2,215 results match your criteria dentine exposure

The Role of canonical Wnt signaling in dentin bridge formation.

J Oral Biosci 2021 Apr 9. Epub 2021 Apr 9.

Department of Oral Histology, Matsumoto Dental University, 1780 Hirooka-gobara, Shiojiri, Nagano 399-0781, Japan. Electronic address:

Objective: Wnt signaling has been reported to be involved in dentin bridge formation. However, the detailed mechanism has not yet been clarified. We elucidated the localization of canonical Wnt signaling molecules during dentin bridge formation. Read More

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Dentinal tubule occlusion using Er:YAG Laser: an in vitro study.

J Appl Oral Sci 2021 2;29:e20200266. Epub 2021 Apr 2.

Southern Medical University, Nanfang Hospital, Department of Stomatology, Guangzhou, Guangdong, China.

Objectives: We analyzed the effects of the Er:YAG laser used with different parameters on dentinal tubule (DT) occlusion, intrapulpal temperature and pulp tissue morphology in order to determine the optimal parameters for treating dentin hypersensitivity.

Methodology: Dentin specimens prepared from 36 extracted human third molars were randomized into six groups according to the treatment method (n=6 each): control (A); Gluma desensitizer (B); and Er:YAG laser treatment at 0.5 W , 167 J/cm2 (50 mJ, 10 Hz) (C), 1 W , 334 J/cm2 (50 mJ, 20 Hz) (D), 2 W , 668 J/cm2 (100 mJ, 20 Hz) (E), and 4 W and 1336 J/cm2 (200 mJ, 20 Hz) (F). Read More

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Artemisinin protects DPSC from hypoxia and TNF-α mediated osteogenesis impairments through CA9 and Wnt signaling pathway.

Life Sci 2021 Mar 31:119471. Epub 2021 Mar 31.

School of Medicine, JingGangShan University, Ji'an 343009, China. Electronic address:

Dental pulp stem cells (DPSCs) possess the ability of multi-lineage differentiation, and are excellent sources of tissue engineering and regenerative medicine. Oxygen concentration and inflammation are two critical environmental factors that affect the osteogenic differentiation of DPSCs. We aimed to study the role of the antimalarial drug artemisinin on the osteogenic differentiation of human DPSCs under the hypoxia and inflammation conditions. Read More

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Adjunctive procedure with solvent mixtures in non-surgical endodontic retreatment: does it affect root dentin hardness?

Odontology 2021 Apr 2. Epub 2021 Apr 2.

Faculty of Dental Medicine, CINTESIS, University of Porto, Porto, Portugal.

The aim of this study was to compare the effects of new irrigation solvent mixtures with Methyl ethyl ketone (MEK)/Tetrachloroethylene (TCE) and MEK/Orange oil (OOil), and different agitation techniques on dentin hardness. One hundred forty-four mandibular teeth were prepared and standardized, with each root's middle part transversely sectioned. Initial hardness was measured using a Vickers microhardness tester. Read More

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A Bioinformatics Systems Biology Analysis of the Current Oral Proteomic Biomarkers and Implications for Diagnosis and Treatment of External Root Resorption.

Int J Mol Sci 2021 Mar 20;22(6). Epub 2021 Mar 20.

Department of Endodontics, University of Florida College of Dentistry, Gainesville, FL 32610, USA.

External root resorption (ERR) is a silent destructive phenomenon detrimental to dental health. ERR may have multiple etiologies such as infection, inflammation, traumatic injuries, pressure, mechanical stimulations, neoplastic conditions, systemic disorders, or idiopathic causes. Often, if undiagnosed and untreated, ERR can lead to the loss of the tooth or multiple teeth. Read More

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Potential of tailored amorphous multiporous calcium silicate glass for pulp capping regenerative endodontics-A preliminary assessment.

J Dent 2021 Mar 30;109:103655. Epub 2021 Mar 30.

Department of Bioscience Research, College of Dentistry, University of Tennessee Health Science Center, Memphis, TN, 38163, United States. Electronic address:

Introduction/objective: The tailored amorphous multi-porous (TAMP) material fabrication technology has led to a new class of bioactive materials possessing versatile characteristics. It has not been tested for dental applications. Thus, we aimed to assess its biocompatibility and ability to regenerate dental mineral tissue. Read More

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Effect of ionizing radiation and cariogenic biofilm challenge on root-dentin caries.

