1,421 results match your criteria demands insights


Comprehensive Review of Cardiovascular Involvement in COVID-19.

AACN Adv Crit Care 2021 Apr 15:e1-e19. Epub 2021 Apr 15.

Ruff Joseph Macale Cajanding is Charge Nurse, Adult Critical Care Unit, 6th Floor, King George V Building, St. Bartholomew's Hospital, Barts Health NHS Trust, 2 King Edward Street, London EC1A 1HQ, United Kingdom

COVID-19 has emerged as one of the most devastating and clinically significant infectious diseases of the last decade. It has reached global pandemic status at an unprecedented pace and has placed significant demands on health care systems worldwide. Although COVID-19 primarily affects the lungs, epidemiologic reports have shown that the disease affects other vital organs of the body, including the heart, vasculature, kidneys, brain, and the hematopoietic system. Read More

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Effect of Stapling on the Thermodynamics of mdm2-p53 Binding.

J Chem Inf Model 2021 Apr 8. Epub 2021 Apr 8.

Department of Chemistry, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India.

Protein-protein interaction (PPI) is one of the key regulatory features driving biomolecular processes and hence is targeted for designing therapeutics against diseases. Small peptides are a new and emerging class of therapeutics owing to their high specificity and low toxicity. For achieving efficient targeting of the PPI, amino acid side chains are often stapled together, resulting in the rigidification of these peptides. Read More

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Contrasting strategies of hypoxic cardiac performance and metabolism in cichlids and armoured catfish.

J Exp Zool A Ecol Integr Physiol 2021 Apr 8. Epub 2021 Apr 8.

Département de Biologie, Université de Moncton, Moncton, New Brunswick, Canada.

The heart of tropical fishes is a particularly useful model system in which to investigate mechanisms of hypoxic tolerance. Here we focus on insights gained from two groups of fishes, cichlids and armoured catfishes. Cichlids respond to hypoxia by entering a sustained hypometabolism with decreased heart performance to match whole animal circulatory needs. Read More

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Illegitimate tasks in health care: Illegitimate task types and associations with occupational well-being.

J Clin Nurs 2021 Apr 7. Epub 2021 Apr 7.

Department of Psychology, University of Jyväskylä, Jyväskylä, Finland.

Aims And Objectives: The aims of the study were to identify content categories of unreasonable and unnecessary illegitimate tasks and to investigate how unreasonable and unnecessary tasks relate to occupational wellbeing.

Background: Illegitimate tasks are a common stressor among healthcare professionals, and they have been shown to have negative associations with occupational well-being. Despite this evidence, research has not yet uncovered what kinds of tasks healthcare professionals consider illegitimate. Read More

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Microsaccades: Empirical Research and Methodological Advances - Introduction to Part 1 of the Thematic Special Issue.

J Eye Mov Res 2020 Jun 19;12(6). Epub 2020 Jun 19.

University of Bern and SciAns GmbH, Iffwil, Switzerland.

Recent technical developments and increased affordability of high-speed eye tracking devices have brought microsaccades to the forefront of research in many areas of sensory, perceptual, and cognitive processes. The present thematic issue on "Microsaccades: Empirical Research and Methodological Advances" invited authors to submit original research and reviews encompassing measurements and data analyses in fundamental, translational, and applied studies. We present the first volume of this special issue, comprising 14 articles by research teams around the world. Read More

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Mini-gut feelings: perspectives of people with cystic fibrosis on the ethics and governance of organoid biobanking.

Per Med 2021 Apr 7. Epub 2021 Apr 7.

Julius Center for Health Sciences & Primary Care, Department of Medical Humanities, University Medical Center Utrecht, Internal post Str. 6.131, P.O. Box 85500, GA Utrecht 3508, The Netherlands.

Organoid technology has enormous potential for precision medicine, such as has recently been demonstrated in the field of cystic fibrosis. However, storage and use of organoids has been associated with ethical challenges and there is currently a lack of harmony in regulation and guidelines to govern the rapid emergence of 'organoid medicine'. Developing sound governance demands incorporation of the perspectives of patients as key stakeholders. Read More

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Succession of endophytic fungi and arbuscular mycorrhizal fungi associated with the growth of plant and their correlation with secondary metabolites in the roots of plants.

