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Procurement, commissioning and QA of AI based solutions: An MPE's perspective on introducing AI in clinical practice.

Phys Med 2021 May 10;83:257-263. Epub 2021 May 10.

University Hospitals of the KU Leuven, Leuven, Belgium. Electronic address:

Purpose: In this study, we propose a framework to help the MPE take up a unique and important role at the introduction of AI solutions in clinical practice, and more in particular at procurement, acceptance, commissioning and QA.

Material And Methods: The steps for the introduction of Medical Radiological Equipment in a hospital setting were extrapolated to AI tools. Literature review and in-house experience was added to prepare similar, yet dedicated test methods. Read More

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Artificial Intelligence and Cheminformatics-guided Modern Privileged Scaffold Research.

Curr Top Med Chem 2021 May 11. Epub 2021 May 11.

Nanjing University, State Key Laboratory of Pharmaceutical Biotechnology, China.

With the rapid development of computer science in scopes of theory, software, and hardware, artificial intelligence (mainly in the form of machine learning and more complex deep learning) combined with advanced cheminformatics is playing an increasingly important role in the drug discovery process. This development has also facilitated privileged scaffold-related research. By definition, a privileged scaffold is a structure that frequently occurs in diverse bioactive molecules. Read More

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Embedding interactive, three-dimensional content in portable document format (PDF) to deliver gross anatomy information and knowledge.

Jon Jatsu Azkue

Clin Anat 2021 May 12. Epub 2021 May 12.

Department of Neurosciences, School of Medicine and Nursery, University of the Basque Country, UPV/EHU, Leioa, Bizkaia, Spain.

Introduction: The Portable Document Format (PDF) is likely the most widely used digital file format for scholarly and scientific electronic publishing. Since format specification version 1.6, three-dimensional (3D) models in Universal 3D (U3D) format can be embedded into PDF files. Read More

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Celebrating 60 Years of Accomplishments of the Armed Forces Radiobiology Research Institute1.

Radiat Res 2021 May 12. Epub 2021 May 12.

Scientific Research Department.

Chartered by the U.S. Congress in 1961, the Armed Forces Radiobiology Research Institute (AFRRI) is a Joint Department of Defense (DoD) entity with the mission of carrying out the Medical Radiological Defense Research Program in support of our military forces around the globe. Read More

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QSARINS-Chem standalone version: A new platform-independent software to profile chemicals for physico-chemical properties, fate, and toxicity.

J Comput Chem 2021 May 11. Epub 2021 May 11.

Department of Theoretical and Applied Sciences, University of Insubria, Varese, Italy.

The new software QSARINS-Chem standalone version is a multiplatform tool, freely downloadable, for the in silico profiling of multiple properties and activities of organic chemicals. This software, which is based on the concept of the QSARINS-chem module embedded in the QSARINS software, has been fully redesigned and redeveloped in the Java™ language. In addition to a selection of models included in the old module, the new software predicts biotransformation rates and aquatic toxicities of pharmaceuticals and personal care products in multiple organisms, and offers a suite of tools for the analysis of predictions. Read More

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Preliminary Outcomes of Viabahn Balloon-Expandable Endoprosthesis as Bridging Stent in Renal Arteries During Fenestrated Endovascular Aortic Repair.

J Endovasc Ther 2021 May 11:15266028211012403. Epub 2021 May 11.

Vascular and Endovascular Surgery, Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padua, Padua, Italy.

Purpose: To report preliminary outcomes of Viabahn Balloon-Expandable Endoprosthesis (VBX) stent-graft as bridging stent for renal arteries in fenestrated endovascular aneurysm repair (FEVAR).

Materials And Methods: Between 2018 and 2019, patients undergoing FEVAR at 3 referral Italian university hospitals were prospectively collected. During the study period, VBX was the first-line choice as bridging stent for renal arteries. Read More

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A nationwide survey of emergency medicine resident workflow efficiency: Are training programs teaching residents to be efficient?

AEM Educ Train 2021 Apr 30;5(2):e10598. Epub 2021 Apr 30.

Department of Emergency Medicine UC Davis Sacramento California USA.

Background: Workflow efficiency (WFE) is essential to the practice of emergency medicine (EM), but a standardized approach to measuring and teaching it during residency is lacking. In this study we sought to describe how EM residency programs in the United States currently measure and teach WFE and to assess the relative importance of WFE teaching to EM residency program leaders.

Methods: We conducted a cross-sectional survey of all accredited EM residency training programs in the United States in Fall 2019. Read More

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Architecture for an ultrasound advanced open platform with an arbitrary number of independent channels.

IEEE Trans Biomed Circuits Syst 2021 May 6;PP. Epub 2021 May 6.

Ultrasound open platforms are programmable and flexible tools for the development and test of novel methods. In most cases, they embed the electronics for the independent control of (maximum) 256 probe elements. However, a higher number of channels is needed for the control of 2-D array probes. Read More

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Epicardial Adipose Tissue Volume Is Associated with High Risk Plaque Profiles in Suspect CAD Patients.

Oxid Med Cell Longev 2021 12;2021:6663948. Epub 2021 Apr 12.

