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The relationship between global cardiac and regional left atrial sympathetic innervation and epicardial fat in patients with atrial fibrillation.

Ann Nucl Med 2021 Jun 14. Epub 2021 Jun 14.

Clinical Cardiovascular Research Center, School of Medicine & Dentistry, University of Rochester, Rochester, NY, USA.

Aim: To investigate the relationship between epicardial adipose tissue (EAT) volume and distribution and the parameters of global cardiac and regional left atrial (LA) sympathetic activity in patients with atrial fibrillation (AF).

Methods And Results: The data of the 45 consecutive patients scheduled for an index catheter ablation (CA) for AF were analyzed. Total and peri-atrial EAT volumes were measured by cardiac CT. Read More

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Effectiveness of porcine-derived xenograft with enamel matrix derivative for periodontal regenerative treatment of intrabony defects associated with a fixed dental prosthesis: a 2-year follow-up retrospective study.

J Periodontal Implant Sci 2021 Jun;51(3):179-188

Department of Periodontology, Daejeon Dental Hospital, Institute of Wonkwang Dental Research, Wonkwang University College of Dentistry, Daejeon, Korea.

Purpose: Due to the difficulty of the hygienic care and sanitary management of abutment teeth and subpontic areas associated with fixed dental prostheses (FDPs), intrabony defects occur and accelerate due to the accumulation of plaque and calculus. This study aimed to evaluate the efficacy of regenerative periodontal surgery for intrabony defects associated with FDPs.

Methods: The study inclusion criteria were met by 60 patients who underwent regenerative treatment between 2016 and 2018, involving a total of 82 intrabony defects associated with FDPs. Read More

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Comparison of the early cardiac electromechanical remodeling following transcatheter and surgical secundum atrial septal defect closure in adults.

Egypt Heart J 2021 Jun 10;73(1):53. Epub 2021 Jun 10.

Cardiology Department, Faculty of Medicine, Assiut University, Assiut, Egypt.

Background: Secundum atrial septal defect (ASD) closure leads to electrical and mechanical remodeling that occurs early after shunt disappearance. The relationship between electromechanical remodeling using electrocardiogram (ECG) and cardiac magnetic resonance (CMR) after percutaneous and surgical closure has not yet been recorded in prospective studies.

Objective: We thought to study right atrium (RA) and right ventricle (RV) changes by CMR 3 months after transcatheter and surgical closure and their comparison with electrical remodeling by ECG. Read More

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[Pre-clinical evaluation study on a new Chinese-made surgical biopatch for atrial septum].

Zhonghua Wai Ke Za Zhi 2021 Jun;59(6):513-519

Animal Experimental Center, Beijing Key Laboratory of Pre-clinical Research and Evaluation for Cardiovascular Implant Materials, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, National Center for Cardiovascular Diseases, Beijing 102300, China.

To evaluate the safety and effectiveness of a new Chinese-made surgical biopatch for atrial septum under the establishment of atrial septal defect animal model in miniature pigs. From June 2018 to April 2019, 26 pigs were divided into experimental group (15 pigs) and the control group (11 pigs). Animal models of atrial septal defect were established by traditional surgical methods. Read More

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Association between maternal exposure to gaseous pollutants and atrial septal defect in China: A nationwide population-based study.

Environ Res 2021 Jun 9;200:111472. Epub 2021 Jun 9.

The Joint Laboratory for Pulmonary Development and Related Diseases, West China Institute of Women and Children's Health, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, Sichuan, 610041, China; National Center for Birth Defects Monitoring, West China Second University Hospital, Sichuan University, Chengdu, Sichuan, 610041, China; Med-X Center for Informatics, Sichuan University, Chengdu, Sichuan, 610041, China. Electronic address:

Background: The association between maternal exposure to gaseous air pollutants and congenital heart defects (CHD) remains unclear. The concentration-response relationship and the time windows of susceptibility to gaseous pollutants may vary by pollutant species and CHD subtypes.

Objective: We aimed to examine the relationship between maternal exposures to four species of gaseous pollutants (NO, O, SO, and CO) and atrial septal defect (ASD), which is a common subtype of CHD, and to determine the critical time windows of susceptibility for each gaseous pollutant. Read More

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The diagnostic accuracy of stress myocardial perfusion scintigraphy in patients with end-stage renal disease.

Am J Cardiovasc Dis 2021 15;11(2):246-252. Epub 2021 Apr 15.

