4,014 results match your criteria degree flexibility


Shape-Preserving Stereo Object Remapping via Object-Consistent Grid Warping.

IEEE Trans Image Process 2021 Jun 22;PP. Epub 2021 Jun 22.

Viewing various stereo images under different viewing conditions has escalated the need for effective object-level remapping techniques. In this paper, we propose a new object spatial mapping scheme, which adjusts the depth and size of the selected object to match user preference and viewing conditions. Existing warping-based methods often distort the shape of important objects or cannot faithfully adjust the depth/size of the selected object due to improper warping such as local rotations. Read More

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High Li-Ion Conductivity Artificial Interface Enabled by Li-Grafted Graphene Oxide for Stable Li Metal Pouch Cell.

ACS Appl Mater Interfaces 2021 Jun 22. Epub 2021 Jun 22.

Advanced Li-ion Battery Engineering Laboratory of Zhejiang Province, Key Laboratory of Graphene Technologies and Applications of Zhejiang Province, and CAS Engineering Laboratory for Graphene, Ningbo Institute of Materials Technology & Engineering, Chinese Academy of Sciences, Zhejiang 315201, P. R. China.

The fragile electrolyte/Li interface is responsible for the long-lasting consumption of Li resources and fast failure of Li metal batteries. The polymer artificial interface with high mechanical flexibility is a promising candidate to maintain the stability of the electrolyte/Li interface; however, sluggish Li-ion transportation of the conventional polymer interface hinders the application. In this work, Li-functionalized graphene oxide (GO-ADP-Li), which is synthesized by covalent grafting of adenosine 5'-diphosphate lithium on GO nanosheets, is used as a functional additive to improve the Li-ion conductivity of the polymer artificial interface based on PVDF-HFP/LiTFSI. Read More

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Effects of scapular stabilization exercises on posture and muscle imbalances in women with upper crossed syndrome: A randomized controlled trial.

J Back Musculoskelet Rehabil 2021 Jun 18. Epub 2021 Jun 18.

Background: Scapular stabilization exercises can improve forward shoulder posture in young women. However, the effects of optimal exercise protocols on neck and shoulder postures, scapular muscle imbalance and thoracic kyphosis are still unclear.

Objectives: To investigate the effects of scapular stabilization exercises on neck and shoulder postures, scapular muscle imbalance and thoracic kyphosis in young women with upper crossed syndrome. Read More

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Bariatric and Metabolic Endoscopy: A New Paradigm.

Clin Transl Gastroenterol 2021 Jun 18;12(6):e00364. Epub 2021 Jun 18.

Department of Gastrointestinal Services, University College London Hospital, London, UK.

The prevalence of obesity, type 2 diabetes mellitus, and metabolic syndromes is increasing globally. Minimally invasive metabobariatric (MB) endoscopic therapies are adjunct treatments that can potentially bridge the gap between surgical interventions and medical therapy. A growing number of MB techniques are becoming available, allowing for more personalized and patient-targeted treatment options for specific disease states. Read More

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Head and mandible shapes are highly integrated yet represent two distinct modules within and among worker subcastes of the ant genus .

Ecol Evol 2021 Jun 1;11(11):6104-6118. Epub 2021 May 1.

Departamento de Zoologia Universidade Federal do Paraná Curitiba Brazil.

Ants use their mandibles for a wide variety of tasks related to substrate manipulation, brood transport, food processing, and colony defense. Due to constraints involved in colony upkeep, ants evolved a remarkable diversity of mandibular forms, often related to specific roles such as specialized hunting and seed milling. Considering these varied functional demands, we focused on understanding how the mandible and head shape vary within and between subcastes. Read More

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Macrodiolide Diversification Reveals Broad Immunosuppressive Activity That Impairs the cGAS-STING Pathway.

Angew Chem Int Ed Engl 2021 Jun 14. Epub 2021 Jun 14.

Aarhus University, Chemistry, Langelandsgade 140, 8000, Aarhus C, DENMARK.

The development of new immunomodulatory agents can impact various areas of medicine. In particular, compounds with the ability to modulate innate immunological pathways hold significant unexplored potential. Here, we report a modular synthetic approach to the macrodiolide natural product (-)-vermiculine, an agent previously shown to possess diverse biological effects including cytotoxic and immunosuppressive activity. Read More

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Improving Physical Activity Levels in Prevocational Students by Student Participation: Protocol for a Cluster Randomized Controlled Trial (SALVO study).

JMIR Res Protoc 2021 Jun 11. Epub 2021 Jun 11.

University of Amsterdam, Faculty of Social and Behavioural Sciences, Amsterdam, NL.

