116,822 results match your criteria density lipoprotein


Janus effects of NaCl on structure of egg yolk granules.

Food Chem 2021 Sep 15;371:131077. Epub 2021 Sep 15.

School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310018, China. Electronic address:

Egg yolk granules are supramolecular assembly of high-density lipoproteins and phosvitin driven by calcium bridges. However, applications of granules are severely restricted by the large particle size and poor water dispersibility. This study revealed the Janus effects of NaCl on structure of granules at varied pH values. Read More

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September 2021

ANGPTL3 and ANGPTL8 in Thai subjects with hyperalphalipoproteinemia and severe hypertriglyceridemia.

J Clin Lipidol 2021 Sep 1. Epub 2021 Sep 1.

Division of Endocrinology and Metabolism, Department of Medicine, and Hormonal and Metabolic Disorders Research Unit, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Department of Medicine, and Excellence Center for Diabetes, Hormone, and Metabolism, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand. Electronic address:

Background: The role of ANGPTL3 and ANGPTL8 in lipid regulation in patients with very high levels of HDL-cholesterol and triglyceride is unknown.

Objective: We examined plasma levels of ANGPTL3 and ANGPTL8 in subjects with hyperalphalipoproteinemia (HALP) and in those with severe hypertriglyceridemia (HTG).

Methods: Plasma ANGPTL3 and ANGPTL8 levels were measured by ELISA in 320 subjects, consisting of HALP subjects with HDL-cholesterol ≥100 mg/dl (n=90) and healthy controls (n=90) and subjects with triglyceride ≥886 mg/dl (n=89) and control subjects (n=51). Read More

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September 2021

A hypolipoprotein sepsis phenotype indicates reduced lipoprotein antioxidant capacity, increased endothelial dysfunction and organ failure, and worse clinical outcomes.

Crit Care 2021 Sep 17;25(1):341. Epub 2021 Sep 17.

Division of Cardiology, Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.

Objective: Approximately one-third of sepsis patients experience poor outcomes including chronic critical illness (CCI, intensive care unit (ICU) stay > 14 days) or early death (in-hospital death within 14 days). We sought to characterize lipoprotein predictive ability for poor outcomes and contribution to sepsis heterogeneity.

Design: Prospective cohort study with independent replication cohort. Read More

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September 2021

Mendelian randomization rules out the causal relationship between serum lipids and cholecystitis.

BMC Med Genomics 2021 Sep 17;14(1):224. Epub 2021 Sep 17.

Secondary Department of Hepatobiliary and Pancreatic Surgery, The First Hospital of Jilin University, Changchun, 130021, China.

Background: The relationship between serum lipids and cholecystitis is still under investigation. To examine the causal effect of serum lipids on cholecystitis using the Mendelian randomization method.

Methods: We conducted univariable Mendelian randomization (MR) analyses using summary statistics from two independent genome-wide association studies (GWAS) on serum lipids (n = 132,908) and cholecystitis (n = 361,194). Read More

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September 2021

Associations of metabolomic profiles with circulating vitamin E and urinary vitamin E metabolites in middle-aged individuals.

Nutrition 2021 Jul 29;93:111440. Epub 2021 Jul 29.

Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.

Vitamin E (α-tocopherol [α-TOH]) is transported in lipoprotein particles in blood, but little is known about the transportation of its oxidized metabolites. In the Netherlands Epidemiology of Obesity Study, we aimed to investigate the associations of 147 circulating metabolomic measures obtained through targeted nuclear magnetic resonance with serum α-TOH and its urinary enzymatic (α-CEHC) and oxidized (α-TLHQ) metabolites from 24-h urine quantified by liquid chromatography with tandem mass spectrometry. Multivariable linear regression analyses, in which multiple testing was taken into account, were performed to assess associations between metabolomic measures (determinants; standardized to mean = 0, SD = 1) and vitamin E metabolites (outcomes), adjusted for demographic factors. Read More

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Efficacy of a family-based cardiovascular risk reduction intervention in individuals with a family history of premature coronary heart disease in India (PROLIFIC): an open-label, single-centre, cluster randomised controlled trial.

Lancet Glob Health 2021 Oct;9(10):e1442-e1450

Public Health Foundation of India, New Delhi, India; Centre for Chronic Disease Control, New Delhi, India; Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, UK.

