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Feasibility and incremental benefit of puffed-cheek 18F-FDG PET/CT on oral cancer patients.

Clin Nucl Med 2013 Oct;38(10):e374-8

From the *Department of Nuclear Medicine, Taipei Veterans General Hospital and National Yang-Ming University, Taipei, Taiwan, ROC; †School of Medicine, National Defense Medical Center, Taipei, Taiwan, ROC; and ‡ Department of Radiology, University of Kentucky, Lexington, KY.

Purpose: The complexity of small oral cavity and intimate apposition of the oral cavity mucosal surfaces make CT identification of obvious masses difficult. Puffed-cheek CT improves the evaluation of oral cavity lesions. We used the puffed-cheek maneuver with 18F-FDG PET/CT scans to determine the feasibility and accuracy in clinical practice and to identify any benefits. Read More

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October 2013

Intensity-modulated and image-guided radiation therapy for head and neck cancers.

Front Radiat Ther Oncol 2011 20;43:217-254. Epub 2011 May 20.

Radiation therapy is a key component of the multidisciplinary treatment of head and neck cancers (HNC), which are ideal tumors for intensity-modulated radiation therapy (IMRT) because of their location and intimate relationship to the surrounding critical structures. Several institutional studies have suggested that IMRT is superior to conventional radiation therapy in salivary preservation and holds promises for improved locoregional control of these tumors. Small randomized studies have supported the role of IMRT in reducing xerostomia and possibly improving quality of life. Read More

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September 2011

Gauze padding: a simple technique to delineate small oral cavity tumors.

AJNR Am J Neuroradiol 2011 May 31;32(5):934-7. Epub 2011 Mar 31.

Department of Oral and Maxillofacial Surgery, University of Washington, Seattle, USA.

Background And Purpose: Small oral cavity tumors are an imaging challenge. Intimate apposition of vestibular oral mucosa to the alveolar mucosa makes tumor assessment difficult. In CT imaging, the "puffed cheek" method has been used to separate surfaces, though this is not feasible with long MR imaging sequences. Read More

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Eosinophil-rich squamous carcinoma of the oral cavity: a study of 13 cases and delineation of a possible new microscopic entity.

Ann Diagn Pathol 2008 Oct 26;12(5):322-7. Epub 2008 Jun 26.

Department of Pathology, General Hospital S. Maria della Misericordia, I 33100 Udine, Italy.

We report 13 cases of squamous cell carcinoma (SCC) of the oral cavity characterized by a prominent eosinophilic infiltration of the stroma. All patients were adults, 10 men and 3 women (aged 54 to 92 years; median, 71 years). They presented with tumors of the gingiva (5 cases), tongue (3 cases), palatine tonsil (2 cases), palate (2 cases), and mucosal aspect of lip (1 case). Read More

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October 2008

Nasopharyngeal and oropharyngeal carcinomas: target delineation, therapy delivery and stereotactic boost procedures with intensity-modulated/ image-guided radiation therapy.

Quynh-Thu Le

Front Radiat Ther Oncol 2007 ;40:208-231

Department of Radiation Oncology, Stanford University, Stanford, Calif. , USA.

Radiation therapy is a key component of the multidisciplinary treatment of nasopharyngeal and oropharyngeal carcinomas, which are ideal tumors for intensity-modulated radiation therapy (IMRT) because of their location and intimate relationship to the surrounding critical structures. Several studies have suggested that IMRT is superior to conventional radiation therapy in salivary preservation and holds promise for improved locoregional control of these tumors. Target delineation for IMRT in these tumors is complex and requires detailed knowledge of head and neck anatomy and pathways of tumor spread. Read More

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September 2007

New insights into the immunology and evolution of HIV.

Cell Res 2003 Feb;13(1):1-7

Department of Immunology, Division of Investigative Science, Faculty of Medicine, Imperial College of Science, Technology and Medicine, The Chelsea and Westminster Hospital, 369 Fulham Road, London SWIO 9NH, United Kingdom.

