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Psychopharmacology Algorithms for Major Depressive Disorder: Current Status.

Adv Exp Med Biol 2021 ;1305:429-445

UT Health Center of Excellence on Mood Disorders, Faillace Department of Psychiatry & Behavioral Sciences, McGovern Medical School, Houston, TX, USA.

Major depressive disorder (MDD) is one of the leading causes of disability worldwide, and a considerable portion of depressed patients does not respond well to available treatment strategies. Algorithm-based treatment may contribute to improving the MDD outcomes and have the potential to homogenize the pharmacological treatment of MDD patients, facilitating outcome research and cost-effectiveness analysis. This chapter provides a critical review of the available literature on the use of treatment algorithms for the management of MDD. Read More

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January 2021

Novel insight into GLUT1 Deficiency Syndrome: screening for emotional and behavioral problems in youths following ketogenic diet.

Minerva Pediatr (Torino) 2021 Apr 2. Epub 2021 Apr 2.

Department of Child Neurology and Psychiatry, IRCCS Mondino Foundation, Pavia, Italy.

Background: Glucose Transporter Type 1 Deficiency Syndrome (GLUT1DS) is a rare disorder with a broad spectrum of neurological manifestations. The ketogenic diet (KD) is, to date, the gold standard treatment. Behavioral problems, well recognized in patients with chronic conditions, have not been, so far, deeply investigated in GLUT1DS patients. Read More

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Psychosocial factors associated with frailty in the community-dwelling aged population with depression. A cross-sectional study.

Aten Primaria 2021 Apr 1;53(5):102048. Epub 2021 Apr 1.

Primary Care Department, Consorci Sanitari del Maresme, Barcelona, Spain.

Objective: There is a two-way relationship between frailty and depression, but the mechanisms by which one may influence the other are not well understood. The objective of this study was to evaluate the relationship between psychosocial factors and frailty in community-dwelling aged populations with depression.

Design: Observational cross-sectional study. Read More

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[Falls in patients with chronic systolic heart failure 65 and more years old.]

Adv Gerontol 2020 ;33(6):1103-1106

Voroneg State Medical University, 10 Studencheskaya str. Voroneg 394036, Russian Federation.

Today we can see a rapidly growing number of patients with systolic heart failure (HF) 65 and over years old. Geriatric conditions may play an important role in such patients. Falls are one of geriatric syndromes, which can influence in prognosis and quality of life in patients with chronic systolic heart failure. Read More

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Distinct trajectories of antidepressant response to intravenous ketamine.

J Affect Disord 2021 Mar 9;286:320-329. Epub 2021 Mar 9.

Michael E. DeBakey VA Medical Center, 2002 Holcomb Boulevard, Houston, TX, 77030, USA; Baylor College of Medicine, Menninger Department of Psychiatry and Behavioral Sciences, 1977 Butler Boulevard, Houston, TX, 77030, USA; The Menninger Clinic, 12301 S Main Street, Houston, TX, 77035, USA.

Background: The N-methyl-D-aspartate receptor antagonist ketamine is potentially effective in treatment resistant depression. However, its antidepressant efficacy is highly variable, and there is little information about predictors of response.

Methods: We employed growth mixture modeling (GMM) analysis to examine specific response trajectories to intravenous (IV) ketamine (three infusions; mean dose 0. Read More

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Predictors of change in depressive symptoms in older and multimorbid patients: a longitudinal analysis of the multicare cohort.

Aging Ment Health 2021 Mar 25:1-10. Epub 2021 Mar 25.

Institute of General Practice, Goethe-University Frankfurt, Frankfurt am Main, Germany.

Background: Depression in older adults is becoming an increasing concern. As depressive symptoms change over time, it is important to understand the determinants of change in depressive symptoms. The aim of our study is to use a longitudinal study design to explore the predictors of change, remission and incident depression in older patients with multimorbidity. Read More

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Analysis of Antidepressant Activity of Huang-Lian Jie-Du Decoction Through Network Pharmacology and Metabolomics.