Background: Coronary heart disease, a leading cause of death globally, is amenable to lifestyle interventions. The family environment can affect the ability or willingness of individuals to make lifestyle changes. We aimed to investigate the efficacy of a targeted family-based intervention for reduction of total cardiovascular risk in individuals with a family history of premature coronary heart disease. Read More

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October 2021

Association of serum proprotein convertase Subtilisin/Kexin Type 9 (PCSK9) level with thyroid function disorders.

Eur Rev Med Pharmacol Sci 2021 Sep;25(17):5511-5517

Department of Internal Medicine, University of Health Sciences, Malatya Training and Research Hospital, Malatya, Turkey.

Objective: We aimed at demonstrating the effect of thyroid function status on proprotein convertase subtilisin kexin type 9 (PCSK9) and determining the effect of thyroid hormones on lipid metabolism by comparing the PCSK9 levels of patients with subclinical hypothyroidism, overt hypothyroidism, and hyperthyroidism.

Patients And Methods: 124 patients with thyroid disorders, aged between 18 and 65 years, were included in this study. The participants were divided into 3 groups. Read More

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September 2021

Case study of hypertriglyceridemia from COVID-19 Pfizer-BioNTech vaccination in a patient with familial hypercholesteremia.

Eur Rev Med Pharmacol Sci 2021 Sep;25(17):5525-5528

Saint Bernards Healthcare, Jonesboro, AR, USA.

The Pfizer-BioNTech coronavirus disease 2019 (COVID-19) vaccine is the first novel nucleoside-modified messenger ribonucleic acid (modRNA) vaccine to receive Emergency Use Authorization from the Food and Drug Administration in the United States. It is indicated to be used in patients ≥12 years-of-age as of May 25th, 2021, including populations with high atherosclerotic cardiovascular disease (ASCVD) burden. However, little is known about the potential impact this vaccine may have on serum lipoprotein levels in patients with familial hypercholesteremia (FH), who are predisposed to high ASCVD burden due to elevated low-density lipoprotein cholesterol (LDL-C). Read More

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September 2021

Muscle strength and its association with cardiometabolic variables in adolescents: does the expression of muscle strength values matter?

World J Pediatr 2021 Sep 17. Epub 2021 Sep 17.

Research Center in Kinanthropometry and Human Performance, Federal University of Santa Catarina, Trinity University Campus, Florianópolis, SC, CEP 88010-970, Brazil.

Background: We investigate the association between different muscle strength (MS) indices with cardiometabolic variables in adolescents.

Methods: Cross-sectional study comprising 351 adolescents (male 44.4%, age 16. Read More

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September 2021

Does Losing 5-7% of Prediabetic Body Weight from a Diabetes Prevention Program decrease Cardiovascular Risks?

Spartan Med Res J 2021 30;6(2):27627. Epub 2021 Aug 30.

Beaumont Farmington Hills.

Introduction: According to the Centers for Disease Control and Prevention (CDC), one-third of adults have prediabetes (i.e., at risk for developing type 2 diabetes), a leading risk factor for cardiovascular disease. Read More

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Development of the Bone Phenotype and microRNA Profile in Adults With Low-Density Lipoprotein Receptor-Related Protein 5-High Bone Mass (LRP5-HBM) Disease.

JBMR Plus 2021 Sep 1;5(9):e10534. Epub 2021 Sep 1.

Department of Endocrinology and Metabolism Odense University Hospital Odense Denmark.

Pathogenic variants in the Wnt-pathway co-receptor low-density lipoprotein (LDL) receptor-related protein 5 (LRP5) cause high bone mass (LRP5-HBM) due to insensitivity to the endogenous antagonist of Wnt-signaling. Although indicating incessant progression of BMD and biomarkers reflecting bone formation, this has not been confirmed in individuals with LRP5-HBM. We investigated how the LRP5-HBM bone phenotype changes with age in adults and is associated with quantitative changes of bone turnover markers and bone-related microRNAs (miRNAs) in the circulation. Read More

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September 2021

Differential Iron Requirements for Osteoblast and Adipocyte Differentiation.

JBMR Plus 2021 Sep 26;5(9):e10529. Epub 2021 Jul 26.

Department of Medical and Molecular Genetics School of Medicine, Indiana University Indianapolis IN USA.

