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Neonatal Lymphopenia Screening Is Important For Early Diagnosis of Severe Combined Immunodeficiency.

Am J Perinatol 2021 Jun 11. Epub 2021 Jun 11.

Division of Hematology and Oncology, Immunology, Department of Pediatrics, Erciyes University, School of Medicine, Kayseri, Turkey.

Objective:  T-cell receptor excision circles are expensive for neonatal severe combined immunodeficiency screening in developing countries. We aimed to detect immunodeficiencies presenting with lymphopenia to enable screening in the general population and to improve awareness regarding lymphopenia among clinicians.

Study Design:  This study was conducted prospectively. Read More

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[Early Pulmonary Rehabilitation after Long Term Mechanical Ventilation].

Pneumologie 2021 Jun 11;75(6):432-438. Epub 2021 Jun 11.

Fachkrankenhaus Kloster Grafschaft GmbH, Abteilung Pneumologie I.

Background:  The term early rehabilitation is defined as a rehabilitation that begins in the early phase after acute illness and is statutory positioned in § 39SGB V. Aim of this investigation is to describe the quality of outcome of pulmonary early rehabilitation.

Method:  Prospective census of functional parameters, status of ventilation and discharge-disposition in a specialized unit for early pulmonary rehabilitation over a period of one year. Read More

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Inches, Centimeters, and Yards: Overlooked Definition Choices Inhibit Interpretation of Morphine Equivalence.

Clin J Pain 2021 Jun 11. Epub 2021 Jun 11.

Injury Prevention Research Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA Department of Health Outcomes & Biomedical Informatics, University of Florida College of Medicine, Gainesville, Florida, USA Institute for Pharmaceutical Outcomes & Policy, University of Kentucky College of Pharmacy, Lexington, Kentucky, USA Department of Pharmacy Practice and Science, University of Kentucky College of Pharmacy, Lexington, Kentucky, USA Division of Pharmaceutical Outcomes and Policy, University of North Carolina School of Pharmacy, Chapel Hill, North Carolina, USA Cecil G. Sheps Center for Health Services Research, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA UNC Hospitals Pain Management Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA Department of Anesthesiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.

Objective: Morphine-standardized doses are used in clinical practice and research to account for molecular potency. 90 milligrams of morphine equivalents (MME) per day are considered a "high dose" risk threshold in guidelines, laws, and by payers. Although ubiquitously cited, the "CDC definition" of daily MME lacks a clearly defined denominator. Read More

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Cutting Edge: Novel Treatment Options Targeting Corneal Neovascularization to Improve High-Risk Corneal Graft Survival.

Cornea 2021 Jun 9. Epub 2021 Jun 9.

Department of Ophthalmology, University of Cologne, Faculty of Medicine, University Hospital Cologne, Cologne, Germany; and Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany.

Purpose: Corneal neovascularization is an important risk factor for graft rejection after keratoplasty, although its role in posterior lamellar keratoplasty is not yet well defined. The aim of this work was to describe clinically available approaches that target corneal neovascularization preoperatively to improve graft survival after subsequent penetrating keratoplasty (PK) and to present findings on Descemet membrane endothelial keratoplasty (DMEK) in eyes with neovascularization.

Methods: Recent work on the use of anti-vascular endothelial growth factor agents, fine needle diathermy (FND), and corneal collagen crosslinking (CXL) to regress corneal neovascularization before PK is summarized. Read More

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Confinement Driven Anomalous Freezing in Nano Porous Spray Dried Microspheres.

Nanotechnology 2021 Jun 11. Epub 2021 Jun 11.

Bhabha Atomic Research Centre, Glass and Advanced Materials Division, Mumbai, 400085, INDIA.

One-step evaporative jamming of colloidal silica particles in contact-free spray droplets resulted in well-defined powder micro-granules with interstitial nanopores. This paper reports the anomalous freezing behaviour of confined water in the microspheres synthesized using spray drying. It has been revealed that the freezing point of water in these microspheres gets significantly lowered (~ -45o C) owing to confinement effect. Read More

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Late morbidity and mortality following revascularization surgery for moyamoya disease in the pediatric population.

J Neurosurg Pediatr 2021 Jun 11:1-6. Epub 2021 Jun 11.

Objective: There are limited reports on long-term morbidity in pediatric patients who have undergone surgical revascularization for moyamoya disease (MMD). Here, the authors report long-term morbidity and mortality in a population of pediatric patients who underwent pial synangiosis for MMD from 1988 through 2016.

