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Early platelet dysfunction in patients receiving extracorporeal membrane oxygenation is associated with mortality.

J Thromb Thrombolysis 2021 Sep 16. Epub 2021 Sep 16.

Department of Cardiology and Angiology I, University Heart Center Freiburg - Bad Krozingen, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

Extracorporeal membrane oxygenation (ECMO) is used for patients with cardiopulmonary failure and is associated with severe bleeding and poor outcome. Platelet dysfunction may be a contributing factor. The aim of this prospective observational study was to characterize platelet dysfunction and its relation to outcome in ECMO patients. Read More

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September 2021

Protein kinase N2 mediates flow-induced eNOS activation and vascular tone regulation.

J Clin Invest 2021 Sep 9. Epub 2021 Sep 9.

Department of Pharmacology, Max Planck Institute for Heart and Lung Research, Bad Nauheim, Germany.

Formation of nitric oxide (NO) by the endothelial NO-synthase (eNOS) is a central process in the homeostatic regulation of vascular functions including blood pressure regulation and fluid shear stress exerted by the flowing blood is a main stimulus of eNOS activity. Previous work has identified several mechanosensing and -transducing processes in endothelial cells, which mediate this process and result in the stimulation of eNOS activity through phosphorylation of the enzyme via various kinases including AKT. How the initial mechanosensing and signaling processes are linked to eNOS phosphorylation is unclear. Read More

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September 2021

Ferric carboxymaltose in patients with pulmonary arterial hypertension and iron deficiency: a long-term study.

J Cachexia Sarcopenia Muscle 2021 Sep 9. Epub 2021 Sep 9.

Klinik III für Innere Medizin, Herzzentrum der Universität zu Köln, Cologne, Germany.

Background: Pulmonary arterial hypertension (PAH) is a progressive disease with limited survival. Iron deficiency (ID) correlates with disease severity and mortality. While oral iron supplementation was shown to be insufficient in such patients, the potential impact of parenteral iron on clinical measures warrants further investigation. Read More

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September 2021

Deficiency of Axl aggravates pulmonary arterial hypertension via BMPR2.

Commun Biol 2021 08 24;4(1):1002. Epub 2021 Aug 24.

Universities of Giessen and Marburg Lung Center (UGMLC), Excellence Cluster Cardio-Pulmonary System (ECCPS), Member of the German Center for Lung Research (DZL), Justus-Liebig-University Giessen, Giessen, Germany.

Pulmonary arterial hypertension (PAH), is a fatal disease characterized by a pseudo-malignant phenotype. We investigated the expression and the role of the receptor tyrosine kinase Axl in experimental (i.e. Read More

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Adherence to iron and folic acid supplementation during pregnancy among postnatal mothers seeking maternal and child healthcare at Kakamega level 5 hospital in Kenya: a cross-sectional study.

Wellcome Open Res 2021 5;6:80. Epub 2021 Jul 5.

Environmental Health and Disease Control, Jomo Kenyatta University of Agriculture and Technology, Nairobi, Nairobi, 62 000 - 00200, Kenya.

Maternal anaemia is a public health problem worldwide, and its aetiology is linked to iron deficiency. The high nutrient demand during pregnancy exacerbates the condition. To meet the increased nutritional demand, supplementation of iron and folic acid (IFA) is key. Read More

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Effects of Cocoa Genotypes on Coat Color, Platelets and Coagulation Parameters in French Bulldogs.

Genes (Basel) 2021 Jul 19;12(7). Epub 2021 Jul 19.

Laboklin GmbH&Co.KG, Steubenstraße 4, 97688 Bad Kissingen, Germany.

A nonsense variant in , c.2420G>A or p.Trp807*, was recently discovered as the cause for a brown coat color termed cocoa in French Bulldogs. Read More

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The role of vitamin D and vitamin D deficiency in orthopaedics and traumatology-a narrative overview of the literature.

Ann Transl Med 2021 Jun;9(11):942

Department of Orthopaedics, Koenig-Ludwig-Haus, Julius-Maximilians-University, Wuerzburg, Germany.