Bone marrow mesenchymal progenitor cells are precursors for various cell types including osteoblasts, adipocytes, and chondrocytes. The external environment and signals act to direct the pathway of differentiation. Importantly, situations such as aging and chronic kidney disease display alterations in the balance of osteoblast and adipocyte differentiation, adversely affecting bone integrity. Read More

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September 2021

Admission LDL-C and long-term mortality in patients with acute aortic dissection: a survival analysis in China.

Ann Transl Med 2021 Aug;9(16):1345

Department of Cardiovascular Internal Medicine, The First Affiliated Hospital of Shantou University Medical College, Shantou, China.

Background: The level of blood lipid is closely related to prognosis in cardiovascular diseases. This study aims to analyze the effect of serum low-density lipoprotein cholesterol (LDL-C) levels on the long-term mortality in acute aortic dissection (AAD). A lower admission LDL-C level is associated with an increased risk of long-term mortality in AAD. Read More

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Guideline-directed low-density lipoprotein management in high-risk ischemic stroke or transient ischemic attack admissions in China from 2015 to 2019.

Ann Transl Med 2021 Aug;9(15):1224

China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Background: Lowering low-density lipoprotein cholesterol (LDL-C) is crucial for secondary stroke prevention in stroke patients with preexisting cardiovascular diseases (CVD) or cerebrovascular diseases (CeVD). However, data on attainment of guideline-recommended LDL-C levels are lacking.

Methods: We analyzed data from the Chinese Stroke Center Alliance (CSCA) program for patients with ischemic stroke and transient ischemic attack (TIA) hospitalized between August 2015 and July 2019. Read More

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Antidiabetic effects of the ethanolic extract of R.M. Fritsch on streptozotocin-induced diabetes in a mice model.

Food Sci Nutr 2021 Sep 18;9(9):4815-4826. Epub 2021 Jun 18.

Department of Basic Sciences and Pathobiology Faculty of Veterinary Medicine Razi University Kermanshah Iran.

Medicinal plants can protect different organs against diabetes-induced oxidative stress due to their antioxidant compounds. The present study was designed to investigate the potential of R.M. Read More

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September 2021

Non-traditional Lipid Parameters as Potential Predictors of Asymptomatic Intracranial Arterial Stenosis.

Front Neurol 2021 31;12:679415. Epub 2021 Aug 31.

Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.

Intracranial arterial stenosis (ICAS) is a common cause of stroke. Identifying effective predictors of ICAS that could be easily obtained in clinical practice is important. The predictive values of serum individual lipid parameters have been well-established. Read More

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Beta-cell failure rather than insulin resistance is the major cause of abnormal glucose tolerance in Africans: insight from the Africans in America study.

BMJ Open Diabetes Res Care 2021 Sep;9(1)

NIDDK, National Institutes of Health, Bethesda, Maryland, USA

Introduction: Uncertainties exist on whether the main determinant of abnormal glucose tolerance (Abnl-GT) in Africans is β-cell failure or insulin resistance (IR). Therefore, we determined the prevalence, phenotype and characteristics of Abnl-GT due to β-cell failure versus IR in 486 African-born blacks (male: 64%, age: 38±10 years (mean±SD)) living in America.

Research Design And Methods: Oral glucose tolerance test were performed. Read More

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September 2021

Study protocol for yoga-based lifestyle intervention for healthy ageing phenotype in the older adults (yHAP): a two-armed, waitlist randomised controlled trial with multiple primary outcomes.

BMJ Open 2021 Sep 16;11(9):e051209. Epub 2021 Sep 16.

Swami Vivekananda Yoga Anusandhana Samsthana, Bengaluru, Karnataka, India.

Introduction: The conceptualisation of healthy ageing phenotype (HAP) and the availability of a tentative panel for HAP biomarkers raise the need to test the efficacy of potential interventions to promote health in older adults. This study protocol reports the methodology for a 24-week programme to explore the holistic influence of the yoga-based intervention on the (bio)markers of HAP.

Methods And Analysis: The study is a two-armed, randomised waitlist controlled trial with blinded outcome assessors and multiple primary outcomes. Read More

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September 2021

High-Intensity Statins Benefit High-Risk Patients: Why and How to Do Better.

Mayo Clin Proc 2021 Sep 14. Epub 2021 Sep 14.

Baylor College of Medicine and Michael E. DeBakey VA Medical Center, Houston, TX.

