Aging (Albany NY) 2021 Jul 29;13(undefined). Epub 2021 Jul 29.
Institute of Anatomy and Cell Biology and Sir Run Run Shaw Hospital, Medical College, Zhejiang University, Hangzhou, China.
Dystonia is a disorder associated with abnormalities in many brain regions including the basal ganglia and cerebellum. The toxin 3-Nitropropionic acid (3-NP) can induce neuropathologies in the mice striatum and nigra substance, including excitotoxicity, neuroinflammation, and extensive neuronal atrophy, characterized by progressive motor dysfunction, dystonia, and memory loss, mimicking those observed in humans. We established a mouse model of dystonia by administering 3-NP. Read More