133,007 results match your criteria definition brostallicin

Flood insurance: The propensity and attitudes of informed people with disabilities towards risk.

J Environ Manage 2021 Jun 12;294:113032. Epub 2021 Jun 12.

University of São Paulo, Av. Prof. Luciano Gualberto, 908 - Butantã, São Paulo, SP, 05508-010, Brazil. Electronic address:

The literature documents that individual behavior and climatic change have recently been given more and more space in the definition of company strategies. However, in terms of preparing for catastrophes, few inquiries have been made into the individual propensity to acquire insurance, especially in terms of People with Disabilities (PwD). In this study, we assess the effect of information on the propensity of heads of households to acquire home insurance against forms of natural disasters, particularly flooding. Read More

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No clarity on the definition of parity: A survey accessing interpretation of the word parity amongst obstetricians and midwives and a literature review.

Eur J Obstet Gynecol Reprod Biol 2021 May 27;263:15-19. Epub 2021 May 27.

Department of Obstetrics and Gynaecology, Wrexham Maelor Hospital, Wrexham, LL13 7TD, United Kingdom.

Objectives: We assessed clinical interpretation of the word parity amongst obstetricians and midwives in Wales and performed a literature review to identify a standardised definition.

Study Design: A survey was conducted by electronic questionnaire to obstetricians across Wales and midwives across North Wales. The questionnaire was distributed to obstetricians using the Wales Information System. Read More

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United States Air Force Academy Cadets' Unprompted Knowledge of Concussions and Bell-Ringers/Dings: Perceived Differences and Similarities.

J Athl Train 2021 Jun 15. Epub 2021 Jun 15.

Associate Professor, Twitter:

Context: After a potential concussion mechanism, a cadet is unlikely to have a list of concussion signs and symptoms at their disposal. As such, unprompted concussion knowledge may be an essential factor in personal recognition.

Objective: The primary purpose of an overall study was to explore determinants that contributed to United States Air Force Academy (USAFA) cadets to disclose a concussion. Read More

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Population-based incidence and mortality of community-acquired pneumonia in Germany.

PLoS One 2021 15;16(6):e0253118. Epub 2021 Jun 15.

Pfizer Deutschland GmbH, Berlin, Germany.

Background: Little information on the current burden of community-acquired pneumonia (CAP) in adults in Germany is available.

Methods: We conducted a retrospective cohort study using a representative healthcare claims database of approx. 4 million adults to estimate the incidence rates (IR) and associated mortality of CAP in 2015. Read More

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Defining Death: Reasonableness and Legitimacy.

J Clin Ethics 2021 ;32(2):109-113

Neurocritical Care, Departments of Neurology/Neurosurgery, MacLean Center for Clinical Ethics, University of Chicago, 5841 S. Maryland Ave|MC 2030, Chicago, Illinois 60637 USA.

The recently published World Brain Death Project aims in alleviating inconsistencies in clinical guidelines and practice in the determination of death by neurologic criteria. However, critics have taken issue with a number of epistemic and metaphysical assertions that critics argue are either false, ad hoc, or confused. In this commentary, I discuss the nature of a definition of death; the plausibility of neurologic criteria as a sensible social, medical, and legal policy; and within a Rawlsian liberal framework, reasons for personal choice or accommodation among neurologic and circulatory definitions. Read More

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Randomness in Cancer Breakpoint Prediction.

J Comput Biol 2021 Jun 15. Epub 2021 Jun 15.

Laboratory of Bioinformatics, Faculty of Computer Science, National Research University Higher School of Economics, Moscow, Russia.

Cancer genomes are susceptible to multiple rearrangements by deleting, inserting, and translocating genomic regions. Recently, the problem of finding determinants of breakpoint formations was approached with machine learning methods; however, unlike cancer point mutations, breakpoint prediction appeared to be a more difficult task, and various machine learning models did not achieve high prediction power often slightly exceeding the threshold of random guessing. This raised the question of whether the breakpoints are random noise in cancer mutagenesis or there exist determinants in structural mutagenesis. Read More

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Diagnosis and treatment of Chiari malformation and syringomyelia in adults: international consensus document.

Neurol Sci 2021 Jun 15. Epub 2021 Jun 15.

Department of Neurosurgery, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.

