407,349 results match your criteria defined study


Investigation of the prevalence of non-COVID-19 infectious diseases during the COVID-19 pandemic.

Authors:
C Tanislav K Kostev

Public Health 2021 Dec 11;203:53-57. Epub 2021 Dec 11.

Epidemiology, IQVIA, Frankfurt Am Main, Germany.

Objectives: This study aimed to investigate non-COVID-19-related upper respiratory tract infections (URTIs), gastrointestinal infections (GIIs) and urinary tract infections (UTIs) during the COVID-19 pandemic in Germany.

Study Design: Cross-sectional study.

Methods: Patients with diagnoses of URTIs, GIIs and UTIs from 994 general practitioners (GP) and 192 paediatric practices that routinely send anonymous data to the Disease Analyzer database (IQVIA) were investigated. Read More

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December 2021

Adherence to Guideline-Recommended Cancer Screening in Stroke Survivors: A Nationwide Analysis.

J Stroke Cerebrovasc Dis 2022 Jan 12;31(3):106297. Epub 2022 Jan 12.

Clinical and Translational Neuroscience Unit, Department of Neurology and Feil Brain and Mind Research Institute, Weill Cornell Medicine, New York, USA. Electronic address:

Objectives: Cancer can present as stroke. Several cancer types have established screening guidelines. We investigated adherence to guideline-recommended cancer screening in stroke survivors versus the general population. Read More

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January 2022

Compliance with recommended Varroa destructor treatment regimens improves the survival of honey bee colonies over winter.

Res Vet Sci 2021 Dec 31;144:1-10. Epub 2021 Dec 31.

Agroscope, Swiss Bee Research Centre, Bern, Switzerland; Department of Ecology and Evolution, Biophore, UNIL-Sorge, University of Lausanne, Lausanne, Switzerland.

The ectoparasitic mite Varroa destructor affects honey bee colony health and survival negatively, thus compelling beekeepers to treat their colonies every year. A broadly used mite control regimen is based on two organic molecules: formic and oxalic acids. To ensure optimal efficiency, several applications of these acids at pre-defined time points are recommended. Read More

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December 2021

Distribution of chronic cough phenotypes in the general population: A cross-sectional analysis of the LEAD cohort in Austria.

Respir Med 2021 Dec 30;192:106726. Epub 2021 Dec 30.

Ludwig Boltzmann Institute for Lung Health, Vienna, Austria; Sigmund Freud University, Faculty of Medicine, Vienna, Austria.

Rationale: Recent guidelines consider chronic cough to be a unique clinical entity with different phenotypes. We aimed to investigate them in a general population and to describe prevalence, distribution, and characteristics of these phenotypes within the Austrian general population.

Methods: From the LEAD study, a longitudinal observational population-based cohort, data from questionnaires and spirometry of 10,057 adult participants was analysed. Read More

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December 2021

A Population-Based Study of Patients with Sleep-Wake Disorders Undergoing Elective Instrumented Spinal Surgery.

World Neurosurg 2022 Jan 12. Epub 2022 Jan 12.

Division of Neurosurgery, Department of Surgery, College of Medicine and Life Sciences, The University of Toledo, Toledo, OH, USA; ProMedica Physicians Neurosurgery, Toledo, OH, USA.

Background: Sleep-wake disorders are associated with multisystemic pathologies, but the clinical risk that such disorders carry for spinal surgery patients is not well understood. This population-based study comprehensively evaluates the significance of sleep-related risk factors on instrumented spinal surgery outcomes.

Methods: National Inpatient Sample data for hospitalizations of patients undergoing elective instrumented spine surgery between 2008 and 2014 was analyzed using national estimates. Read More

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January 2022

Mitochondrial DNA Sequence Variation and Risk of Glioma.

Mitochondrion 2022 Jan 12. Epub 2022 Jan 12.

Department of Cancer Epidemiology, H. Lee Moffitt Cancer Center, Tampa, FL.

Background: Malignant gliomas are the most common primary adult brain tumors, with a poor prognosis and ill-defined etiology. Mitochondrial DNA (mtDNA) sequence variation has been linked with certain cancers; however, research on glioma is lacking.

Methods: We examined the association of common (minor allele frequency ≥ 5%) germline mtDNA variants and haplogroups with glioma risk in 1,653 glioma cases and 1,065 controls from a US case-control study, and 432 glioma cases and 1,556 matched controls from the UK Biobank cohort (UKB). Read More

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January 2022

Non-contact whole-chamber charge density mapping of the left ventricle: preclinical evaluation in a sheep model.