Department of Radiology, Nuclear Medicine and Cardiovascular Imaging, King Faisal Specialist Hospital & Research Center P. O Box 3354, Riyadh, Saudi Arabia.

Objective: This study examined the diagnostic accuracy of myocardial perfusion scintigraphy (MPS) in end-stage renal disease (ESRD) patients and the incidence and clinical and biochemical predictors of myocardial perfusion abnormalities.

Methods: We evaluated 500 asymptomatic ESRD patients on hemodialysis referred for MPS for cardiac risk stratification before renal transplant surgery. Patients with abnormal MPS and an additional few patients without abnormal MPS underwent invasive coronary angiography (ICA). Read More

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Effect of immersion in sodium hypochlorite on the cyclic fatigue resistance of three rotary instruments.

J Conserv Dent 2020 Nov-Dec;23(6):554-557. Epub 2021 Feb 11.

Postgraduate Program in Health Sciences, Pontifical Catholic University of Campinas, São Paulo, Brazil.

Context: It is essential to know if the immersion in sodium hypochlorite (NaOCl) influences the cyclic fatigue resistance of nickel-titaniumm (NiTi) files.

Aim: This study was aimed to evaluate the resistance to the cyclic fatigue of three NiTi systems, as well as the influence of 5.25% NaOCl on their resistance. Read More

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February 2021

Defining Critical Glenoid Bone Loss in Posterior Shoulder Capsulolabral Repair.

Am J Sports Med 2021 Jun 3:3635465211016804. Epub 2021 Jun 3.

The Steadman Clinic, Vail, Colorado, USA.

Background: Although critical bone loss for anterior instability is well defined, a clinically significant threshold of posterior bone loss has not been elucidated.

Hypothesis: Patients with failed arthroscopic posterior shoulder capsulolabral repair will have increased posterior glenoid bone loss with a defined critical threshold.

Study Design: Case control study; Level of evidence, 3. Read More

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Plasma Epstein-Barr virus DNA and risk of nasopharyngeal carcinoma in a prospective seropositive population.

BMC Cancer 2021 Jun 1;21(1):651. Epub 2021 Jun 1.

Department of Cancer Prevention, Cancer Prevention Center, State Key Laboratory of Oncology in Southern China, Sun Yat-sen University Cancer Center, Guangzhou, China.

Objective: Plasma Epstein-Barr virus (EBV) DNA is considered a biomarker for nasopharyngeal carcinoma (NPC). However, its long-term role in NPC development is unclear.

Materials And Methods: A total of 1363 participants seropositive for EBV VCA-IgA and EBNA1-IgA in a community-based NPC screening program in southern China were tested for plasma EBV DNA levels by real-time qPCR between 2008 and 2015. Read More

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Vessel Density Loss of the Deep Peripapillary Area in Glaucoma Suspects and Its Association with Features of the Lamina Cribrosa.

J Clin Med 2021 May 28;10(11). Epub 2021 May 28.

Department of Ophthalmology, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul 06591, Korea.

Purpose: To investigate the association of decreased vessel density (VD) in the deep peripapillary region and structural features of the lamina cribrosa (LC).

Materials And Methods: 70 eyes of glaucoma suspects with enlarged cup-to-disc ratio were scanned and 51 eyes with adequate image quality were included in this study. All subjects had localized VD defects in the deep layer but intact VD in the superficial layer around the peripapillary region using optical coherence tomography angiography (OCTA). Read More

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Bone Regeneration Using PEVAV/β-Tricalcium Phosphate Composite Scaffolds in Standardized Calvarial Defects: Micro-Computed Tomographic Experiment in Rats.

Materials (Basel) 2021 May 3;14(9). Epub 2021 May 3.

Restorative Dental Sciences Department, College of Dentistry, King Saud University, Riyadh 11545, Saudi Arabia.

Bone regeneration using beta-tricalcium phosphate (β-TCP) can be practiced using a biocomposite scaffold. Poly(ethylene-co-vinylalcohol)/poly(δ-valerolactone)/β-tricalcium phosphate (PEVAV/β-TCP) composite scaffolds showed promising in vitro results. This study evaluated the bone regenerative potential of PEVAV/β-TCP biocomposite scaffolds in standardized calvarial defects in a rat model over 4 and 10 weeks. Read More

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Micro-CT and Histomorphometric Study of Bone Regeneration Effect with Autogenous Tooth Biomaterial Enriched with Platelet-Rich Fibrin in an Animal Model.