Background: Syringomyelia and Chiari malformation are classified as rare diseases on Orphanet, but international guidelines on diagnostic criteria and case definition are missing.

Aim Of The Study: to reach a consensus among international experts on controversial issues in diagnosis and treatment of Chiari 1 malformation and syringomyelia in adults.

Methods: A multidisciplinary panel of the Chiari and Syringomyelia Consortium (4 neurosurgeons, 2 neurologists, 1 neuroradiologist, 1 pediatric neurologist) appointed an international Jury of experts to elaborate a consensus document. Read More

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A Vignette Study Analyzing Contextual Factors that Influence Emerging Adults' Definitions of Virginity Loss in German-Speaking Countries.

J Sex Res 2021 Jun 15:1-15. Epub 2021 Jun 15.

Gender Medicine Unit, Medical University of Innsbruck.

Past research on virginity loss definitions revealed that emerging adults' definitions of virginity loss are associated with emerging adults' own sociodemographic characteristics. However, previous research has not systematically studied whether emerging adults applied different criteria for virginity loss depending on the context of the judged behavior. The current study used vignettes to explore which contextual factors of an intimate partnered behavior influence emerging adults' definition of virginity loss. Read More

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A review of the evidence on the risk of congenital malformations and neurodevelopmental disorders in association with antiseizure medications during pregnancy.

Expert Opin Drug Saf 2021 Jun 15. Epub 2021 Jun 15.

Hospital Pharmacy, University Hospital Basel, Basel, Switzerland.

IntroductionThe majority of women with epilepsy require treatment with antiseizure medications (ASM) throughout pregnancy. However, in utero exposure to several ASM has been associated with an increased risk of congenital malformations and/or neurodevelopmental disorders (CM/NDD) in the child, but observational evidence is methodologically heterogeneous.Areas coveredWe critically evaluate current evidence on the risk of CM/NDD in children of women with epilepsy after in utero exposure to different ASM. Read More

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Fiber orientation distribution from diffusion MRI: Effects of inaccurate response function calibration.

J Neuroimaging 2021 Jun 15. Epub 2021 Jun 15.

Image Sciences Institute, University Medical Center Utrecht, Utrecht University, Utrecht, Netherlands.

Background And Purpose: Diffusion MRI of the brain enables to quantify white matter fiber orientations noninvasively. Several approaches have been proposed to estimate such characteristics from diffusion MRI data with spherical deconvolution being one of the most widely used methods. Spherical deconvolution requires to define--or derive from the data--a response function, which is used to compute the fiber orientation distribution (FOD). Read More

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Rapid diagnostic testing for antimicrobial stewardship: Utility in Asia Pacific.

Infect Control Hosp Epidemiol 2021 Jun 15:1-5. Epub 2021 Jun 15.

Clinical Pathology, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

Rapid diagnostic testing (RDT) can provide prompt, accurate identification of infectious organisms and be a key component of antimicrobial stewardship (AMS) programs. However, their use is less widespread in Asia Pacific than western countries. Cost can be prohibitive, particularly in less resource-replete settings. Read More

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The medical therapy for cerebellar mutism syndrome: a case report and literature review.

Childs Nerv Syst 2021 Jun 14. Epub 2021 Jun 14.

Neurosurgery and Functional Neurosurgery Unit, Department of Neurosciences, Meyer Children's Hospital Florence, Viale Gaetano Pieraccini, 24, 50139, Florence, Italy.

Purpose: Cerebellar mutism syndrome (CMS) represents a major complication affecting many children that undergo surgery for posterior fossa lesions. Etiology and pathophysiology are still not fully understood. CMS deeply influences quality of life and recovery of these patients. Read More

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Phase behavior and surface tension of soft active Brownian particles.

Soft Matter 2021 Jun 15. Epub 2021 Jun 15.

Department of Applied Physical Sciences, University of North Carolina at Chapel Hill, USA.

We study quasi two-dimensional, monodisperse systems of active Brownian particles (ABPs) for a range of activities, stiffnesses, and densities. We develop a microscopic, analytical method for predicting the dense phase structure formed after motility-induced phase separation (MIPS) has occurred, including the dense cluster's area fraction, interparticle pressure, and radius. Our predictions are in good agreement with our Brownian dynamics simulations. Read More

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Frequency of Post Treatment Control Varies by ART Restart and Viral Load Criteria.

