20,266 results match your criteria dehydrogenase aspartate

A preliminary study on the mechanism of the neurosteroid-mediated ionotropic receptor dysfunction in neurodevelopmental toxicity induced by decabromodiphenyl ether.

Ecotoxicol Environ Saf 2021 Apr 13;217:112198. Epub 2021 Apr 13.

Department of Nutrition and Food Hygiene, Guilin Medical University, Guilin, Guangxi 541004, People's Republic of China; Guangxi Colleges and University Key Laboratory of Preventive Medicine, Guilin Medical University, Guilin, Guangxi 541004, People's Republic of China. Electronic address:

The mechanism of neurodevelopmental toxicity of decabromodiphenyl ether (BDE209) remains unclear. Recent evidence suggests that neurosteroids disorders play a vital role in BDE209 induced-neurodevelopmental toxicity. To explore the mechanism of it, pregnant ICR mice were orally gavaged with 0, 225, and 900 mg kg BDE209 for about 42 days. Read More

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Clinical characteristics of Egyptian male patients with COVID-19 acute respiratory distress syndrome.

PLoS One 2021 16;16(4):e0249346. Epub 2021 Apr 16.

Department of Microbiology and Immunology, Faculty of Pharmacy, Fayoum University, Fayoum, Egypt.

Background: Coronavirus disease 2019 (COVID-19) is a serious illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and in severe cases associated with acute respiratory distress syndrome (ARDS).

Objective: To describe the clinical characteristics of patients with ARDS-COVID-19.

Materials And Methods: This study involved 197 male Egyptian participants, among them111 COVID-19 patients presented with ARDS, 60 COVID-19 patients presented with non-ARDS, and 26 Non-COVID-19 patients. Read More

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Metformin's Therapeutic Action in the Treatment of Diabetes Does Not Involve Inhibition of Mitochondrial Glycerol Phosphate Dehydrogenase.

Diabetes 2021 Apr 13. Epub 2021 Apr 13.

University of Wisconsin School of Medicine and Public Health 3459 Medical Science Center 1300 University Ave. Madison, WI 53706.

Mitochondrial glycerol phosphate dehydrogenase (mGPD) is the rate-limiting enzyme of the glycerol phosphate redox shuttle. It was recently claimed that metformin, a first line drug used for the treatment of type 2 diabetes, inhibits liver mGPD 30-50% suppressing gluconeogenesis through a redox mechanism. Various factors cast doubt on this idea. Read More

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Association of preoperative seizures with tumor metabolites quantified by magnetic resonance spectroscopy in gliomas.

Sci Rep 2021 Apr 12;11(1):7927. Epub 2021 Apr 12.

Department of Neurosurgery, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan.

Seizures are common in patients with gliomas; however, the mechanisms of epileptogenesis in gliomas have not been fully understood. This study hypothesized that analyzing quantified metabolites using magnetic resonance spectroscopy (MRS) might provide novel insights to better understand the epileptogenesis in gliomas, and specific metabolites might be indicators of preoperative seizures in gliomas. We retrospectively investigated patient information (gender, age at diagnosis of tumor, their survival time) and tumor information (location, histology, genetic features, and metabolites according to MRS) in patients with gliomas. Read More

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Protective Effects of Mill. Fruit on Carbon Tetrachloride-induced Hepatotoxicity Mediated through Mitochondria and Restoration of Cellular Energy Content.

Iran J Pharm Res 2020 ;19(4):354-364

Department of Medicinal Chemistry, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran.

Quince ( Mill.) is one of the medicinal plant with a broad range of pharmacological activities such as hepatoprotective effect. The present study was conducted to evaluate the effect of aqueous extract of Mill. Read More

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January 2020

White Tip Silver Needle (Slightly Fermented White Tea) Flavonoids Help Prevent Aging via Antioxidative and Anti-Inflammatory Effects.

Drug Des Devel Ther 2021 31;15:1441-1457. Epub 2021 Mar 31.

Chongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education, Chongqing, 400067, People's Republic of China.

Aim: White tip silver needle, a slightly fermented white tea, is abundant in flavonoids, and it has great significance in terms of D-galactose/lipopolysaccharide-induced aging in mice.