Vitamin D is considered to play an important role in musculoskeletal health. It's classical function is the regulation of calcium and phosphate homeostasis, thus ensuring a balanced bone metabolism that is characterised by an equal amount of bone resorption and bone formation. In the past decades, a plethora of pre-clinical and clinical studies reporting on potential health-beneficial properties of vitamin D have emerged. Read More

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Genetic Deficiency of TRAF5 Promotes Adipose Tissue Inflammation and Aggravates Diet-Induced Obesity in Mice.

Arterioscler Thromb Vasc Biol 2021 Aug 5:ATVBAHA121316677. Epub 2021 Aug 5.

Department of Cardiology, Medical University of Graz, Austria (N.A.M., H.B., A.Z.).

Objective: The accumulation of inflammatory leukocytes is a prerequisite of adipose tissue inflammation during cardiometabolic disease. We previously reported that a genetic deficiency of the intracellular signaling adaptor TRAF5 (TNF [tumor necrosis factor] receptor-associated factor 5) accelerates atherosclerosis in mice by increasing inflammatory cell recruitment. Here, we tested the hypothesis that an impairment of TRAF5 signaling modulates adipose tissue inflammation and its metabolic complications in a model of diet-induced obesity in mice. Read More

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Deletion of the SELENOP gene leads to CNS atrophy with cerebellar ataxia in dogs.

PLoS Genet 2021 Aug 2;17(8):e1009716. Epub 2021 Aug 2.

Institute of Genetics, Vetsuisse Faculty, University of Bern, Bern, Switzerland.

We investigated a hereditary cerebellar ataxia in Belgian Shepherd dogs. Affected dogs developed uncoordinated movements and intention tremor at two weeks of age. The severity of clinical signs was highly variable. Read More

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Circ_0025908 regulates cell vitality and proliferation via miR-137/HIPK2 axis of rheumatic arthritis.

J Orthop Surg Res 2021 Jul 30;16(1):472. Epub 2021 Jul 30.

Department of Traumatic Orthopedics, Institute of Orthopedics, Huizhou Central People's Hospital, No. 41, North E'ling Road, Huizhou, 516000, Guangdong Province, China.

Background: Rheumatic arthritis (RA) is an autoimmune disease with bad effects. Recent researches have shown that circular RNAs (circRNAs) could affect the progress of RA, but the mechanism still indistinct. In this work, we explored the roles of circ_0025908 in RA. Read More

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Cardiac-specific β-catenin deletion dysregulates energetic metabolism and mitochondrial function in perinatal cardiomyocytes.

Mitochondrion 2021 Jul 21;60:59-69. Epub 2021 Jul 21.

Department of Human Genetics, Institute of Molecular Biology and Genetics, National Academy of Sciences of Ukraine, 150 Akad. Zabolotnogo Str, Kyiv 03680, Ukraine. Electronic address:

β-Catenin signaling pathway regulates cardiomyocytes proliferation and differentiation, though its involvement in metabolic regulation of cardiomyocytes remains unknown. We used one-day-old mice with cardiac-specific knockout of β-catenin and neonatal rat ventricular myocytes treated with β-catenin inhibitor to investigate the role of β-catenin metabolism regulation in perinatal cardiomyocytes. Transcriptomics of perinatal β-catenin-ablated hearts revealed a dramatic shift in the expression of genes involved in metabolic processes. Read More

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Micronutrients deficiences in patients after bariatric surgery.

Eur J Nutr 2021 Jul 23. Epub 2021 Jul 23.

Faculty of Medicine, Ovidius University of Constanta, Constanta, Romania.

Bariatric surgery is an effective option for managing obesity and has gained general acceptance among patients in recent years. Generally, despite the high caloric intake, a bad nutritional habit of obese people results in the deficiency of several vitamins, minerals, and trace elements essential for body metabolism and normal physiological processes. Additionally, the current bariatric surgical approaches such as sleeve gastrectomy (SG), Roux-en-Y-gastric bypass (RYGB), laparoscopic adjustable gastric banding (LAGB), and jejunoileal bypass (JIB) can cause or exacerbate these deficiencies. Read More

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Mild Acquired Factor XIII Deficiency and Clinical Relevance at the ICU-A Retrospective Analysis.