AIDS 2021 Jun 14. Epub 2021 Jun 14.

Brigham and Women's Hospital, Harvard Medical School Harvard T.H. Chan School of Public Health, Boston, Massachusetts University of California, San Francisco, San Francisco, California Case Western Reserve University, Cleveland, Ohio University of Arizona, Tucson, Arizona University of Massachusetts-Baystate, Springfield, Massachusetts University of North Carolina, Chapel Hill, North Carolina National Institute of Allergy and Infectious Diseases, Bethesda, Maryland University of Caliornia, San Diego, San Diego, California Weill Cornell Medicine, New York, New York University of Pittsburgh, Pittsburgh, Pennsylvania Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts University of California, Los Angeles, Los Angeles, California University of Minnesota, Minneapolis, Minnesota University of Pennsylvania, Philadelphia, Pennsylvania University of Washington, Seattle, Washington, USA.

Clinical trials including an analytical treatment interruption (ATI) are vital for evaluating the efficacy of novel strategies for HIV remissions. We briefly describe an interactive tool for predicting viral rebound timing in ATI trials and the impact of posttreatment controller (PTC) definitions on PTC frequency estimates. A 4-week viral load threshold of 1000 cps/ml provides both high specificity and sensitivity for PTC detection. Read More

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[Intermittent Claudication Secondary to Spine and/or Spinal Cord Diseases].

Toshio Fukutake

Brain Nerve 2021 Jun;73(6):671-683

Department of Neurology, Kameda Medical Center.

Currently, intermittent claudication is classified into the vascular (mainly secondary to peripheral arterial disease) and neurogenic (mainly secondary to lumbar canal stenosis) types. Intermittent claudication due to spinovascular insufficiency (myelopathy) has rarely been reported since it was first described by J. Dejerine in 1894. Read More

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Defining the Molecular Hallmarks of T-Cell Memory.

Cold Spring Harb Perspect Biol 2021 Jun 14. Epub 2021 Jun 14.

Department of Microbiology and Immunology, Emory University School of Medicine, Atlanta, Georgia 30322, USA.

The pool of memory CD8 T cells is comprised of highly specialized subpopulations of cells with both shared and distinct functions. The ongoing study of T-cell memory is focused on how these different subpopulations arise, how the cells are maintained over the life of the host, and how the cells protect a host against reinfection. As a field we have used the convenience of a narrow range of surface markers to define and study these memory T-cell subsets. Read More

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Variation in definitions of burn wound infection limits the validity of systematic review findings in burn care: A systematic review of systematic reviews.

Burns 2021 May 15. Epub 2021 May 15.

Centre for Academic Child Health, University of Bristol, 1-5 Whiteladies Road, Bristol BS8 1NU, United Kingdom. Electronic address:

Introduction: Systematic reviews (SR) of high-quality randomised controlled trials can identify effective treatments for burn wound infections (BWIs). Clinical heterogeneity in outcome definitions can prevent valid evidence synthesis, which may limit the reliability of the findings of SRs affected by this heterogeneity. This SR aimed to investigate whether there is variation BWI definitions across studies in SRs of burn care interventions and its impact on identification of effective treatments for patients with burn injuries. Read More

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Case studies for implementing MCDA for tender and purchasing decisions in hospitals in Indonesia and Thailand.

J Pharm Policy Pract 2021 Jun 14;14(1):52. Epub 2021 Jun 14.

Abbott Laboratories ltd, No.1, Q House Lumpini, 30th & 33rd Floor, South Sathorn Road, Thungmahamek, Sathorn, Bangkok, 10120, Thailand.

Background: A multi-criteria decision analysis (MCDA) approach has been suggested for helping purchasers in low- and middle-income countries in an evidence-based assessment of multi-source pharmaceuticals to mitigate potential adverse consequences of price-based decisions on patient access to effective medicines. Six workshops for developing MCDA-instruments for purchasing were conducted in Indonesia, Kazakhstan, Thailand, and Kuwait in 2017-2020. In Indonesia and Thailand, two pilot-initiatives aimed to implement the instruments for hospital drug purchasing decisions. Read More

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Diagnostic tools for neurosyphilis: a systematic review.

BMC Infect Dis 2021 Jun 14;21(1):568. Epub 2021 Jun 14.