Heart Rhythm 2022 Jan 12. Epub 2022 Jan 12.

Electrophysiology and Heart Modelling Institute (LIRYC), Bordeaux-Pessac, France; Department of Electrophysiology and Cardiac Stimulation, Centre Hospitalier Universitaire de Bordeaux, Bordeaux-Pessac, France; inHEART, Bordeaux-Pessac, France. Electronic address:

Background: Conventional contact-based electroanatomic mapping is poorly suited for rapid or dynamic ventricular arrhythmias. Whole-chamber charge density (CD) mapping could efficiently characterize complex ventricular tachyarrhythmias and yield insights into their underlying mechanisms.

Objective: This study sought to evaluate the feasibility and accuracy of non-contact whole-chamber left ventricular (LV) CD mapping, and to characterize CD activation patterns during sinus rhythm, ventricular pacing, and ventricular fibrillation (VF). Read More

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January 2022

Neutrophil to Lymphocyte Ratio and Platelet to Lymphocyte Ratio Reflect Disease Activity and Flares in Patients with Systemic Lupus Erythematosus - a Prospective Study.

Joint Bone Spine 2022 Jan 12:105342. Epub 2022 Jan 12.

Division of Rheumatology, University Medicine Cluster, National University Hospital, 5 Lower Ken Ridge Road, 119074, SINGAPORE; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 10 Medical Drive, 117597, SINGAPORE. Electronic address:

Objectives: To determine the association between neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) with disease activity and flares in an inception cohort of patients with systemic lupus erythematosus (SLE) using a prospective study design.

Methods: Consecutive adult patients (age≥21) who fulfilled the 1997 American College of Rheumatology (ACR) or the 2012 Systemic Lupus International Collaboration Clinic Classification (SLICC) Criteria for SLE were followed every 3 months, with SLE disease activity assessed by using SLEDAI-2K, and disease flares defined and captured by the SELENA-SLEDAI Flare Index (SFI). NLR and PLR were computed from the automated machine-counted blood count differentials. Read More

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January 2022

Indication for Proximal Femoral Replacement is Associated with Risk of Failure.

J Arthroplasty 2022 Jan 12. Epub 2022 Jan 12.

Department of Orthopaedic Surgery, Rush University Medical Center, 1611 W. Harrison St, Chicago, IL, 60612 USA.

Background: Proximal femoral replacement (PFR) is reserved as a salvage procedure following failed total hip arthroplasty (THA) or after wide margin resection of tumors involving the proximal femur. Although failure of the PFR construct remains a significant problem, indication has not previously been investigated as a risk factor for failure.

Methods: This study retrospectively evaluated patients who underwent PFR over a consecutive fifteen-year period for primary sarcoma or metastatic disease of the proximal femur, compared to conversion to PFR after failed THA. Read More

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January 2022

Factors Associated with Progression of Different Prediabetic Status to Diabetes: A Community-based Cohort Study.

Diabetes Res Clin Pract 2022 Jan 12:109193. Epub 2022 Jan 12.

Department of Endocrinology and Metabolism, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200080, China. Electronic address:

Aims: To examine the predictive factors associated with the progression of different prediabetic status to diabetes.

Methods: A two-year retrospective cohort study was conducted on 5741 participants aged 40 years or older. Finally, 1685 participants with prediabetes defined by IFG (impaired fasting glucose), IGT (impaired glucose tolerance) and CGI (combined IFG and IGT) were included. Read More

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January 2022

Associations of variability in body weight and glucose levels with the risk of hip fracture in people with diabetes.

Metabolism 2022 Jan 12:155135. Epub 2022 Jan 12.

Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea; Department of Medical Informatics, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea. Electronic address:

Background: Diabetes is associated with a high risk of fragility fracture. However, there are controversies regarding the effect of fluctuations in metabolic parameters on the risk of fracture. We aimed to investigate the associations of body weight or glucose variability or their combination with the risk of hip fracture in people with diabetes. Read More

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January 2022

A Prospective cross-sectional study estimated glomerular filtration rate from creatinine and cystatin C in adults with solid tumors.

Kidney Int 2022 Jan 12. Epub 2022 Jan 12.

LIM 12, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP, BR.