Clin Oral Investig 2021 Mar 25. Epub 2021 Mar 25.

Department of Operative Dentistry and Dental Materials, School of Dentistry, Federal University of Uberlândia, Uberlândia, MG, Brazil.

Objectives: To evaluate the effect of ionizing radiation and cariogenic biofilm challenge using two continuous flow models, normal and reduced salivary flow, on the development of initial root-dentin caries lesions.

Materials And Methods: Microcosm biofilms were grown under two salivary flow rates (0.06 and 0. Read More

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Pulp tissue reaction to a self-adhesive, resin-based direct pulp capping material containing surface pre-reacted glass-ionomer filler.

Dent Mater 2021 Mar 17. Epub 2021 Mar 17.

Advanced Operative Dentistry-Endodontics, The Nippon Dental University Graduate School of Life Dentistry at Niigata, Japan; Department of Operative Dentistry, The Nippon Dental University School of Life Dentistry at Niigata, Japan. Electronic address:

Objective: This study aimed to evaluate the effect of direct pulp capping using an experimental self-adhesive resin for direct pulp capping (SRD) containing silica and surface pre-reacted glass-ionomer (S-PRG) filler on pulpal healing and to monitor the dentin bridge formation in rat pulp 2-4 weeks after operation.

Methods: Five types of SRDs (SRD-0: S-PRG fillers 0 wt%; SRD-1: S-PRG fillers 9.1 wt%; SRD-2: S-PRG fillers 18. Read More

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The effect of surface pre-reacted glass-ionomer filler eluate on dental pulp cells and mineral deposition on dentin: In vitro study.

Eur J Oral Sci 2021 Mar 16:e12777. Epub 2021 Mar 16.

Department of Cariology and Operative Dentistry, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan.

The effects of surface pre-reacted glass-ionomer (S-PRG) filler on pulpal cells and on the composition of dentinal deposits were investigated. Proliferation (CCK-8), cytotoxicity (LDH), and differentiation activity (ALP) tests, along with cell morphology observations, were conducted at 6 and 24 h after treatment of pulpal cells with different S-PRG filler eluate concentrations. Dentinal surfaces were immersed in deionized water or S-PRG filler eluate followed by immersion in deionized water or simulated body fluid and observed under scanning electron microscope and elemental analysis using energy dispersive x-ray spectrometer. Read More

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Teeth reveal juvenile diet, health and neurotoxicant exposure retrospectively: What biological rhythms and chemical records tell us.

Bioessays 2021 Mar 15:e2000298. Epub 2021 Mar 15.

Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Integrated developmental and elemental information in teeth provide a unique framework for documenting breastfeeding histories, physiological disruptions, and neurotoxicant exposure in humans and our primate relatives, including ancient hominins. Here we detail our method for detecting the consumption of mothers' milk and exploring health history through the use of laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) mapping of sectioned nonhuman primate teeth. Calcium-normalized barium and lead concentrations in tooth enamel and dentine may reflect milk and formula consumption with minimal modification during subsequent tooth mineralization, particularly in dentine. Read More

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Analysis of narwhal tusks reveals lifelong feeding ecology and mercury exposure.

Curr Biol 2021 Mar 5. Epub 2021 Mar 5.

Department of Bioscience, Arctic Research Centre, Aarhus University, Aarhus 4000, Denmark.

The ability of animals to respond to changes in their environment is critical to their persistence. In the Arctic, climate change and mercury exposure are two of the most important environmental threats for top predators. Rapid warming is causing precipitous sea-ice loss, with consequences on the distribution, composition, and dietary ecology of species and, thus, exposure to food-borne mercury. Read More

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Evaluation of dental trauma in inmates of the most highly populated Brazilian prison complex.

Dent Traumatol 2021 Feb 18. Epub 2021 Feb 18.

Federal University of Pernambuco, Recife, Brazil.

