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Differential characteristics and management of pseudoseptic arthritis following hyaluronic acid injection is a rare complication: a systematic review.

J ISAKOS 2021 Mar 3;6(2):94-101. Epub 2020 Nov 3.

Division of Orthopaedic Surgery, Department of Surgery, McMaster University Medical Centre, Hamilton, Ontario, Canada

Importance: Acute pseudoseptic arthritis is a rare complication of hyaluronic acid (HA) injections that is not well documented in the literature. Practitioners initially suspect the symptoms of this complication to represent septic arthritis, cautiously prescribing antibiotics. This review identifies that time to presentation of symptoms postinjection, negative cell cultures and lack of crystallisation could be used as differentials to suspect pseudoseptic arthritis and to prescribe anti-inflammatory drugs while closely monitoring change of symptoms. Read More

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Pharmacotherapy for Nonconvulsive Seizures and Nonconvulsive Status Epilepticus.

Drugs 2021 Apr 8. Epub 2021 Apr 8.

Comprehensive Epilepsy Center, Department of Neurology, Yale University School of Medicine, New Haven, CT, USA.

Most seizures in critically ill patients are nonconvulsive. A significant number of neurological and medical conditions can be complicated by nonconvulsive seizures (NCSs) and nonconvulsive status epilepticus (NCSE), with brain infections, hemorrhages, global hypoxia, sepsis, and recent neurosurgery being the most prominent etiologies. Prolonged NCSs and NCSE can lead to adverse neurological outcomes. Read More

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Incidental lymphomas in surgical pathology: diagnostic clues and clinical-pathological correlations.

Virchows Arch 2021 Apr 8. Epub 2021 Apr 8.

Surgical Pathology and Cytopathology Unit, Department of Medicine-DIMED, University of Padua, Padua, Italy.

Incidental lymphomas (ILs) are rare and challenging lesions with poorly characterized clinical-epidemiological and histological features. The present study addressed the open issues concerning these tumors, by assessing the clinical-pathological features of 28 consecutive ILs, diagnosed over a 10-year period at a tertiary center for surgical pathology. ILs were more frequently documented in elderly males (mean age at surgery 70. Read More

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Herpes simplex virus esophagitis-clinical challenges in the elderly.

BMJ Case Rep 2021 Apr 7;14(4). Epub 2021 Apr 7.

Department of Internal Medicine, Centro Hospitalar de Lisboa Ocidental EPE Hospital de Egas Moniz, Lisboa, Portugal.

A 77-year-old woman presented with a 2-week history of malaise, prostration, anorexia, abdominal pain, vomiting and diarrhoea. She had been taking systemic corticosteroids for the past year. During hospitalisation, renal insufficiency, ionic changes and liver function abnormalities were detected and corrected. Read More

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Motion-compensated FDG PET/CT for oesophageal cancer.

Strahlenther Onkol 2021 Apr 7. Epub 2021 Apr 7.

Department of Radiation Oncology, The Netherlands Cancer Institute-Antoni van Leeuwenhoek, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands.

Purpose: Respiratory-induced motion of oesophageal tumours and lymph nodes can influence positron-emission tomography/computed tomography (PET/CT). The aim was to compare standard three-dimensional (3D) and motion-compensated PET/CT regarding standardized uptake value (SUV), metabolic tumour volume (MTV) and detection of lymph node metastases.

Methods: This prospective observational study (NCT02424864) included 37 newly diagnosed oesophageal cancer patients. Read More

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Nasal-type extranodal NK/T-cell lymphoma presenting as recurrent periorbital cellulitis.

BMJ Case Rep 2021 Apr 1;14(4). Epub 2021 Apr 1.

Otolaryngology, Tallaght University Hospital, Dublin, Dublin, Ireland.