Front Pharmacol 2021 4;12:619288. Epub 2021 Mar 4.

Jiangsu Key Laboratory for High Technology Research of TCM Formulae, Nanjing University of Chinese Medicine, Nanjing, China.

Depressive disorder is a common mental disorder characterized by depressed mood and loss of interest or pleasure. As the Herbal medicines are mainly used as complementary and alternative therapy for depression. This study aimed at exploring antidepressant activity of Huang-lian Jie-du Decoction (HLJDD), and evaluating active components and potential depression-associated targets. Read More

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Characteristics of Glaucoma Patients Attending a Vision Rehabilitation Service.

Ophthalmol Glaucoma 2021 Mar 12. Epub 2021 Mar 12.

Richard E. Hoover Low Vision Rehabilitation Center, Greater Baltimore Medical Center.

Purpose: In this study, we describe common demographic and clinical characteristics of the glaucoma patient population attending vision rehabilitation.

Design: Cross sectional study.

Participants: Patients attending a hospital-based vision rehabilitation center with a primary ocular diagnosis of glaucoma. Read More

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Facilitating factors and barriers in help-seeking behaviour in adolescents and young adults with depressive symptoms: A qualitative study.

PLoS One 2021 8;16(3):e0247516. Epub 2021 Mar 8.

Amsterdam UMC, Department of Psychiatry, Amsterdam Public Health Institute and GGZ inGeest Specialized Mental Health Care, Vrije Universiteit, Amsterdam, The Netherlands.

Objective: Despite the availability of mental health care, only a minority of depressed adolescents and young adults receive treatment. This study aimed to investigate facilitating factors and barriers in help-seeking behaviour of adolescents and young adults with depressive symptoms, using qualitative research methods.

Methods: In-depth, semi-structured interviews with 32 participants with current or previous depressive symptoms aged 16 to 24 years using thematic content analysis. Read More

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Folic acid supplementation acts as a chemopreventive factor in tumorigenesis of hepatocellular carcinoma by inducing H3K9Me2-dependent transcriptional repression of LCN2.

Oncotarget 2021 Feb 16;12(4):366-378. Epub 2021 Feb 16.

Department of Medical Genetics, College of Basic Medical Sciences, Second Military Medical University, Shanghai, 200433, China.

The effects and mechanisms of folic acid (FA) as a chemopreventive agent for tumorigenesis of hepatocellular carcinoma (HCC) remain unclear. In this study, the QSG-7701, a human normal liver cell line, was cultured in different FA levels (High, Normal or No) for 6 months. Then, the biological characteristics, the expression of main stem cell-like genes or epithelial-mesenchymal transition (EMT) related genes and the tumorigenicity of cells cultured in different treatment groups were detected. Read More

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February 2021

Social factors associated with reversing frailty progression in community-dwelling late-stage elderly people: An observational study.

PLoS One 2021 3;16(3):e0247296. Epub 2021 Mar 3.

Department of Physical Therapy, Faculty of Health Science, Kio University, Koryo, Kitakatsuragi-gun, Nara, Japan.

Frailty is considered to be a complex concept based mainly on physical vulnerability, but also vulnerabilities in mental/psychological and social aspects. Frailty can be reversible with appropriate intervention; however, factors that are important in recovering from frailty have not been clarified. The aim of the present study was to identify factors that help an individual reverse frailty progression and characteristics of individuals that have recovered from frailty. Read More

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The clinical effectiveness of using a predictive algorithm to guide antidepressant treatment in primary care (PReDicT): an open-label, randomised controlled trial.

Neuropsychopharmacology 2021 Feb 26. Epub 2021 Feb 26.

P1vital Ltd, Howbery Park, Wallingford, UK.

Depressed patients often do not respond to the first antidepressant prescribed, resulting in sequential trials of different medications. Personalised medicine offers a means of reducing this delay; however, the clinical effectiveness of personalised approaches to antidepressant treatment has not previously been tested. We assessed the clinical effectiveness of using a predictive algorithm, based on behavioural tests of affective cognition and subjective symptoms, to guide antidepressant treatment. Read More

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February 2021

Effects of diminished positive mood and depressed mood upon verbal learning and memory among people with multiple sclerosis.