Scanning 2021 11;2021:6656791. Epub 2021 May 11.

Department of Oral and Maxillofacial Surgery, Graduate School of Clinical Dentistry, Korea University, Seoul 08308, Republic of Korea.

The aim of this study was to evaluate the potential of tooth biomaterials as bone graft biomaterials for bone healing in rabbits. We prepared tooth biomaterial and platelet-rich fibrin (PRF) to fill the round-shaped defect in the skull of New Zealand white rabbits. These cranial defects were treated with different conditions as follows: group 1, a mixture of tooth biomaterials and platelet-rich fibrin (PRF); group 2, only tooth biomaterials; group 3, only PRF; and group 4, the unfilled control group. Read More

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Establishment of a C57BL/6 Mandibular Critical-Size Bone Defect Model.

J Craniofac Surg 2021 May 28. Epub 2021 May 28.

Department of Orthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, China.

Purpose: The goal of this study was to identify bone defects of critical size in C57BL/6 mouse mandibles.

Materials And Methods: Twenty-four male mice were included in this study. All mice underwent surgeries on their left mandibles. Read More

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Long-term stability of adjunctive use of enamel matrix protein derivative on porcine-derived xenograft for the treatment of one-wall intrabony defects: A 4-year extended follow-up of a randomized controlled trial.

J Periodontol 2021 May 29. Epub 2021 May 29.

Department of Periodontology, Daejeon Dental Hospital, Institute of Wonkwang Dental Research, Wonkwang University College of Dentistry, Daejeon, Korea.

Background: The long-term outcomes of demineralized porcine bone matrix (DPBM) in combination with enamel matrix protein derivative (EMD) for the treatment of one-wall intrabony defects have not yet been evaluated. Therefore, this study aimed to assess the clinical, radiographic, and patient-reported outcomes of regenerative therapy using DPBM with EMD (test group) in comparison with DPBM alone (control group) for the treatment of one-wall intrabony defects in the molar regions.

Methods: Thirty-four patients (control group, n = 18, and test group, n = 16) were available at the 4-year follow-up assessment. Read More

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Determinants of stillbirth in hospitals of North Shoa Zone, Oromia region, Central Ethiopia: A case control study.

Heliyon 2021 May 18;7(5):e07070. Epub 2021 May 18.

Department of Public Health, College of Health Sciences, Mizan Tepi University, Mizan Aman, Ethiopia.

Background: World Health Organization defined stillbirth as birth of fetus at 28 weeks or above gestation with a birth weight of ≥1000 g or body length of ≥35 cm. Majority of stillbirths occur in low and middle income nations. Efforts made in Ethiopia to improve maternal and child health are showing encouraging results, even though the magnitude didn't reach the expected level. Read More

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Congenital anomalies among newborn babies in Felege-Hiwot Comprehensive Specialized Referral Hospital, Bahir Dar, Ethiopia.

Sci Rep 2021 May 26;11(1):11027. Epub 2021 May 26.

Department of Occupational and Environmental Health, Institute of Public Health, College of Medicine and Health Sciences, The University of Gondar, Central Gondar, Ethiopia.

Congenital anomaly is a structural or functional defect which could occur in any organ system. The aim of this study was to determine the prevalence and associated factors of congenital anomalies among newborn babies delivered at Felege-Hiwot Comprehensive Specialized Referral Hospital, Bahir Dar, Ethiopia. A cross-sectional study design was used to review medical records/charts of 11,177 new born babies born at the delivery ward of Felege-Hiwot Comprehensive Specialized Referral Hospital, Ethiopia. Read More

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Study on Closure of Skull Base Defect Post-Endoscopic Endonasal Transsphenoid Pituitary Surgery: A Novel Flap Design.

J Neurol Surg B Skull Base 2021 Jun 14;82(3):313-320. Epub 2019 Nov 14.

Department of ENT and HNS, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India.

 This study was aimed to compare the closure of skull base defect in endoscopic endonasal transsphenoid surgery of pituitary tumors, using bipedicled nasal septal flap versus fascial closure. The study hypothesis being that bipedicled nasal septal flap is better, compared with fascial closure of skull base defect post-endoscopic endonasal transsphenoid surgery of pituitary tumors.  All the eligible patients were randomly divided into two groups and then randomly allocated to the surgeons. Read More

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Midazolam for conscious sedation in transcatheter device closure of atrial septal defects guided solely by transthoracic echocardiography.

