2,489 results match your criteria dense fibrous


IgG4 producing POEMS syndrome: A rarely recognized subtype.

Indian J Pathol Microbiol 2021 Jul-Sep;64(3):584-586

University of Health Sciences Bakırkoy Dr. Sadi Konuk Training and Research Hospital, Pathology Clinic, Istanbul, Turkey.

Serum IgG4 is typically measured for Immunoglobulin G4-related Disease (IgG4-RD), a fibroinflammatory condition associated with polyclonal increase in serum IgG4. Yet, increased IgG4 may still be monoclonal, and little is known about IgG4 POEMS syndrome. We present a case of 40-year-old male with a mass lesion in the left sacral ala. Read More

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Intrahepatic bile duct rupture associated with IgG4-related sclerosing cholangitis presenting hepatic inflammatory pseudotumor.

Clin J Gastroenterol 2021 Jul 27. Epub 2021 Jul 27.

Department of Surgery, Kyoto Katsura Hospital, 17 Yamadahirao-cho, Nishikyo-ku, Kyoto City, Kyoto, 615-8256, Japan.

A 67-year-old man with a low-grade fever was found to have a 25-mm diameter tumor of the left hepatic umbilical portion. The tumor was accompanied by occlusion of the left portal vein. Positron emission tomography using fluorodeoxyglucose showed that the tumor had abnormally high metabolic activity. Read More

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RASGRF2 gene fusions identified in a variety of melanocytic lesions with distinct morphological features.

Pigment Cell Melanoma Res 2021 Jul 26. Epub 2021 Jul 26.

University of Lyon, Université Claude Bernard Lyon 1, CNRS, UMR 5286, INSERM U1052, Cancer Research Centre of Lyon, Lyon, France.

The WHO classification identifies nine classes of melanocytic proliferations according to location, UV-exposure, histological and genetic features. Only a minority of lesions remain unclassified. We describe five cases that harbored either an ERBIN-RASGRF2 or an ATP2B4-RASGRF2 in frame fusion transcript. Read More

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Characterization of different oligomeric forms of CRISP2 in the perinuclear theca versus the fibrous tail structures of boar spermatozoa.

Biol Reprod 2021 Jul 26. Epub 2021 Jul 26.

Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, the Netherlands.

Mammalian sperm carry a variety of highly condensed insoluble protein structures such as the perinuclear theca, the fibrous sheath and the outer dense fibers, which are essential to sperm function. We studied the role of cysteine rich secretory protein 2 (CRISP2); a known inducer of non-pathological protein amyloids, in pig sperm with a variety of techniques. CRISP2, which is synthesized during spermatogenesis, was localized by confocal immunofluorescent imaging in the tail and in the post-acrosomal region of the sperm head. Read More

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Morphology and histology of paryphasmata and hemibaculum of Varanus salvator based on sexual maturity.

Open Vet J 2021 Apr-Jun;11(2):330-336. Epub 2021 Jun 30.

Division of Veterinary Clinic, Faculty of Veterinary Medicine, Universitas Airlangga, Surabaya, Indonesia.

Background: is one of the reptiles being hunted by human beings for several purposes, including traditional medicine. The studies about reproductive biology aspects were limited.

Aim: This study aimed to determine the morphology, histology, and histometry of paryphasmata and hemibaculum based on Snout-Vent Length (SVL) as an indicator of sexual maturity. Read More

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Nanofiber-Mâché Hollow Ball Mimicking the Three-Dimensional Structure of a Cyst.

Polymers (Basel) 2021 Jul 11;13(14). Epub 2021 Jul 11.

Department of Advanced Interdisciplinary Science and Technology, Graduate School of Engineering, University of Fukui, 3-9-1 Bukyo, Fukui-shi 910-8507, Japan.

The occasional malignant transformation of intracranial epidermoid cysts into squamous cell carcinomas remains poorly understood; the development of an in vitro cyst model is urgently needed. For this purpose, we designed a hollow nanofiber sphere, the "nanofiber-mâché ball." This hollow structure was fabricated by electrospinning nanofiber onto alginate hydrogel beads followed by dissolving the beads. Read More

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Glandular Tissue Component and Breast Cancer Risk in Mammographically Dense Breasts at Screening Breast US.

Radiology 2021 Jul 20:210367. Epub 2021 Jul 20.

