earlier studies demonstrate reduced GABA in lower-order occipital cortex in acute MDD leaving open its validity and significance for higher-order visual perception, though. The goal of our study is to fill that gap by combining psychophysical investigation of visual perception with measurement of GABA concentration in middle temporal visual area (hMT+) in acute depressed MDD. Read More

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Research approaches for evaluating opioid sparing in clinical trials of acute and chronic pain treatments: IMMPACT recommendations.

Pain 2021 Apr 8. Epub 2021 Apr 8.

University of Rochester Medical Center, Rochester, NY, USA University of Washington, Seattle, WA, USA Stony Brook School of Medicine, Stony Brook, NY, USA Queens University, Kingston, Ontario, Canada (Formally) U.S. Food and Drug Administration, Silver Spring, MD, USA WCG Analgesic Solutions, Wayland, MA, USA John's Hopkins School of Medicine, Baltimore, MD, USA University of California San Francisco, San Francisco, CA, USA University of Pennsylvania, Philadelphia, PA, USA Indiana University School of Medicine, Indianapolis, IN, USA Brigham and Women's Hospital / Harvard Medical School, Boston, MA, USA Carolinas Pain Institute, Charlotte, NC, USA Innocoll, Athlone, Ireland American Chronic Pain Association, Rocklin, CA, USA Wake Forest School of Medicine, Winston-Salem, NC, USA Southern Illinois University Edwardsville, Edwardsville, IL, USA GW Pharmaceuticals, Carlsbad, CA, USA Biogen, Cambridge, MA, USA University at Buffalo, Buffalo, NY, USA McGill University, Montreal, Canada MCPHS University, Boston, MA National Institutes of Health, Bethesda, MD, USA U.S. Department of Veterans Affairs / George Washington University, Washington, DC, USA (Formally) Pacira , Parsippany, NY, USA SDG LLC, Cambridge, MA, USA Sarepta, Cambridge, MA, USA Pfizer, NYC, NY, USA University of Pittsburgh, Pittsburgh, PA, USA Flexion Therapeutics, Burlington, MA, USA.

Abstract: Randomized clinical trials have demonstrated the efficacy of opioid analgesics for the treatment of acute and chronic pain conditions, and for some patients, these medications may be the only effective treatment available. Unfortunately, opioid analgesics are also associated with major risks (e.g. Read More

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The effects of booster sessions on self-management interventions for chronic musculoskeletal pain: a systematic review and meta-analysis of randomised controlled trials.

Pain 2021 Apr 9. Epub 2021 Apr 9.

University College London London North West University Healthcare NHS Trust University College London, Royal National Orthopaedic Hospital.

Abstract: Our objective was to investigate the effectiveness of booster sessions after self-management interventions as a means of maintaining self-management behaviours in the treatment of chronic musculoskeletal pain. We searched MEDLINE, EMBASE, Science Citation Index, Cochrane Central Register of Controlled Trials and PsycINFO. Two authors independently identified eligible trials and collected data. Read More

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Effect of nurse-led care on outcomes in patients with ACPA/RF-positive rheumatoid arthritis with active disease undergoing treat-to-target: a multicentre randomised controlled trial.

RMD Open 2021 Apr;7(1)

Rheumatologie and Immunologie, Medizinische Hochschule Hannover, Hannover, Germany

Objective: To determine the non-inferiority of nurse-led care (NLC) in patients with anticitrullinated protein antibody (ACPA)-positive and/or rheumatoid factor (RF)-positive rheumatoid arthritis (RA) with active disease who are starting disease-modifying antirheumatic drug therapy, following treat-to-target (T2T) recommendations.

Methods: A multicentre, pragmatic randomised controlled trial was conducted to assess clinical effectiveness, anxiety, depression and patient satisfaction following a non-inferiority design. The participants were 224 adults with ACPA/RF-positive RA who were randomly assigned to either NLC or rheumatologist-led care (RLC). Read More

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Disability-free survival after major cardiac surgery: a population-based retrospective cohort study.

CMAJ Open 2021 Apr-Jun;9(2):E384-E393. Epub 2021 Apr 16.

The Division of Cardiac Anesthesiology, Department of Anesthesiology and Pain Medicine (Sun), University of Ottawa Heart Institute; the School of Epidemiology and Public Health (Sun), University of Ottawa; the Institute for Clinical Evaluative Sciences (Sun, Bader Eddeen); the Division of Cardiac Surgery, Department of Surgery (Mesana), University of Ottawa Heart Institute, Ottawa, Ont.

Background: Cardiovascular research has traditionally been dedicated to "tombstone" outcomes, with little attention dedicated to the patient's perspective. We evaluated disability-free survival as a patient-defined outcome after cardiac surgery.

Methods: We conducted a retrospective cohort study of patients aged 40 years and older who underwent coronary artery bypass grafting (CABG) or single or multiple valve (aortic, mitral, tricuspid) surgery in Ontario between Oct. Read More

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Spouse's Diabetes Status and Incidence of Depression and Anxiety: An 18-Year Prospective Study.

Diabetes Care 2021 Apr 16. Epub 2021 Apr 16.

Emory Global Diabetes Research Center, Hubert Department of Global Health, Rollins School of Global Health, Emory University, Atlanta, GA.

Objective: We investigated the risk of depression and anxiety in people whose spouse did or did not have diabetes. We also examined associations between depression and anxiety and severity of spouse's diabetes.

Research Design And Methods: We analyzed prospective self-reported data about diagnosed depression/anxiety and diabetes in cohabiting couples in the national Panel Study of Income Dynamics (PSID) during 1999-2017 ( = 13,500, 128,833 person-years of follow-up, median follow-up 8. Read More

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The impact of the first COVID-19 surge on the mental well-being of ICU nurses: A nationwide survey study.

Intensive Crit Care Nurs 2021 Mar 20:103034. Epub 2021 Mar 20.

Radboud University Medical Center, Radboud Institute for Health Sciences, Department Intensive Care, Nijmegen, the Netherlands.

Objectives: To determine the impact of the first COVID-19 surge (March through June 2020) on mental well-being and associated risk factors among intensive care unit nurses.

Research Methodology: In September 2020, a nationwide cross-sectional survey study among Dutch intensive care nurses was carried out to measure prevalence rates of symptoms of anxiety, depression, posttraumatic stress disorder, and need for recovery (NFR), objectified by the HADS-A, HADS-D, IES-6 and NFR questionnaires, respectively. Associated risk factors were determined using multivariate logistic regression analyses. Read More

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Predictors of sleep quality in medical students during COVID-19 confinement.

Encephale 2021 Mar 18. Epub 2021 Mar 18.

Psychiatry Department, Farhat Hached University Hospital, Ibn Jazzar Avenue, Sousse 4000, Tunisia; University of Sousse, Tunisia; Faculty of medicine of Sousse, Sousse, Tunisia.

Objectives: We aimed to assess sleep quality of Tunisian medical students during home confinement due to the COVID-19 pandemic, and to analyze the relationship between sleep quality and sociodemographic, clinical, confinement-related and psychological variables.

Methods: A correlational cross-sectional study was conducted from April 11th to May 3rd 2020. Medical students who have been in home confinement and who accepted to participate in an online survey were targeted. Read More

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