7,745 results match your criteria delayed cord

Remodeling of extracellular matrix in the urinary bladder of paraplegic rats results in increased compliance and delayed fiber recruitment 16 weeks after spinal cord injury.

Acta Biomater 2022 Jan 12. Epub 2022 Jan 12.

Michigan State University, Department of Mechanical Engineering, 428 S. Shaw Lane, Rm 2555, East Lansing, MI 48824. Electronic address:

The ability of the urinary bladder to maintain low intravesical pressures while storing urine is key in ensuring proper organ function and highlights the key role that tissue mechanics plays in the lower urinary tract. Loss of supraspinal neuronal connections to the bladder after spinal cord injury can lead to remodeling of the structure of the bladder wall, which may alter its mechanical characteristics. In this study, we investigate if the morphology and mechanical properties of the bladder extracellular matrix are altered in rats 16 weeks after spinal cord injury as compared to animals who underwent sham surgery. Read More

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January 2022

Comparison of Three Different Cord Clamping Techniques Regarding Oxidative-antioxidative Capacity in Term Newborns.

Am J Perinatol 2022 Jan 13. Epub 2022 Jan 13.

Biochemistry, Gaziantep University, Gaziantep, Turkey.

Objective As newborns are exposed to oxidative stress during delivery, cord clamping techniques play significant role on antioxidant status. In this study, we aimed to show the relationship between early cord clamping (ECC), delayed cord clamping (DCC) and cut umblical cord milking (C-UCM) techniques with total oxidant capacity (TOC), total antioxidant capacity (TAC) and peroxynitrite levels. Study Design Sixty-nine term infants were selected with APGAR score of 7 and above in the first and fifth minutes. Read More

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January 2022

A Quality Improvement Project to Delay Umbilical Cord Clamping Time.

Pediatr Qual Saf 2021 Sep-Oct;6(5):e452. Epub 2021 Sep 24.

Department of Pediatrics, Joan C Edwards School of Medicine, Marshall University, Huntington, W.Va.

Delayed cord clamping (DCC) has numerous benefits to the neonate, including increased hemoglobin levels, decreased need for red blood cell transfusions, and decreased incidence of necrotizing enterocolitis and intraventricular hemorrhage. A preliminary observational study at our institution demonstrated 12% of the observed deliveries met the DCC standard, defined as umbilical cord clamping at least 30-60 seconds after birth. Therefore, we designed a quality improvement project to increase the percentage of deliveries using DCC. Read More

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September 2021

Testicular Necrosis Post Kidney Transplantation: Lessons Learned.

Transplant Proc 2022 Jan 7. Epub 2022 Jan 7.

Department of Surgery, Tulane School of Medicine, New Orleans, Louisiana.

There is a paucity of literature on testicular complications after kidney transplant. Testicular necrosis after kidney transplantation has only been reported twice before. We present a 60- year-old man with end-stage renal disease who underwent uneventful deceased-donor kidney transplant. Read More

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January 2022

Unruptured aneurysm with intramural thrombus is an unusual cause of spinal cord infarction: a case report.

Radiol Case Rep 2022 Mar 28;17(3):706-709. Epub 2021 Dec 28.

Radiology Department, Mohammed V Military Hospital, Rabat, Morocco.

Infarction of the spinal cord is a rather rare occurrence. Paraparesis or quadriparesis with vibration and proprioceptive senses sparing are symptoms of anterior cord syndrome. Ischemic anterior cord syndrome can result from an obstruction of the anterior spinal artery or the Adamkiewicz Artery. Read More

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Numb is required for optimal contraction of skeletal muscle.

J Cachexia Sarcopenia Muscle 2022 Jan 9. Epub 2022 Jan 9.

National Center for the Medical Consequences of Spinal Cord Injury, James J. Peters VA, Bronx, NY, USA.

Background: The role of Numb, a protein that is important for cell fate and development and that, in human muscle, is expressed at reduced levels with advanced age, was investigated; adult mice skeletal muscle and its localization and function within myofibres were determined.