Methods: We analyzed the antioxidant capacity of white tip silver needle flavonoids (WTSNF) in vitro, assessed the effects of WTSNF on organ indexes, pathological changes, liver function indexes, biochemical indicators, molecular biological indicators, and genes related to oxidation and inflammation.

Results: Ultra-high performance liquid chromatography-tandem mass spectrometry results showed that WTSNF contained baicalin, kaempferol, kaempferide, quercetin, isorhamnetin, lespenephryl, and rutin. Read More

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Development of a multivariable prediction model for severe COVID-19 disease: a population-based study from Hong Kong.

NPJ Digit Med 2021 Apr 8;4(1):66. Epub 2021 Apr 8.

Department of Cardiothoracic Surgery, Wuhan Asia Heart Hospital Affiliated to Wuhan University of Science and Technology, Hubei, Wuhan, China.

Recent studies have reported numerous predictors for adverse outcomes in COVID-19 disease. However, there have been few simple clinical risk scores available for prompt risk stratification. The objective is to develop a simple risk score for predicting severe COVID-19 disease using territory-wide data based on simple clinical and laboratory variables. Read More

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Sudden death of COVID-19 patients in Wuhan, China: A retrospective cohort study.

J Glob Health 2021 Mar 27;11:05006. Epub 2021 Mar 27.

Department of Epidemiology and Biostatistics, Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China.

Background: In December 2019, coronavirus disease 2019 (COVID-19) emerged in Wuhan city and rapidly spread throughout China. So far, it has caused ~ 4000 deaths in this country. We aimed to systematically characterize clinical features and determine risk factors of sudden death for COVID-19 patients. Read More

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Physiological and immune responses to long road transportation in Andaman local pigs.

Trop Anim Health Prod 2021 Apr 5;53(2):247. Epub 2021 Apr 5.

Animal Science Division, ICAR-Central Island Agricultural Research Institute, Port Blair, Andaman and Nicobar Islands, 744101, India.

Transportation of farm animals is a routine management practice. During transportation, animals experience physiological and psychological stress which has negative consequences on health and welfare of animals. Effect of transportation on pig health and welfare in island ecosystem is not properly known. Read More

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Exercise-induced haemoglobin oxygen desaturation in patients with SCD.

Am J Cardiovasc Dis 2021 15;11(1):87-92. Epub 2021 Feb 15.

Department of Medicine and Therapeutics, University of Ghana Medical School, University of Ghana Accra, Ghana.

Background: Patients with sickle cell disease (SCD) may experience severe clinical complications when there is low tissue oxygenation due to the increased risk of the polymerization of haemoglobin S in deoxygenated environment. The predictors of oxygen desaturation after exercise is not clear in patients with SCD. The current study compared lung function and six-minute walk test (6MWT) between SCD patients with oxygen desaturation after exercise and those without oxygen desaturation. Read More

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February 2021

Safety of Polyethylene Glycol Solution plus Ascorbic Acid for Bowel Preparation for Colonoscopy in Patients with Chronic Kidney Disease.

Gastroenterol Res Pract 2021 15;2021:6696591. Epub 2021 Mar 15.

Department of Gastroenterology, Fujita Health University School of Medicine, Toyoake, Aichi, Japan.

Introduction: Polyethylene glycol-electrolyte lavage solution plus ascorbic acid (PEG-ELS-Asc) has been recommended for colonoscopy, but little is known about the safety of PEG-ELS-Asc in patients with chronic kidney disease (CKD). The aim of this study was to determine its safety and efficacy in CKD patients.

Methods: Blood and urine samples prospectively collected before and after same-day bowel preparation for colonoscopy with the conventional volume of PEG-ELS-Asc, vital signs before and after colonoscopy, and adverse events within 30 days postcolonoscopy were analyzed in consenting patients with CKD. Read More

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The Archaeal Small Heat Shock Protein Hsp17.6 Protects Proteins from Oxidative Inactivation.

Int J Mol Sci 2021 Mar 4;22(5). Epub 2021 Mar 4.

State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.

