6,301 results match your criteria defined physiologic

Mental Health in Early Childhood and Changes in Cardiometabolic Dysregulation by Preadolescence.

Psychosom Med 2021 Apr;83(3):256-264

From the Department of Social and Behavioral Sciences (Qureshi, Tiemeier, Kubzansky), Harvard T.H. Chan School of Public Health, Boston, Massachusetts; Department of Psychology, Education and Child Studies (Derks), Erasmus University Rotterdam, Rotterdam, the Netherlands; Department of Child and Adolescent Psychiatry/Psychology (Derks) and; The Generation R Study Group, Department of Pediatrics (Jaddoe), Erasmus Medical Center Rotterdam, Rotterdam, the Netherlands; and Department of Epidemiology (Williams, Koenen), Harvard T.H. Chan School of Public Health, Boston, Massachusetts.

Objective: Poor mental health in childhood is associated with a greater risk of cardiometabolic disease in adulthood, but less is known about when these associations begin to emerge. This study tests whether poor mental health (indexed by emotional and behavioral problems) in early childhood predicts increases in cardiometabolic dysregulation over 4 years of follow-up.

Methods: Data are from 4327 participants in the Generation R Study. Read More

View Article and Full-Text PDF

CRISPR screens in physiologic medium reveal conditionally essential genes in human cells.

Cell Metab 2021 Feb 23. Epub 2021 Feb 23.

Morgridge Institute for Research, Madison, WI 53715, USA; Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA; Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI 53706, USA; University of Wisconsin Carbone Cancer Center, Madison, WI 53705, USA. Electronic address:

Forward genetic screens across hundreds of cancer cell lines have started to define the genetic dependencies of proliferating human cells and how these vary by genotype and lineage. Most screens, however, have been carried out in culture media that poorly reflect metabolite availability in human blood. Here, we performed CRISPR-based screens in traditional versus human plasma-like medium (HPLM). Read More

View Article and Full-Text PDF
February 2021

Head to head comparison of Ga-NGUL and Ga-PSMA-11 in patients with metastatic prostate cancer: a prospective study.

J Nucl Med 2021 Feb 26. Epub 2021 Feb 26.

Seoul National University College of Medicine, Korea, Republic of.

Ga-NOTA Glu-Urea-Lys (NGUL) is a novel prostate-specific membrane antigen (PSMA) targeting tracer used for positron emission tomography/computed tomography (PET/CT) imaging. This study aims to compare the performance in the detection of primary and metastatic lesions, and to compare biodistribution between Ga-NGUL and Ga-PSMA-11 in the same patients with metastatic prostate cancer. Eleven patients with histologically proven, metastatic prostate cancer were prospectively recruited. Read More

View Article and Full-Text PDF
February 2021

An Evidence Based Review of Epidurolysis for the Management of Epidural Adhesions.

Psychopharmacol Bull 2020 Oct;50(4 Suppl 1):74-90

Urits, MD, Department of Anesthesiology, Louisiana State University School of Medicine, Shreveport, LA; Beth Israel Deaconess Medical Center, Department of Anesthesiology, Critical Care and Pain Medicine, Harvard Medical School, Boston, MA. Berger, MD, PhD, Beth Israel Deaconess Medical Center, Department of Anesthesiology, Critical Care, and Pain Medicine, Harvard Medical School, Boston, MA. Schwartz, DO, Kassem, MD, Mount Sinai Medical Center, Department of Anesthesiology, Miami Beach, FL. Brinkman, BS, Foster, BS, Miro, BS, University of Arizona College of Medicine-Phoenix, Department of Anesthesiology, Phoenix, AZ. Kaye, MD, PhD, Departments of Anesthesiology and Pharmacology, Toxicology and Neurosciences, Louisiana State University School of Medicine, Shreveport, LA. Manchikanti, MD, Pain Management Centers of America, Paducah, KY. Viswanath, MD, Department of Anesthesiology, Louisiana State University School of Medicine, Shreveport, LA; Valley Pain Consultants - Envision Physician Services, Phoenix, AZ; University of Arizona College of Medicine-Phoenix, Department of Anesthesiology, Phoenix, AZ; Creighton University School of Medicine, Department of Anesthesiology, Omaha, NE.