Methods: Numb expression was evaluated by western blot. Numb localization was determined by confocal microscopy. Read More

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January 2022

Oxygen saturation and heart rate in healthy term and late preterm infants with delayed cord clamping.

Pediatr Res 2022 Jan 7. Epub 2022 Jan 7.

Neonatal Research Group, Health Research Institute and University and Polytechnic Hospital La Fe, Valencia, Spain.

Blood oxygen in the fetus is substantially lower than in the newborn infant. In the minutes after birth, arterial oxygen saturation rises from around 50-60% to 90-95%. Initial respiratory efforts generate negative trans-thoracic pressures that drive liquid from the airways into the lung interstitium facilitating lung aeration, blood oxygenation, and pulmonary artery vasodilatation. Read More

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January 2022

Risk and predictive factors for candidemia after allogeneic hematopoietic cell transplantation: JSTCT Transplant Complications Working Group.

Transplant Cell Ther 2022 Jan 4. Epub 2022 Jan 4.

Division of Hematology, Jichi Medical University Saitama Medical Center, Saitama, Japan; Transplant Complications Working Group of the Japan Society for Transplantation and Cellular Therapy (JSTCT).

Background: Although antifungal prophylaxis that covers Candida species is a standard of care in allogeneic hematopoietic cell transplantation (HCT), candidemia mainly caused by non-albicans Candida species still occurs and is associated with a high mortality rate.

Objective: This study aimed to evaluate the risk factors for candidemia after allogeneic HCT. Particularly, we evaluated the impact of patient factors such as hematopoietic cell transplantation-specific comorbidity index (HCT-CI) and performance status (PS) in addition to well-recognized risk factors including donor type, delayed engraftment and graft-versus-host disease (GVHD). Read More

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January 2022

Protective Effect of Mild Hypothermia on Spinal Cord Ischemia-Induced Delayed Paralysis and Spinal Cord Injury.

Neurochem Res 2022 Jan 6. Epub 2022 Jan 6.

Department of Anesthesiology, Affiliated Hospital of Guilin Medical University, Guilin, 541000, Guangxi, People's Republic of China.

To explore the mechanism regarding the regulation of spinal cord ischemia (SCI) in rats by mild hypothermia. A SCI rat model was established through aorta occlusion, and in some cases, the rats were intervened with mild hypothermia, after which motor function, microglia activation, and M1/M2 polarization in rats were measured. Also, the expression of inflammatory cytokines (IL-1β, IL-6 and TNF-α) and neuronal apoptosis were examined. Read More

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January 2022

Periodic limb movements during sleep: a narrative review.

J Thorac Dis 2021 Nov;13(11):6476-6494

Sleep and Brain Plasticity Centre, CNS, IoPPN, King's College London, London, UK.

Objective: Using narrative review techniques, this paper evaluates the evidence for separable underlying patho-mechanisms of periodic limb movements (PLMs) to separable PLM motor patterns and phenotypes, in order to elucidate potential new treatment modalities.

Background: Periodic limb movement disorder (PLMD) is estimated to occur in 5-8% of the paediatric population and 4-11% of the general adult population. Due to significant sleep fragmentation, PLMD can lead to functional impairment, including hyperactivity and delayed language development in children, and poor concentration and work performance in adults. Read More

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November 2021

Ectopic adrenocortical adenoma in the renal hilum mimicking a renal cell carcinoma.

Radiol Case Rep 2022 Mar 20;17(3):619-622. Epub 2021 Dec 20.

Department of Radiology, Jichi Medical University, School of Medicine, Tochigi, Japan.

Ectopic adrenocortical tissue can arise along the path of embryonic migration, such as the celiac axis, broad ligament, adnexa of the testis, and spermatic cord. Occasionally, ectopic adrenocortical tissues undergo marked hyperplasia and develop into ectopic adrenocortical adenomas. This report describes the case of a 60-year-old man who was incidentally found to have a lipid-containing mass with early enhancement and delayed washout in the right renal hilum. Read More

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HLA 1-3 antigen-mismatched related peripheral blood stem cells transplantation using low-dose antithymocyte globulin versus unrelated cord blood transplantation.