Small heat shock proteins (sHsps) are widely distributed among various types of organisms and function in preventing the irreversible aggregation of thermal denaturing proteins. Here, we report that Hsp17.6 from exhibited protection of proteins from oxidation inactivation. Read More

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Abnormal Liver Function Test in Patients Infected with Coronavirus (SARS-CoV-2): A Retrospective Single-Center Study from Spain.

J Clin Med 2021 Mar 3;10(5). Epub 2021 Mar 3.

Department of Immunology, Ophthalmology & ENT, Complutense University School of Medicine, 28040 Madrid, Spain.

The outbreak of the novel coronavirus SARS-CoV-2 epidemic has rapidly spread and still poses a serious threat to healthcare systems worldwide. In the present study, electronic medical records containing clinical indicators related to liver injury in 799 COVID-19-confirmed patients admitted to a hospital in Madrid (Spain) were extracted and analyzed. Correlation between liver injury and disease outcome was also evaluated. Read More

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Clinical Characteristics of Aortic Aneurysm in MIMIC-III.

Heart Surg Forum 2021 04 2;24(2):E351-E358. Epub 2021 Apr 2.

Department of Emergency Medicine, Changsha Central Hospital, University of South China, Hengyand, Hunan, China.

Background: Aortic aneurysm (AA) is an aortic disorder prone to sudden, life-threatening aortic dissection or rupture, with poor clinical outcomes. In this study, we aimed to analyze the clinical characteristics of AA in MIMIC-III to explore implications for management.

Methods: All patients with AA, including abdominal aortic aneurysm (AAA) and thoracic aortic aneurysm (TAA), in the MIMIC-III database were included. Read More

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Ginsenoside Rg3 ameliorates acetaminophen-induced hepatotoxicity by suppressing inflammation and oxidative stress.

J Pharm Pharmacol 2021 Mar;73(3):322-331

Department of Pharmacy, Xuanwu Hospital of Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing Engineering Research Center for Nervous System Drugs, Beijing Institute for Brain Disorders, Key Laboratory for Neurodegenerative Diseases of Ministry of Education, Beijing, China.

Objectives: Improper usage of acetaminophen (APAP) leads to morbidity and also mortality secondary to liver damage. Ginseng could suppress APAP-induced hepatotoxicity and ginsenoside Rg3 is a kind of major component in ginseng against liver damage. Herein, we intended to estimate the beneficial function and molecular mechanism of Rg3 on APAP-caused hepatotoxicity and identified hepatoprotection. Read More

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Molecular profile of oral fluid in new coronavirus infection.

Klin Lab Diagn 2021 Mar;66(3):133-138

Samara State Medical University.

Oral fluid is an alternative biological material that confirms correlations with blood parameters in various pathological conditions of the body. In order to find a non-invasive approach to stratification of patients with COVID-19 disease, molecular biomarkers of the oral fluid have been determined in patients with moderate coronavirus infection in comparison with clinically healthy individuals. It has been shown that proteomic, carbohydrate, macro- and microelement profiles of the oral fluid in coronavirus infection can be used for diagnostics. Read More

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The Age-AST-D Dimer (AAD) Regression Model Predicts Severe COVID-19 Disease.

Dis Markers 2021 23;2021:6658270. Epub 2021 Mar 23.

Multidisciplinary Team for the Attention and Care of Patients with COVID-19, Hospital General de México ¨Dr. Eduardo Liceaga¨, Mexico City, Mexico.

Aim: Coronavirus disease (COVID-19) ranges from mild clinical phenotypes to life-threatening conditions like severe acute respiratory syndrome (SARS). It has been suggested that early liver injury in these patients could be a risk factor for poor outcome. We aimed to identify early biochemical predictive factors related to severe disease development with intensive care requirements in patients with COVID-19. Read More

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-Allylmercaptocysteine improves alcoholic liver disease partly through a direct modulation of insulin receptor signaling.

Acta Pharm Sin B 2021 Mar 13;11(3):668-679. Epub 2020 Nov 13.

Clinical Medicine Research Institute, the First Affiliated Hospital of Jinan University, Guangzhou 510632, China.