Purpose Of Review: This review presents epidurolysis as a procedure to alleviate pain and disability from epidural adhesions. It reviews novel and groundbreaking evidence, describing the background, indications, benefits and adverse events from this procedure in an effort to provide healthcare experts with the data required to decide on an intervention for their patients.

Recent Findings: Epidural adhesions (EA) or epidural fibrosis (EF) is defined as non-physiologic scar formation secondary to a local inflammatory reaction provoked by tissue trauma in the epidural space. Read More

View Article and Full-Text PDF
October 2020

Liver epigenome changes in patients with hepatopulmonary syndrome: A pilot study.

PLoS One 2021 25;16(2):e0245046. Epub 2021 Feb 25.

Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain.

The hepatopulmonary syndrome (HPS) is defined by the presence of pulmonary gas exchange abnormalities due to intrapulmonary vascular dilatations in patients with chronic liver disease. Changes in DNA methylation reflect the genomic variation. Since liver transplant (LT) reverts HPS we hypothesized that it may be associated with specific liver epigenetic changes. Read More

View Article and Full-Text PDF
February 2021

Low energy availability and impact sport participation as risk factors for urinary incontinence in female athletes.

J Pediatr Urol 2021 Jan 30. Epub 2021 Jan 30.

Division of Sports Medicine, Department of Orthopedics, Boston Children's Hospital, 319 Longwood Avenue, Ste 6, Boston, MA, 02115, USA; Harvard Medical School, 25 Shattuck St, Boston, MA, 02115, USA; Neuroendocrine Unit, Massachusetts General Hospital, 55 Fruit Street, 457B, Boston, MA, 02114, USA. Electronic address:

Introduction: Relative Energy Deficiency in Sport (RED-S) is a clinical syndrome that includes the many complex health and performance consequences of low energy availability (EA) in athletes, when there is insufficient caloric intake to meet exercise-related energy expenditure and to support basic physiologic functions. There is a high prevalence of urinary incontinence (UI) in female athletes and it is more common in female athletes than non-athletes. The objective of this study was to determine if low EA is associated with UI in a population of adolescent and young adult female athletes and to evaluate for an association between sport categories and UI. Read More

View Article and Full-Text PDF
January 2021

Domain-independent simulation of physiologically relevant callus shape in mechanoregulated models of fracture healing.

J Biomech 2021 Mar 6;118:110300. Epub 2021 Feb 6.

Department of Mechanical Engineering and Mechanics, Lehigh University, Bethlehem, PA, USA.

Mechanoregulatory models have been used to predict the progression of bone fracture healing for more than two decades. However, many published studies share the same fundamental limitation: callus development proceeds within a pre-defined domain that both restricts and directs healing and leads to some non-physiologic healing patterns. To address this limitation, we added two spatial proximity functions to an existing mechanoregulatory model of fracture healing to control the localization of callus within the healing domain. Read More

View Article and Full-Text PDF

Circulating serum miR-200c and miR-34a-5p as diagnostic biomarkers for endometriosis.

J Gynecol Obstet Hum Reprod 2021 Apr 15;50(4):102092. Epub 2021 Feb 15.

Department of Medical Biochemistry, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkiye.

Objective: Endometriosis is defined by the presence of endometrial glands and stroma grow in areas outside the uterus. A simple blood test for endometriosis-specific biomarkers would offer a more timely accurate diagnosis of the disease and could lead to earlier treatment intervention. Alterations in microRNA (miRNA) levels in blood may reflect changes during normal physiologic processes and have been related to several pathologic conditions, including gynecologic diseases. Read More

View Article and Full-Text PDF

Do all cardiac surgery patients benefit from antifibrinolytic therapy?

J Card Surg 2021 Apr 14;36(4):1450-1457. Epub 2021 Feb 14.