Fewer than one million HIV infected individuals are currently receiving anti-retroviral therapy. The limitations of such treatment have underscored the need to develop more effective strategies to control the spread and pathogenesis of HIV. Typically, naturally occurring protective immune responses provide the for such development. Read More

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February 2003

Clarifying the boundaries between the inflammatory and dystrophic myopathies: insights from molecular diagnostics and microarrays.

Rheum Dis Clin North Am 2002 Nov;28(4):743-57

Center for Genetic Medicine, Children's National Medical Center, Washington, DC 20010, USA.

Clinical and histopathologic overlaps between the muscular dystrophies and inflammatory myopathies are being increasingly recognized. Most patients with a muscular dystrophy show improvement with prednisone treatment, although they will not be cured; many patients with idiopathic inflammatory myopathies are cured. Dysferlin-deficiency was recently recognized as a cause of late-onset dystrophy with substantial inflammation in muscle. Read More

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November 2002

The origins of asymmetry in the folding transition states of protein L and protein G.

Protein Sci 2002 Oct;11(10):2351-61

Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

Topology has been shown to be an important determinant of many features of protein folding; however, the delineation of sequence effects on folding remains obscure. Furthermore, differentiation between the two influences proves difficult due to their intimate relationship. To investigate the effect of sequence in the absence of significant topological differences, we examined the folding mechanisms of segment B1 peptostreptococcal protein L and segment B1 of streptococcal protein G. Read More

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October 2002

Is couple therapy indicated for borderline personality disorder?

Am J Psychother 2001 ;55(4):491-506

University of Toronto, St. Michael's Hospital, Toronto, ON.

The healing aspects of intimate relationships are being recognized by therapists and supported by empirical findings. Little has been written regarding the indications for couple therapy for individuals with borderline personality disorder. This paper proposes a three-level hierarchy for deciding on the suitability of couple therapy for patients with borderline personality disorder. Read More

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Role of ultrasound guided percutaneous antegrade pyelography (USPCAP) in the diagnosis of obstructive uropathy.

Indian Pediatr 1992 Apr;29(4):425-31

Department of Pediatric Surgery, All India Institute of Medical Sciences, New Delhi.

Ultrasound guided percutaneous antegrade pyelography (USPCAP) was performed in 6 cases between 1 month and 8 years age, presenting with obstructive uropathy. The procedure in this age group was characterized by (i) ease of performance without sedation in the neonates and with sedation in older children, and (ii) use of smaller needles and catheters. The procedure enabled delineation of the intimate anatomy of complicated urological abnormalities such as obstructed duplex system, primary megaureters, posterior urethral valves, prune belly syndrome, obstructive hydronephrosis and vesicoureteric reflux. Read More

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Evaluation of facial skeletal aesthetics and surgical planning.

Clin Plast Surg 1991 Jan;18(1):1-9

University of Pennsylvania School of Medicine, Philadelphia.

Proper surgical planning for aesthetic facial skeletal surgery requires of the surgeon not only intimate knowledge of available techniques but also an understanding of how and when to apply those techniques. To this end, proper facial form analysis is essential. In this introduction we have attempted to describe the elements of such an analysis, realizing that much remains to be learned about how the bone and soft tissue interact. Read More

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January 1991

Virologic and immunologic aspects of acquired immunodeficiency syndrome.

H C Lane

Surg Gynecol Obstet 1990 ;171 Suppl:11-8

Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda 20892.

From the initial clinical descriptions of the acquired immunodeficiency syndrome (AIDS) in 1981 to the present time, much has been discovered concerning the epidemiologic factors, pathogenesis, treatment and prevention of this disease. Recent advances in epidemiology have included a better understanding of the occupational risk of human immunodeficiency virus (HIV) infection after percutaneous exposure (responsible for approximately 0.4 per cent of instances), an appreciation of the potential variability in the time interval between infection and seroconversion (generally on the order of three months but occasionally longer) and establishment of the need for intimate contact to transmit infection. Read More

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December 1990

The role of cognitions in marital relationships: definitional, methodological, and conceptual issues.