Alcoholic liver disease (ALD) causes insulin resistance, lipid metabolism dysfunction, and inflammation. We investigated the protective effects and direct regulating target of -allylmercaptocysteine (SAMC) from aged garlic on liver cell injury. A chronic ethanol-fed ALD model (the NIAAA model) was used to test the protective functions of SAMC. Read More

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The Impact of Antarctic Ice Microalgae Polysaccharides on D-Galactose-Induced Oxidative Damage in Mice.

Front Nutr 2021 9;8:651088. Epub 2021 Mar 9.

Chongqing Collaborative Innovation Center for Functional Food, Chongqing University of Education, Chongqing, China.

Antarctic ice microalgae ( sp.) are a polysaccharide-rich natural marine resource. In this study, we evaluated the impact of Antarctic ice microalgae polysaccharides (AIMP) on D-galactose-induced oxidation in mice. Read More

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Allicin mitigates hepatic injury following cyclophosphamide administration via activation of Nrf2/ARE pathways and through inhibition of inflammatory and apoptotic machinery.

Environ Sci Pollut Res Int 2021 Mar 24. Epub 2021 Mar 24.

Department of Zoology and Entomology, Faculty of Science, Helwan University, Cairo, Egypt.

Treatment with anti-neoplastic agents, including cyclophosphamide (CP), is associated with several adverse reactions. Here, we distinguished the potential protective effect of allicin against CP-mediated hepatotoxicity in rats. To assess the effect of allicin, four experimental groups were used, with 7 rats per group, including control, allicin (10 mg/kg), CP (200 mg/kg), and allicin + CP-treated groups. Read More

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Exogenous melatonin alleviates hemorrhagic shock‑induced hepatic ischemic injury in rats by inhibiting the NF‑κB/IκBα signaling pathway.

Mol Med Rep 2021 May 24;23(5). Epub 2021 Mar 24.

Department of Emergency, Taizhou First People's Hospital, Taizhou, Zhejiang 318020, P.R. China.

Melatonin (MT) is an indoleamine hormone that can counteract ischemia‑induced organ injury through its antioxidant effects. The aim of the present study was to investigate the protective effects of exogenous MT against hemorrhagic shock (HS)‑induced hepatic ischemic injury in rats, and the role of the nuclear factor (NF)‑κB signaling pathway in this process. A rat model of HS‑induced hepatic ischemic injury was established. Read More

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Lyciumamide A, a dimer of phenolic amide, protects against NMDA-induced neurotoxicity and potential mechanisms in vitro.

J Mol Histol 2021 Mar 23. Epub 2021 Mar 23.

Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China.

Currently, the excessive activation of N-methyl-D-aspartate receptors (NMDARs) is considered to be a crucial mechanism of brain injury. Lycium barbarum A (LyA) is a dimer of phenol amides isolated from the fruit of Lycium barbarum. Our previous studies have shown that LyA has potential antioxidant activity. Read More

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Cardioprotective Effects of Mebudipine in a Rat Model of Doxorubicin-Induced Heart Failure.

Iran J Med Sci 2021 Mar;46(2):136-143

Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Background: Mebudipine, a dihydropyridine calcium-channel blocker (CCB), shows greater time- and voltage-dependent inhibitory effects than nifedipine. Its significant negative chronotropic effects without having considerable negative inotropic properties may make it a suitable candidate for the pharmacotherapy of heart failure (HF). This study aimed to investigate the possible beneficial action of mebudipine in a rat model of HF. Read More

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N-Methyl-D-aspartate receptor hyperfunction contributes to D-serine-mediated renal insufficiency.

Am J Physiol Renal Physiol 2021 Mar 22. Epub 2021 Mar 22.

School of Medicine, Fu Jen Catholic University, Taiwan.

Glutamate N-methyl-D-aspartate receptor (NMDAR) hyperfunction is known to contribute to acute renal failure due to ischemia/reperfusion and endotoxemia. D-Serine is a co-agonist for NMDAR activation, but whether NMDARs play a role in D-serine-mediated nephrotoxicity remains unclear. Here, we demonstrate that NMDAR blockade ameliorates D-serine-induced renal injury. Read More

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Meta-analysis of laboratory results in patients with severe coronavirus disease 2019.

Exp Ther Med 2021 May 1;21(5):449. Epub 2021 Mar 1.