Am J Hematol 2022 Jan 3. Epub 2022 Jan 3.

Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.

Little information is available regarding whether unrelated cord blood transplantation (CBT) or an HLA 1-3 antigen-mismatched related donor peripheral blood stem-cell transplantation (PBSCT) using low-dose anti-thymocyte globulin (ATG) is superior as an alternative transplantation for patients who lack an HLA-matched sibling or unrelated donor. Therefore, we evaluated 7861 patients with hematologic malignancies (aged 0 to 70 years) who received either a CBT without ATG (CBT-no ATG, n = 7034) or an HLA 1-3 antigen-mismatched related donor PBSCT using low-dose ATG (PBSCT-ATG, n = 827). CBT-no ATG was associated with significantly better overall survival (OS) than the use of a PBSCT-ATG (hazard ratio [HR], 0. Read More

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January 2022

Outcomes of Early Versus Delayed Completion Thyroidectomy for Malignancy.

Am Surg 2022 Jan 3:31348211067999. Epub 2022 Jan 3.

Loma Linda University School of Medicine, Loma Linda, CA, USA.

Purpose: To determine whether time interval between hemi-thyroidectomy and subsequent completion thyroidectomy impacts outcomes.

Methods: Retrospective review of 68 patients having completion thyroidectomy from August 2012 to December 2019. Patients were separated into two groups based on the time interval between surgeries: early (≤10 days) or delayed (≥90 days). Read More

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January 2022

Clinically relevant mitochondrial-targeted therapy improves chronic outcomes after traumatic brain injury.

Brain 2021 Dec;144(12):3788-3807

Spinal Cord and Brain Injury Research Center, University of Kentucky, Lexington, KY 40536, USA.

Pioglitazone, an FDA-approved compound, has been shown to target the novel mitochondrial protein mitoNEET and produce short-term neuroprotection and functional benefits following traumatic brain injury. To expand on these findings, we now investigate the dose- and time-dependent effects of pioglitazone administration on mitochondrial function after experimental traumatic brain injury. We then hypothesize that optimal pioglitazone dosing will lead to ongoing neuroprotection and cognitive benefits that are dependent on pioglitazone-mitoNEET signalling pathways. Read More

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December 2021

Delayed presentation of syringomyelia after retrosigmoid craniectomy and resection of vestibular schwannoma: discussion of mechanisms.

BMJ Case Rep 2021 Dec 30;14(12). Epub 2021 Dec 30.

Department of Neurosurgery, Queen's Medical Centre, Nottingham, UK.

We present a case of syringomyelia following retrosigmoid craniectomy and resection of vestibular schwannoma complicated by Cerebrospinal fluid (CSF) leak, multiple infections and CSF diversion procedures. We believe this is the first reported case of syrinx formation after this type of surgery. Potential mechanisms by which the syrinx may have developed are discussed. Read More

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December 2021

Differential time course of glycogen synthase kinase-3 inhibition in experimental autoimmune encephalomyelitis.

Malays J Pathol 2021 Dec;43(3):413-424

Universiti Putra Malaysia, Faculty of Medicine and Health Sciences, Department of Pathology, Serdang 43400, Selangor, Malaysia.

Introduction: GSK-3 is an immune regulator that plays a role in the modulation of cytokine-producing effector T cells associated with inflammation and demyelination of the CNS in EAE.

Objective: This study aimed to evaluate the treatment paradigm of a single dose of GSK-3 inhibitor administration at various time courses for the protection of the CNS from EAE.

Materials And Methods: Effects of GSK-3 inhibition on intracellular cytokine levels were evaluated from in vitro naïve CD4+ T cell cultures. Read More

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December 2021

Human Olfactory Mesenchymal Stem Cells Are a Novel Candidate for Neurological Autoimmune Disease.

Front Pharmacol 2021 10;12:770884. Epub 2021 Dec 10.