BMC Plant Biol 2021 Apr 5;21(1):165. Epub 2021 Apr 5.

College of life Sciences, Shihezi University, Shihezi City, 832003, Xinjiang, China.

Background: To decipher the root and microbial interaction, secondary metabolite accumulation in roots and the microbial community's succession model during the plant's growth period demands an in-depth investigation. However, till now, no comprehensive study is available on the succession of endophytic fungi and arbuscular mycorrhizal fungi (AMF) with roots of medicinal licorice plants and the effects of endophytic fungi and AMF on the secondary metabolite accumulation in licorice plant's root.

Results: In the current study, interaction between root and microbes in 1-3 years old medicinal licorice plant's root and rhizospheric soil was investigated. Read More

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Legal document similarity: a multi-criteria decision-making perspective.

PeerJ Comput Sci 2020 23;6:e262. Epub 2020 Mar 23.

Department of Information Science and Engineering, CMR Institute of Technology, Bangalore, Karnataka, India.

The vast volume of documents available in legal databases demands effective information retrieval approaches which take into consideration the intricacies of the legal domain. Relevant document retrieval is the backbone of the legal domain. The concept of relevance in the legal domain is very complex and multi-faceted. Read More

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Sticky problems: extraction of nucleic acids from molluscs.

Authors:
Coen M Adema

Philos Trans R Soc Lond B Biol Sci 2021 May 5;376(1825):20200162. Epub 2021 Apr 5.

Center for Evolutionary and Theoretical Immunology, Department of Biology, University of New Mexico, Albuquerque, NM 87112, USA.

Traditional molecular methods and omics-techniques across molluscan taxonomy increasingly inform biology of Mollusca. Recovery of DNA and RNA for such studies is challenged by common biological properties of the highly diverse molluscs. Molluscan biomineralization, adhesive structures and mucus involve polyphenolic proteins and mucopolysaccharides that hinder DNA extraction or copurify to inhibit enzyme-catalysed molecular procedures. Read More

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Transcriptomic Analyses Shed Light on Critical Genes Associated with Bibenzyl Biosynthesis in .

Plants (Basel) 2021 Mar 26;10(4). Epub 2021 Mar 26.

Key Laboratory for Forest Resources Conservation and Utilization in the Southwest Mountains of China, Ministry of Education, Southwest Forestry University, Kunming 650224, China.

The plants (members of the Orchidaceae family) are used as traditional Chinese medicinal herbs. Bibenzyl, one of the active compounds in , occurs in low amounts among different tissues. However, market demands require a higher content of thes compounds to meet the threshold for drug production. Read More

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Untargeted Metabolomics Analysis by UHPLC-MS/MS of Soybean Plant in a Compatible Response to Infection.

Metabolites 2021 Mar 19;11(3). Epub 2021 Mar 19.

Laboratory of Biomolecules and Mass Spectrometry, Department of Chemistry, State University of Maringá, 5790, Colombo Av, Maringá 87020-080, PR, Brazil.

is a biotrophic fungus, causer of the disease Asian Soybean Rust, a severe crop disease of soybean and one that demands greater investment from producers. Thus, research efforts to control this disease are still needed. We investigated the expression of metabolites in soybean plants presenting a resistant genotype inoculated with through the untargeted metabolomics approach. Read More

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Real-Time Digital Biometric Monitoring during Elite Athletic Competition: System Feasibility with a Wearable Medical-Grade Sensor.

Digit Biomark 2021 Jan-Apr;5(1):37-43. Epub 2021 Feb 3.

FutureTech Strategies Inc., Natick, Massachusetts, USA.

Introduction: Real-time digital heart rate (HR) monitoring in sports can provide unique physiological insights into athletic performance. However, most HR monitoring of elite athletes is limited to non-real-time, non-competition settings while utilizing sensors that are cumbersome. The present study was undertaken to test the feasibility of using small, wearable medical-grade sensors, paired with a novel technology system, to capture and process real-time HR data from elite athletes during professional competition. Read More

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February 2021

Effect of force accuracy on hemodynamic response: an fNIRS study using fine visuomotor task.

J Neural Eng 2021 Mar 30. Epub 2021 Mar 30.