From the Departments of Radiology (S.H.L., S.M.H., S.Y.K., J.M.C., N.C., W.K.M.) and Pathology (H.S.R.), College of Medicine, Seoul National University, 101 Daehak-ro, Jongno-gu, Seoul 03080, Republic of Korea; Medical Research Collaborating Center, Seoul National University Hospital, Seoul, Republic of Korea (M.J.J.); and Department of Radiology, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, Republic of Korea (A.Y.).

Background Breast density at mammography is an established risk factor for breast cancer, but it cannot be used to distinguish between glandular and fibrous tissue. Purpose To evaluate the association between the glandular tissue component (GTC) at screening breast US and the risk of future breast cancer in women with dense breasts and the association between the GTC and lobular involution. Materials and Methods Screening breast US examinations performed in women with no prior history of breast cancer and with dense breasts with negative findings from mammography from January 2012 to December 2015 were retrospectively identified. Read More

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Subcutaneous, abdominal, and thoracic encapsulated fat necrosis in bowhead whales Balaena mysticetus from Alaska, USA.

Dis Aquat Organ 2021 Jul 15;145:159-164. Epub 2021 Jul 15.

Department of Wildlife Management, North Slope Borough, PO Box 69, Utqiagvik, Alaska 99723, USA.

We describe a case series of encapsulated fat necrosis with subcutaneous, abdominal, and thoracic locations in 7 subsistence-harvested bowhead whales Balaena mysticetus. Masses had a variably-dense fibrous capsule surrounding necrotic adipocytes and calcium salts (saponification). One animal also had prior concussive injury, pleural fibrosis, and hepatic lipoma; the other animals had no significant findings. Read More

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Multiple system atrophy variant with severe hippocampal pathology.

Brain Pathol 2021 Jul 13:e13002. Epub 2021 Jul 13.

Department of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, Nagakute, Japan.

The striatonigral and olivopontocerebellar systems are known to be vulnerable in multiple system atrophy (MSA), showing neuronal loss, astrogliosis, and alpha-synuclein-immunoreactive inclusions. MSA patients who displayed abundant neuronal cytoplasmic inclusions (NCIs) in the regions other than the striatonigral or olivopontocerebellar system have occasionally been diagnosed with variants of MSA. In this study, we report clinical and pathologic findings of MSA patients characterized by prominent pathologic involvement of the hippocampus. Read More

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Possible spontaneous regression of hepatocellular carcinoma with unique histopathological features confirmed by surgical resection: a case report.

Surg Case Rep 2021 Jul 13;7(1):162. Epub 2021 Jul 13.

Department of Human Pathology, Kanazawa University Graduate School of Medicine, 13-1, Takara-machi, Kanazawa, Ishikawa, 920-8640, Japan.

Background: Spontaneous regression of hepatocellular carcinoma (HCC) is a rare event, and its clinicopathological features and underlying mechanism are not fully understood.

Case Presentation: An 84-year-old female with hepatitis C virus infection and diabetes mellitus was referred to our hospital for further examination. Abdominal ultrasonography showed a 3. Read More

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Cutaneous Lymphadenoma Is a Distinct Trichoblastoma-like Lymphoepithelial Tumor With Diffuse Androgen Receptor Immunoreactivity, Notch1 Ligand in Reed-Sternberg-like Cells, and Common EGFR Somatic Mutations.

Am J Surg Pathol 2021 May 12. Epub 2021 May 12.

*Department of Pathology, University Clinic Hospital, INCLIVA Biomedical Research Institute Departments of †Pathology §Biochemistry and Molecular Biology, University of Valencia, Valencia ‡Department of Pathology, Costa del Sol Health Agency, Málaga, Spain ∥Barr Dermatopathology, Laguna Beach, CA.

The term "cutaneous lymphadenoma" was coined in this journal for an unusual lymphoepithelial cutaneous adnexal neoplasm, possibly with immature pilosebaceous differentiation. Some authors further proposed that cutaneous lymphadenoma was an adamantinoid trichoblastoma. However, although a hair follicle differentiation is widely accepted, the fact that this is a lymphoepithelial tumor is not appropriately explained by the trichoblastoma hypothesis. Read More

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Magnetic Alignment of Electrospun Fiber Segments Within a Hydrogel Composite Guides Cell Spreading and Migration Phenotype Switching.