Divisions of Trauma, Surgical Critical Care, and Burns, Daughtry Family Department of Surgery, University of Miami Miller School of Medicine and Jackson Memorial Hospital, Miami, Florida, USA.

Background: In trauma patients, the recognition of fibrinolysis phenotypes has led to a re-evaluation of the risks and benefits of antifibrinolytic therapy (AF). Many cardiac patients also receive AF, but the distribution of fibrinolytic phenotypes in that population is unknown. The purpose of this hypothesis-generating study was to fill that gap. Read More

View Article and Full-Text PDF

Human Health Risks of Conducted Electrical Weapon Exposure: A Systematic Review.

JAMA Netw Open 2021 02 1;4(2):e2037209. Epub 2021 Feb 1.

Netherlands Institute for Health Services Research (Nivel), Utrecht, the Netherlands.

Importance: Conducted electrical weapons (CEWs) are used broadly as a less-lethal force option for police officers. However, there is no clear picture of the possible health risks in humans on the basis of rigorously assessed scientific evidence from the international peer-reviewed literature.

Objective: To synthesize and systematically evaluate the strength of published evidence for an association between exposure to different models of CEWs and adverse acute as well as chronic conditions. Read More

View Article and Full-Text PDF
February 2021

Hypolipidemia contributing to the severity of sepsis triggered by influenza a virus: A case report.

J Clin Transl Res 2020 Dec 11;6(6):198-202. Epub 2020 Dec 11.

Department of Internal Medicine, Creighton University, Nebraska, United States.

Hypolipidemia, an increasingly diagnosed disorder, is defined as a low-density lipoprotein serum level of <50 mg/dL. Hypolipidemia can be asymptomatic. However, the effect of hypolipidemia on sepsis survival and severity is still to be identified. Read More

View Article and Full-Text PDF
December 2020

P38MAPK inhibition in aged astrocytes decreases reactive astrocytes, inflammation and increases nutritive capacity after oxygen-glucose deprivation.

Aging (Albany NY) 2021 02 9;13(5):6346-6358. Epub 2021 Feb 9.

Department for Neonatology, Charité University Medical Center, Berlin 13353, Germany.

Proper astroglial functioning is essential for the development and survival of neurons and oligodendroglia under physiologic and pathological circumstances. Indeed, malfunctioning of astrocytes represents an important factor contributing to brain injury. However, the molecular pathways of this astroglial dysfunction are poorly defined. Read More

View Article and Full-Text PDF
February 2021

An approach to define newborns´ sniffing position using an angle based on reproducible facial landmarks.

Paediatr Anaesth 2021 Apr 28;31(4):404-409. Epub 2021 Feb 28.

Department of Neonatology, University Children's Hospital of Tuebingen, Tuebingen, Germany.

Background: The neutral or sniffing position is advised for mask ventilation in neonates to avoid airway obstruction. As definitions are manifold and often unspecific, we wanted to investigate the reliability and reproducibility of angle measurements based on facial landmarks that may be used in future clinical trials to determine a hypothetical head position with minimal airway obstruction during mask ventilation.

Methods: In a prospective single-center observational study, 2D sagittal photographs of 24 near-term and term infants were taken, with five raters marking facial landmarks to assess interobserver agreement of those landmarks and angle δ, defined as the angle between the line parallel to the lying surface and the line crossing Subnasale (Sn) and Porion' (P'). Read More

View Article and Full-Text PDF

Lymphocyte-Specific Biomarkers Associated With Preterm Birth and Bronchopulmonary Dysplasia.

Front Immunol 2020 21;11:563473. Epub 2021 Jan 21.

Division of Neonatology, Department of Pediatrics, University of Rochester, Rochester, NY, United States.