Background: A consistent finding in literature is the decline of Physical Activity during adolescence resulting in activity levels below recommended guidelines. Therefore, promotion of physical activity within the school context is recommended specifically in prevocational students. Prevocational education prepares students for entry into further vocational or technical education programmes. Read More

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Influence of Surface Ligand Molecular Structure on Phospholipid Membrane Disruption by Cationic Nanoparticles.

Langmuir 2021 Jun 11;37(24):7600-7610. Epub 2021 Jun 11.

Department of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.

Cationic nanoparticles are known to interact with biological membranes and often cause serious membrane damage. Therefore, it is important to understand the molecular mechanism for such interactions and the factors that impact the degree of membrane damage. Previously, we have demonstrated that spatial distribution of molecular charge at cationic nanoparticle surfaces plays an important role in determining the cellular uptake and membrane damage of these nanoparticles. Read More

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Characterization of the Differential Pathogenicity of Candida auris in a Galleria mellonella Infection Model.

Microbiol Spectr 2021 Jun 9:e0001321. Epub 2021 Jun 9.

Severe Infection Research Group, Health Research Institute La Fe, Valencia, Spain.

Candida auris is an emergent multidrug-resistant fungal pathogen considered a severe global threat due to its capacity to cause nosocomial outbreaks and deep-seated infections with high transmissibility and mortality. However, evidence on its pathogenicity and the complex host-pathogen interactions is still limited. This study used the invertebrate model in Galleria mellonella to assess its virulence, exploring the mortality kinetics, melanization response, and morphological changes after fungal infection compared to Candida albicans and Candida parapsilosis, with known high and low pathogenicity, respectively. Read More

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On the specificity of protein-protein interactions in the context of disorder.

Biochem J 2021 Jun;478(11):2035-2050

The Linderstrøm-Lang Centre for Protein Science, Department of Biology, University of Copenhagen, DK-2200 Copenhagen N, Denmark.

With the increased focus on intrinsically disordered proteins (IDPs) and their large interactomes, the question about their specificity - or more so on their multispecificity - arise. Here we recapitulate how specificity and multispecificity are quantified and address through examples if IDPs in this respect differ from globular proteins. The conclusion is that quantitatively, globular proteins and IDPs are similar when it comes to specificity. Read More

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Weak Human Preference Supervision for Deep Reinforcement Learning.

IEEE Trans Neural Netw Learn Syst 2021 Jun 8;PP. Epub 2021 Jun 8.

The current reward learning from human preferences could be used to resolve complex reinforcement learning (RL) tasks without access to a reward function by defining a single fixed preference between pairs of trajectory segments. However, the judgment of preferences between trajectories is not dynamic and still requires human input over thousands of iterations. In this study, we proposed a weak human preference supervision framework, for which we developed a human preference scaling model that naturally reflects the human perception of the degree of weak choices between trajectories and established a human-demonstration estimator through supervised learning to generate the predicted preferences for reducing the number of human inputs. Read More

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A comparison of five epidemiological models for transmission of SARS-CoV-2 in India.

BMC Infect Dis 2021 Jun 7;21(1):533. Epub 2021 Jun 7.

Department of Biostatistics, University of Michigan, Ann Arbor, MI, 48109, USA.

Background: Many popular disease transmission models have helped nations respond to the COVID-19 pandemic by informing decisions about pandemic planning, resource allocation, implementation of social distancing measures, lockdowns, and other non-pharmaceutical interventions. We study how five epidemiological models forecast and assess the course of the pandemic in India: a baseline curve-fitting model, an extended SIR (eSIR) model, two extended SEIR (SAPHIRE and SEIR-fansy) models, and a semi-mechanistic Bayesian hierarchical model (ICM).

Methods: Using COVID-19 case-recovery-death count data reported in India from March 15 to October 15 to train the models, we generate predictions from each of the five models from October 16 to December 31. Read More

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Indications for Lumbar Fusion in the Skeletally Mature Adolescent: How to Address Oblique Takeoff and Limb Length Discrepancy.

J Pediatr Orthop 2021 Jul;41(Suppl 1):S59-S63

Department of Orthopaedic Surgery, Emory University, Children's Healthcare of Atlanta, Atlanta, GA.