Clin Appl Thromb Hemost 2021 Jan-Dec;27:10760296211024741

Institute of IMD Blood Coagulation Centre, Frankfurt/Bad Homburg, Germany.

Acquired FXIII deficiency is a relevant complication in the perioperative setting; however, we still have little evidence about the incidence and management of this rarely isolated coagulopathy. This study aims to help find the right value for the substitution of patients with an acquired mild FXIII deficiency. In this retrospective single-center cohort study, we enrolled critically ill patients with mild acquired FXIII deficiency (>5% and ≤70%) and compared clinical and laboratory parameters, as well as pro-coagulatory treatments. Read More

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Bad Prognosis in Critical Ill Patients with COVID-19 during Short-Term ICU Stay regarding Vitamin D Levels.

Nutrients 2021 Jun 9;13(6). Epub 2021 Jun 9.

Department of Physiology, Institute of Nutrition and Food Technology "Jose Mataix", School of Pharmacy, University of Granada, 18071 Granada, Spain.

Background And Aims: Vitamin D inadequacy may be involved in the mechanisms of SARS-CoV-2 infection and in potential risk factors for disease propagation or control of coronavirus disease 2019 (COVID-19). This study assessed a short-term evolution of vitamin D status and its influence upon different clinical parameters in critically ill patients with COVID-19.

Methods: A prospective analytical study in which 37 critically ill volunteers between 41 and 71 years of age with COVID-19 were evaluated at baseline and three days of intensive care unit (ICU) stay. Read More

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SLC10A2 deficiency-induced congenital chronic bile acid diarrhea and stunting.

Mol Genet Genomic Med 2021 Aug 30;9(8):e1740. Epub 2021 Jun 30.

Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, Department of Pediatrics, Sichuan University, Chengdu, Sichuan, China.

Background: Diarrhea is a common occurrence in children below the age of 5 years. In chronic cases, it induces malnutrition that severely stunts growth. Bile acid diarrhea (BAD), caused by malabsorption of bile acid (BA), is a rare form of chronic diarrhea seldom observed in pediatric patients. Read More

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Which triggers could support timely identification of primary antibody deficiency? A qualitative study using the patient perspective.

Orphanet J Rare Dis 2021 06 29;16(1):289. Epub 2021 Jun 29.

Department of Tranzo, TSB, Tilburg University, PO Box 90153, 5000 LE, Tilburg, The Netherlands.

Background: Patients with predominantly (primary) antibody deficiencies (PADs) commonly develop recurrent respiratory infections which can lead to bronchiectasis, long-term morbidity and increased mortality. Recognizing symptoms and making a diagnosis is vital to enable timely treatment. Studies on disease presentation have mainly been conducted using medical files rather than direct contact with PAD patients. Read More

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Genome sequencing in families with congenital limb malformations.

Hum Genet 2021 Aug 22;140(8):1229-1239. Epub 2021 Jun 22.

Institute of Medical Genetics and Human Genetics, Charité-Universitätsmedizin Berlin, Corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.

The extensive clinical and genetic heterogeneity of congenital limb malformation calls for comprehensive genome-wide analysis of genetic variation. Genome sequencing (GS) has the potential to identify all genetic variants. Here we aim to determine the diagnostic potential of GS as a comprehensive one-test-for-all strategy in a cohort of undiagnosed patients with congenital limb malformations. Read More

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Ageing, ACE2 deficiency and bad outcome in COVID-19.

Clin Chem Lab Med 2021 06 14;59(10):1607-1609. Epub 2021 Jun 14.

Fondazione Umbra Cuore e Ipertensione-ONLUS and Division of Cardiology, Hospital S. Maria della Misericordia, Perugia, Italy.

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Rubella vaccine-induced granulomas are a novel phenotype with incomplete penetrance of genetic defects in cytotoxicity.