Nasal-type extranodal natural killer/T-cell lymphoma (ENKTCL) is a rare disease with a poor prognosis. It has features similar to other granulomatous and infectious diseases of the nose and paranasal sinuses, which can make diagnosis challenging and delayed. We present a case of 38-year-old man who was admitted to the hospital on three occasions over a 3-month period for right periorbital erythema, nasal congestion and discharge. Read More

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Clinical Practice Guidelines for diagnosis of amyloidosis: Part 1/3 Year 2020

Rev Fac Cien Med Univ Nac Cordoba 2021 03 12;78(1):74-82. Epub 2021 Mar 12.

Sección de Hematologia, Servicio de Clinica Médica, Hospital Italiano de Buenos AIres, Argentina.

Method: Use the PICO format to generate a series of questions, focusing on the specificity and sensitivity of the amyloidosis diagnostic test. PubMed searches were conducted in English and Spanish from July to August 2019. The level of evidence and recommendation are based on the GRADE system (http://www. Read More

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A Case of Histoplasmosis Mimicking Primary Lung Cancer With Liver Metastasis.

Cureus 2021 Feb 23;13(2):e13517. Epub 2021 Feb 23.

Internal Medicine, Sanford Health, University of North Dakota School of Medicine, Fargo, USA.

Histoplasmosis is usually self-limiting in healthy individuals but often fatal in immunocompromised patients. It can mimic primary lung malignancy and liver metastasis, causing a delay in appropriate therapy. We report a case of a 58-year-old male, with a 20 pack-year smoking habit, who presented with a three-week history of persistent fevers and productive cough with night sweats. Read More

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February 2021

Undiagnosed Wilson's Disease and Fibromyalgia Masking Bowel Perforation.

Cureus 2021 Feb 23;13(2):e13504. Epub 2021 Feb 23.

Medicine, University of Florida College of Medicine, Gainesville, USA.

Wilson's disease is a complex multi-organ disease characterized by impaired biliary excretion of copper and resulting deposition of excess copper in the liver and other organs. It has a wide range of clinical presentations, and diagnosis often requires a high degree of clinical suspicion, especially in patients with multiple other comorbidities. We present the case of a 37-year-old woman with a complex medical and psychiatric history who was admitted for chronic diarrhea, hepatic enzyme elevation, electrolyte abnormalities, hyperammonemia, and methicillin-sensitive bacteremia. Read More

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February 2021

Performance of imaging interpretation, intra- and inter-reader agreement for diagnosis of pelvic endometriosis: comparison between an abbreviated and full MRI protocol.

Abdom Radiol (NY) 2021 Mar 27. Epub 2021 Mar 27.

Grupo Fleury, Rua Cincinato Braga, 282, Bela Vista, São Paulo, SP, 01333-010, Brazil.

Purpose: To compare the performance of imaging interpretation, intra- and inter-reader agreement between an abbreviated (aMRI) and full (fMRI) MRI protocol for diagnosis of pelvic endometriosis.

Methods: Seventy consecutive fMRI exams performed under suspicion of pelvic endometriosis were selected. Four radiologists (Rd) (1-10 years experience) independently evaluated presence/absence of endometriosis at 9 anatomic sites (AS). Read More

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Role of plasma exchange in management of patients clinically diagnosed of postpartum thrombotic microangiopathies: A retrospective observation from a tertiary health-care center.

Asian J Transfus Sci 2020 Jul-Dec;14(2):142-148. Epub 2020 Dec 19.

Department of Nephrology, Jaypee Hospital, Noida, Uttar Pradesh, India.

Introduction: Diagnosis of postpartum thrombotic microangiopathies in pregnancy is a challenge, but plasma exchange (PE) is life-saving in such cases. This study was conducted with the aim to find the result of the early start of PE in such patients.

Materials And Methods: There were a total of seven clinically diagnosed cases of post partum thrombotic microangiopathies (PP-TMA) where PE was done. Read More

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December 2020

A case of idiopathic retroperitoneal fibrosis presenting as gallbladder carcinoma.

BMC Surg 2021 Mar 25;21(1):162. Epub 2021 Mar 25.

Department of Surgery, Changxing People's Hospital, No. 66, Taihu Road, Changxing, Huzhou, 313100, Zhejiang, China.

