J Affect Disord 2021 Mar 9;286:320-329. Epub 2021 Mar 9.
Michael E. DeBakey VA Medical Center, 2002 Holcomb Boulevard, Houston, TX, 77030, USA; Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences, 1977 Butler Boulevard, Houston, TX, 77030, USA; The Menninger Clinic, 12301 S Main Street, Houston, TX, 77035, USA.
Background: The N-methyl-D-aspartate receptor antagonist ketamine is potentially effective in treatment resistant depression. However, its antidepressant efficacy is highly variable, and there is little information about predictors of response.
Methods: We employed growth mixture modeling (GMM) analysis to examine specific response trajectories to intravenous (IV) ketamine (three infusions; mean dose 0. Read More