Current guidelines recommend estimating glomerular filtration rate (eGFR) using creatinine (eGFRcr) with the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation as the first test for GFR evaluation, but the Cockcroft-Gault (CG) equation is still commonly used in oncology practice and clinical trials despite increasing evidence of its inaccuracy compared to measured GFR (mGFR). Guidelines recommend eGFR using cystatin C (eGFRcys) or both markers (eGFRcr-cys) as a confirmatory test, but neither was carefully evaluated in cancer patients. Therefore, we compared performance of the CKD-EPI equations and others to the CG equation in adults with a variety of solid tumors. Read More

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January 2022

Role of pulmonary function in predicting new-onset cardiometabolic diseases and cardiometabolic multimorbidity.

Chest 2022 Jan 12. Epub 2022 Jan 12.

Department of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, Suzhou 215123, P. R. China. Electronic address:

Background: Although pulmonary function has been studied in relation to individual cardiometabolic diseases, uncertainty persists about the difference in risk magnitudes of pulmonary function for these diseases and its association with cardiometabolic multimorbidity (CM).

Research Question: Does pulmonary function have different risk magnitudes for cardiometabolic diseases and CM?

Study Design And Methods: This study used data from the UK Biobank, including 357,433 individuals with no cardiometabolic diseases at baseline (stage I) and 35,034 individuals with 1 cardiometabolic disease at baseline (stage II). Pulmonary function was measured by forced vital capacity (FVC) or forced expiratory volume in 1 second (FEV1). Read More

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January 2022

Acute respiratory deterioration in rheumatoid arthritis-associated interstitial lung disease: a single-center study.

Chest 2022 Jan 12. Epub 2022 Jan 12.

Department of Pulmonary and Critical Care Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea. Electronic address:

Background: Interstitial lung disease (ILD) is associated with increased morbidity and mortality in rheumatoid arthritis (RA). Moreover, acute exacerbation (AE) is a devastating complication of RA-ILD. However, there is little data on AE in RA-ILD. Read More

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January 2022

Prenatal Exposure to Teratogenic Medications in the Era of Risk Evaluation and Mitigation Strategies (REMS).

Am J Obstet Gynecol 2022 Jan 12. Epub 2022 Jan 12.

Department of Pharmaceutical Outcomes and Policy, College of Pharmacy, University of Florida; Department of Epidemiology, College of Medicine and College of Public Health and Health Professions, University of Florida; Center for Drug Evaluation and Safety (CoDES), University of Florida. Electronic address:

Background: Prevention of prenatal exposures to teratogenic drugs is a significant clinical and public health concern. With the enactment of the FDA Amendment Act in 2007, the Food and Drug Administration has begun to require manufacturers to implement Risk Evaluation and Mitigation Strategies (REMS) to prevent prenatal exposures. Among 12 REMS drugs, several had predecessor risk mitigation plans (e. Read More

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January 2022

The deterioration of calcified cartilage integrity reflects the severity of osteoarthritis-A structural, molecular, and biochemical analysis.

FASEB J 2022 Feb;36(2):e22142

Centre for Biomedical Technologies, Queensland University of Technology, Brisbane, Queensland, Australia.

The calcified cartilage zone (CCZ) is a thin interlayer between the hyaline articular cartilage and the subchondral bone and plays an important role in maintaining the joint homeostasis by providing biological and mechanical support from unmineralized cartilage to the underlying mineralized subchondral bone. The hallmark of CCZ characteristics in osteoarthritis (OA) is less well known. The aim of our study is to evaluate the structural, molecular, and biochemical composition of CCZ in tissues affected by primary knee OA and its relationship with disease severity. Read More

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February 2022

Comparison of the long-term oncologic outcomes of robotic-assisted and video-assisted thoracoscopic lobectomy for resectable non-small cell lung carcinoma.

J Robot Surg 2022 Jan 15. Epub 2022 Jan 15.

Division of Thoracic Surgery, The Ohio State University Wexner Medical Center, 410 West 10th Avenue, N846a Doan Hall, Columbus, OH, 43210, USA.

The current oncologic outcomes of robotic-assisted lobectomy compared to video-assisted thoracoscopic lobectomy are currently not well defined. This study compares the overall survival and recurrence-free survival rates between the two approaches for patients with resectable non-small cell lung carcinoma. This is a retrospective review of 200 patients diagnosed with resectable primary lung carcinoma who underwent minimally invasive lobectomy from March 2014 to May 2018. Read More

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January 2022

Development and future prospective of treatment for localized prostate cancer with high-intensity focused ultrasound.

J Med Ultrason (2001) 2022 Jan 15. Epub 2022 Jan 15.

Department of Urology, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa, 259-1193, Japan.