Background: Retroperitoneal fibrosis (RPF) is a rare disease with a poor prognosis characterized by systemic inflammation and fibroinflammatory tissue. Idiopathic RPF (IRPF) accounts for approximately two-thirds of RPF cases.

Case Presentation: A 56-year-old female patient with abdominal distension was admitted to Changxing Hospital. Read More

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Challenges in management of an isolated intrapancreatic Common Bile Duct injury in an abdominal trauma.

Int J Surg Case Rep 2021 Mar 13;81:105765. Epub 2021 Mar 13.

Topiwala National Medical College, Department of General Surgery, 2nd Floor, College Building, Mumbai Central, Mumbai, 400008, India. Electronic address:

Introduction: Biliary tract injuries are rare following abdominal trauma. If detected late, outcome is less favourable. It adds to morbidity if there is involvement of head of pancreas or duodenal wall. Read More

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An Uncommon Cause of Dysphagia: Postpneumonectomy Syndrome.

Case Rep Otolaryngol 2021 8;2021:6658690. Epub 2021 Mar 8.

Division of Laryngology, Department of Otolaryngology- Head and Neck Surgery, Stanford University, Stanford, CA, USA.

Objective: Dysphagia after pneumonectomy is uncommon but concerning. The purpose of this paper is to present a case of dysphonia secondary to postpneumonectomy syndrome. . Read More

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Granulosa cell ovarian cancer with synchronous multiple bone metastases: case report of extreme rarity.

Tumori 2021 Mar 22:3008916211001438. Epub 2021 Mar 22.

Department of Gynaecologic Oncology, St James' University Hospital, Leeds, UK.

Background: Adult granulosa cell tumor (AGCT) of the ovary generally has a good prognosis. Recurrences tend to be late and confined to the abdominopelvis. Bone metastases are extremely rare. Read More

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A Belief Degree-Associated Fuzzy Multifactor Dimensionality Reduction Framework for Epistasis Detection.

Methods Mol Biol 2021 ;2212:307-323

Department of Computer Science, College of Engineering, City University of Hong Kong, Kowloon Tong, Hong Kong.

Epistasis is a challenge in prediction, classification, and suspicion of human genetic diseases. Many technologies, methods, and tools have been developed for epistasis detection. Multifactor dimensionality reduction (MDR) is the method commonly used in epistasis detection. Read More

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Aortic aneurysm and aortic graft infection related to Mycobacterium bovis after intravesical Bacille Calmette-Guérin therapy-a case series.

BMC Surg 2021 Mar 17;21(1):138. Epub 2021 Mar 17.

Department of Vascular and Endovascular Surgery, Charité - Universitätsmedizin Berlin, corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Hindenburgdamm 30, 12203, Berlin, Germany.

Background: So called "mycotic" aortic aneurysms account for only 0.7 to 1.3% of all aortic aneurysms and are commonly caused by Staphylococcus aureus and Salmonella species. Read More

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The Harder the Heart, the Harder It Breaks: A Case of Complete Atrioventricular Block Secondary to Tertiary Hyperparathyroidism.

Cureus 2021 Feb 11;13(2):e13276. Epub 2021 Feb 11.

Cardiology, University of Miami at Holy Cross Hospital, Fort Lauderdale, USA.

The appearance of first-degree atrioventricular block and mitral annulus calcification in an end-stage renal failure patient with elevated parathyroid hormone levels should raise the suspicion of metastatic cardiac calcification. Measures should be taken to normalize the parathyroid hormone, calcium, and phosphorus levels to limit the progression of atrioventricular block. Exploration or removal of parathyroid glands should be considered if heart block worsens. Read More

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February 2021

Common Fractures of the Radius and Ulna.

Am Fam Physician 2021 03;103(6):345-354

Rush Copley Family Medicine Residency, Aurora, IL, USA.