Front Bioeng Biotechnol 2021 16;9:679165. Epub 2021 Jun 16.

Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, United States.

Fibrous extracellular matrix (ECM) proteins provide mechanical structure and adhesive scaffolding to resident cells within stromal tissues. Aligned ECM fibers play an important role in directing morphogenetic processes, supporting mechanical loads, and facilitating cell migration. Various methods have been developed to align matrix fibers in purified biopolymer hydrogels, such as type I collagen, including flow-induced alignment, uniaxial tensile deformation, and magnetic particles. Read More

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A case of primary carcinosarcoma of the liver with combined hepatocellular carcinoma and cholangiocarcinoma.

Clin J Gastroenterol 2021 Jul 2. Epub 2021 Jul 2.

Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, 1-1-1 Honjo, Chuo-ku, Kumamoto, 860-8556, Japan.

Primary carcinosarcoma of the liver is extremely rare. Here, we report an unusual case of carcinosarcoma of the liver containing combined hepatocellular carcinoma and cholangiocarcinoma. A 66-year-old man with a history of viral hepatitis B was admitted for investigation of multiple liver masses. Read More

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A quantitative score of immune cell infiltration predicts the prognosis in pancreatic ductal adenocarcinoma.

Int Immunopharmacol 2021 Jun 24;98:107890. Epub 2021 Jun 24.

Department of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, PR China. Electronic address:

Pancreatic Ductal Adenocarcinoma (PDAC) is characterized by an extensive and dense fibrous stroma, which plays an active role in tumor growth and metastasis. Despite the growing importance of the tumor microenvironment in PDAC prognosis, the immune cell infiltration landscape of PDAC has not been elucidated. In this study, we applied a credible computational algorithm to comprehensively estimate the immune cell infiltration (ICI) patterns of 876 PDAC patients. Read More

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Extensive Facial Trichoblastoma - A Rare and Disfiguring Condition.

Am J Case Rep 2021 Jun 25;22:e932320. Epub 2021 Jun 25.

Department of Primary Care Medicine, Faculty of Medicine, Universiti Teknologi MARA, Batu Caves, Selangor, Malaysia.

BACKGROUND Trichoblastoma is a rare, benign, cutaneous adnexal neoplasm arising from rudimentary hair follicles. The incidence and prevalence in the general population is unknown. However, most cases occur in adults aged 40 years and older. Read More

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The eggshell membrane: A potential biomaterial for corneal wound healing.

J Biomater Appl 2021 Jun 18:8853282211024040. Epub 2021 Jun 18.

School of Clinical and Pharmaceutical Sciences, University of Hertfordshire, Hatfield, UK.

The eggshell membrane (ESM) is an abundant resource with innate complex structure and composition provided by nature. With at least 60 million tonnes of hen eggs produced globally per annum, utilisation of this waste resource is highly attractive in positively impacting sustainability worldwide. Given the morphology and mechanical properties of this membrane, it has great potential as a biomaterials for wound dressing. Read More

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Clinicopathological features of sclerosing angiomatoid nodular transformation of the spleen.

Pathol Res Pract 2021 May 24;224:153490. Epub 2021 May 24.

Department of Pathology, the First Medical Center of the Chinese People's Liberation Army (PLA) General Hospital, Beijing, 100083, China. Electronic address:

Purpose: To explore the clinicopathological features of sclerosing angiomatoid nodular transformation (SANT) of the spleen.

Methods: The clinicopathological data of 26 SANT patients were analyzed.

Result: There were 15 men and 11 women, aged 23-62 years (mean: 43. Read More

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Gingival salivary gland choristoma: An unusual case report.

J Oral Maxillofac Pathol 2021 Mar 19;25(Suppl 1):S90-S93. Epub 2021 Mar 19.

Department of Microbiology and Pathology, Pathology Research and Diagnosis Center, University Center of Health Sciences, University of Guadalajara, Guadalajara, Jalisco, México.

The gingival salivary gland choristoma, a highly unusual tumor-like mass alteration constituted by normal salivary gland cells in an abnormal location, reported for the first time in 1964 by Moskow and Baden. To our knowledge, only 12 cases of this entity (including present case) are reported to date, the majority observed as asymptomatic, solitary, smooth-surfaced tumor-like masses, measuring 0.5-1. Read More

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Homologous amniotic membrane as a dural substitute in decompressive craniectomies.

J Clin Neurosci 2021 Jul 26;89:412-421. Epub 2021 May 26.

Department of Neurosurgery, Aulss 2 Marca Trevigiana, Treviso, Italy.

Introduction: A dura mater substitute in decompressive craniectomies must protect the brain while providing a dissection plane between the cortex and myocutaneous layer. The human amniotic membrane (AM) has anti-inflammatory, wound healing, and differentiation properties. We tested AM properties as a dural substitute by comparing the outcomes to biological ones. Read More

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Cytokeratin-positive Malignant Tumor in the Abdomen With EWSR1/FUS-CREB Fusion: A Clinicopathologic Study of 8 Cases.

Am J Surg Pathol 2021 May 27. Epub 2021 May 27.

Departments of Diagnostic Pathology Medical Oncology Hepatic and Pancreatobiliary Oncology Pediatric Oncology Head and Neck Medical Oncology Division Rare Cancer Center, National Cancer Center Hospital, Tokyo, Japan.

ATF1, CREB1, and CREM, which encode the CREB family of transcription factors, are fused with EWSR1 or FUS in human neoplasms, such as angiomatoid fibrous histiocytoma. EWSR1/FUS-CREB fusions have recently been reported in a group of malignant epithelioid tumors with a predilection to the peritoneal cavity and frequent cytokeratin expression. Here, we studied 8 cytokeratin-positive abdominal malignancies with these fusions for further characterization. Read More

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Superhydrophobic Poly(l-lactic acid) Membranes with Fish-Scale Hierarchical Microstructures and Their Potential Application in Oil-Water Separation.

Langmuir 2021 06 24;37(22):6765-6775. Epub 2021 May 24.

State Key Laboratory of Silicate Materials for Architectures, Wuhan University of Technology, Wuhan 430070, P. R. China.

In this work, superhydrophobic poly(l-lactic acid) (PLLA) hierarchical membranes exhibiting excellent oil-removal performance, which is of great importance in curbing the oil-pollution environment, were fabricated by a simple solvent-evaporation-induced precipitation method. PLLA membranes with hierarchical micro/nanostructures (fish scales, fibrous sheets, and petal-like morphology) can be conveniently prepared by adjusting the preparation parameters including PLLA concentration, precipitation temperature, type of solvent and nonsolvent, and the addition of nano-SiO. The results show that the water contact angle of the fish-scale-structured PLLA membrane was 138. Read More

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Retroperitoneal fibrosis as a postoperative complication following renal transplantation in cats.

J Feline Med Surg 2021 May 21:1098612X211018976. Epub 2021 May 21.

Department of Surgical Sciences, University of Wisconsin-Madison, Madison, WI, USA.

Objectives: The aim of this report was to describe the clinical signs, diagnostic imaging findings, surgical management, histopathological findings, outcome and possible risk factors for cats that developed retroperitoneal fibrosis (RPF) following renal transplantation.

Methods: Medical records of cats that underwent renal transplantation and developed clinically significant RPF between 1995 and 2019 were reviewed.

Results: Eighty-one cats underwent 83 renal transplantations. Read More

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Reconstruction of Ultra-thin Alveolar-capillary Basement Membrane Mimics.

Adv Biol (Weinh) 2021 May 13:e2000427. Epub 2021 May 13.

DWI-Leibniz Institute for Interactive Materials, Forckenbeckstr. 50, 52056, Aachen, Germany.

Alveolar-capillary basement membrane (BM) is ultra-thin (<2 µm) extracellular matrix that maintains integral epithelial-endothelial cell layers. In vitro reconstructions of alveolar-capillary barrier supported on synthetic scaffolds closely resembling the fibrous and ultra-thin natural BM are essential in mimicking the lung pathophysiology. Although BM topology and dimensions are well known to significantly influence cellular behavior, conventionally used BM mimics fail to recreate this natural niche. Read More

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Autoamputated pharyngeal hairy polyp presented with aero-digestive obstruction: A case report.

Radiol Case Rep 2021 Jun 20;16(6):1570-1573. Epub 2021 Apr 20.

Department of Radiology, Rush University Medical Center, Chicago, IL.