Infection Control Department, Hospital das Clinicas, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.

Purpose: Increasing incidences of syphilis highlight the preoccupation with the occurrence of neurosyphilis. This study aimed to understand the current diagnostic tools and their performance to detect neurosyphilis, including new technologies and the variety of existing methods.

Methods: We searched databases to select articles that reported neurosyphilis diagnostic methods and assessed their accuracy, presenting sensitivity and specificity values. Read More

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Which factors contribute to sexual well-being? A comparative study among 17 to 20 year old boys and girls in Belgium and Ecuador.

Cult Health Sex 2021 Jun 14:1-17. Epub 2021 Jun 14.

Department of Public Health and Primary Care, Ghent University, Ghent, Belgium.

Despite recognition that sexual well-being is an important part of adolescent sexual and reproductive health, a clear description of adolescent sexual well-being does not yet exist. Through six in-depth interviews and four focus group discussions with 56 young people in two distinct contexts (Belgium and Ecuador), we used the social-ecological framework to identify factors influencing adolescent sexual well-being. According to respondents, the main factors that influence adolescent sexual well-being are not only situated at the individual (having knowledge and skills and being physically, sexually and mental mature and healthy) and interpersonal levels (positive attraction towards others and communication about sexuality), but at a broader societal level, including social acceptance of sex, gender and sexual diversity and its (legal) translation into comprehensive sexuality education and the ready availability of contraceptives. Read More

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Improving interprofessional handover on labor and delivery: A needs assessment study.

J Interprof Care 2021 Jun 14:1-7. Epub 2021 Jun 14.

Faculty of Nursing, Department of Health Quality, Queens University, Kingston, ON, Canada.

Handover is the transfer of important clinical information between health providers. The current report describes a needs assessment of interprofessional labor and delivery handover at an urban hospital in Canada. The goal of this study was to explore the perceptions of the current handover meeting and opportunities for improvement. Read More

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An unsupervised multi-scale framework with attention-based network (MANet) for lung 4D-CT registration.

Phys Med Biol 2021 Jun 14. Epub 2021 Jun 14.

Shandong Provincial Third Hospital, Jinan, Shandong, CHINA.

Deformable image registration (DIR) of 4D-CT is very important in many radiotherapeutic applications including tumor target definition, image fusion, dose accumulation and response evaluation. It is a challenging task to performing accurate and fast DIR of lung 4D-CT images due to its large and complicated deformations. In this study, we propose an unsupervised multi-scale DIR framework with attention-based network (MANet). Read More

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Governance of maternity services: Effects on the management of perinatal deaths and bereavement services.

Midwifery 2021 May 28;101:103049. Epub 2021 May 28.

Pregnancy Loss Research Group, The Irish Centre for Maternal and Child Health Research (INFANT), University College Cork, Cork University Maternity Hospital, 5th floor, Wilton, Cork, Ireland; Cork University Maternity Hospital, Wilton, Cork, Ireland.

Background: External inquiries are carried out following adverse maternal/perinatal events, to examine the care provided and make recommendations to improve it. Clinical governance ensures that organisations promote high-quality care and are accountable for the care they provide, thus contributing to its improvement.

Objective: This study examined how Irish perinatal bereavement services and the management of perinatal deaths (including events leading up to the deaths) were affected by developments in maternity services governance as described in ten Irish enquiry reports published over 14 years (2005-18). Read More

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Breast reconstruction and radiation therapy: An Italian expert Delphi consensus statements and critical review.

Cancer Treat Rev 2021 May 27;99:102236. Epub 2021 May 27.

Group for Reconstructive and Therapeutic Advancements (G.RE.T.A.), Milan, Naples, Catania, Italy.

Breast conserving surgery (BCS) plus radiation therapy (RT) or mastectomy have shown comparable oncological outcomes in early-stage breast cancer and are considered standard of care treatments. Postmastectomy radiation therapy (PMRT) targeted to both the chest wall and regional lymph nodes is recommended in high-risk patients. Oncoplastic breast conserving surgery (OBCS) represents a significant recent improvement in breast surgery. Read More

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Patterns of failure and implications for clinical target volume definition of locally advanced T4b rectal cancer identified with magnetic resonance imaging and treated using neoadjuvant chemoradiotherapy and surgery.