State Key Laboratory of Virtual Reality Technology and Systems, 37 Xueyuan Road, Haidian District, Beijing, P.R. China, Beijing, 100191, CHINA.

Objective: Despite converging neuroimaging studies investigating how neural activity is modulated by various motor related factors, such as movement velocity and force magnitude, little has been devoted to identifying the effect of force accuracy. This study thus aimed to investigate the effect of task difficulty on cortical neural responses when participants performed a visuomotor task with varying demands on force accuracy.

Approach: Fourteen healthy adults performed a set of force generation operations with six levels of force accuracy. Read More

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American Academy of Optometry Microbial Keratitis Think Tank.

Optom Vis Sci 2021 Mar;98(3):182-198

Department of Ophthalmology and Visual Sciences, Case Western Reserve University, and University Hospitals of Cleveland Eye Institute, Cleveland, Ohio Northeastern Eye Institute, Scranton, Pennsylvania C Schnider Insights & More, Brush Prairie, Washington Toronto Eye Care, Toronto, Ontario, Canada Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, Florida School of Optometry and Vision Science, University of New South Wales, Sydney, New South Wales, Australia Clinical Trial Consultant, Atlanta, Georgia U.S. Centers for Disease Control and Prevention, Atlanta, Georgia Massachusetts Eye and Ear, Cornea Service, Harvard Medical School, Boston, Massachusetts Department of Ophthalmology and Visual Science, College of Medicine, Division of Epidemiology and Biostatistics, School of Public Health, University of Illinois at Chicago, Chicago, Illinois School of Optometry, University of California, Berkeley, Berkeley, California iBiomedical Consulting, Jacksonville, Florida University of Houston College of Optometry, Houston, Texas Departments of Ophthalmology, and Physiology and Biophysics, University of California, Irvine, Irvine, California Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland University of Illinois Eye and Ear Infirmary, Chicago, Illinois

Significance: Think Tank 2019 affirmed that the rate of infection associated with contact lenses has not changed in several decades. Also, there is a trend toward more serious infections associated with Acanthamoeba and fungi. The growing use of contact lenses in children demands our attention with surveillance and case-control studies. Read More

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Conflicting Logics in a Changing Action Space: Challenges Related to Type 1 Diabetes in Work Life.

Qual Health Res 2021 Mar 26:10497323211001857. Epub 2021 Mar 26.

Steno Diabetes Center Copenhagen, Gentofte, Denmark.

Well-being at work is important to quality of life. However, reconciling work and diabetes management is often challenging; failing to do so threatens the well-being of people with type 1 diabetes (T1D). We explored the mechanisms underlying diabetes-specific challenges at work using theories of logics, involvement, and action space. Read More

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Health and medical care for refugees: design and evaluation of a multidisciplinary clinical elective for medical students.

GMS J Med Educ 2021 15;38(2):Doc39. Epub 2021 Feb 15.

Heidelberg University Hospital, Section Health Equity Studies & Migration, Department of General Medicine and Health Services Research, Heidelberg, Germany.

Caring for refugee patients places special demands on health professionals. To date, medical students in Germany have rarely been systematically prepared for these challenges. This article reports on the development, conceptualisation, implementation, evaluation, and relevance of a multidisciplinary elective for medical students in the clinical study phase. Read More

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February 2021

Experiences and insights of college students with autism spectrum disorder: an exploratory assessment to inform interventions.

J Am Coll Health 2021 Mar 24:1-4. Epub 2021 Mar 24.

Waisman Center, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Objective: College students with autism spectrum disorder (ASD) experience elevated drop-out rates, peer difficulties, and mental health concerns compared to their neurotypical counterparts. Thus, the firsthand concerns of college students with ASD were examined, so that supports can be appropriately tailored. Responses of 31 college students with ASD were examined in relation to 39 demographically similar neurotypical students regarding students' college experiences (e. Read More

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Healthcare professionals' perspective on treatment burden and patient capacity in low-income rural populations: challenges and opportunities.

BMC Fam Pract 2021 Mar 9;22(1):50. Epub 2021 Mar 9.

La Trobe University Rural Health School, 471 Benetook Avenue, Mildura, VIC, 3500, Australia.