J Allergy Clin Immunol 2021 May 24. Epub 2021 May 24.

Division of Pediatric Hematology and Oncology, Department of Pediatrics, University Hospital Erlangen, Erlangen, Germany.

Background: Rubella virus-induced granulomas have been described in patients with various inborn errors of immunity. Most defects impair T-cell immunity, suggesting a critical role of T cells in rubella elimination. However, the molecular mechanism of virus control remains elusive. Read More

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How can the orthopedic surgeon ensure optimal vitamin D status in patients operated for an osteoporotic fracture?

Osteoporos Int 2021 May 20. Epub 2021 May 20.

Service of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.

In this narrative review, the role of vitamin D deficiency in the pathophysiology, healing of fragility fractures, and rehabilitation is discussed. Vitamin D status can be assessed by measuring serum 25(OH)-vitamin D level with standardized assays. There is a high prevalence of vitamin D insufficiency (25(OH)D < 50 nmol/l (i. Read More

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BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models.

Nat Commun 2021 05 19;12(1):2939. Epub 2021 May 19.

Department of Biochemistry, University of Alberta, Edmonton, AB, Canada.

Elucidation of non-canonical protein functions can identify novel tissue homeostasis pathways. Herein, we describe a role for the Bcl-2 family member BAD in postnatal mammary gland morphogenesis. In Bad knock-in mice, where BAD cannot undergo phosphorylation at 3 key serine residues, pubertal gland development is delayed due to aberrant tubulogenesis of the ductal epithelium. Read More

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Joseon physician Heo Joon's Smallpox Medicine and 'Syndrome differentiation'.

Authors:
Chaekun Oh

Uisahak 2021 Apr;30(1):35-68

Associate Professor, College of Korean Medicine, Daejeon University; Research fellow, Institute of Medical Humanities, Inje University.

In this research, I have tried to overview the diagnosis and treatment of smallpox performed by Heo Joon, a representative physician of Joseon dynasty. In order to accomplish this, I analyzed the smallpox related contents shown in the Essentials of Smallpox translated in Korean and a comprehensive medical book Treasured Mirror of Eastern Medicine, both written by Heo Joon. In examining these sources, I found out that Heo Joon used a medical method called 'Syndrome differentiation' in treating smallpox. Read More

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Involvement of Nrf2-HO-1/JNK-Erk Signaling Pathways in Aconitine-Induced Developmental Toxicity, Oxidative Stress, and ROS-Mitochondrial Apoptosis in Zebrafish Embryos.

Front Pharmacol 2021 21;12:642480. Epub 2021 Apr 21.

Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China.

Aconitine (AC), one of the bioactive diterpenoid alkaloids extracted from plants, is widely used in traditional herbal medicine to treat various diseases. Emerging evidence indicates that AC has attracted great interest for its wide cardiotoxicity and neurotoxicity. However, the toxic effects of AC on embryonic development and its underlying mechanisms remain unclear. Read More

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Idiopathic Gingival Enlargement Causing Social Stigma.

Authors:
Divya Kothari

Contemp Clin Dent 2021 Jan-Mar;12(1):63-66. Epub 2021 Mar 20.

Professor and Head, Department of Periodontics, Pacific Dental College and Research Centre, Udaipur, Rajasthan, India.

Gingival enlargement can be multifactorial; it can be due to nutritional deficiency or can be because of several drugs. Poor oral hygiene may further worsen the gingival hyperplasia, because of which the patient may have difficulty in chewing the food, and the speech may get affected. It may end up in psychosocial stigma for the patient as the patient is even neglected by friends or relatives due to poor oral hygiene and horrifying look of gingival overgrowth. Read More

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Inhibition of acid sphingomyelinase increases regulatory T cells in humans.

Brain Commun 2021 5;3(2):fcab020. Epub 2021 Mar 5.

Institute for Virology and Immunobiology, University of Würzburg, Würzburg 97078, Germany.