Department of Rehabilitation Medicine, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.

Human olfactory mesenchymal stem cells (OMSC) have become a novel therapeutic option for immune disorder or demyelinating disease due to their immunomodulatory and regenerative potentials. However, the immunomodulatory effects of OMSC still need to be elucidated, and comparisons of the effects of different MSCs are also required in order to select an optimal cell source for further applications. In animal experiments, we found neural functional recovery and delayed EAE attack in the OMSC treatment group. Read More

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December 2021

Intra-epidermal evoked potentials: A promising tool for spinal disorders?

Neurophysiol Clin 2021 Dec 22. Epub 2021 Dec 22.

Spinal Cord Injury Center, Balgrist University Hospital, University of Zurich, Zurich, Switzerland.

Objectives: To test the robustness and signal-to-noise ratio of pain-related evoked potentials following intra-epidermal electrical stimulation (IES) compared to contact heat stimulation in healthy controls, and to explore the feasibility and potential added value of IES in the diagnosis of spinal disorders.

Methods: Pain-related evoked potentials induced by IES (custom-made, non-invasive, concentric triple pin electrode with steel pins protruding 1 mm from the anode, triangularly separated by 7-10 mm respectively) and contact heat stimulation were compared in 30 healthy subjects. Stimuli were applied to four different body sites. Read More

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December 2021

Growth in achondroplasia including stature, weight, weight-for-height and head circumference from CLARITY: achondroplasia natural history study-a multi-center retrospective cohort study of achondroplasia in the US.

Orphanet J Rare Dis 2021 Dec 23;16(1):522. Epub 2021 Dec 23.

Greenberg Center for Skeletal Dysplasias, McKusick-Nathans Department of Genetic Medicine, Johns Hopkins University, 733 N. Broadway Suite 579, Baltimore, MD, 21205, USA.

Background: Achondroplasia is the most common genetic skeletal disorder causing disproportionate short stature/dwarfism. Common additional features include spinal stenosis, midface retrusion, macrocephaly and a generalized spondylometaphyseal dysplasia which manifest as spinal cord compression, sleep disordered breathing, delayed motor skill acquisition and genu varus with musculoskeletal pain. To better understand the interactions and health outcomes of these potential complications, we embarked on a multi-center, natural history study entitled CLARITY (achondroplasia natural history study). Read More

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December 2021

Glial-Neuronal Interactions in Pathogenesis and Treatment of Spinal Cord Injury.

Int J Mol Sci 2021 Dec 17;22(24). Epub 2021 Dec 17.

Institute of Neurobiology, Biomedical Research Centre, Slovak Academy of Sciences, Soltesovej 4-6, 040 01 Kosice, Slovakia.

Traumatic spinal cord injury (SCI) elicits an acute inflammatory response which comprises numerous cell populations. It is driven by the immediate response of macrophages and microglia, which triggers activation of genes responsible for the dysregulated microenvironment within the lesion site and in the spinal cord parenchyma immediately adjacent to the lesion. Recently published data indicate that microglia induces astrocyte activation and determines the fate of astrocytes. Read More

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December 2021

Locomotor Behavior Analysis in Spinal Cord Injured after Predegenerated Peripheral Nerve Grafting-A Preliminary Evidence.

Vet Sci 2021 Nov 23;8(12). Epub 2021 Nov 23.

Department of Physiology, Dr. ALM PGIBMS, University of Madras, Chennai 600113, India.

Introduction: Primate animal models are being utilized to explore novel therapies for spinal cord injuries. This study aimed to evaluate the efficiency of the transplantation of predegenerated nerve segments in unilateral spinal cord-hemisected bonnet monkeys' () locomotor functions using the complex runways.

Materials And Methods: The bonnet monkeys were initially trained to walk in a bipedal motion on grid and staircase runways. Read More

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November 2021

Management of inflammatory bowel disease and serum level of infliximab in newborn exposed to anti-TNF therapy during pregnancy: Case report and literature review.