Department of Cardiovascular Medicine, Sixth Medical Center, Chinese PLA General Hospital, Beijing, China.

Objective: To explore the association between EAT volume and plaque precise composition and high risk plaque detected by coronary computed tomography angiography (CCTA).

Methods: 101 patients with suspected coronary artery disease (CAD) underwent CCTA examination from March to July 2019 were enrolled, including 70 cases acute coronary syndrome (ACS) and 31 cases stable angina pectoris (SAP). Based on CCTA image, atherosclerotic plaque precise compositions were analyzed using dedicated quantitative software. Read More

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The feasibility of a public-private mix program on pulmonary tuberculosis screening in Penang: A pilot study.

Malays Fam Physician 2021 Mar 31;16(1):75-83. Epub 2021 Jan 31.

M.D.(UNIMAS), Master in Family Medicine (UKM), Jalan Perak Health Clinic.

Background: The low detection rate of tuberculosis (TB) cases in Malaysia remains a challenge in the effort to end TB by 2030. The collaboration between private and public health care facilities is essential in addressing this issue. As of now, no private-public health care collaborative program in pulmonary tuberculosis (PTB) screening exists in Malaysia. Read More

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Ultrasonography in the Diagnosis of Adnexal Lesions: The Role of Texture Analysis.

Diagnostics (Basel) 2021 Apr 29;11(5). Epub 2021 Apr 29.

Radiology and Imaging Department, County Emergency Hospital, Clinicilor Street 5, 400006 Cluj-Napoca, Romania.

The classic ultrasonographic differentiation between benign and malignant adnexal masses encounters several limitations. Ultrasonography-based texture analysis (USTA) offers a new perspective, but its role has been incompletely evaluated. This study aimed to further investigate USTA's capacity in differentiating benign from malignant adnexal tumors, as well as comparing the workflow and the results with previously-published research. Read More

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Design and Evaluation of Hybrid Composite Plates for Ballistic Protection: Experimental and Numerical Investigations.

Polymers (Basel) 2021 Apr 30;13(9). Epub 2021 Apr 30.

School of Civil Engineering, College of Engineering, Sudan University of Science and Technology, Khartoum P.O. Box 72, Sudan.

In this paper, hybrid composite plates for ballistic protection were investigated experimentally and numerically, with a target to reduce the weight of currently used body armor inserts and, at the same time, satisfy the requirements of the National Institute of Justice's (NIJ) ballistic protection standards. The current study has three phases to improve the ballistic plate's energy absorption capability. The first phase is devoted to studying the effect of the material types, including three different fibers: carbon fiber, date palm fiber, and Kevlar fiber. Read More

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Endodontic length measurements using cone beam computed tomography with dedicated or conventional software at different voxel sizes.

Khoa Van Pham

Sci Rep 2021 May 3;11(1):9432. Epub 2021 May 3.

Department of Operative Dentistry and Endodontics, Faculty of Odonto-Stomatology, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, 700000, Vietnam.

The aim of this study is to investigate the accuracies and the agreements of the 3D Endo software, conventional CBCT software Romexis Viewer at three voxel sizes, and the EAL ProPex Pixi in endodontic length measurements. Three hundred and twenty-nine root canals in 120 intact human extracted molars were accessed. The actual lengths (AL) and electronic lengths (EL) were measured using the ruler and electronic apex locator (EAL), respectively. Read More

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Quantification of Pancreas Surface Lobularity on CT: A Feasibility Study in the Normal Pancreas.

Korean J Radiol 2021 Apr 23. Epub 2021 Apr 23.

Department of Radiology, Hôpital Beaujon, Clichy, France.

Objective: To assess the feasibility and reproducibility of pancreatic surface lobularity (PSL) quantification derived from abdominal computed tomography (CT) in a population of patients free from pancreatic disease.

Materials And Methods: This retrospective study included 265 patients free from pancreatic disease who underwent contrast-enhanced abdominal CT between 2017 and 2019. A maximum of 11 individual PSL measurements were performed by two abdominal radiologists (head [5 measurements], body, and tail [3 measurements each]) using dedicated software. Read More

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A Novel Phantom and a Dedicated Developed Software for Image Quality Controls in X-Ray Intraoral Devices.

J Biomed Phys Eng 2021 Apr 1;11(2):151-162. Epub 2021 Apr 1.

PhD, Department of Biomedical and Dental Sciences and Morphofunctional Imaging (BIOMORF), University of Messina, Italy.

Background: Periodic quality control (QC) procedures are important in order to guarantee the image quality of radiological equipment and are also conducted using phantoms simulating human body.

Objective: To perform (QC) measurements in intraoral imaging devices, a new and simple phantom was manufactured. Besides, to simplify QC procedures, computerized LabView-based software has been devised, enabling determination of image quantitative parameters in real time or during post processing. Read More

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Digital health technology for remote care in response to the COVID-19 pandemic: a scoping review.

Eur Rev Med Pharmacol Sci 2021 Apr;25(8):3386-3394

Department of Occupational Therapy, College of Rehabilitation Sciences, University of Manitoba, Winnipeg (MB), Canada.