Background: The challenges of chronic disease self-management in multimorbidity are well-known. Shippee's Cumulative Complexity Model provides useful insights on burden and capacity factors affecting healthcare engagement and outcomes. This model reflects patient experience, but healthcare providers are reported to have a limited understanding of these concepts. Read More

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What motivates people to commence a graduate entry nursing programme: a mixed method scoping review.

BMC Nurs 2021 Mar 20;20(1):47. Epub 2021 Mar 20.

Department of Nursing, Faculty of Medicine, Dentistry and Health Sciences, 161 Barry Street, The University of Melbourne, Victoria, 3010, Australia.

Background: The global deficit of nurses demands urgent attention in the recruitment and education of this future workforce. Graduate entry nursing (GEN) programmes are one option for people with undergraduate degrees who are seeking nursing education. Determining the key motivations for enrolling in these programmes will support the development of new initiatives in the education sector to both recruit and retain this future workforce and inform future primary research. Read More

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Host-dependent molecular factors mediating SARS-CoV-2 infection to gain clinical insights for developing effective targeted therapy.

Mol Genet Genomics 2021 Mar 20. Epub 2021 Mar 20.

iNDX.Ai, Cupertino, CA, USA.

Coronavirus disease 2019 (COVID-19), a recent viral pandemic that first began in December 2019, in Hunan wildlife market, Wuhan, China. The infection is caused by a coronavirus, SARS-CoV-2 and clinically characterized by common symptoms including fever, dry cough, loss of taste/smell, myalgia and pneumonia in severe cases. With overwhelming spikes in infection and death, its pathogenesis yet remains elusive. Read More

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AI for Improving Children's Health: A Community Case Study.

Front Artif Intell 2020 6;3:544972. Epub 2021 Jan 6.

Saathealth, Mumbai, India.

The Indian health care system lacks the infrastructure to meet the health care demands of the country. Physician and nurse availability is 30 and 50% below WHO recommendations, respectively, and has led to a steep imbalance between the demand for health care and the infrastructure available to support it. Among other concerns, India still struggles with challenges like undernutrition, with 38% of children under the age of five being underweight. Read More

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January 2021

Converging functionality: Strategies for 3D hybrid-construct biofabrication and the role of composite biomaterials for skeletal regeneration.

Acta Biomater 2021 Mar 10. Epub 2021 Mar 10.

Christchurch Regenerative Medicine and Tissue Engineering (CReaTE) Group, Department of Orthopaedics Surgery and Musculoskeletal Medicine, University of Otago Christchurch, Christchurch, New Zealand; Centre of Research Excellence in Medical Technologies (MedTech CoRE), Auckland, New Zealand. Electronic address:

The evolution of additive manufacturing (AM) technologies, biomaterial development and our increasing understanding of cell biology has created enormous potential for the development of personalized regenerative therapies. In the context of skeletal tissue engineering, physical and biological demands play key roles towards successful construct implantation and the achievement of bone, cartilage and blood vessel tissue formation. Nevertheless, meeting such physical and biological demands to mimic the complexity of human tissues and their functionality is still a significant ongoing challenge. Read More

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Acetyl-CoA and Metabolite Fluxes Regulate White Adipose Tissue Expansion.

Trends Endocrinol Metab 2021 May 9;32(5):320-332. Epub 2021 Mar 9.

Division of Diabetes, Endocrinology, and Metabolism, Baylor College of Medicine, Houston, TX, USA; Department of Medicine, Baylor College of Medicine, Houston, TX, USA; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA. Electronic address:

White adipose tissue (WAT) depends on coordinated regulation of transcriptional and metabolic pathways to respond to whole-body energy demands. We highlight metabolites that contribute to biosynthetic reactions for WAT expansion. Recent studies have precisely defined how byproducts of carbohydrate and lipid metabolism affect physiological and endocrine functions in adipocytes. Read More

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Complications of articular distal humerus fracture fixation: A systematic review and meta-analysis.

J Shoulder Elbow Surg 2021 Mar 9. Epub 2021 Mar 9.