High-intensity focused ultrasound (HIFU) was experimentally used for focal therapy for anti-cancer effects in prostate cancer (PC). Focal therapy is a diagnosis-based investigational treatment option for localized PC that cures clinically significant PC (csPC) while preserving the anatomical structures related to urinary and sexual function based on its spread observed using multi-parametric magnetic resonance imaging (mpMRI). The European Association of Urology indicated that the current status of focal therapy for localized PC was an investigational modality and encouraged prospective recording of outcomes and recruitment of suitable patients in 2018. Read More

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January 2022

Plasma metabolomic profiles for colorectal cancer precursors in women.

Eur J Epidemiol 2022 Jan 15. Epub 2022 Jan 15.

Department of Nutrition, Harvard T.H. Chan School of Public Health, 667 Huntington Avenue, Kresge 906A, Boston, MA, 02115, USA.

How metabolome changes influence the early process of colorectal cancer (CRC) development remains unknown. We conducted a 1:2 matched nested case-control study to examine the associations of pre-diagnostic plasma metabolome (profiled using LC-MS) with risk of CRC precursors, including conventional adenomas (n = 586 vs. 1141) and serrated polyps (n = 509 vs. Read More

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January 2022

A retrospective study to evaluate the CT and MR imaging findings of non-Hodgkin's lymphoma affecting the jaw bones.

Oral Radiol 2022 Jan 15. Epub 2022 Jan 15.

Department of Radiology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, No. 639, ZhiZaoJu Road, Shanghai, 200011, China.

Objective: To explore the CT and MR imaging findings of non-Hodgkin's lymphoma (NHL) involving the jaw bones.

Methods: Gnathic NHLs were retrospectively analyzed in 52 patients. The imaging findings were observed from the lesion number, location, size, shape, margin, density and signal intensity, CT value, bone structure change, and soft tissue mass. Read More

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January 2022

Quantitative evaluation of PSMA PET imaging using a realistic anthropomorphic phantom and shell-less radioactive epoxy lesions.

EJNMMI Phys 2022 Jan 15;9(1). Epub 2022 Jan 15.

Functional Imaging, BC Cancer, 600 W 10th Avenue, Vancouver, BC, V5Z4E6, Canada.

Background: Positron emission tomography (PET) with prostate specific membrane antigen (PSMA) have shown superior performance in detecting metastatic prostate cancers. Relative to [F]fluorodeoxyglucose ([F]FDG) PET images, PSMA PET images tend to visualize significantly higher-contrast focal lesions. We aim to evaluate segmentation and reconstruction algorithms in this emerging context. Read More

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January 2022

Lindane removal in contaminated soil by defined microbial consortia and evaluation of its effectiveness by bioassays and cytotoxicity studies.

Int Microbiol 2022 Jan 15. Epub 2022 Jan 15.

Department of Biotechnology, National Institute of Technology Durgapur, Mahatma Gandhi Avenue, Durgapur, 713209, West Bengal, India.

Lindane contamination in different environmental matrices has been a global concern for long. Bacterial consortia consisting of Paracoccus sp. NITDBR1, Rhodococcus rhodochrous NITDBS9, Ochrobactrum sp. Read More

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January 2022

Virologic non-suppression and early loss to follow up among pregnant and non-pregnant adolescents aged 15-19 years initiating antiretroviral therapy in South Africa: a retrospective cohort study.

J Int AIDS Soc 2022 Jan;25(1):e25870

Centre for Infectious Disease Epidemiology and Research, School of Public Health and Family Medicine, University of Cape Town, Cape Town, South Africa.

Introduction: Older adolescents aged 15-19 years continue to have high rates of loss to follow up (LTFU), and high rates of virologic non-suppression (VNS) compared to younger adolescents and adults. Adolescent females are at risk of pregnancy, which puts those living with HIV at a dual vulnerability. Our study assessed the factors associated with VNS and LTFU in older adolescents (including pregnant females) who initiated antiretroviral therapy (ART) in South Africa. Read More

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January 2022

Investigating Membrane-Mediated Antimicrobial Peptide Interactions with Synchrotron Radiation Far-Infrared Spectroscopy.

Chemphyschem 2022 Jan 14:e202100815. Epub 2022 Jan 14.

Department 7.1 Radiometry with Synchrotron Radiation and, Department 7.2 X-Ray Metrology with Synchrotron Radiation, Physikalisch-Technische Bundesanstalt (PTB), Abbestr. 2-12, 10587, Berlin, Germany.