Fractures of the radius and ulna are the most common fractures of the upper extremity, with distal fractures occurring more often than proximal fractures. A fall onto an outstretched hand is the most common mechanism of injury for fractures of the radius and ulna. Evaluation with radiography or ultrasonography usually can confirm the diagnosis. Read More

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Complete heart block in cardiac sarcoidosis reversed by corticosteroid therapy: time course of resolution.

BMJ Case Rep 2021 Mar 9;14(3). Epub 2021 Mar 9.

Cardiovascular Disease, VCU Health, Richmond, Virginia, USA

A 53-year-old man was admitted for recurrent syncope and found to have complete heart block (CHB). Cardiac magnetic resonance imaging MRI) showed extensive patchy late gadolinium enhancement in the apical and lateral walls, consistent with cardiac sarcoidosis (CS) but no scar in the septum. A fluorodeoxyglucose (FDG)-positron emission tomography showed FDG uptake in the septum and basal lateral walls. Read More

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Pasteurella multocida Bacteremia in an Immunocompromised Patient After Multiple Cat Scratches.

Cureus 2021 Jan 27;13(1):e12938. Epub 2021 Jan 27.

Internal Medicine, Medical Center of Trinity, Trinity, USA.

(P. multocida) is a zoonotic organism found in the normal flora of domestic and wild animals. In this case report, we present a 70-year-old Caucasian male who presented with fever, chills, and greenish sputum which began hours prior to presentation. Read More

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January 2021

Rheumatoid arthritis mimicking infective endocarditis with severe aortic regurgitation and aortic root abscess: a case report.

Eur Heart J Case Rep 2021 Jan 25;5(1):ytaa561. Epub 2021 Jan 25.

Department of Cardiology, The Heart Centre, University Hospital of Copenhagen, Rigshospitalet, Copenhagen, Denmark.

Background: Rheumatoid arthritis (RA) may involve the cardiovascular system and can cause significant structural cardiac disease. RA mimicking infective endocarditis (IE) is rarely reported.

Case Summary: A 46-year-old man with a medical history of seropositive RA attended a planned outpatient visit for infliximab treatment. Read More

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January 2021

Unexpected Fatal Tension Pneumothorax: A Case Report Regarding a Patient With Multiple Traumas on Air Medical Transportation.

Air Med J 2021 Mar-Apr;40(2):127-129. Epub 2021 Jan 15.

Medical Faculty, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

A 45-year-old male driver was assessed by the road rescue team after a car crash. He was in shock and had a deep second-degree burn, multiple bone fractures, and chest wounds. After stabilization, he was delivered to the nearest local clinic by an ambulance. Read More

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January 2021

COVID-19 in children ranging from asymptomatic to a multi-system inflammatory disease: A single-center study.

Saudi Med J 2021 Mar;42(3):299-305

From the Department of Pediatrics (Shahin), Faculty of Medicine, from the Department of Clinical and Chemical Pathology (Rabie), Kasr Alainy Faculty of Medicine, Cairo University, Cairo, Egypt; and from the Department of Pediatrics (Shahin, Alyossof, Alasiri, Alfaki, Mahmoud, Hijazi, El Faraidi, Alahmari), Prince Sultan Military Medical City, Riyadh, Kingdom of Saudi Arabia.

Objectives: To identify clinical and laboratory characteristics of the Saudi children with confirmed COVID-19.

Methods: Eighty-eight children (0-14 years) with COVID-19 who were admitted to Prince Sultan Military Medical City (PSMMC), Riyadh, Saudi Arabia from April to June 2020 were recruited.

Results: Mean age was 5. Read More

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Is there an association between electroneuromyography and ultrasound in the diagnosis of carpal tunnel syndrome?

Rev Bras Ortop (Sao Paulo) 2021 Feb 9;56(1):69-73. Epub 2020 Oct 9.

Serviço de Cirurgia da Mão, Hospital de Clínicas, Universidade Federal do Triângulo Mineiro, Uberaba, MG, Brasil.