Background/aim: Due to the increase in incarceration rates, the prison community has attracted much concern in the recent past. Although people in prison are often socially disadvantaged and vulnerable to a range of health problems, there is a lack of information on the oral health conditions of prisoners. Thus, the aim of this study was to survey the oral problems of a sample of the male incarcerated population of Brazil, focusing on dental trauma. Read More

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February 2021

Effect of Propolis Nanoparticles against Biofilm in the Root Canal.

Molecules 2021 Jan 30;26(3). Epub 2021 Jan 30.

School of Dentistry, International Medical University, Kuala Lumpur 57000, Malaysia.

To determine the antibacterial effect of propolis nanoparticles (PNs) as an endodontic irrigant against biofilm inside the endodontic root canal system. Two-hundred-ten extracted human teeth were sectioned to obtain 6 mm of the middle third of the root. The root canal was enlarged to an internal diameter of 0. Read More

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January 2021

Effect of surface preparation and light curing on penetration of silver particles from 38% silver diamine fluoride in dentin of primary teeth: An in vitro evaluation.

Am J Dent 2021 Feb;34(1):44-48

Department of Restorative Dentistry & Prosthodontics, University of Texas School of Dentistry at Houston, Houston, Texas, USA.

Purpose: To evaluate the effect of light cure, as well as various dentin surface treatment approaches, on the penetration depth of silver precipitating from 38% silver diamine fluoride into primary dentin tubules.

Methods: The occlusal dentin surfaces of 42 non-carious primary molars were exposed and then sectioned into halves bucco-lingually. The halves from each tooth pair were randomly split in two mega-groups, and each mega-group was divided randomly as follows into six experimental groups: prepared by either carbide bur (G1, G2), ceramic bur (G3, G4), or erbium laser (G5, G6). Read More

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February 2021

A novel bio-active adhesive monomer induces odontoblast differentiation: a comparative study.

Int Endod J 2020 Oct 30;53(10):1413-1429. Epub 2020 Jul 30.

Division of Clinical Cariology and Endodontology, Department of Oral Rehabilitation, Health Sciences University of Hokkaido, Hokkaido, Japan.

Aim: To evaluate the in vitro effect of the novel adhesive monomer CMET, a calcium salt of 4-methacryloxyethyl trimellitate (4-MET), on the proliferation, mineralization and differentiation of odontoblast-like cells, comparing with 4-MET, calcium hydroxide (CH) and mineral trioxide aggregate (MTA).

Methodology: Rat odontoblast-like MDPC-23 cells were cultured in Dulbecco's modified Eagle's medium (DMEM) supplemented with 5% foetal bovine serum. The powder of four tested materials (CMET, 4-MET, CH and MTA) was first dissolved in distilled water (dHO) and then was diluted by DMEM to yield final concentrations. Read More

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October 2020

Polymodal Activation and Desensitization of TRPV1 Receptor in Human Odontoblasts-Like Cells with Eugenol.

Int J Dent 2020 29;2020:8813979. Epub 2020 Dec 29.

Grupo de Investigaciones Básicas y Aplicadas en Odontología (IBAPO), Universidad Nacional de Colombia, Bogotá, Colombia.

Dentinal hypersensitivity is a frequent reason for dental consultation, and its pathophysiology has not been fully clarified. Previous findings have made it possible to establish a relationship between the cellular sensory capacity and the activation of the polymodal transient receptor potential vanilloid 1 (TRPV1), which is responsible for the nociceptive response and whose desensitization could cause analgesia. Thus, the objective of this study was to determine the expression, localization, and functional activity of TRPV1 in human odontoblasts-like-cells (hOLCs) and the effect of eugenol (EUG) on its activation and desensitization. Read More

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December 2020

Remineralization of dentine tubules induced by phosphate-terminated PAMAM dendrimers.

Heliyon 2020 Dec 29;6(12):e05886. Epub 2020 Dec 29.

State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, 610041, China.

Various sealants have been developed to treat the exposure of dentinal tubules (DTs) and further dental hypersensitivity. Herein, the phosphate-terminated fourth generation polyamidoamine dendrimers (PAMAM-POH) was successfully synthesized. Six duplicates of demineralized dentin and type I collagen matrix were incubated in artificial saliva solution with or without PAMAM-POH treatment at 37 °C for 2 weeks, respectively. Read More

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December 2020

Cavity Disinfection With a 445 nm Diode Laser Within the Scope of Restorative Therapy - A Pilot Study.