Review of the US and European literature indicates that most patients at high risk for atherosclerotic cardiovascular disease (ASCVD are not treated with high-intensity statins, despite strong clinical-trial evidence of maximal statin benefit. High-intensity statins are recommended for 2 categories of patients: those with ASCVD (secondary prevention) and high-risk patients without clinical ASCVD. Most patients with ASCVD are candidates for high-intensity statins, with a goal for low-density lipoprotein cholesterol reduction of 50% or greater. Read More

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September 2021

Association between low-density cholesterol change and outcomes in acute ischemic stroke patients who underwent reperfusion therapy.

BMC Neurol 2021 Sep 16;21(1):360. Epub 2021 Sep 16.

Center of Cerebrovascular Diseases, Department of Neurology, West China Hospital, Sichuan University, No.37 Guo Xue Xiang, Sichuan, 610041, Chengdu, China.

Background: Low-density lipoprotein cholesterol (LDL-C) can increase cardiovascular risk. However, the association between LDL-C change and functional outcomes in acute ischemic stroke (AIS) patients who underwent reperfusion therapy remains unclear.

Methods: Patients who received reperfusion therapy were consecutively enrolled. Read More

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September 2021

High fat / high cholesterol diet does not provoke atherosclerosis in the ω3-and ω6-polyunsaturated fatty acid synthesis inactivated Δ6-fatty acid desaturase deficient mouse.

Mol Metab 2021 Sep 13:101335. Epub 2021 Sep 13.

Laboratory of Molecular Neuroscience, Institute of Biochemistry, University of Cologne, 50931, Cologne, Germany.

Objective: Increased ω6/ω3-polyunsaturated fatty acid ratio in current Western diet is regarded as critical epigenetic nutritional factor in the pathogenesis of several human life style diseases, of metabolic syndrome, of cardiovascular disease, of central nervous system and of the female and male reproductive system. The impact of nutrient ω3-and ω6-PUFAs in the pathogenesis of dyslipoproteinemia and atherosclerosis has been the topic of intense efforts for several decades. Homeostasis of the cellular of ω3-and ω6- PUFA-pool is maintained by the synthesis of ω3-and ω6-PUFAs from essential fatty acids (EFA) (linoleic and α-linolenic acid) and their dietary supply. Read More

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September 2021

Modulation of broiler plasma metabolic spectrum by the addition of lysine residue to the diet.

J Anim Physiol Anim Nutr (Berl) 2021 Sep 16. Epub 2021 Sep 16.

School of Life Sciences, Ningxia Feed Engineering Technology Research Center, Ningxia University, Yinchuan, China.

Flavour is an important factor in evaluating meat quality, and amino acids and fats are important components affecting meat flavour. In this study, we evaluated the relationship between the variation of lysine residue addition and the slaughter performance and meat quality of broilers, which decreased with the addition of lysine residues but improved the meat quality of the broilers. 10% lysine residue addition was the most beneficial for reducing feed cost and improving meat quality. Read More

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September 2021

LRP6 as a biomarker of poor prognosis of breast cancer.

Gland Surg 2021 Aug;10(8):2414-2427

Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Background: Recently, low-density lipoprotein receptor (LDLR)-related protein 6 (LRP6) has been the focus of molecular targeted therapy for breast cancer; however, its role in breast cancer is still controversial. The purpose of this study was to investigate the effect of LRP6 overexpression on the prognosis of breast cancer.

Methods: We used immunohistochemistry to detect the expression of LRP6 via tissue microarrays in breast cancer samples, Chi-square test analyze the relationship between LRP6 expression and clinicopathological features of breast cancer, the Kaplan-Meier method to perform survival analysis, and the Cox proportional hazards regression model to explore the potential risk factors of breast cancer. Read More

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Association between non-culprit healed plaque and plaque progression in acute coronary syndrome patients: an optical coherence tomography study.

J Geriatr Cardiol 2021 Aug;18(8):631-644

Department of Cardiology, Chinese PLA General Hospital, Beijing, China.

Background: Healed plaques are frequently found in patients with acute coronary syndrome, but the prognostic value is debatable. This study investigated the clinical features of non-culprit healed plaques detected by optical coherence tomography (OCT) with the aim of predicting plaque progression of healed plaques.

Methods: This study retrospectively analyzed 113 non-culprit lesions from 85 patients who underwent baseline OCT imaging and follow-up angiography from January 2015 to December 2019. Read More

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Impact of statin intensity on adverse cardiac and cerebrovascular events in older adult patients with myocardial infarction.