COVID-19 pandemic has forced the emergency deployment of digital health technology (DHT) to provide remote care. DHT is a promising option to enable telehealth, and, by the same token, it contributes to the implementation of social distance measures. The objective of this scoping review is to investigate existing DHT solutions that have been put in place to enable remote care in response to the COVID-19 pandemic. Read More

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In Silico Prediction of Drug-Drug Interactions Mediated by Cytochrome P450 Isoforms.

Pharmaceutics 2021 Apr 13;13(4). Epub 2021 Apr 13.

Laboratory of Structure-Function Based Drug Design, Department of Bioinformatics, Institute of Biomedical Chemistry, Pogodinskaya Str. 10, bldg. 8, 119121 Moscow, Russia.

Drug-drug interactions (DDIs) can cause drug toxicities, reduced pharmacological effects, and adverse drug reactions. Studies aiming to determine the possible DDIs for an investigational drug are part of the drug discovery and development process and include an assessment of the DDIs potential mediated by inhibition or induction of the most important drug-metabolizing cytochrome P450 isoforms. Our study was dedicated to creating a computer model for prediction of the DDIs mediated by the seven most important P450 cytochromes: CYP1A2, CYP2B6, CYP2C19, CYP2C8, CYP2C9, CYP2D6, and CYP3A4. Read More

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Three-Dimensional Urethral Profilometry-A Global Urethral Pressure Assessment Method.

Diagnostics (Basel) 2021 Apr 12;11(4). Epub 2021 Apr 12.

Department of Gynecology and Obstetrics, Faculty of Medicine and Health Sciences, Andrzej Frycz Modrzewski Krakow University, 30-705 Krakow, Poland.

Background: To present a new method of urethral pressure examination, and to evaluate diagnostic capabilities of three-dimensional profilometry, as an alternative to classical urethral profile (UPP). Using five channel catheters and dedicated software, a global urethral pressure image is obtained. The method eliminates the main limitation of classical urethral profilometry, where the catheter orientation determines the pressure picture limited to only one point in the urethral circumference; we observed up to 50% differences in pressure measures depending on the point of urethral circumference where the measurement was taken. Read More

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The Anatomical Conditions of the Alveolar Process of the Anterior Maxilla in Terms of Immediate Implantation-Radiological Retrospective Case Series Study.

J Clin Med 2021 Apr 14;10(8). Epub 2021 Apr 14.

Department of Animal Physiology, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 3 Instytucka Street, 05-110 Jabłonna, Poland.

The feasibility and the level of difficulty of immediate flapless implantation depend largely on the residual alveolar bone. The purpose of the study was to determine how often immediate flapless implantation in the anterior maxilla is feasible and assess the difficulty level using cone-beam computed tomography (CBCT) scans. A radiological retrospective case series study was conducted. Read More

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Petrographic and Geotechnical Characteristics of Carbonate Aggregates from Poland and Their Correlation with the Design of Road Surface Structures.

Materials (Basel) 2021 Apr 18;14(8). Epub 2021 Apr 18.

Eko Cinere Ltd., Warszawska 6/32, 15-063 Białystok, Poland.

The paper presents the basic problem related with practical application of carbonate rocks in construction: are carbonate aggregates produced from such rocks favorable for building engineering, particularly for road design and construction? To resolve this problem, (1) the geological-engineering properties of aggregates are presented, (2) the correlation between petrographic and engineering parameters is shown, and (3) a strict correlation between the geological-engineering properties and the freezing-thawing and crushing resistance is recognized. This knowledge has allowed to assess the usefulness of asphalt concrete (AC) made from dolomite and limestone aggregates in the design and construction of road surface structures. The petrography was characterized using optical microscopy and scanning electron microscopy (SEM) coupled with energy-dispersive X-ray spectroscope (EDS). Read More

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Performance evaluation of pipelines for mapping, variant calling and interval padding, for the analysis of NGS germline panels.

BMC Bioinformatics 2021 Apr 28;22(1):218. Epub 2021 Apr 28.

Department of Electron Microscopy/Molecular Pathology, The Cyprus Institute of Neurology and Genetics, 2371, Nicosia, Cyprus.

Background: Next-generation sequencing (NGS) represents a significant advancement in clinical genetics. However, its use creates several technical, data interpretation and management challenges. It is essential to follow a consistent data analysis pipeline to achieve the highest possible accuracy and avoid false variant calls. Read More

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Assisted Fluid Management Software Guidance for Intraoperative Fluid Administration.

Anesthesiology 2021 Apr 26. Epub 2021 Apr 26.

Background: Excessive or inadequate fluid administration causes complications, but despite this, fluid administration during noncardiac surgery is highly variable. Goal-directed management helps optimize the amount and timing of fluid administration; however, implementation is difficult because algorithms are complex. The authors therefore tested the performance of the Acumen Assisted Fluid Management software (Edwards Lifesciences, USA), which is designed to guide optimal intravenous fluid administration during surgery. Read More

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Super-resolution structured illumination microscopy: past, present and future.

Philos Trans A Math Phys Eng Sci 2021 Jun 26;379(2199):20200143. