J Patient Saf 2021 Feb 11. Epub 2021 Feb 11.
From the *Pharmacovigilance, Pharmacoepidemiology, and Drug Information Centre, Department of Clinical Pharmacology, Rennes University Hospital, Rennes, France †Geriatrics Department, Rennes University Hospital, Rennes, France ‡Univ Rennes, CHU Rennes, Inserm, LTSI - UMR 1099, Rennes, France §Univ Rennes, CHU Rennes, REPERES (Pharmacoepidemiology and Health Services Research), Rennes, France ∥Medical Faculty, Rennes 1 University, Rennes, France ¶National Scientific Research Centre ARENES, UMR 6051 Rennes, France.
Objective: The main objective was to assess the feasibility of the trigger tool method for the retrospective detection of adverse drug reactions (ADRs) in the Rennes University Hospital. The secondary objective was to describe the performance of the method in terms of positive predictive values (PPVs) and severity or preventability of ADRs.
Methods: Using the Rennes University Hospital clinical data warehouse, pharmacovigilance experts performed a retrospective review of a random sample of 30 inpatient hospital medical records per month using the triggers "fall" and "delirium" to identify related ADRs among patients 65 years and older in 2018 in the geriatrics department. Read More