Radiother Oncol 2021 Jun 11. Epub 2021 Jun 11.

Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital & Institute, Beijing 100142, PR China. Electronic address:

Background And Purpose: Elective irradiation of the external iliac lymph nodes (EIN) has always been advocated for T4b rectal cancer with anterior organ invasion without convincing evidence. This study aimed to explore the patterns of treatment failure for locally advanced T4b rectal cancer treated using neoadjuvant chemoradiotherapy (NCRT) and surgery. This information may help to clarify whether the current definition of the clinical target volume (CTV) is still appropriate. Read More

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Definition, prevalence, and risk factors of low sex hormone-binding globulin in US adults.

Yutang Wang

J Clin Endocrinol Metab 2021 Jun 14. Epub 2021 Jun 14.

School of Science, Psychology and Sport, Federation University Australia, Ballarat, VIC, Australia.

Context: Lower sex hormone-binding globulin (SHBG) is associated with many diseases including cardiovascular disease, cancer, polycystic ovarian syndrome, arthritis, and liver disease. However, the definition of low SHBG and its prevalence in US adults are unknown.

Objective: To define low SHBG and to determine its prevalence and risk factors in US adults. Read More

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Effect of rK39 testing in guiding treatment initiation and outcome in patients with visceral leishmaniasis in Ethiopia: A prospective cohort study.

PLoS One 2021 14;16(6):e0253303. Epub 2021 Jun 14.

Mekelle University College of Health Sciences, Mekelle, Ethiopia.

Background: The rapid diagnostic test (RDT) rK39 is currently being used for routine diagnosis of visceral leishmaniasis (VL) in East Africa. However, continuous monitoring of the performance of the assay, in particular its impact on the clinical decision in initiating anti-leishmanial treatment and outcomes remains needed as there are concerns about the diagnostic performance of this test.

Methods: VL patients prospectively enrolled in a diagnostic trial and with rK39 RDT were included. Read More

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Synchronization Rather Than Finite-Time Synchronization Results of Fractional-Order Multi-Weighted Complex Networks.

IEEE Trans Neural Netw Learn Syst 2021 Jun 14;PP. Epub 2021 Jun 14.

This article investigates the synchronization of fractional-order multi-weighted complex networks (FMWCNs) with order α∈ (0,1). A useful fractional-order inequality t₀C Dtα V(x(t))≤ -μ V(x(t)) is extended to a more general form t₀C Dtα V(x(t))≤ -μ Vɣ(x(t)),ɣ∈ (0,1], which plays a pivotal role in studies of synchronization for FMWCNs. However, the inequality t₀C Dtα V(x(t))≤ -μ Vɣ(x(t)),ɣ∈ (0,1) has been applied to achieve the finite-time synchronization for fractional-order systems in the absence of rigorous mathematical proofs. Read More

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Developing Empirical Latent Profiles of Impulsive Aggression and Mood in Youths across Three Outpatient Samples.

J Clin Child Adolesc Psychol 2021 Jun 14:1-16. Epub 2021 Jun 14.

Department of Psychiatry, Virginia Commonwealth University.

: Aggression with impulsivity and reactivity (AIR) may distinguish a subset of youth from those with attention problems, rule-breaking behavior, or mood disorders, potentially with differential treatment response. Yet, DSM-5 and ICD-10 do not include an AIR diagnosis. Thus, we empirically grouped youths into profiles based on AIR, manic, depressive, rule-breaking, and self-harm behaviors; examined which profiles replicated across three samples; and characterized profile sets on demographic and clinical features. Read More

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Manometric parameters, when measured with the 3-dimensional high-definition anorectal manometry probe, poorly predict prolonged balloon expulsion time.

Neurogastroenterol Motil 2021 Jun 14:e14180. Epub 2021 Jun 14.

Division of Gastroenterology and Hepatology, University of Calgary, Calgary, AB, Canada.

Background: There are little data evaluating the performance of the 3-dimensional high-definition anorectal manometry (3D-HDAM) system in the diagnosis of dyssynergic defecation. Physical properties of the thicker, rigid, 3D-HDAM probe may have implications on the measurements of anorectal pressures.

Aim: Our aim was to compare 3D-HDAM to balloon expulsion test and magnetic resonance (MR) defecography. Read More

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