Methods: A single-center retrospective review of the hospital and personal operative databases of the senior authors was carried out to identify all patients who were treated for MMD at Boston Children's Hospital between 1988 and 2016, and who experienced any episode of late morbidity or mortality, which the authors defined as an event resulting in significant neurological deficit or death occurring more than 1 year after revascularization surgery. Read More

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The effect of minimally invasive lumbar decompression surgery on sagittal spinopelvic alignment in patients with lumbar spinal stenosis: a 5-year follow-up study.

J Neurosurg Spine 2021 Jun 11:1-8. Epub 2021 Jun 11.

1Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, Osaka; and.

Objective: Several studies have examined the relationship between sagittal spinopelvic alignment and clinical outcomes after spinal surgery. However, the long-term reciprocal changes in sagittal spinopelvic alignment in patients with lumbar spinal stenosis after decompression surgery remain unclear. The aim of this study was to investigate radiographic changes in sagittal spinopelvic alignment and clinical outcomes at the 2-year and 5-year follow-ups after minimally invasive lumbar decompression surgery. Read More

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Neurosurgery Research and Education Foundation funding conversion to National Institutes of Health funding.

J Neurosurg 2021 Jun 11:1-8. Epub 2021 Jun 11.

1Department of Neurological Surgery, Ohio State University Wexner Medical Center, Columbus, Ohio.

Objective: The Neurosurgery Research and Education Foundation (NREF) provides research support for in-training and early career neurosurgeon-scientists. To define the impact of this funding, the authors assessed the success of NREF awardees in obtaining subsequent National Institutes of Health (NIH) funding.

Methods: NREF in-training (Research Fellowship [RF] for residents) and early career awards/awardees (Van Wagenen Fellowship [VW] and Young Clinician Investigator [YCI] award for neurosurgery faculty) were analyzed. Read More

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Fabrication and measurement of fiber optic localized surface plasmon resonance sensor based on gold nanoparticle dimer.

Spectrochim Acta A Mol Biomol Spectrosc 2021 May 29;261:120034. Epub 2021 May 29.

Department of Electronics and Electrical Engineering, Dankook University, Yongin 16890, South Korea. Electronic address:

Fiber optic localized surface plasmon resonance (FO LSPR) sensors capable of portable, real-time, and remote sensing are emerging with the progress of lab-on-fiber technology. However, the small area of the substrate by the optical fiber often restricts the sensitivity of the FO LSPR sensors. To improve the performance of the FO LSPR sensors, it is necessary to enhance the interactions between incident light and plasmonic nanostructures within a defined region. Read More

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Association of short-term fine particulate matter exposure with pulmonary function in populations at intermediate to high-risk of cardiovascular disease: A panel study in three Chinese cities.

Ecotoxicol Environ Saf 2021 Jun 8;220:112397. Epub 2021 Jun 8.

Department of Epidemiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China; Key Laboratory of Cardiovascular Epidemiology, Chinese Academy of Medical Sciences, Beijing 100037, China. Electronic address:

Background: Decline in pulmonary function contributes to increasing cardiovascular disease (CVD) risk. Although adverse effects of short-term exposure to fine particulate matter (PM) on pulmonary function have been recognized in healthy people or patients with respiratory disease, these results were not well illustrated among people with elevated CVD risk.

Materials And Methods: A panel study was conducted in three Chinese cities with three repeated visits among populations at intermediate to high-risk of CVD, defined as treated hypertension patients or those with blood pressure ≥ 130/80 mmHg, who met any of the three conditions including abdominal obesity, dyslipidemia, and diabetes mellitus. Read More

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Energy balance of torrefied microalgal biomass with production upscale approached by life cycle assessment.

J Environ Manage 2021 Jun 8;294:112992. Epub 2021 Jun 8.

Mechanical Engineering Department, De La Salle University, 2401 Taft Avenue, 0922, Manila, Philippines; Center for Engineering and Sustainable Development Research, De La Salle University, Manila, 0922, Philippines.

Torrefaction is a thermochemical process used to convert the biomass into solid fuel. In this study, torrefaction increased the raw microalgal biomass' energy content from 20.22 MJ⋅kg to 27. Read More

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Characterizing the river water quality in China: Recent progress and on-going challenges.

Water Res 2021 May 29;201:117309. Epub 2021 May 29.