A pharyngeal hairy polyp (HP) is a rare benign mass that can be surgical detached with few complications. In this report, we describe a hairy polyp in a 7-day-old neonate presented with intermittent respiratory distress and feeding difficulties since birth. Neck computed tomography was performed, and demonstrated a well-defined pedunculated heterogeneous mass arising from the right lateral wall of the nasopharynx extending downward and nearly completely obstructing of the nasopharynx and oropharynx. Read More

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Electron microscopy of juvenile nasopharyngeal angiofibroma: clinical and histopathological correlates.

Eur Arch Otorhinolaryngol 2021 Apr 29. Epub 2021 Apr 29.

Department of Otorhinolaryngology-Head and Neck Surgery, King George's Medical University, Lucknow, India.

Background: The histological and electron-microscopic (EM) characteristics of juvenile nasopharyngeal angiofibroma (JNA) have been described but no study has compared them with one another or with clinical features. The objective is to compare ultrastructural characteristics of JNA with clinical parameters.

Methods: This prospective study included histology of 21 samples of which only 13 underwent transmission-EM. Read More

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Structure and Properties of Biopolymeric Fibrous Materials Based on Polyhydroxybutyrate-Metalloporphyrin Complexes.

Russ J Gen Chem 2021 18;91(3):546-553. Epub 2021 Apr 18.

Semenov Institute of Chemical Physics, Russian Academy of Sciences, 119991 Moscow, Russia.

Ultrathin fibrous materials based on natural bacterial polymer polyhydroxybutyrate (PHB) were prepared by the electrospinning method. Using scanning electron and optical microscopy techniques the macrophysical characteristics of the fibrous layer were determined and classified. The physicomechanical characteristics of the resultant materials and their changes caused by ozonation were determined as well. Read More

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CD26 as a target against fibrous formation in chronic airway rejection lesions.

Life Sci 2021 Aug 21;278:119496. Epub 2021 Apr 21.

Department of Thoracic Surgery, University Hospital Zurich, Zurich, Switzerland.

Aims: Chronic lung allograft dysfunction (CLAD) after lung transplantation (Tx) is the clinical result of chronic airway rejection lesions (CARL), histomorphologically described as either obliterative remodeling of small airways or alveolar fibroelastosis, or as a combination of both. We here investigated the CD26-inhibitory effect on CD26-expressing CARL.

Main Methods: CARL were induced by BALB/c → C57BL/6 mouse Tx under mild immunosuppression. Read More

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A case of idiopathic portal hypertension accompanying multiple hepatic nodular regenerative hyperplasia in a patient with systemic sclerosis.

Clin J Gastroenterol 2021 Jun 22;14(3):820-826. Epub 2021 Apr 22.

Second Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, 23-3 Matsuoka Shimoaizuki, Eiheiji-cho, Yoshida-gun, Fukui, 910-1193, Japan.

Idiopathic portal hypertension (IPH) is one of the background diseases causing nodular regenerative hyperplasia (NRH). Furthermore, IPH patients accompanied with autoimmune diseases, such as systemic lupus erythematosus (SLE) and systemic sclerosis (SSc), are more likely to form NRH in the liver. A 76-year-old woman had been aware of the Raynaud's phenomenon and scleroderma for the past 30 years. Read More

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An enhanced periosteum structure/function dual mimicking membrane forrestorations of periosteum and bone.

Biofabrication 2021 05 10;13(3). Epub 2021 May 10.

Key Laboratory of Textile Science and Technology of Ministry of Education and College of Textiles, Donghua University, 2999 North Renmin Road, Shanghai 201620, People's Republic of China.

Periosteum plays a pivotal role in bone formation and reconstruction. The ideal repair process for critical-size bone defects with periosteum damage is to induce regeneration of periosteum tissue and the subsequent bone regeneration derived by the periosteum. Inspired by the bilayer structure of the natural periosteum, we develop a periosteum structure/function dual mimicking membrane for therestoration of periosteum and bone tissue. Read More

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[Immunoglobulin G4( IgG4)-related Fibrosing Mediastinitis Localized in the Retrosternal Area:Report of a Case].

Kyobu Geka 2021 Apr;74(4):317-320

Department of Thoracic Surgery, Kanazawa Medical Center, Kanazawa, Japan.

An 84-year-old man was referred to our out-patient clinic with an elongated mass localized to the retrosternal area that was incidentally identified by computed tomography. On 18F-fluorodeoxyglucose-positron emission tomography, this lesion showed intense tracer uptake. Thus, a surgical biopsy under thoracoscopy was performed. Read More

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