J Clin Exp Neuropsychol 2021 Feb 23:1-12. Epub 2021 Feb 23.

Department of Psychology, University of Texas at Tyler, Tyler, TX, USA.

: Cognitive impairment affects as many as 65% of people with multiple sclerosis (PWMS), and memory impairment confers greater severity of disability and functional impairment. Depression is also common among PWMS, and lifetime prevalence rates are as high as 50%. Research has yet to clearly define the relationship between memory dysfunction and depression among PWMS, and may reflect incomplete assessment of depressive symptoms. Read More

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February 2021

The associations of pregnancy-related symptoms with health-related quality of life at midpregnancy: the PregnActive project.

J Matern Fetal Neonatal Med 2021 Feb 21:1-9. Epub 2021 Feb 21.

Physical Performance and Sports Research Center, Department of Sports and Computer Science, Section of Physical Education and Sports, Universidad Pablo de Olavide, Seville, Spain.

Aim: To analyze the associations between the wide range of pregnancy-related symptoms and health-related quality of life.

Material And Methods: A cross-sectional study was developed among 155 healthy low-risk pregnant women, aged 18-45 years, participated in the study at midpregnancy. Health-related quality of life and pregnancy symptoms were assessed using the Medical Outcome Study 36-item short form questionnaire and the Pregnancy Symptoms Inventory, respectively. Read More

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February 2021

Soybean anthracnose caused by Colletotrichum species: Current status and future prospects.

Mol Plant Pathol 2021 Apr 20;22(4):393-409. Epub 2021 Feb 20.

Instituto Hispano-Luso de Investigaciones Agrarias (CIALE), Universidad de Salamanca, Salamanca, Spain.

Soybean (Glycine max) is one of the most important cultivated plants worldwide as a source of protein-rich foods and animal feeds. Anthracnose, caused by different lineages of the hemibiotrophic fungus Colletotrichum, is one of the main limiting factors to soybean production. Losses due to anthracnose have been neglected, but their impact may threaten up to 50% of the grain production. Read More

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Effects of hypoxia on the respiratory and metabolic responses to progressive cooling in newborn rodents that range in heterothermic expression.

Exp Physiol 2021 Apr 8;106(4):1005-1023. Epub 2021 Mar 8.

Department of Zoology, University of British Columbia, Vancouver, British Columbia, Canada.

New Findings: What is the central question of this study? Adult homeotherms and heterotherms differ in cold and hypoxia tolerance and in how they match O supply and demand in response to these stressors. It has never been ascertained whether these differences reflect different developmental trajectories or whether they are already present at birth. What is the main finding and its importance? When exposed to cold and hypoxia, newborn rodents differed in how they matched O supply and demand, with responses reflecting the degree of heterothermic expression and tolerance. Read More

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Irritable Mood and Subthreshold Hypomanic Episodes Correlate with More Severe Major Depression.

Neuropsychobiology 2021 Feb 18:1-11. Epub 2021 Feb 18.

Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.

Introduction: Irritable mood (IM) and subthreshold hypomanic symptoms are reported in half and two-fifths of major depressed subjects respectively, but their clinical and prognostic meanings remain unclear. The aim of this study was to test the clinical usefulness of 2 specifiers in DSM-IV major depressive disorder (MDD): IM occurring during an index episode (IM+) and lifetime episodes of elated mood or IM with at least 2 concurrent hypomanic symptoms (subthreshold hypomanic episodes [SHEs]).

Method: We included 482 outpatients with MDD participating in the Combining Medications to Enhance Depression Outcome study (mean age 43. Read More

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February 2021

Larval tolerance to food limitation is stronger in an exotic barnacle than in its native competitor.

Zoology (Jena) 2021 Apr 17;145:125891. Epub 2020 Dec 17.