J Lasers Med Sci 2020 3;11(4):417-426. Epub 2020 Oct 3.

Center of Dento-Maxillo-Facial Medicine, Bonn University, Welschnonnenstrasse 17, D-53111 Bonn, Germany.

Cavity disinfection is necessary to prevent a progressive infection of the crown dentin and pulp. Increasing intolerance and resistance to antiseptics and antibiotics as well as the controversy over the effects of those on the dental hard tissue and composite have prompted the investigation of alternative treatment options. The objective of this pilot study is to evaluate the antibacterial potential of a diode laser with a wavelength of 445 nm in the cavity preparation using the bacterium associated with caries in conjunction with the characteristics and influences of dentin on light transmission. Read More

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October 2020

Erosive effect of industrialized fruit juices exposure in enamel and dentine substrates: An study.

J Clin Exp Dent 2021 Jan 1;13(1):e48-e55. Epub 2021 Jan 1.

Department of Clinic and Social Dentistry, Federal University of Paraiba-UFPB, João Pessoa/Paraiba, Brazil.

Background: Erosive tooth wear has been a highly prevalent and emerging phenomenon related to eating habits of the population. Aim: This study sought to investigate industrialized fruit juices exposure in enamel and dentine substrates in terms of erosive effect.

Material And Methods: Human enamel and dentine specimens were randomized into 8 groups (n=8): Grape juice - Ades®, Grape juice - Del Valle Kapo®, Grape juice - Aurora®, Orange juice - Del Valle Kapo®, Orange juice - Ades®, Strawberry juice - Mais Vita®, Strawberry juice - Ades®, Citrus fruit juice - Tampico®. Read More

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January 2021

Pulp liner materials in selective caries removal: study protocol for a randomised controlled trial.

BMJ Open 2021 01 8;11(1):e029612. Epub 2021 Jan 8.

Department of Pediatric Dentistry, Orthodontics and Public Health, School of Dentistry of Bauru, University of São Paulo, São Paulo, Brazil

Introduction: The literature shows that selective carious tissue removal (SCTR) decreases the number and diversity of bacteria, stops the caries process and reduces the risk of pulp exposure. However, no consensus exists on which pulp liner would be suitable for teeth undergoing SCTR. So, this study will verify the in vivo response of dentine-pulp complex after SCTR in primary teeth with or without pulp liner material. Read More

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January 2021

Impact of graphene oxide and silver diamine fluoride in comparison to photodynamic therapy on bond integrity and microleakage scores of resin modified glass ionomer cement to demineralized dentin.

Photodiagnosis Photodyn Ther 2021 Mar 28;33:102163. Epub 2020 Dec 28.

Consultant in Restorative Dentistry Department, Ministry of Health, Abha, Saudi Arabia. Electronic address:

Aim: To evaluate the impact of graphene oxide (GO) and silver diammine fluoride (SDF) in comparison to photodynamic therapy (PDT) on adhesive bond integrity and microleakage scores of resin-modified glass ionomer cement (RMGIC) to demineralized dentin.

Methods: 80 non-carious and atraumatic third molars were mounted inside the segments of polyvinyl pipes. Exposure, homogenization, and polishing of dentinal tubules was performed. Read More

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Tooth shell technique: A proof of concept with the use of autogenous dentin block grafts.

M Korsch

Aust Dent J 2020 Dec 28. Epub 2020 Dec 28.

Head of Oral Surgery, Dental Academy for Continuing Professional Development, Karlsruhe, Germany.

Background: Autogenous bone block graft is considered the gold standard for lateral bony defects. Dentin has been identified to be a suitable autogenous bone graft material due to its structural and chemical similarities to the alveolar bone.

Methods: This proof of concept study describes the clinical application of the tooth shell technique in 24 sites with 27 implants of 22 patients. Read More

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December 2020


Probl Radiac Med Radiobiol 2020 Dec;25:18-55

O. O. Bogomolets National Medical University of the Ministry of Health of Ukraine, 13 Tarasa Shevchenka Blvd., Kyiv, 01601, Ukraine.

Background: Odontological effects of ionizing radiation (IR) as a result of radiotherapy, the consequences of accidents at nuclear power plants and industry, individual occupational exposure, etc. deserve significant attention interns of radiation medicine and radiation safety.

