AIDS 2021 Jun 14. Epub 2021 Jun 14.
Brigham and Women's Hospital, Harvard Medical School Harvard T.H. Chan School of Public Health, Boston, Massachusetts University of California, San Francisco, San Francisco, California Case Western Reserve University, Cleveland, Ohio University of Arizona, Tucson, Arizona University of Massachusetts-Baystate, Springfield, Massachusetts University of North Carolina, Chapel Hill, North Carolina National Institute of Allergy and Infectious Diseases, Bethesda, Maryland University of Caliornia, San Diego, San Diego, California Weill Cornell Medicine, New York, New York University of Pittsburgh, Pittsburgh, Pennsylvania Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts University of California, Los Angeles, Los Angeles, California University of Minnesota, Minneapolis, Minnesota University of Pennsylvania, Philadelphia, Pennsylvania University of Washington, Seattle, Washington, USA.
Clinical trials including an analytical treatment interruption (ATI) are vital for evaluating the efficacy of novel strategies for HIV remissions. We briefly describe an interactive tool for predicting viral rebound timing in ATI trials and the impact of posttreatment controller (PTC) definitions on PTC frequency estimates. A 4-week viral load threshold of 1000 cps/ml provides both high specificity and sensitivity for PTC detection. Read More