School of Ocean Sciences, Bangor University, Askew Street, LL59 5AB, Anglesey, Wales, United Kingdom; Marine Station of Helgoland, Alfred Wegener Institute, Helmholtz Centre for Polar and Marine Research, Ostkaje 1118, DE-27498, Helgoland, Germany. Electronic address:

A critical question in marine ecology is understanding how organisms will cope with environmental conditions under climate change. Increasing temperatures not only have a direct effect on marine organisms but may also lead to food limitation through for example trophic mismatches, or by the increased metabolic demands imposed by developing at high temperatures. Using barnacles from a population of North Wales, we studied the combined effect of temperature and food density on the survival, settlement success, developmental time and body size of larvae of the native barnacle Semibalanus balanoides and its exotic competitor, the barnacle Austrominius modestus. Read More

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Infantile functional gastrointestinal disorders and maternal psychological status: a narrative review.

Curr Pediatr Rev 2021 Feb 8. Epub 2021 Feb 8.

Department of Biomedical Science and Human Oncology, Section of Neonatology and Neonatal Intensive Care Unit, "Aldo Moro" University of Bari, Bari 70124. Italy.

Background: Functional gastrointestinal disorders are often extremely distressing for the infant and parents, leading to infant discomfort and crying, parental anxiety, repeated healthcare consultations, and escalating healthcare costs.

Aim: In this narrative review we analyzed the relationship between maternal psychological status during pregnancy and postpartum and the main infantile functional gastrointestinal disorders.

Materials And Methods: The narrative reviewwas conducted searching scientific databases for articles reporting on infantile functional gastrointestinal disorders in association with maternal depressive or anxiety disorders. Read More

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February 2021

Impact of COVID19 on resident physicians of a community hospital in New York city.

J Community Hosp Intern Med Perspect 2021 Jan 26;11(1):4-8. Epub 2021 Jan 26.

Department of Pulmonary Medicine, Interfaith Medical Center, Brooklyn, NY, USA.

Novel Corona Virus Disease 19 has created unforeseen burden on health care. New York city is one of the epicenters of pandemic and here we explore physical, mental and social impact of COVID 19 on Resident Physicians (RP) working within the center of this epicenter. This is a single-center cross-sectional web-based survey involving RP of a community hospital in Brooklyn, New York. Read More

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January 2021

Temperature adaptations of the thermophilic snail : insights from metabolomic analysis.

J Exp Biol 2021 Mar 15;224(Pt 6). Epub 2021 Mar 15.

The Key Laboratory of Mariculture, Ministry of Education, Fisheries College, Ocean University of China, Qingdao 266003, China

The periwinkle snail , for which the upper lethal temperature is near 55°C, is one of the most heat-tolerant eukaryotes known. We conducted a multi-level investigation - including cardiac physiology, enzyme activity, and targeted and untargeted metabolomic analyses - that elucidated a spectrum of adaptations to extreme heat in this organism. All systems examined showed heat intensity-dependent responses. Read More

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Health and social care service utilisation and associated expenditure among community-dwelling older adults with depressive symptoms.

Epidemiol Psychiatr Sci 2021 Feb 2;30:e10. Epub 2021 Feb 2.

Sau Po Centre on Ageing, The University of Hong Kong, Hong Kong, SAR, China.

Aims: Late-life depression has substantial impacts on individuals, families and society. Knowledge gaps remain in estimating the economic impacts associated with late-life depression by symptom severity, which has implications for resource prioritisation and research design (such as in modelling). This study examined the incremental health and social care expenditure of depressive symptoms by severity. Read More

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February 2021

Epilepsy and quality of life in Iranian epileptic patients.

J Patient Rep Outcomes 2021 Jan 28;5(1):16. Epub 2021 Jan 28.

Faculty of Medicine, Mashhad Branch, Islamic Azad University, Mashhad, Iran.

Background: Epilepsy is one of the most common neurological disorders with physical, emotional, and social consequences. Previous studies indicate that epilepsy symptoms can highly affect the epileptic patients' satisfaction in life. The aim of the present study is to investigate the QOL of People with Epilepsy (PWE) in Khorasan Razavi province, Iran. Read More

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January 2021

Poly(butylene succinate--butylene acetylenedicarboxylate): Copolyester with Novel Nucleation Behavior.