Genetic deficiency for acid sphingomyelinase or its pharmacological inhibition has been shown to increase Foxp3 regulatory T-cell frequencies among CD4 T cells in mice. We now investigated whether pharmacological targeting of the acid sphingomyelinase, which catalyzes the cleavage of sphingomyelin to ceramide and phosphorylcholine, also allows to manipulate relative CD4 Foxp3 regulatory T-cell frequencies in humans. Pharmacological acid sphingomyelinase inhibition with antidepressants like sertraline, but not those without an inhibitory effect on acid sphingomyelinase activity like citalopram, increased the frequency of Foxp3 regulatory T cell among human CD4 T cells . Read More

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Platelet CD36 deficiency is present in 2.6% of Arabian individuals and can cause NAIT and platelet refractoriness.

Transfusion 2021 06 6;61(6):1932-1942. Epub 2021 Apr 6.

German Red Cross Blood Service West, Hagen, Germany.

Background: CD36 isoantibodies are capable of inducing neonatal alloimmune thrombocytopenia (NAIT) and platelet refractoriness. As to now the CD36 type I deficiency has been reported in East Asian and African individuals. However, it is virtually unknown in Caucasians. Read More

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Vitamin D and Cardiovascular Disease: An Updated Narrative Review.

Int J Mol Sci 2021 Mar 12;22(6). Epub 2021 Mar 12.

Department of Internal Medicine, Division of Endocrinology and Diabetology, Medical University of Graz, 8036 Graz, Austria.

During the last two decades, the potential impact of vitamin D on the risk of cardiovascular disease (CVD) has been rigorously studied. Data regarding the effect of vitamin D on CVD risk are puzzling: observational data indicate an inverse nonlinear association between vitamin D status and CVD events, with the highest CVD risk at severe vitamin D deficiency; however, preclinical data and randomized controlled trials (RCTs) show several beneficial effects of vitamin D on the surrogate parameters of vascular and cardiac function. By contrast, Mendelian randomization studies and large RCTs in the general population and in patients with chronic kidney disease, a high-risk group for CVD events, largely report no significant beneficial effect of vitamin D treatment on CVD events. Read More

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Timolol induces necroptosis, apoptosis and senescence concentration-dependently in rabbit Limbal stem cells in vitro.

Life Sci 2021 Jul 31;277:119453. Epub 2021 Mar 31.

Laboratory for corneal tissue engineering, College of marine life sciences, Ocean university of China, Qingdao, Shandong province 266003, China. Electronic address:

Limbal stem cells (LSCs) are crucial for corneal transparency and vision. Any damages to LSCs might lead to limbal stem cell deficiency resulting in corneal opacification and even blindness. Here, we investigated the cytotoxicity of timolol and its underlying mechanisms in rabbit LSCs (rLSCs) in vitro. Read More

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Supplementation with Iron in Pulmonary Arterial Hypertension. Two Randomized Crossover Trials.

Ann Am Thorac Soc 2021 06;18(6):981-988

National Heart and Lung Institute and.

Iron deficiency, in the absence of anemia, is common in patients with idiopathic and heritable pulmonary arterial hypertension (PAH) and is associated with a worse clinical outcome. Oral iron absorption may be impeded by elevated circulating hepcidin concentrations. The safety and benefit of parenteral iron replacement in this patient population is unclear. Read More

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Endophytic Microbial Diversity: A New Hope for the Production of Novel Anti-tumor and Anti-HIV Agents as Future Therapeutics.

Curr Microbiol 2021 May 16;78(5):1699-1717. Epub 2021 Mar 16.

Faculty of Applied Sciences and Biotechnology, Shoolini University, Solan, Himachal Pradesh, India.

Cancer is a collective name for a variety of diseases that can begin in virtually every organ or body tissue as abnormal cells develop uncontrollably and ten million new cancer cases are diagnosed all over the world at present. Whereas HIV is a virus that makes people susceptible to infection and contributes to the condition of acquired immune deficiency syndrome (AIDS). Almost 37 million people are currently diagnosed with HIV and 1 million people die every year, which is the worst-case scenario. Read More

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