Ecological Modelling Laboratory, Department of Physical & Environmental Sciences, University of Toronto, Toronto, ON, M1C 1A4, Canada. Electronic address:

Food production systems, urbanization, and other anthropogenic activities dramatically alter natural hydrological and nutrient cycles, and are primarily responsible for water quality impairments in China's rivers. This study compiled a 16-year (2003-2018) dataset of river water quality (161,337 records from 2424 sites), watershed/landscape features, and meteorological conditions to investigate the spatial water quality patterns and underlying drivers of river impairment (defined as water quality worse than Class V according to China's Environmental Quality Standards for Surface Waters, GB3838-2002) at a national scale. Our analysis provided evidence of a distinct water quality improvement with a gradual decrease in the frequency of prevalence of anoxic conditions, an alleviation of the severity of heavy metal pollution, whereas the cultural eutrophication has only been moderately mitigated between 2003 and 2018. Read More

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Chemotherapy-induced ovarian failure in young women with early breast cancer: Prospective analysis of four randomised neoadjuvant/adjuvant breast cancer trials.

Eur J Cancer 2021 Jun 8;152:193-203. Epub 2021 Jun 8.

German Breast Group, Neu-Isenburg, Germany.

Background: Young women receiving chemotherapy for early breast cancer (EBC) have a high probability for ovarian failure, defined by chemotherapy-induced amenorrhea (CIA) as a surrogate. CIA is insufficiently reliable and reproducible. We analysed chemotherapy-induced ovarian failure (CIOF) by assessing hormone parameters, CIA, and antral follicle count (AFC). Read More

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Predicting the effect of salt on heat tolerance of Listeria monocytogenes in meat and fish products.

Int J Food Microbiol 2021 Jun 1;352:109265. Epub 2021 Jun 1.

The National Food Institute, Technical University of Denmark, Division for Microbiology and Production, Kemitorvet, Building 202, DK-2800 Kgs. Lyngby, Denmark.

Listeria monocytogenes is a potentially fatal foodborne pathogen that can be found in various ready-to-eat (RTE) products. It tolerates adverse conditions such as high salt concentrations and refrigerated storage, thus, the elimination of the pathogen in food processing often relies on heat processing. The objective of this study was to create a model to predict the effect of salt on heat tolerance of L. Read More

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FACTORS ASSOCIATED WITH INPATIENT ENDOSCOPY DELAY AND ITS IMPACT ON HOSPITAL LENGTH-OF-STAY AND 30-DAY READMISSION.

Clin Gastroenterol Hepatol 2021 Jun 8. Epub 2021 Jun 8.

Backgrounds And Aims: Inpatient endoscopy delay (IED) negatively impacts the delivery of high-quality care. We aimed to identify factors associated with IED and evaluate its effect on hospital length-of-stay (LOS) and re-admission.

Methods: Retrospective analysis of all inpatient endoscopies performed between November 2017 to November 2019 at a tertiary care center. Read More

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Metformin and primary bone cancer risk in Taiwanese patients with type 2 diabetes mellitus.

Authors:
Chin-Hsiao Tseng

Bone 2021 Jun 8:116037. Epub 2021 Jun 8.

Department of Internal Medicine, National Taiwan University College of Medicine, Taipei, Taiwan; Division of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan; Division of Environmental Health and Occupational Medicine of the National Health Research Institutes, Zhunan, Taiwan. Electronic address:

Background: The effect of metformin on primary bone cancer risk has not been researched. This retrospective cohort study investigated the risk of primary bone cancer between metformin initiators and non-metformin initiators in patients with type 2 diabetes mellitus.

Methods: A total of 673,532 patients with newly diagnosed type 2 diabetes mellitus and had been prescribed antidiabetic drugs for 2 or more times during 1999-2009 were enrolled from Taiwan's National Health Insurance. Read More

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Improvement of pneumococcal pneumonia diagnosis using quantitative real-time PCR targeting lytA in adult patients: A prospective cohort study.

Clin Microbiol Infect 2021 Jun 8. Epub 2021 Jun 8.

Infectious Diseases Unit, Hospital Universitari Mútua de Terrassa, Barcelona; Universitat Internacional de Catalunya. Electronic address:

Objectives: The aim of the study was to assess the performance of real-time polymerase chain reaction (PCR) targeting the lytA gene (rtPCR-lytA) in plasma, urine and nasopharyngeal (NP) samples for the diagnosis of pneumococcal community-acquired pneumonia (P-CAP).

Methods: Prospective observational study including all consecutive adult CAP patients from November 2015 to May 2017. P-CAP was defined if pneumococcus was identified using conventional methods (CM) and/or a positive rtPCR-lytA was detected in blood, urine or NP samples (NP cut-off ≥8000 copies/mL). Read More

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Consensus Statement on the Treatment of Massive Irreparable Rotator Cuff Tears - A Delphi Approach by the Neer Circle of the American Shoulder and Elbow Surgeons.

J Shoulder Elbow Surg 2021 Jun 8. Epub 2021 Jun 8.