Background: Indications for posterior spinal fusion (PSF) with segmental spinal instrumentation (SSI) of a scoliotic deformity in a skeletally mature individual are based on the balance between the anticipated benefit of stopping future curve progression and the potential downside of loss of spinal mobility. The dilemma regarding PSF with SSI in the adolescent population is exacerbated by the patient's participation in athletics requiring flexibility and motion of the spine, the location of the curve, the presence of pelvic obliquity, and the impact of a limb length discrepancy. The purpose of this review is to discuss the potential advantages and disadvantages of PSF with SSI in a hypothetical skeletally mature adolescent with a 45-degree lumbar curve, pelvic obliquity, and limb length discrepancy. Read More

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DNA Origami Penetration in Cell Spheroid Tissue Models is Enhanced by Wireframe Design.

Adv Mater 2021 Jun 6:e2008457. Epub 2021 Jun 6.

Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, SE-17177, Sweden.

As DNA origami applications in biomedicine are expanding, more knowledge is needed to assess these structures' interaction with biological systems. Here, uptake and penetration in cell and cell spheroid tissue models (CSTMs) are studied to elucidate whether differences in internal structure can be a factor in the efficacy of DNA-origami-based delivery. Two structures bearing largely similar features in terms of both geometry and molecular weight, but with different internal designs-being either compact, lattice-based origami or following an open, wireframe design-are designed. Read More

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NAD Metabolism, Metabolic Stress, and Infection.

Front Mol Biosci 2021 19;8:686412. Epub 2021 May 19.

Department of Microbiology and Molecular Genetics, College of Biological Sciences, University of California, Davis, Davis, CA, United States.

Nicotinamide adenine dinucleotide (NAD) is an essential metabolite with wide-ranging and significant roles in the cell. Defects in NAD metabolism have been associated with many human disorders; it is therefore an emerging therapeutic target. Moreover, NAD metabolism is perturbed during colonization by a variety of pathogens, either due to the molecular mechanisms employed by these infectious agents or by the host immune response they trigger. Read More

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The structure-function relationship of a signaling-competent, dimeric Reelin fragment.

Structure 2021 Jun 1. Epub 2021 Jun 1.

Child Health Institute of New Jersey, New Brunswick, NJ 08901, USA; Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901, USA; School of Biological Sciences, Victoria University of Wellington, Wellington 6012, New Zealand. Electronic address:

Reelin operates through canonical and non-canonical pathways that mediate several aspects of brain development and function. Reelin's dimeric central fragment (CF), generated through proteolytic cleavage, is required for the lipoprotein-receptor-dependent canonical pathway activation. Here, we analyze the signaling properties of a variety of Reelin fragments and measure the differential binding affinities of monomeric and dimeric CF fragments to lipoprotein receptors to investigate the mode of canonical signal activation. Read More

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Geometry and water accessibility of the inhibitor binding site of Na-pump: pulse- and CW-EPR study.

Biophys J 2021 Jun 1. Epub 2021 Jun 1.

Department of Biomedicine, Aarhus University, DK-8000, Aarhus, Denmark;. Electronic address:

Spin labels based on cinobufagin, a specific inhibitor of the Na,K-ATPase, have proved valuable tools to characterize the binding site of cardiotonic steroids (CTS), which also constitutes the extracellular cation pathway. Because existing literature suggests variations in the physiological responses caused by binding of different CTS, we extended the original set of spin-labelled inhibitors to the more potent bufalin derivatives. Positioning of the spin labels within the Na,K-ATPase site was defined and visualized by molecular docking. Read More

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Synthesis of a novel superabsorbent with slow-release urea fertilizer using modified cellulose as a grafting agent and flexible copolymer.

Int J Biol Macromol 2021 May 31;182:1893-1905. Epub 2021 May 31.

Department of Chemistry, University of Isfahan, P. O. Box 81746-734 41, Isfahan, Iran.

In this work, a number of glucose unites in polymeric structure of cellulose was converted to 2,4-dihydroxy-3-(1-hydroxy-2-oxoethoxy)butanal (cellulose containing di aldehyde units (CCDAUs)) by oxidation with sodium periodate, followed by condensation with acetone to produce 5,7-dihydroxy-6-((1-hydroxy-4-oxopent-2-en-1-yl)oxy)hept-3-en-2-one unites (cellulose containing di ene units (CCDEUs)). This modified cellulose was characterized by different methods and applied as a copolymer and grafting agent to synthesize an eco-friendly (CCDEUs-g-poly(AA)/urea) superabsorbent with slow-release urea fertilizer. The created double bonds in C and C positions of β-d-glucose units increased the linkage between cellulose and acrylic acid, leading to the formation of a strong network for slow-release urea fertilizer. Read More

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Structural Characterization of Endogenous Tuberous Sclerosis Protein Complex Revealed Potential Polymeric Assembly.

Biochemistry 2021 Jun 3;60(23):1808-1821. Epub 2021 Jun 3.

Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada.

Tuberous sclerosis protein complex (pTSC) nucleates a proteinaceous signaling hub that integrates information about the internal and external energy status of the cell in the regulation of growth and energy consumption. Biochemical and cryo-electron microscopy studies of recombinant pTSC have revealed its structure and stoichiometry and hinted at the possibility that the complex may form large oligomers. Here, we have partially purified endogenous pTSC from fasted mammalian brains of rat and pig by leveraging a recombinant antigen binding fragment (F) specific for the TSC2 subunit of pTSC. Read More

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Curriculum initiatives to enhance research skills acquisition by medical students: a scoping review.

BMC Med Educ 2021 Jun 2;21(1):312. Epub 2021 Jun 2.

School of Medicine, University College Dublin, Dublin, Ireland.

Background: Although it is accepted that providing medical students with opportunities to engage in research activity is beneficial, little data has been collated on how medical degree curricula may address this issue. This review aims to address this knowledge gap by conducting a scoping review examining curriculum initiatives that seek to enhance research experience for medical students.

Methods: This review looks to specifically look at 'doing research' as defined by the MEDINE 2 consensus rather than 'using research' for the bachelor component of the Bologna Cycle. Read More

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PyFF: A Fog-Based Flexible Architecture for Enabling Privacy-by-Design IoT-Based Communal Smart Environments.

Sensors (Basel) 2021 May 24;21(11). Epub 2021 May 24.

Grup de Recerca en Internet Technologies & Storage (GRITS), La Salle-Universitat Ramon Llull, C/Quatre Camins, 30, 08022 Barcelona, Spain.

The advent of the Internet of Things (IoT) and the massive growth of devices connected to the Internet are reshaping modern societies. However, human lifestyles are not evolving at the same pace as technology, which often derives into users' reluctance and aversion. Although it is essential to consider user involvement/privacy while deploying IoT devices in a human-centric environment, current IoT architecture standards tend to neglect the degree of trust that humans require to adopt these technologies on a daily basis. Read More

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How to Obtain the Maximum Properties Flexibility of 3D Printed Ketoprofen Tablets Using Only One Drug-Loaded Filament?

Molecules 2021 May 22;26(11). Epub 2021 May 22.

Department of Pharmaceutical Technology and Biopharmaceutics, Jagiellonian University Medical College, Medyczna 9, 30-688 Krakow, Poland.

The flexibility of dose and dosage forms makes 3D printing a very interesting tool for personalized medicine, with fused deposition modeling being the most promising and intensively developed method. In our research, we analyzed how various types of disintegrants and drug loading in poly(vinyl alcohol)-based filaments affect their mechanical properties and printability. We also assessed the effect of drug dosage and tablet spatial structure on the dissolution profiles. Read More

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From Amorphous Silicones to Si-Containing Highly Ordered Polymers: Some Romanian Contributions in the Field.

Polymers (Basel) 2021 May 16;13(10). Epub 2021 May 16.

Department of Inorganic Polymers, "Petru Poni" Institute of Macromolecular Chemistry, Aleea Gr. Ghica, Voda 41A, 700487 Iasi, Romania.

Polydimethylsiloxane (PDMS), in spite of its well-defined helical structure, is an amorphous fluid even at extremely high molecular weights. The cause of this behavior is the high flexibility of the siloxane backbone and the lack of intermolecular interactions attributed to the presence of methyl groups. These make PDMS incompatible with almost any organic or inorganic component leading to phase separation in siloxane-siloxane copolymers containing blocks with polar organic groups and in siloxane-organic copolymers, where dimethylsiloxane segments co-exist with organic ones. Read More

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Viewing SARS-CoV-2 Nucleocapsid Protein in Terms of Molecular Flexibility.

Authors:
Tatsuhito Matsuo

Biology (Basel) 2021 May 21;10(6). Epub 2021 May 21.

Institute for Quantum Life Science, National Institutes for Quantum and Radiological Science and Technology, 2-4 Shirakata, Tokai-mura, Naka-gun, Ibaraki 319-1106, Japan.

The latest coronavirus SARS-CoV-2, which causes coronavirus disease 2019 (COVID-19) pneumonia leading to the pandemic, contains 29 proteins. Among them, nucleocapsid protein (N) is one of the abundant proteins and shows multiple functions including packaging the RNA genome during the infection cycle. It has also emerged as a potential drug target. Read More

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Salmon sperm DNA binding study to cabozantinib, a tyrosine kinase inhibitor: Multi-spectroscopic and molecular docking approaches.