Department of Pharmacy, Ningbo Medical Center, Li Huili Hospital, Ningbo, Zhejiang 315040, P.R. China.

The aim of the present study was to analyze the differences in laboratory results between patients with severe and moderate coronavirus disease 2019 (COVID-19) for clinical intervention. The laboratory results of patients with COVID-19 between December 2019 and May 2020 were assembled from the Medline, Embase and Cochrane Library databases. A meta-analysis was conducted, calculating the individual and pooled odds ratios (ORs) with relative 95% confidence intervals (95% CIs) using Review Manager 5. Read More

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Gender and age-specific reference intervals of common biochemical analytes in Chinese population: Derivation using real laboratory data.

J Med Biochem 2020 Sep;39(3):384-391

Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Department of Health Care, Dongcheng District, Beijing, China.

Background: Indirect sampling methods are not only inexpensive but also efficient for establishing reference intervals (RIs) using clinical data. This study was conducted to select fully normal records to establish ageand gender-specific RIs for common biochemical analytes by laboratory data mining.

Methods: In total, 280,206 records from 2014 to 2018 were obtained from Peking Union Medical College Hospital. Read More

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September 2020

Development of a Rapid Intraoperative Point-of-Care Method Using Tissue Suspension to Differentiate Parathyroid Tissue: A Possible Substitute for Frozen Sections.

World J Surg 2021 Mar 19. Epub 2021 Mar 19.

Department of Breast and Endocrine Surgery, Nagoya University Hospital, Nagoya, Japan.

Background: We reported that aspartate aminotransferase (AST)/lactate dehydrogenase (LDH) ratio of a tissue suspension can precisely differentiate normal and hyperfunctioning parathyroid tissue (PT) from other tissues. However, in these studies, LDH and AST were measured using the standard method for blood samples, with a turnaround time of approximately 1 h, hampering clinical application. Here, we developed a rapid and robust method to differentiate PT instead of using frozen sections. Read More

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[Cardiac presentations in severe and critical coronavirus disease 2019].

Zhonghua Wei Zhong Bing Ji Jiu Yi Xue 2021 Feb;33(2):229-232

Department of Infectious Disease, the Eighth People's Hospital of Guangzhou, Guangzhou 510000, Guangdong, China. Corresponding author: Lei Chunliang, Email:

Objective: To investigate the cardiac presentations and the possible influencing factors of severe and critical coronavirus disease 2019 (COVID-19).

Methods: A retrospective study was conducted. Patients with severe and critical COVID-19 admitted to the Eighth People's Hospital of Guangzhou from January 21st to February 24th 2020 were enrolled. Read More

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February 2021

A review on the protective effects of naringenin against natural and chemical toxic agents.

Phytother Res 2021 Mar 16. Epub 2021 Mar 16.

Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Naringenin (NRG), as a flavanone from flavonoids family, is widely found in grapefruit, lemon tomato, and Citrus fruits. NRG has shown strong anti-inflammatory and antioxidant activities in body organs via mechanisms such as enhancement of glutathione S-transferase (GST), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) activity, but reduction of serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), and malondialdehyde (MDA). Furthermore, NRG anti-apoptotic potential was indicated to be mediated by regulating B-cell lymphoma (Bcl-2), Bcl-2-associated X protein (Bax) and caspase3/9. Read More

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Antioxidant and Protective Effects of Essential Oil Against Chlorpyrifos-Induced Kidney and Liver Injuries in Rats.

Front Physiol 2021 24;12:618582. Epub 2021 Feb 24.

Animal Ecophysiology Laboratory, Sciences Faculty of Sfax, University of Sfax, Sfax, Tunisia.

This study is aimed to elucidate the possible antioxidant and protective effects of essential oil (ACEO) against the deleterious effects of chlorpyrifos (CPF) in rats. The study revealed increases in aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), and alkaline phosphatase (ALP) activities and the serum contents of creatinine, urea, uric acid, cholesterol, triglycerides, low density lipoproteins (LDL), and glucose in rats treated with CPF as compared to controls. Meanwhile, hepatic and renal activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in liver and kidney decreased and the content of malondialdehyde (MDA) increased. Read More

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February 2021