Objective: to analyze and summarize clinical and experimental data on the odontological radiation effects. Read More

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December 2020

Substantial regional differences in the biomechanical behavior of molar treated with selective caries tissue removal technique: a finite element study.

Dent Mater 2021 Mar 7;37(3):e162-e175. Epub 2021 Jan 7.

Materials Science and Engineering, Technische Universität Berlin, Berlin, Germany. Electronic address:

Objectives: Selective caries removal (SCR) is recommended over non-selective removal for managing deep carious lesions to avoid pulp exposure and maintain pulp vitality. During SCR, residual carious dentin is left behind and sealed beneath the restoration. The biomechanical effects of such residual lesions on the restored tooth remain unclear and were assessed using finite element modeling (FEM). Read More

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Smear Layer Removal from Root Canal Dentin and Antimicrobial Effect of Citric Acid-modified Chlorhexidine.

Eur Endod J 2020 12;5(3):257-263

Department of Restorative Dentistry and Periodontology and Endodontics, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand.

Objective: To study the effectiveness of various concentrations of citric acid (CA) added to 2% chlorhexidine (CHX) on smear layer removal from the root canal wall and antimicrobial efficacy against Enterococcus faecalis (E. faecalis) and Candida albicans (C. albicans). Read More

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December 2020

EDTA Promotes the Mineralization of Dental Pulp In Vitro and In Vivo.

J Endod 2021 Mar 20;47(3):458-465. Epub 2020 Dec 20.

State Key Laboratory of Oral Diseases, National Clinical Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China. Electronic address:

Introduction: Dentin regeneration is one of the main goals of vital pulp treatment in which the biological properties of dental pulp cells (DPCs) need to be considered. In our previous study, we showed that EDTA could enhance the stromal cell-derived factor 1 alpha-induced migration of DPCs. The purpose of this study was to explore the effects of EDTA on the mineralization of dental pulp in vitro and in vivo. Read More

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The effects of low-dose 2-hydroxyethyl methacrylate on apoptosis and survival in human dental pulp cells.

J Formos Med Assoc 2020 Dec 16. Epub 2020 Dec 16.

Graduate Institute of Clinical Dentistry, School of Dentistry, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan; School of Dentistry, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address:

Background/purpose: 2-hydroxyethyl methacrylate (HEMA) is one of the most major components in dentin bonding systems. Uncured HEMA is eluted through the dentin and harmful to pulp cells. The study aimed to investigate the death pattern, morphological change and factors of human dental pulp cells (HDPCs) cultured with low-dose HEMA. Read More

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December 2020

Role of enamel and dentin on color changes after internal bleaching associated or not with external bleaching.

J Appl Oral Sci 2020 16;29:e20200511. Epub 2020 Dec 16.

Departamento de Odontologia, Universidade Federal de Sergipe, Aracaju, SE, Brasil.

Objective: To evaluate the effect of the association between external and internal tooth bleaching on color changes in dentin and enamel, individually or recombined, previously stained with triple antibiotic paste (TAP).

Methodology: Forty enamel-dentin specimens from bovine incisors were separated into ten blocks according to similarity in their whiteness index (WID). Three specimens within each block were stained by dentin exposure to TAP, and the remaining specimen was used as control to estimate color changes. Read More

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January 2021

OCT evaluation of the internal adaptation of ceramic veneers depending on preparation design and ceramic thickness.

Dent Mater 2021 Mar 4;37(3):423-431. Epub 2020 Dec 4.

Department of Cariology, Endodontology and Periodontology, University of Leipzig, Liebigstr. 12, 04103 Leipzig, Germany. Electronic address:

Objectives: In-vitro evaluation of the influence of preparation design and thickness of ceramic veneers on the interfacial bond using optical coherence tomography (OCT).

Methods: Sixty-four central incisors were randomly assigned to four preparation designs differing from no to complete dentine exposure (n = 16 each): non-prep (NP), minimal-invasive (MI, no dentine exposure), semi-invasive (SI, 50% dentine) and invasive (I, 100% dentine). Ceramic veneers (IPS InLine Veneer) of two thicknesses (0. Read More

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