J Consult Clin Psychol 1989 Feb;57(1):31-8

Although there have recently been numerous investigations exploring the role of couples' cognitions in an attempt to understand marital distress, at present there is little cohesion and direction in the study of how couples think about their relationships. The current article asserts that this lack of direction results from at least three factors: (a) a lack of delineation of the important cognitive variables to be considered in marital functioning, (b) conceptual and methodological difficulties that arise in attempts to operationalize cognitive variables, and (c) a dearth of models of marital functioning that incorporate cognitions in a detailed manner. These three factors are discussed, along with a review of empirical investigations supporting the importance of cognitions in intimate relationships. Read More

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February 1989

Neurotic depression: delineation of symptom profiles and their relation to outcome.

Br J Psychiatry 1988 Jan;152:15-23

University of New South Wales, Prince of Wales Hospital, Randwick, Australia.

Ninety-one subjects diagnosed clinically as having a 'neurotic depression' were interviewed and then re-assessed at 6 weeks and 20 weeks. Four symptom profiles of clinical features were derived: 'negative cognition', 'lack of drive', 'anxiety', and 'arousal', the last being independent of the other three dimensions and of the severity of depression. Symptom profile scores were then examined against antecedent risk variables and outcome. Read More

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January 1988

Delineation of the normal esophagus at computed tomography.

Acta Radiol Diagn (Stockh) 1985 Nov-Dec;26(6):665-9

It has been accepted by many that the esophagus in its entire length is easy to delineate at CT in most patients due to surrounding fat planes. As this is not the experience of the present authors, the CT of the thorax in 100 normal men and women without mediastinal disease and in good nutritional status was reviewed, to record the relationship between the esophagus and neighbouring structures. In the upper third of the esophagus there is almost never a definite border between its wall and that of the trachea, while a separating border or even a fat plane can be seen to the spine in between 25 and 50 per cent of those tested. Read More

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February 1986

Galloylglucoses of low molecular weight as mordant in electron microscopy. I. Procedure, and evidence for mordanting effect.

J Cell Biol 1976 Sep;70(3):608-21

Gallotannin, consisting mainly of low molecular weight esters such as penta- and hexagalloylglucoses (commercially available as tannic acid produced from Turkish nutgall), can be used for increasing and diversifying tissue contrast in electron microscopy. When applied on tissue specimens previously fixed by conventional methods (aldehydes and OsO4), the low molecular weight galloylglucoses (LMGG) penetrate satisfactorily the cells and induce general high contrast with fine delineation of extra- and intracellular structures, especially membranes. In some features, additional details of their intimate configuration are revealed. Read More

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September 1976

[Azygography in the study of malignant tumours of the oesophagus (author's transl)].

J Radiol Electrol Med Nucl 1975 Mar;56(3):227-34

Up to the present time, no simple method has existed for gauging the true size of an oesophageal tumour. The intimate relations between the azygos vein and the oesophagus in the thorax between D3 and D8 justifies this new study: azygography. On the basis of 40 examinations, 13 of which were followed by surgery in patients suffering from carcinoma of the oesophagus, as was indicated by classical anatomical data, azygography made possible the evaluation of tumour extension in the mediastinum and the involvement of adjacent structures, such as the right pulmonary artery. Read More

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Classification: purposes, principles, progress, prospects.

R R Sokal

Science 1974 Sep;185(4157):1115-23

There is an intimate interrelation between principles and procedures in classification, and modern work in this field has been profoundly affected by the development of electronic computers. Besides the delineation of natural systems and the achievement of economy of memory and ease of manipulation, the primary purpose of classification is the description of the structure and relationship of groups of similar objects. Successful classifications generate scientific hypotheses, although much classificatory work has applied, practical goals. Read More

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September 1974
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