Many premature babies who are born with neonatal respiratory distress syndrome (RDS) go on to develop Bronchopulmonary Dysplasia (BPD) and later Post-Prematurity Respiratory Disease (PRD) at one year corrected age, characterized by persistent or recurrent lower respiratory tract symptoms frequently related to inflammation and viral infection. Transcriptomic profiles were generated from sorted peripheral blood CD8+ T cells of preterm and full-term infants enrolled with consent in the NHLBI Prematurity and Respiratory Outcomes Program (PROP) at the University of Rochester and the University at Buffalo. We identified outcome-related gene expression patterns following standard methods to identify markers for oxygen utilization and BPD as outcomes in extremely premature infants. Read More

View Article and Full-Text PDF

Correlation Between Peak Expiratory Flow Rate, Markers of Adiposity, and Anthropometric Measures in Medical Students in Pakistan.

Cureus 2020 Dec 31;12(12):e12408. Epub 2020 Dec 31.

Physiology, Combined Military Hospital (CMH) Medical College, Lahore, PAK.

Obesity has been defined as the excessive deposition of fats on the body. It presents a very significant risk to humanity, with debilitating consequences for healthcare systems worldwide. It has multiple effects on the body, including grave consequences on the cardiovascular and respiratory systems. Read More

View Article and Full-Text PDF
December 2020

Prediction of Late-Onset Sepsis in Preterm Infants Using Monitoring Signals and Machine Learning.

Crit Care Explor 2021 Jan 27;3(1):e0302. Epub 2021 Jan 27.

Department of Applied Physics, Eindhoven University of Technology, Eindhoven, The Netherlands.

Objectives: Prediction of late-onset sepsis (onset beyond day 3 of life) in preterm infants, based on multiple patient monitoring signals 24 hours before onset.

Design: Continuous high-resolution electrocardiogram and respiration (chest impedance) data from the monitoring signals were extracted and used to create time-interval features representing heart rate variability, respiration, and body motion. For each infant with a blood culture-proven late-onset sepsis, a Cultures, Resuscitation, and Antibiotics Started Here moment was defined. Read More

View Article and Full-Text PDF
January 2021

A "Smart" Biosensor-Enabled Intravascular Catheter and Platform for Dynamic Delivery of Propofol to "Close the Loop" for Total Intravenous Anesthesia.

Mil Med 2021 01;186(Suppl 1):370-377

University of Memphis, Department of Biomedical Engineering, Engineering Technology Building Room 321D, Memphis, TN 38152, USA.

Background: Target-controlled infusion anesthesia is used worldwide to provide user-defined, stable, blood concentrations of propofol for sedation and anesthesia. The drug infusion is controlled by a microprocessor that uses population-based pharmacokinetic data and patient biometrics to estimate the required infusion rate to replace losses from the blood compartment due to drug distribution and metabolism. The objective of the research was to develop and validate a method to detect and quantify propofol levels in the blood, to improve the safety of propofol use, and to demonstrate a pathway for regulatory approval for its use in the USA. Read More

View Article and Full-Text PDF
January 2021

Increased immature T-cells detected by flow cytometry in post chemotherapeutic patients with acute myeloid leukemia, a case report and small series study.

Am J Blood Res 2020 15;10(6):351-354. Epub 2020 Dec 15.

Department of Pathology & Laboratory Medicine, University of Kansas Medical Center Kansas City, KS 66160, USA.

Detection of minimal/measurable residual disease (MRD) in bone marrow specimens by flow cytometry is widely used in patients with T cell acute lymphoblastic leukemia (T-ALL). It plays a central role in guiding treatment and assessing prognosis. However, the occurrence of a normal physiologic reactive immature T-cell population in treated bone marrow is unknown. Read More

View Article and Full-Text PDF
December 2020

Cardiac troponin release following left bundle branch pacing.

J Cardiovasc Electrophysiol 2021 Mar 2;32(3):851-855. Epub 2021 Feb 2.

Division of Cardiology, Geisinger Heart Institute, Wilkes-Barre, Pennsylvania, USA.

Left bundle branch pacing (LBBP) has emerged as an alternative to His bundle pacing (HBP) to achieve physiologic ventricular stimulation. The extent of myocardial injury during permanent LBBP implantation is currently not known. The aim of the study was to prospectively assess the extent of myocardial injury during LBBP implantation. Read More

View Article and Full-Text PDF

Exercise Stress Real-Time Cardiac Magnetic Resonance Imaging for Noninvasive Characterization of Heart Failure With Preserved Ejection Fraction: The HFpEF-Stress Trial.