Cardiol Young 2021 May 24:1-5. Epub 2021 May 24.

Department of Cardiac Surgery, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, China.

Objectives: To investigate the safety and feasibility of midazolam for conscious sedation in transcatheter device closure of atrial septal defects guided solely by transthoracic echocardiography.

Methods: A retrospective analysis was performed on 55 patients who underwent transcatheter device closure of atrial septal defects from October, 2019 to May, 2020. All patients received intravenous midazolam and local anesthesia with lidocaine to maintain sedation. Read More

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Comparison of the efficacy of growth factor collagen and antibiotic collagen on colon anastomosis in  experimental animals with peritonitis.

Indian J Gastroenterol 2021 Jun 21;40(3):309-315. Epub 2021 May 21.

Meram Medical Faculty, Department of General Surgery, Necmettin Erbakan University, 42080, Konya, Turkey.

Introduction: In spite of advances in surgical techniques, the significance of anastomosis leak continues in colorectal surgery. There is no ideal method in spite of all studies and technical advances in this field. Our aim of this study was to use fibroblast growth factor collagen (FGF-C) and antibiotic collagen (AB-C) to increase the rate of anastomosis healing in experimental animals with peritonitis. Read More

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Regional gene therapy for bone healing using a 3D printed scaffold in a rat femoral defect model.

J Biomed Mater Res A 2021 May 21. Epub 2021 May 21.

Dimension Inx, Chicago, Illinois, USA.

At the present time there are no consistently satisfactory treatment options for some challenging bone loss scenarios. We have previously reported on the properties of a novel 3D-printed hydroxyapatite-composite material in a pilot study, which demonstrated osteoconductive properties but was not tested in a rigorous, clinically relevant model. We therefore utilized a rat critical-sized femoral defect model with a scaffold designed to match the dimensions of the bone defect. Read More

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Thermal Transfer on Splinted Implants During Diode Laser Irradiation .

Photobiomodul Photomed Laser Surg 2021 May 18. Epub 2021 May 18.

Department of Prosthodontics and Digital Technology, School of Dental Medicine, Stony Brook University, Stony Brook, New York, USA.

Laser irradiation is being used for treatment of peri-implantitis. Therefore, this study aimed to assess the heat transfer from laser irradiation on an implant-supported, metal-ceramic fixed prosthesis . Two titanium implants were placed in artificial type I bone, and after abutment connection, a bridge was fabricated and cemented. Read More

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Prognostic factors affecting macular hole closure types.

Ther Adv Ophthalmol 2021 Jan-Dec;13:25158414211009007. Epub 2021 Apr 22.

Biostatistics Department, Mersin University, Mersin, Turkey.

Purpose: In this study, we aimed to evaluate the relationship between macular hole closure types assessed by optical coherence tomography (OCT) and the preoperative prognostic factors.

Materials And Methods: In total, 183 patients who underwent pars plana vitrectomy and internal limiting membrane peeling for idiopathic macular hole between August 2014 and August 2019 were reviewed retrospectively. The preoperative measurements of the macular hole including minimum linear diameter (MLD), basal hole diameter (BHD) and hole height (HH) were measured on OCT images. Read More

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The effect of substance use during pregnancy on neonatal outcomes in Ethiopia: A systematic review and meta-analysis.

Heliyon 2021 Apr 22;7(4):e06740. Epub 2021 Apr 22.

Debre Tabor University, Ethiopia.

Background: Substance use during pregnancy mainly khat chewing (20%) and alcohol drinking (18.1%) are commonly practiced in Ethiopia. However, the effect of using these substances has not been studied nationally yet. Read More

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Temporal Changes in Reverse Torque of Locking-Head Screws Used in the Locking Plate in Segmental Tibial Defect in Goat Model.

Front Surg 2021 27;8:637268. Epub 2021 Apr 27.

Department of Large Animal Clinical Sciences, College of Veterinary Medicine, The University of Tennessee, Knoxville, Knoxville, TN, United States.

The objective of this study was to evaluate changes in peak reverse torque (PRT) of the locking head screws that occur over time. A locking plate construct, consisting of an 8-hole locking plate and 8 locking screws, was used to stabilize a tibia segmental bone defect in a goat model. PRT was measured after periods of 3, 6, 9, and 12 months of ambulation. Read More

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Evaluation of uterine scar healing by transvaginal ultrasound in 607 nonpregnant women with a history of cesarean section.