Medicine (Baltimore) 2021 Dec;100(51):e28274

Department of Internal Medicine, São Paulo State University (Unesp), Medical School, Botucatu, São Paulo, Brazil.

Rationale: Heightened inflammatory bowel disease (IBD) activity during pregnancy is associated with higher rates of preterm birth, miscarriage, and low birth weight. Therefore, its adequate treatment is essential, considering the risk-benefit of medication use. Although previous literature has described the management of IBD during pregnancy, few studies have assessed the pharmacokinetics of IBD drugs in the newborn. Read More

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December 2021

Single Cord Blood Transplantation Versus HLA-Haploidentical-related Donor Transplantation Using Posttransplant Cyclophosphamide in Patients With Hematological Malignancies.

Transplantation 2021 Dec 20. Epub 2021 Dec 20.

Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan. Department of Hematology, Kobe City Medical Center General Hospital, Kobe, Japan. Department of Hematology, Tenri Hospital, Nara, Japan. Department of Hematology, Kurashiki Central Hospital, Okayama, Japan. Department of Hematology, Kansai Electric Power Hospital, Osaka, Japan. Department of Hematology, Shizuoka General Hospital, Shizuoka, Japan. Department of Hematology, Takatsuki Red Cross Hospital, Osaka, Japan. Department of Hematology, Hyogo Prefectural Amagasaki General Medical Center, Amagasaki, Japan. Division of Hematology and Stem Cell Transplantation, Shizuoka Cancer Center, Shizuoka, Japan. Department of Hematology, Kokura Memorial Hospital, Fukuoka, Japan. Department of Hematology, Japanese Red Cross Osaka Hospital, Osaka, Japan. Department of Hematology, Kyoto City Hospital, Kyoto, Japan. Department of Hematology, Kitano Hospital, Osaka, Japan. Department of Hematology, Japan Red Cross Otsu Hospital, Shiga, Japan. Department of Hematology, Kyoto-Katsura Hospital, Kyoto, Japan. Department of Hematology, Japanese Red Cross Wakayama Medical Center, Wakayama, Japan. Department of Hematology, Shinko Hospital, Hyogo, Japan. Department of Hematology, Shiga General Hospital, Shiga, Japan.

Background: Unrelated cord blood (UCB) and haploidentical related donor transplantation using posttransplant cyclophosphamide (PTCy-haplo) have become alternative options to treat patients with hematological malignancies without a HLA-matched donor.

Methods: We conducted a retrospective study using registry data from the Kyoto Stem Cell Transplantation Group for patients with hematological malignancies who received their first allogeneic hematopoietic cell transplantation using a single UCB unit (n = 460) or PTCy-haplo (N = 57) between 2013 and 2019.

Results: We found that overall survival in the UCB group was comparable to that in the PTCy-haplo group (hazard ratio, 1. Read More

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December 2021

Intraoperative neurophysiologic monitoring prevented iatrogenic spinal cord injury during robotic-assisted transabdominal adrenalectomy: a case report.

Gland Surg 2021 Nov;10(11):3155-3162

Department of Surgery, Tulane University School of Medicine, New Orleans, LA, USA.

Cervical spondylotic myelopathy (CSM) is the most common disease of the cervical spinal cord in patients older than 55 and is characterized by an initial asymptomatic period followed by progressive neurological deficit from degenerative changes of the cervical vertebrae. These changes cause compression and vascular compromise to the cervical spinal cord. Because there are no pathognomonic symptoms, its diagnosis is commonly delayed. Read More

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November 2021

An NIR-Triggered Au Nanocage Used for Photo-Thermo Therapy of Chronic Wound in Diabetic Rats Through Bacterial Membrane Destruction and Skin Cell Mitochondrial Protection.

Front Pharmacol 2021 30;12:779944. Epub 2021 Nov 30.

Jinzhou Medical University, Jinzhou, China.