J Geriatr Cardiol 2021 Aug;18(8):609-622

Department of Cardiology, Incheon Sejong Hospital, Incheon, South Korea.

Background: There is insufficient evidence regarding the effect of high-intensity statin therapy in older adults. This study aimed to investigate the effects of high-intensity statin treatment on the clinical outcomes in older adults with myocardial infarction (MI).

Methods: Consecutive patients with MI aged at least 75 years were analyzed retrospectively. Read More

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Difficulty of falling asleep and non-high-density lipoprotein cholesterol level among Canadian older adults: a cross-sectional analysis of the Canadian Longitudinal Study for Aging baseline data.

J Geriatr Cardiol 2021 Aug;18(8):597-608

Department of Health Sciences, Brock University, St. Catharines, Ontario, Canada.

Objective: To examine whether difficulty of falling asleep (DoFA) is associated with non-high-density lipoprotein cholesterol (non-HDL-C) level among Canadian older adults.

Methods: 26,954 individuals aged 45-85 years from the baseline data of the Canadian Longitudinal Study for Aging were included in this study. DoFA was categorized into five groups by answer to the question "Over the last month, how often did it take you more than 30 min to fall asleep?" Response options are "Never, < 1 time/week, 1-2 times/week, 3-5 times/week, or 6-7 times/week". Read More

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The Effects of Statin Dose, Lipophilicity, and Combination of Statins plus Ezetimibe on Circulating Oxidized Low-Density Lipoprotein Levels: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Mediators Inflamm 2021 4;2021:9661752. Epub 2021 Sep 4.

Applied Biomedical Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Background: Elevated plasma low-density lipoprotein cholesterol (LDL-C) is the main risk factor for atherosclerotic cardiovascular disease (ASCVD). Statins are the drugs of choice for decreasing LDL-C and are used for the prevention and management of ASCVD. Guidelines recommend that subjects with high and very high ASCVD risk should be treated with high-intensity statins or a combination of high-intensity statins and ezetimibe. Read More

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September 2021

Efficacy of intensive lipid-lowering therapy with statins stratified by blood pressure levels in patients with type 2 diabetes mellitus and retinopathy: Insight from the EMPATHY study.

Hypertens Res 2021 Sep 15. Epub 2021 Sep 15.

Department of Cardiovascular Medicine, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan.

Intensive lipid-lowering therapy is recommended in individuals exhibiting type 2 diabetes mellitus (T2DM) with microvascular complications (as high-risk patients), even without known cardiovascular disease (CVD). However, evidence is insufficient to stratify the patients who would benefit from intensive therapy among them. Hypertension is a major risk factor, and uncontrolled blood pressure (BP) is associated with increased CVD risk. Read More

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September 2021

Soluble LR11 as a Novel Biomarker in Acute Kawasaki Disease.

Circ J 2021 Sep 16. Epub 2021 Sep 16.

Department of Clinical-laboratory and Experimental-Research Medicine, Toho University Sakura Medical Center.

Background: Intimal smooth muscle cells (SMCs) play an important role in the vasculitis caused by Kawasaki disease (KD). Lipoprotein receptor 11 (LR11) is a member of the low-density lipoprotein receptor family, which is expressed markedly in intimal vascular SMCs and secreted in a soluble form (sLR11). sLR11 has been recently identified as a potential vascular lesion biomarker. Read More

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September 2021

Association between apolipoprotein B/A1 ratio and coronary plaque vulnerability in patients with atherosclerotic cardiovascular disease: an intravascular optical coherence tomography study.

Cardiovasc Diabetol 2021 Sep 15;20(1):188. Epub 2021 Sep 15.

Department of Cardiology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xiwulu 157#, Xi'an, 710004, Shaanxi, China.

Background: Apolipoprotein (Apo) A1 and Apo B are strongly associated with the risk of atherosclerotic cardiovascular disease (ASCVD). However, the relationship between the Apo B/A1 ratio and the morphology of coronary vulnerable plaques has not been fully elucidated in patients with ASCVD.

Methods: A total of 320 patients with ASCVD undergoing percutaneous coronary intervention were enrolled and assigned into acute coronary syndrome (ACS) or chronic coronary syndrome (CCS) group. Read More

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September 2021