BMC Womens Health 2021 05 13;21(1):199. Epub 2021 May 13.

Department of Obstetrics and Gynecology, Xinhua Hospital, Affiliated to Shanghai Jiaotong University, No. 1665 Kong Jiang Road, Shanghai, 200092, China.

Background: Caesarean scar defect (CSD) seriously affects female reproductive health. In this study, we aim to evaluate uterine scar healing by transvaginal ultrasound (TVS) in nonpregnant women with cesarean section (CS) history and to build a predictive model for cesarean scar defects is very necessary.

Methods: A total of 607 nonpregnant women with previous CS who have transvaginal ultrasound measurements of the thickness of the lower uterine segment. Read More

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Pregabalin Does Not Cause Midline Closure Defects But It Is Not As Innocent As Thought.

Turk Neurosurg 2020 Dec 10. Epub 2020 Dec 10.

Kahramanmaras Sutcu Imam University School of Medicine, Department of Neurosurgery, Kahramanmaraş, Turkey.

Aim: Pregabalin binds specifically to α2-δ subunits of voltage gated Ca++ channels. Tissues which are rich in these subunits are the target for possible effects and side effects of Pregabalin. The effect of Pregabalin used during pregnancy was investigated on chicken embryo model against causing neural tube closure defect and other potential effects on other organ systems which are rich in α2-δ subunits. Read More

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December 2020

Hymenal transections in children found by photocolposcopy in suspected sexual abuse cases is associated with a history of bleeding.

J Forensic Leg Med 2021 May 6;80:102176. Epub 2021 May 6.

Department of Forensic Medicine, University of Southern Denmark, J.B.Winsløws Vej 17B, 5000 Odense C, Denmark. Electronic address:

Objective: To investigate the difference in selected variables between children with and without hymenal transection, which is a healed defect that extends through the entire depth of the posterior hymenal membrane to the vaginal wall.

Materials And Methods: All female children from Southern Denmark who were examined by photocolposcopy in a six-year period were included in a retrospective cohort study. Statistical analyses included a chi-square test and a logistic regression analysis. Read More

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Effect of Vitiligo on Auditory Functions: Is There Any Association?

Int Arch Otorhinolaryngol 2021 Apr 23;25(2):e200-e204. Epub 2020 Jun 23.

Department of ENT, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India.

 Vitiligo is an acquired pigmentary disorder of unknown etiology, clinically characterized by whitish macules caused by selective loss of melanocytes. There are many melanocytes in the human cochlea. Recent studies have suggested a direct relation between cochlear dysfunction and decreased amounts of melanin. Read More

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Visual field-based grading of disease severity in newly diagnosed primary open angle glaucoma patients presenting to a tertiary eye care centre in India.

Int Ophthalmol 2021 May 9. Epub 2021 May 9.

Aravind Eye Hospital, Madurai, Tamil Nadu, India.

Purpose: To evaluate the severity of primary open angle glaucoma (POAG) at presentation using visual field analysis and its relationship to demographic and ocular factors in patients presenting to a tertiary eye care centre.

Design: Cross-sectional study.

Methods: Newly diagnosed POAG patients were classified as early, moderate, or severe stage in the worse eye based on the Humphrey visual field testing using Hodapp-Parrish-Andersons criteria. Read More

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[Orbital Fractures in Children].

Acta Chir Orthop Traumatol Cech 2021 ;88(2):101-106

Klinika dětské otorinolaryngologie, Fakultní nemocnice Brno a Lékařská fakulta Masarykovy univerzity, Brno.

PURPOSE OF THE STUDY Diagnosis and treatment of fractures of the facial skeleton in children can be difficult due to the skeletal growth. MATERIAL AND METHODS The 9-year retrospective study included patients admitted with the orbital fracture diagnosis to the University Hospital Brno, Children s Hospital, Department of Paediatric ENT, Department of Paediatric Anaesthesiology and Resuscitation, and Department of Paediatric Surgery, Orthopaedics and Traumatology. We looked into the number of patients admitted to the hospital with the orbital fracture diagnosis and the cause of the injury, the age of patients, and the used treatment method - surgical or non-operative treatment were analysed. Read More

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