Int J Biol Macromol 2021 May 29;182:1852-1862. Epub 2021 May 29.

Pharmaceutical Analytical Chemistry Department, Faculty of Pharmacy, Kafrelsheikh University, Kafrelsheikh, P.O. Box 33511, Egypt; Department of Pharmaceutical Sciences, University of Maryland School of Pharmacy, 20 N. Pine Street, Baltimore, MD 21201, USA.

In the current work, the binding interaction of cabozantinib with salmon sperm DNA (SS-DNA) was studied under simulated physiological conditions (pH 7.4) using fluorescence emission spectroscopy, UV-Vis absorption spectroscopy, viscosity measurement, ionic strength measurement, FT-IR spectroscopy, and molecular modeling methods. The obtained experimental data demonstrated an apparent binding interaction of cabozantinib with SS-DNA. Read More

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Fusing strategic risk and futures methods to inform long-term strategic planning: case of water utilities.

Environ Syst Decis 2021 May 25:1-18. Epub 2021 May 25.

School of Water, Energy and Environment, Cranfield University, College Road, Cranfield, MK42 0AL Bedfordshire UK.

Risks and futures methods have complementary strengths as tools for managing strategic decisions under uncertainty. When combined, these tools increase organisational competency to evaluate and manage long-term risks, improving the flexibility and agility of the organisation to deal with gross uncertainties. Here, we set out a framework to guide the assessment of strategic risks for long-term business planning, based on its application at Portugal's largest water utility, Empresa Portuguesa das Águas Livres. Read More

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Predicting personal protective equipment use, trauma symptoms, and physical symptoms in the USA during the early weeks of the COVID-19 lockdown (April 9-18, 2020).

J Contextual Behav Sci 2021 Jul 20;21:37-47. Epub 2021 May 20.

Bowling Green State University, USA.

The COVID-19 pandemic created a complex psychological environment for Americans. In this study, 450 MTurk workers completed measures of sociodemographic characteristics, perceived risk for COVID-19, general perceived vulnerability to disease, intolerance of uncertainty, and psychological flexibility. These variables were used to predict COVID-19 preventive health behaviors (PPE use), psychological distress, and physical symptoms. Read More

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Dynamic load shifting for the abatement of GHG emissions, power demand, energy use, and costs in metropolitan hybrid wastewater treatment systems.

Water Res 2021 May 9;200:117224. Epub 2021 May 9.

Department of Civil and Environmental Engineering, University of California, Irvine, CA 92697-2175, USA; Water-Energy Nexus Center, University of California, Irvine, CA 92697-2175, USA. Electronic address:

The installation of satellite water resource recovery facilities (WRRFs) has strengthened the ability to provide cheap and reliable recycled water to meet the increasing water demand of expanding cities. As a result, recent studies have attempted to address the problem of how to optimally integrate satellite systems with other sectors of the urban sphere, such as the local economy, the power supply, and the regional carbon footprint. However, such studies are merely based on the spatial domain, thus neglecting potential time-dependent strategies that could further improve the sustainability of metropolitan water systems. Read More

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Solvent-induced conformational tuning of lysozyme protein adlayers on silica surfaces: A QCM-D and LSPR study.

Int J Biol Macromol 2021 May 19;182:1906-1914. Epub 2021 May 19.

School of Chemical Engineering, Sungkyunkwan University, Suwon 16419, Republic of Korea. Electronic address:

There is broad interest in functionalizing solid surfaces with lysozyme, which is a widely studied antimicrobial protein. To date, most efforts have focused on developing more effective immobilization schemes to promote lysozyme attachment in fully aqueous conditions, while there remains an outstanding need to understand how tuning the solution-phase conformational stability of lysozyme proteins can modulate adsorption behavior and resulting adlayer properties. Inspired by the unique conformational behavior of lysozyme proteins in water-ethanol mixtures, we conducted quartz crystal microbalance-dissipation (QCM-D) and localized surface plasmon resonance (LSPR) measurements to systematically investigate the adsorption behavior of lysozyme proteins onto silica surfaces across a wide range of water-ethanol mixtures. Read More

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Evaluation of the effect of a three-color ladder management model for knee osteoarthritis in the community.

Am J Transl Res 2021 15;13(4):3074-3083. Epub 2021 Apr 15.

Xujiahui Community Health Service Center Shanghai City, China.

Objective: To explore the application effect of a three-color ladder management system for knee osteoarthritis in the community.

Methods: Eighty-six patients with knee osteoarthritis in our community were obtained for study and randomly grouped. The control group received routine management, while the research group received three-color ladder management for 12 months. Read More

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