Circulation 2021 Apr 21;143(15):1484-1498. Epub 2021 Jan 21.

From the Department of Cardiology and Pneumology, Georg-August University (S.J.B., T.L., E.F.G., K.H., M.B., R.W., U.R., G.H., T.S., A.S.), University Medical Center Göttingen, Germany.

Background: Right heart catheterization using exercise stress is the reference standard for the diagnosis of heart failure with preserved ejection fraction (HFpEF) but carries the risk of the invasive procedure. We hypothesized that real-time cardiac magnetic resonance (RT-CMR) exercise imaging with pathophysiologic data at excellent temporal and spatial resolution may represent a contemporary noninvasive alternative for diagnosing HFpEF.

Methods: The HFpEF-Stress trial (CMR Exercise Stress Testing in HFpEF; URL: https://www. Read More

View Article and Full-Text PDF

The Role of Mediobasal Hypothalamic PACAP in the Control of Body Weight and Metabolism.

Endocrinology 2021 Apr;162(4)

Indiana Biosciences Research Institute, Diabetes Research Center, Indianapolis, IN, USA.

Body energy homeostasis results from balancing energy intake and energy expenditure. Central nervous system administration of pituitary adenylate cyclase activating polypeptide (PACAP) dramatically alters metabolic function, but the physiologic mechanism of this neuropeptide remains poorly defined. PACAP is expressed in the mediobasal hypothalamus (MBH), a brain area essential for energy balance. Read More

View Article and Full-Text PDF

Vascular Aging Detected by Peripheral Endothelial Dysfunction Is Associated With ECG-Derived Physiological Aging.

J Am Heart Assoc 2021 Feb 17;10(3):e018656. Epub 2021 Jan 17.

Department of Cardiovascular Medicine Mayo Clinic Rochester MN.

Background An artificial intelligence algorithm that detects age using the 12-lead ECG has been suggested to signal "physiologic age." This study aimed to investigate the association of peripheral microvascular endothelial function (PMEF) as an index of vascular aging, with accelerated physiologic aging gauged by ECG-derived artificial intelligence-estimated age. Methods and Results This study included 531 patients who underwent ECG and a noninvasive PMEF assessment using reactive hyperemia peripheral arterial tonometry. Read More

View Article and Full-Text PDF
February 2021

Sagittal curvature of the spine as a predictor of the pediatric spinal deformity development.

Spine Deform 2021 Jan 15. Epub 2021 Jan 15.

Department of Orthopedic Surgery, University Medical Center Utrecht, Utrecht, The Netherlands.

Background: The sagittal curvature of the spine is hypothesized to play an important role in induction of spinal deformities in adolescent idiopathic scoliosis. We previously showed an S shaped flexible rod, with the same curvature as the pediatric sagittal spinal curve, produces scoliotic-like deformities under physiologic loading. Yet, detailed characteristics of the pediatric sagittal spinal curves associated with higher risk of scoliosis are not well defined. Read More

View Article and Full-Text PDF
January 2021

Transcultural Adaptation and Theoretical Models of Validation of the Spanish Version of the Self-Care of Heart Failure Index Version 6.2 (SCHFI v.6.2).

Int J Environ Res Public Health 2021 01 12;18(2). Epub 2021 Jan 12.

Department of Biomedicine and Prevention, University of Rome Tor Vergata, 00133 Rome, Italy.

Background: Heart failure (HF) is a major and growing public health problem worldwide. Across the world, heart failure is associated with high mortality, high hospitalization rates, and poor quality of life. Self-care is defined as a naturalistic decision-making process involving the choice of behaviors that maintain physiologic stability, the response to symptoms when they occur, and the ability to follow the treatment regimen and control symptoms. Read More

View Article and Full-Text PDF
January 2021

The diamond of death: Hypocalcemia in trauma and resuscitation.