Department of Orthopedic Surgery, Mayo Clinic Arizona, Scottsdale, AZ, USA.

Background: Management of massive irreparable rotator cuff tears (MIRCTs) remains controversial due to variability in patient features and outcomes contributing to a lack of unanimity in treatment recommendations. The purpose of this study was to implement the Delphi process using experts from the Neer Circle of the American Shoulder and Elbow Surgeons (ASES) to determine areas of consensus regarding treatment options for a variety of MIRCTs.

Methods: A panel of 120 shoulder surgeons were sent a survey regarding MIRCT treatments including: arthroscopic débridement and partial cuff repair, graft augmentation, reverse shoulder arthroplasty (RSA), superior capsular reconstruction (SCR), and tendon transfers. Read More

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Development of a Pilot-Scale HuskyJet Binder Jet 3D Printer for Additive Manufacturing of Pharmaceutical Tablets.

Int J Pharm 2021 Jun 8:120791. Epub 2021 Jun 8.

Department of Chemical and Biomolecular Engineering, University of Connecticut, Storrs, CT 06084, USA; Polymer Program, Institute of Materials Science, University of Connecticut, Storrs, CT 06084, USA. Electronic address:

This paper reports a custom-built binder jet 3D printer for pilot-scale manufacturing of pharmaceutical tablets. The printer is equipped with high-throughput piezoelectric inkjet print heads and allows direct control of several key process parameters, including the build layer thickness, amount of jetted liquid binder, and powder spreading rate. The effects of these parameters on the properties of the as-printed tablets were studied using a powder mixture of lactose monohydrate and Kollidon® VA64 (KL) and an aqueous binder containing 5% of KL. Read More

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Can we AlphaFold our way out of the next pandemic?

J Mol Biol 2021 Jun 8:167093. Epub 2021 Jun 8.

Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK. Electronic address:

The announcement of the outstanding performance of AlphaFold 2 in the CASP 14 protein structure prediction competition came at the end of a long year defined by the COVID-19 pandemic. With an infectious organism dominating the world stage, the developers of Alphafold 2 were keen to play their part, accurately predicting novel structures of two proteins from SARS-CoV-2. In their blog post of December 2020, they highlighted this contribution, writing "we've also seen signs that protein structure prediction could be useful in future pandemic response efforts". Read More

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Prenatal Antidepressant Use and the Implication of Hypertensive Disorders during Pregnancy.

Am J Obstet Gynecol 2021 Jun 8. Epub 2021 Jun 8.

School of Pharmacy, College of Pharmacy, Taipei Medical University. Electronic address:

Background: Evidence regarding prenatal antidepressant use and the development of hypertensive disorders during pregnancy is inconsistent. Previous studies have reported that antidepressant use during pregnancy increases the risk of gestational hypertension and preeclampsia, but the results of these studies are potentially confounded by important methodologic limitations. Furthermore, it remains unknown whether a higher cumulative dose of antidepressant increases the risk of hypertensive disorders of pregnancy. Read More

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Differences in coronavirus disease 2019 screening, diagnosis, and hospitalization rates among U.S. pregnant women with and without a substance use disorder.

Am J Obstet Gynecol 2021 Jun 8. Epub 2021 Jun 8.

Department of Obstetrics, Gynecology & Reproductive Sciences Magee-Womens Research Institute University of Pittsburgh Pittsburgh, Pennsylvania.

Objective: Pregnant women are at increased risk for severe morbidity and mortality due to respiratory infections like SARS-CoV-2 (COVID-19) during pregnancy. Those with substance use disorders (SUD) may be especially vulnerable due to high rates of smoked tobacco, cannabis and methamphetamine use which adversely affect pulmonary function. However, little is known about differential effects of COVID-19 on pregnant women with and without SUD. Read More

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Optical Coherence Tomography Angiography Compared with Multimodal Imaging for Diagnosing Neovascular Central Serous Chorioretinopathy.

Am J Ophthalmol 2021 Jun 8. Epub 2021 Jun 8.

Department of Ophthalmology & Visual Sciences, The Chinese University of Hong Kong, Hong Kong; 2010 Retina & Macula Centre, Hong Kong.

Purpose: To assess the diagnostic accuracy of optical coherence tomography angiography (OCTA) compared with multimodal imaging for CNV in CSC eyes and to determine the features that predicted CNV.

Design: Prospective cross-sectional study.

Methods: Consecutive CSC patients were recruited from retina clinic. Read More

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Comparison of Cystatin C-based and creatinine-based glomerular filtration rate in the prediction of postoperative residual hypertension in aldosterone-producing adenoma patients after adrenalectomy.