Synchrotron radiation-based Fourier transform infrared spectroscopy enables access to vibrational information from mid over far infrared to even terahertz domains. This information may prove critical for the elucidation of fundamental bio-molecular phenomena including folding-mediated innate host defence mechanisms. Antimicrobial peptides (AMPs) represent one of such phenomena. Read More

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January 2022

Rotation in Correspondence Analysis from the Canonical Correlation Perspective.

Authors:
Naomichi Makino

Psychometrika 2022 Jan 15. Epub 2022 Jan 15.

Benesse Educational Research and Development Institute, 1-34, Ochiai, Tama-shi, Tokyo, Japan.

Correspondence analysis (CA) is a statistical method for depicting the relationship between two categorical variables, and usually places an emphasis on graphical representations. In this study, we discuss a CA formulation based on canonical correlation analysis (CCA). In CCA-based formulation, the correlations within and between row/column categories in a reduced dimensional space can be expressed by canonical variables. Read More

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January 2022

Higher fruit and vegetable variety associated with lower risk of cognitive impairment in Chinese community-dwelling older men: a 4-year cohort study.

Eur J Nutr 2022 Jan 15. Epub 2022 Jan 15.

Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.

Purpose: Few studies have examined the variety in fruit and vegetable (FV) intake with cognitive impairment in older adults. This study examined the associations of variety in fruit, vegetable and combined FV with 4-year incident cognitive impairment in Chinese community-dwelling older adults.

Methods: Data was derived from a cohort study among Chinese community-dwelling older adults aged ≥ 65 years in Hong Kong. Read More

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January 2022

Healed neointima of in-stent restenosis lesions in patients with stable angina pectoris: an intracoronary optical coherence tomography study.

Heart Vessels 2022 Jan 15. Epub 2022 Jan 15.

Department of Cardiovascular Medicine, Toho University Faculty of Medicine, 6-11-1 Omorinishi, Ota-ku, Tokyo, 143-8541, Japan.

The phenomenon to heal neointimal rupture or thrombus after coronary stenting occurs as well as in native coronary artery. We investigated clinical characteristics and neointimal vulnerability of healed neointima by optical coherence tomography (OCT). We treated 67 lesions by percutaneous coronary intervention for in-stent restenosis (ISR) and conducted OCT examinations. Read More

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January 2022

A Retrospective Study of the Differences in the Induction of Regulatory T Cells Between Adult Patients with Eosinophilic Esophagitis and Gastroesophageal Reflux Disease.

Dig Dis Sci 2022 Jan 15. Epub 2022 Jan 15.

Division of Gastroenterology, Department of Internal Medicine 2, Kawasaki Medical School, 2-6-1 Nakasange, Kita-ku, Okayama, 700-8505, Japan.

Background: The incidence of eosinophilic esophagitis (EoE), a Th2-type allergic disease of the esophagus, has increased with the higher prevalence of gastroesophageal reflux disease (GERD). Both conditions are chronic inflammatory diseases with similar clinical presentations, yet their pathogenesis is thought to differ. Recent evidence indicates that forkhead box P3 (FOXP3)-positive regulatory T cells (Tregs) play a critical role in immune tolerance and control of Th2-biased responses in various allergic diseases. Read More

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January 2022

MRI-diagnosis of category LR-M observations in the Liver Imaging Reporting and Data System v2018: a systematic review and meta-analysis.

Eur Radiol 2022 Jan 15. Epub 2022 Jan 15.

Department of Radiology and Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Republic of Korea.

Objectives: We performed a meta-analysis to determine the probability of hepatocellular carcinoma (HCC) and non-HCC malignancies in Liver Imaging Reporting and Data System (LI-RADS) category M (LR-M) observations and the frequency of defined LR-M imaging features on MRI using LI-RADS v2018.

Methods: We searched the MEDLINE and EMBASE databases to identify studies published from 1 January 2018 to 16 March 2021 reporting the probability of category LR-M in HCC and non-HCC malignancies on MRI. The pooled percentages of HCC and non-HCC malignancies in the LR-M observations were evaluated. Read More

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January 2022

Defining research and infrastructure priorities for cancer survivorship in Australia: a modified Delphi study.

Support Care Cancer 2022 Jan 15. Epub 2022 Jan 15.

Department of Health Services Research, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.

Purpose: The aim of this study was to establish research and infrastructure priorities for cancer survivorship.

Methods: A two-round modified online Delphi study was completed by Australian experts in cancer survivorship. Initial priorities were generated from the literature and organized into four research categories: physiological outcomes, psychosocial outcomes, population groups, and health services; and one research infrastructure category. Read More

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January 2022