Am J Emerg Med 2021 03 28;41:104-109. Epub 2020 Dec 28.

Brooke Army Medical Center, 3551 Roger Brooke Dr, Fort Sam Houston, TX 78234, United States of America; Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, United States of America. Electronic address:

Introduction: Early recognition and management of hemorrhage, damage control resuscitation, and blood product administration have optimized management of severe trauma. Recent data suggest hypocalcemia exacerbates the ensuing effects of coagulopathy in trauma.

Objective: This narrative review of available literature describes the physiology and role of calcium in trauma resuscitation. Read More

View Article and Full-Text PDF

ECM-regulation of autophagy: The yin and the yang of autophagy during wound healing.

Matrix Biol 2021 Jan 6. Epub 2021 Jan 6.

Department of Pathology, University of Pittsburgh, Pittsburgh, PA 15261, United States; VA Pittsburgh Healthcare Systems, Pittsburgh, PA 15213, United States; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15260, United States; Department of Computational & Systems Biology, University of Pittsburgh, Pittsburgh, PA 15260, United States; UPMC Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA 15213, United States. Electronic address:

Wound healing is a complex sequence of tissue protection, replacement, and reorganization leading to regenerated tissue. Disruption of any of these steps results in the process being incomplete as an ulcer or over-exuberant as a hypertrophic scar. Over the past decade, it has become evident that the extracellular matrix and associated components orchestrate this process. Read More

View Article and Full-Text PDF
January 2021

Idiopathic pulmonary fibrosis patients with severe physiologic impairment: characteristics and outcomes.

Respir Res 2021 Jan 6;22(1). Epub 2021 Jan 6.

Inova Advanced Lung Disease and Transplant Program, Inova Fairfax Hospital, 3300 Gallows Road, Falls Church, VA, 22042, USA.

Research Question: There is no widely accepted grading system for IPF disease severity, although physiologic impairment based on pulmonary function testing is frequently employed. We sought to describe clinical and functional characteristics as well as outcomes of patients with severe physiologic impairment.

Patients And Methods: IPF patients with severe physiologic impairment defined by FVC ≤ 50% and/or DLco ≤ 30% predicted evaluated in the Inova Advanced Lung Disease Program between 2011 and 2019 were included. Read More

View Article and Full-Text PDF
January 2021

Hyperbaric Oxygen Therapy in Management of Diabetic Foot Ulcers: Indocyanine Green Angiography May Be Used as a Biomarker to Analyze Perfusion and Predict Response to Treatment.

Plast Reconstr Surg 2021 01;147(1):209-214

From the Divisions of Plastic and Reconstructive Surgery and Vascular Surgery, Department of Surgery, Stanford University School of Medicine; the Advanced Wound Care Center, Stanford University Medical Center; and the Division of Plastic Surgery, University of Florida.

Summary: The authors present indocyanine green angiography to assess the effects of hyperbaric oxygen therapy and as a potential biomarker to predict healing of chronic wounds. They hypothesize that favorable initial response to hyperbaric oxygen therapy (improved perfusion) would be an early indicator of eventual response to the treatment (wound healing). Two groups were recruited: patients with chronic wounds and unwounded healthy controls. Read More

View Article and Full-Text PDF
January 2021

Association between long interpregnancy intervals and cesarean delivery due to arrest disorders.

Am J Obstet Gynecol MFM 2020 08 21;2(3):100103. Epub 2020 Mar 21.

Obstetrics and Gynecology, MedStar Georgetown University Hospital, Washington, DC.

Background: It is hypothesized that pregnancy causes time-limited physiologic adaptations of the reproductive system, such as increased blood flow to the uterus. With long interpregnancy intervals, those adaptations may regress, and maternal physiologic characteristics may revert to those of primigravid women. Therefore, it is plausible that long interpregnancy interval is associated with cesarean delivery, especially due to arrest disorders (failed induction of labor, arrest of dilation, or arrest of descent). Read More

View Article and Full-Text PDF