10,415 results match your criteria depleting pi45p

Analyzing the ultimate impact of COVID-19 in Africa.

M Elbany Y Elhenawy

Case Stud Transp Policy 2021 Apr 6. Epub 2021 Apr 6.

Mechanical Power Engineering Department, Faculty of Engineering, Port-Said University, Egypt.

The Covid-19 pandemic has spread quickly across the globe in late 2019 and this has continued into 2020, causing a complete closure of daily routines, depleting global resources and, in extreme cases, causing loss of life. In Africa, with its hot climate, decision makers try to get people to their work as health care professionals or sometimes access health care facilities. For the peak four months; April, May, June, and July, the virus appeared, spread, and began to decrease. Read More

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Evidence of an antidepressant-like effect of xylopic acid mediated by serotonergic mechanisms.

Psychopharmacology (Berl) 2021 Apr 10. Epub 2021 Apr 10.

Department of Pharmacology and Toxicology, School of Pharmacy, University of Health and Allied Sciences, Ho, Ghana.

Background: Depression causes significant debilitating symptoms and economic burden. Current management is challenged by slow onset of action and modest efficacies of antidepressants; thus, the search for newer antidepressants remains relevant. We evaluated the antidepressant effects of a kaurene diterpene, xylopic acid (XA), in zebrafish and mouse models. Read More

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Histone deacetylases control lysine acetylation of ribosomal proteins in rice.

Nucleic Acids Res 2021 Apr 9. Epub 2021 Apr 9.

National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, 430070 Wuhan, China.

Lysine acetylation (Kac) is well known to occur in histones for chromatin function and epigenetic regulation. In addition to histones, Kac is also detected in a large number of proteins with diverse biological functions. However, Kac function and regulatory mechanism for most proteins are unclear. Read More

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Centrosome-mediated microtubule remodeling during axon formation in human iPSC-derived neurons.

EMBO J 2021 Apr 9:e106798. Epub 2021 Apr 9.

Cell Biology, Neurobiology and Biophysics, Department of Biology, Faculty of Science, Utrecht University, Utrecht, The Netherlands.

Axon formation critically relies on local microtubule remodeling and marks the first step in establishing neuronal polarity. However, the function of the microtubule-organizing centrosomes during the onset of axon formation is still under debate. Here, we demonstrate that centrosomes play an essential role in controlling axon formation in human-induced pluripotent stem cell (iPSC)-derived neurons. Read More

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Soluble α-synuclein-antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia.

Proc Natl Acad Sci U S A 2021 Apr;118(15)

Neurodegeneration New Medicines Center, The Scripps Research Institute, La Jolla, CA 92037;

Parkinson's disease is characterized by accumulation of α-synuclein (αSyn). Release of oligomeric/fibrillar αSyn from damaged neurons may potentiate neuronal death in part via microglial activation. Heretofore, it remained unknown if oligomeric/fibrillar αSyn could activate the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin domain-containing 3 (NLRP3) inflammasome in human microglia and whether anti-αSyn antibodies could prevent this effect. Read More

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Stop and go, where is my flow? How and when daily aversive morning commutes are negatively related to employees' motivational states and behavior at work.

J Appl Psychol 2021 Apr 8. Epub 2021 Apr 8.

Norwich Business School.

Despite convincing evidence about the general negative consequences of commuting for individuals and societies, our understanding of how aversive commutes are linked to employees' effectiveness at work is limited. Drawing on theories of self-regulation and by extension a conservation of resources perspective, we develop a framework that explains how an aversive morning commute-a resource-depleting experience characterized by interruptions of automated travel behaviors-impairs employees' immersion in uninterrupted work (i.e. Read More

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Group-2 Innate Lymphoid Cells Promote Hepatocellular Carcinoma Progression via CXCL2-Neutrophil Induced Immunosuppression.

Hepatology 2021 Apr 8. Epub 2021 Apr 8.

Department of Hepatobiliary and Pancreatic Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China.

Background & Aims: Due to their inherent characteristics, the function of group-2 innate lymphoid cells (ILC2s) varies in a context-dependent manner. ILC2s are involved in certain liver diseases; however, their involvement in hepatocellular carcinoma (HCC) is unknown. In the present study, we assessed the role of an HCC-derived ILC2 population in tumor progression. Read More

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Overexpression of AGAMOUS-like gene PfAG5 promotes early flowering in Polypogon fugax.

Funct Plant Biol 2021 Apr 6. Epub 2021 Apr 6.

Herbicides are the major tool for controlling large populations of yield depleting weeds. However, over-reliance on herbicides has resulted in weed adaptation and herbicide resistance. In recent years, early flowering weed species related to herbicide resistance is emerging, which may cause seed loss before crop harvest, creating a new problem for non-chemical weed management. Read More

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HOTAIRM1 Promotes Malignant Progression of Transformed Fibroblasts in Glioma Stem-Like Cells Remodeled Microenvironment Regulating miR-133b-3p/TGFβ Axis.

Front Oncol 2021 19;11:603128. Epub 2021 Mar 19.

Department of Neurosurgery, The Second Affiliated Hospital of Soochow University, Suzhou, China.

Recent studies have reported that cancer associated fibroblasts (CAFs) and glioma stem-like cells (GSCs) played active roles in glioma progression in tumor microenvironment (TME). Long non-coding RNAs (lncRNAs) have been found to be closely associated with glioma development in recent years, however, their molecular regulatory mechanisms on CAFs in GSCs remodeled TME kept largely unelucidated. Our study found that GSCs could induce malignant transformation of fibroblasts (t-FBs) based on dual-color fluorescence tracing orthotopic model. Read More

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Kidney transplantation and COVID-19 renal and patient prognosis.

Clin Kidney J 2021 Mar 26;14(Suppl 1):i21-i29. Epub 2021 Mar 26.

Department of Nephrology, Hospital Universitari Vall d'Hebron, Barcelona, Spain.

Coronavirus disease 2019 (COVD-19) emerged as a pandemic in December 2019. Infection has spread quickly and renal transplant recipients receiving chronic immunosuppression have been considered a population at high risk of infection, complications and infection-related death. During this year a large amount of information from nationwide registries, multicentre and single-centre studies have been reported. Read More

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