Department of Orthopaedic Surgery and Rehabilitation, The University of Texas Medical Branch, 301 University Blvd, Route 0165, Galveston, TX 77555, USA. Electronic address:

Background: Distal humerus fractures are relatively rare injuries in adults. Fractures that involve the articular surface can be particularly challenging to treat. Open reduction and internal fixation (ORIF) remains the preferred treatment for most intra-articular distal humerus fractures, depending on the degree of comminution and functional demands of the patient. Read More

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Exploring Cadaver Skin For Standardization Of Rabbit And Porcine Burn Models In Research.

Ann Burns Fire Disasters 2020 Dec;33(4):334-340

Sree Chitra Tirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India.

Burn animal models provide substantial insights into burn pathophysiology. Choice of the apt model is important for determining the clinical efficacy of new medicines. Therefore, standardization of burn models is crucial for scientific research. Read More

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December 2020

A qualitative exploration of patients' experiences, needs and expectations regarding online access to their primary care record.

BMJ Open 2021 Mar 11;11(3):e044221. Epub 2021 Mar 11.

Centre for Primary Care and Health Services Research, The University of Manchester, Manchester, UK.

Objectives: Primary care records have traditionally served the needs and demands of clinicians rather than those of the patient. In England, general practices must promote and offer registered patients online access to their primary care record, and research has shown benefits to both patients and clinicians of doing so. Despite this, we know little about patients' needs and expectations regarding online access to their record. Read More

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Protein Interaction Interface Region Prediction by Geometric Deep Learning.

Bioinformatics 2021 Mar 6. Epub 2021 Mar 6.

Computer Science Department, Dartmouth, Hanover, 03755, United States.

Motivation: Protein-protein interactions drive wide-ranging molecular processes, and characterizing at the atomic level how proteins interact (beyond just the fact that they interact) can provide key insights into understanding and controlling this machinery. Unfortunately, experimental determination of three-dimensional protein complex structures remains difficult and does not scale to the increasingly large sets of proteins whose interactions are of interest. Computational methods are thus required to meet the demands of large-scale, high-throughput prediction of how proteins interact, but unfortunately both physical modeling and machine learning methods suffer from poor precision and/or recall. Read More

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The evolving landscape of biomarker testing for non-small cell lung cancer in Europe.

Lung Cancer 2021 Apr 22;154:161-175. Epub 2021 Feb 22.

University of Cologne, Cologne Institute of Pathology, Cologne, Germany. Electronic address:

The discovery of oncogenic driver mutations rendering non-small cell lung cancer (NSCLC) targetable by small-molecule inhibitors, and the development of immunotherapies, have revolutionised NSCLC treatment. Today, instead of non-selective chemotherapies, all patients with advanced NSCLC eligible for treatment (and increasing numbers with earlier, less extensive disease) require fast and comprehensive screening of biomarkers for first-line patient selection for targeted therapy, chemotherapy, or immunotherapy (with or without chemotherapy). To avoid unnecessary re-biopsies, biomarker screening before first-line treatment should also include markers that are actionable from second-line onwards; PD-L1 expression testing is also mandatory before initiating treatment. Read More

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Complementary deficits in perceptual classification in pure alexia and acquired prosopagnosia - New insights from two classic cases.

Neuropsychologia 2021 Mar 5;155:107820. Epub 2021 Mar 5.

Institute of Medical Psychology, University of Munich, Germany.

Pure alexia and prosopagnosia traditionally have been seen as prime examples of dissociated, category-specific agnosias affecting reading and face recognition, respectively. More recent accounts have moved towards domain-independent explanations that postulate potential cross-links between different types of visual agnosia. According to one proposal, abnormal crowding, i. Read More

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Nitrogen Sources and Iron Availability Affect Pigment Biosynthesis and Nutrient Consumption in sp. UTEX 2576.

Microorganisms 2021 Feb 19;9(2). Epub 2021 Feb 19.

Cain Department of Chemical Engineering, 3307 Patrick F. Taylor Hall, Louisiana State University and A&M College, Baton Rouge, LA 70803, USA.

sp. UTEX 2576 metabolizes multiple nitrogen (N) sources and is deemed a biotechnological platform for chemical production. Cyanobacteria have been identified as prolific producers of biofertilizers, biopolymers, biofuels, and other bioactive compounds. Read More

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February 2021