Bacterial infection and its severe oxidative stress reaction will cause damage to skin cell mitochondria, resulting in long-lasting wound healing and great pain to patients. Thus, delayed wound healing in diabetic patients with infection is a principal challenge worldwide. Therefore, novel biomaterials with multifunction of bacterial membrane destruction and skin cell mitochondrial protection are urgently needed to be developed to address this challenge. Read More

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November 2021

Maternal opioid use is reflected on leukocyte telomere length of male newborns.

PLoS One 2021 17;16(12):e0261013. Epub 2021 Dec 17.

Department of Clinical Biochemistry, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran.

Opioid use accelerates normal aging in adults that raises a question on whether it may trans-generationally affect aging and aging biomarkers in the offspring of users as well? In the present research, we investigated the relative telomere length in umbilical cord blood of newborns born to opioid consuming mothers compared to normal controls. Telomere length shortening is a known biomarker of aging and aging related diseases. Its measure at birth or early in life is considered as a predictor of individual health in adulthood. Read More

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January 2022

Tracheal rupture after vocal cord polyp resection: A case report.

Medicine (Baltimore) 2021 Dec;100(50):e28106

Department of Otorhinolaryngology - Head and Neck Surgery, Huashan Hospital of Fudan University, Shanghai, China.

Introduction: Transoral laser microsurgery (TLM) is one of the most common operations performed for glottic lesions. Several protection measures are taken to prevent tracheal damage. However, some protection measures and common postoperative complications may still cause delayed tracheal rupture in certain situations. Read More

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December 2021

Inhibiting calcium release from ryanodine receptors protects axons after spinal cord injury.

J Neurotrauma 2021 Dec 16. Epub 2021 Dec 16.

University of Louisville, KSCIRC/ Neurological Surgery , 511 S. Floyd Street, MDR Bldg. 6th floor, Room 608, Louisville, Kentucky, United States, 40292;

Ryanodine receptors (RyR) mediate calcium release from calcium stores and have been implicated in axonal degeneration. Here we use an intravital imaging approach to determine axonal fate after spinal cord injury (SCI) in real-time and assess the efficacy of ryanodine receptor (RyR) inhibition as a potential therapeutic approach to prevent intra-axonal calcium-mediated axonal degeneration. Adult 6-8 week old Thy1YFP transgenic mice that express YFP in axons as well as triple transgenic Avil-Cre:Ai9:Ai95 mice that express the genetically-encoded calcium indicator GCaMP6f in tdTomato positive axons were used to visualize axons and calcium changes in axons respectively. Read More

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December 2021

SIRT6 inhibition delays peripheral nerve recovery by suppressing migration, phagocytosis and M2-polarization of macrophages.

Cell Biosci 2021 Dec 14;11(1):210. Epub 2021 Dec 14.

Department of Histology and Embryology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, China.

Background: Silent information regulator 6 (SIRT6) is a mammalian homolog of the nicotinamide adenine dinucleotide (NAD)-dependent deacetylase sirtuin family. Prior evidences suggested that the anti-inflammatory function of SIRT6 after spinal cord and brain injury, and it plays a crucial role in macrophages polarization of adipose tissue and skin. However, the role of SIRT6 in macrophages involved peripheral nerve injury is still unknown. Read More

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December 2021

Autophagy of Spinal Microglia Affects the Activation of Microglia through the PI3K/AKT/mTOR Signaling Pathway.

Neuroscience 2022 Feb 10;482:77-86. Epub 2021 Dec 10.

Department of Anesthesiology, The Fifth Affiliated Hospital of Southern Medical University, Guangzhou 510900, China. Electronic address:

Delayed paralysis occurs within some patients suffered from ischemic spinal cord injury (ISCI) due to the aorta occlusion during the repair surgery of thoracic and thoracoabdominal aortic aneurysms. Although mild hypothermia has been reported to improve ISCI and prolong the tolerance of rats to ISCI without inducing immediate paralysis, the mechanism remains unclear. Herein, the study revealed that the mild hypothermia treatment indeed partially improved the ISCI in rats caused by cross-clamping at the descending aorta. Read More

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February 2022