Polymers (Basel) 2021 Jan 24;13(3). Epub 2021 Jan 24.

Department of Materials Science and Engineering, China University of Petroleum, Beijing 102249, China.

Big spherulite structure and high crystallinity are the two main drawbacks of poly(butylene succinate) (PBS) and hinder its application. In this work, a new type of copolyester poly(butylene succinate--butylene acetylenedicarboxylate) (PBSAD) is synthesized. With the incorporation of acetylenedicarboxylate (AD) units into PBS chains, the crystallization temperature and crystallinity are depressed by excluding AD units to the amorphous region. Read More

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January 2021

Adolescent Pregnancy and Outcomes: A Hospital-Based Comparative Study at a Tertiary Care Unit in Eastern Province, Sri Lanka.

Cureus 2020 Dec 14;12(12):e12081. Epub 2020 Dec 14.

Pediatrics, Base Hospital, Mahaoya, LKA.

Background Adolescent pregnancy is a high-risk condition that can potentially lead to adverse perinatal and obstetric outcomes. It is a growing concern in developing countries including Sri Lanka. The main objective of this study was to evaluate obstetric and perinatal outcomes amongst adolescent pregnancies and compare them with outcomes of pregnancies of average maternal age (AMA) women. Read More

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December 2020

Protective effect of grape seed extract and orlistat co-treatment against stroke: Effect on oxidative stress and energy failure.

Biomed Pharmacother 2021 Apr 20;136:111282. Epub 2021 Jan 20.

Bioactive Substances Laboratory, Biotechnology Centre, Technopolis Borj-Cedria, BP-901, 2050, Hammam-Lif, Tunisia.

Ischemic stroke is a major health concern and a leading cause of mortality worldwide. Oxidative stress is an early event in the course of stroke inducing neuro-inflammation and cell death. Grape seed extract (GSE) is a natural phytochemical mixture exhibiting antioxidant, anti-inflammatory and neuroprotective properties. Read More

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Suctioning First or Drying First During Delivery Room Resuscitation: A Randomized Controlled Trial.

Indian Pediatr 2021 Jan;58(1):25-29

Biostatistics Unit, Institute of Medical Sciences, Banaras Hindu University, Varanasi, UP, India.

Objective: To compare the effect of suctioning first or drying first on the composite outcome of hypothermia or respiratory distress in depressed newborns requiring delivery room resuscitation.

Design: Open-label, randomized, parallel-group, controlled trial.

Setting: Delivery room and neonatal intensive care unit of a tertiary-care teaching hospital. Read More

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January 2021

When destruction comes first: Two new species of Hypostomus Lacépède, 1803 (Siluriformes: Loricariidae) from a deeply-impacted river in the Rio São Francisco basin in Brazil.

J Fish Biol 2021 Jan 13. Epub 2021 Jan 13.

Universidade Estadual de Maringá, Departamento de Biologia, Núcleo de Pesquisas em Limnologia, Ictiologia e Aquicultura (Nupélia), Maringá, Brazil.

Environmental disasters affecting Brazilian rivers have been frequent recently, especially involving mining activities. Two recent dam-rupture events suddenly released millions of cubic meters of iron tailings downstream into two major Brazilian watersheds. These events generated major losses to the environment and human life. Read More

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January 2021

Prevalence and Associated Factors for Depressive Symptomatology in Chinese Adults During COVID-19 Epidemic.

Front Psychol 2020 23;11:616723. Epub 2020 Dec 23.

Department of Social Medicine and Health Management, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

The coronavirus disease 2019 (COVID-19) has been rapidly transmitted worldwide, which contributed to various psychological problems (such as fear, depression, and anxiety) among the general population in China. The purpose of this study is to investigate the prevalence and associated factors of depressive symptoms among Chinese adults. A cross-sectional study of Chinese adults was conducted during 17-29 February 2020. Read More

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December 2020