Clin Chim Acta 2021 Jun 8. Epub 2021 Jun 8.

Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan. Electronic address:

Renal function is associated with postoperative residual hypertension in aldosterone-producing adenoma(APA) patients. Cystatin C-based glomerular filtration rate (GFR) can more accurately estimate renal function than creatinine-based methods. However, which renal function estimation method can more accurately predict postoperative hypertension in APA patients is still unknown. Read More

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Patient Demographics and Clinic Type Are Associated With Patient Engagement Within a Remote Monitoring Program.

Telemed J E Health 2021 Jun 11. Epub 2021 Jun 11.

Center for Health Disparities Research, Medical University of South Carolina, Charleston, South Carolina, USA.

Remote physiological monitoring (RPM) is accessible, convenient, relatively inexpensive, and can improve clinical outcomes. Yet, it is unclear in which clinical setting or target population RPM is maximally effective. To determine whether patients' demographic characteristics or clinical settings are associated with data transmission and engagement. Read More

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Impurity-Induced Emission in Re-Doped WS Monolayers.

Nano Lett 2021 Jun 11. Epub 2021 Jun 11.

Department of Physics, National University of Singapore, 2 Science Drive 3, 117551 Singapore.

Impurity doping is a viable route toward achieving desired subgap optical response in semiconductors. In strongly excitonic two-dimensional (2D) semiconductors such as transition metal dichalcogenides (TMDs), impurities are expected to result in bound-exciton emission. However, doped TMDs often exhibit a broad Stokes-shifted emission without characteristic features, hampering strategic materials engineering. Read More

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Combining MGMT promoter pyrosequencing and protein expression to optimize prognosis stratification in glioblastoma.

Cancer Sci 2021 Jun 11. Epub 2021 Jun 11.

Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, National Clinical Research Center for Neurological Diseases, Center of Brain Tumor, Institute for Brain Disorders and Beijing Key Laboratory of Brain Tumor, Beijing, China.

Pyrosequencing (PSQ) represents the golden standard for MGMT promoter status determination. Binary interpretation of results based on the threshold from the average of several CpGs tested would neglect the existence of the "gray zone". How to define the gray zone and reclassify patients in this subgroup remains to be elucidated. Read More

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Variables affecting the quality of anticoagulation in atrial fibrillation patients newly initiating vitamin K antagonists: insights from the national and multicentre SULTAN registry.

Europace 2021 Jun 11. Epub 2021 Jun 11.

Department of Cardiology, Hospital Clínico Universitario Virgen de la Arrixaca, University of Murcia, Instituto Murciano de Investigación Biosanitaria (IMIB-Arrixaca), CIBERCV, Ctra. Madrid-Cartagena s/n, 30120 El Palmar, Murcia, Spain.

Aims: Vitamin K antagonists (VKAs) are effective drugs reducing the risk for stroke in atrial fibrillation (AF), but the benefits derived from such therapy depend on the international normalized ratio (INR) maintenance in a narrow therapeutic range. Here, we aimed to determine independent variables driving poor anticoagulation control [defined as a time in therapeutic range (TTR) <65%] in a 'real world' national cohort of AF patients.

Methods And Results: The SULTAN registry is a multicentre, prospective study, involving patients with non-valvular AF from 72 cardiology units expert in AF in Spain. Read More

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Antimicrobial effects of plant extracts against Clostridium perfringens with respect to food-relevant influencing factors.

J Food Prot 2021 Jun 11. Epub 2021 Jun 11.

LMU München: Ludwig-Maximilians-Universitat Munchen Schoenleutner Strasse 8 GERMANY Oberschleissheim 85764.

The application of plant extracts (PEs) could be a promising option to satisfy consumers' demand for natural additives to inhibit growth of variable pathogenic bacteria. Thus, the aim of this study was to develop a standardized microdilution method to examine the antimicrobial effects of ten hydrophilic plant extracts against two strains of C. perfringens facing various food-relevant influencing factors. Read More

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Persistent thrombocytopenia predicts poor long-term survival in patients with antiphospholipid syndrome: a 38-year follow-up study.

Rheumatology (Oxford) 2021 Jun 11. Epub 2021 Jun 11.

Universidad Autonoma de Barcelona, Vall d´Hebron University Hospital, Barcelona, Spain.

Objectives: To investigate the impact of thrombocytopenia on survival in patients with antiphospholipid syndrome (APS).

Methods: Thrombocytopenia and other predictors of outcome were retrospectively evaluated in an antiphospholipid-antibody (aPL)-positive and APS cohort with 38-year follow-up (1980-2018). Thrombocytopenia was defined as < 150 × 109 platelets/l. Read More

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