 To verify whether there is an association between the results of the severity in electroneuromyography and the positivity in ultrasound in the diagnosis of carpal tunnel syndrome.  Sixty-eight patients were included in the study, 61 women and 7 men, with a mean age of 54.4 years. Read More

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February 2021

Be aware of misdiagnosis tied to COVID-19 focusing: a case report of abciximab-induced alveolar haemorrhage thought to be SARS-CoV-2 in a patient with ST-segment elevation myocardial infarction.

Eur Heart J Case Rep 2020 Dec 12;4(6):1-6. Epub 2020 Dec 12.

Department of Cardiology, University of Health Sciences Trabzon Ahi Evren Thoracic and Cardiovascular Surgery Training and Research Hospital, Vatan St., Ortahisar/Trabzon 61000, Turkey.

Background: Early diagnosis of diffuse alveolar haemorrhage (DAH) can be extremely difficult, as the common clinical picture is often attributed to more common clinical conditions. High degree of suspicion is key to diagnosis which can be much more difficult during the coronavirus disease 2019 (COVID-19) pandemic.

Case Summary: A 61-year-old man with inferolateral ST-segment elevation myocardial infarction treated by a stent to the left circumflex artery and intravenous abciximab treatment was started for the high thrombus burden. Read More

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December 2020

Imaging for Pediatric Blunt Abdominal Trauma With Different Prediction Rules: Is the Outcome the Same?

Pediatr Emerg Care 2021 Jan 21. Epub 2021 Jan 21.

From the *Pediatric Emergency Department, Loma Linda University Medical Center, Loma Linda, CA †Pediatric Allergy and Immunology Department, UCLA Mattel Children's Hospital, Los Angeles, CA ‡Pediatric Surgery Department §Pediatric Emergency Department, William Beaumont Hospital, Royal Oak, MI.

Background: Computerized tomography (CT) of the abdomen and pelvis is the standard imaging modality to diagnose intra-abdominal injury (IAI). Clinicians must weigh the risk-benefit of CT compared with the degree of clinical suspicion for an IAI. Pediatric Emergency Care Applied Research Network (PECARN), Streck, and blunt abdominal trauma in children (BATiC) prediction rules have been published to help guide evaluation of these patients. Read More

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January 2021

A liar and a copycat: nonverbal coordination increases with lie difficulty.

R Soc Open Sci 2021 Jan 13;8(1):200839. Epub 2021 Jan 13.

Lancaster University, Lancaster, UK.

Studies of the nonverbal correlates of deception tend to examine liars' behaviours as independent from the behaviour of the interviewer, ignoring joint action. To address this gap, experiment 1 examined the effect of telling a truth and easy, difficult and very difficult lies on nonverbal coordination. Nonverbal coordination was measured automatically by applying a dynamic time warping algorithm to motion-capture data. Read More

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January 2021

Clinical and demographic study of non-tuberculous mycobacterial ocular infections in South India.

Indian J Med Microbiol 2021 Jan 7;39(1):41-47. Epub 2020 Nov 7.

Department of Cornea and Refractive Surgery Services, Aravind Eye Hospital, Madurai, Tamil Nadu, India.

Purpose: To describe demographics, risk factors, antibiotic susceptibility, management and outcomes of ocular infections caused by non-tuberculous mycobacteria (NTM).

Methods: A retrospective review of medical case records and microbiology records of patients with ocular infections that were culture positive for non-tuberculous Mycobacteria from January 2014 to December 2018 was done. Antibiotic susceptibility profile was done based on the CLSI guidelines. Read More

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January 2021

Ancient foe spectra: Case series of Mycobacterium tuberculosis presentations.

Clin Case Rep 2021 Feb 5;9(2):714-717. Epub 2020 Dec 5.

Department of Infectious Diseases Communicable Diseases Centre Doha Qatar.

Extrapulmonary tuberculosis frequently eludes assessment through atypical presentations and constitute diagnostic challenges. High degree of suspicion with aids of GeneXpert MTB/RIF can clinch the diagnosis and avoid unnecessary consequences. Read More

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February 2021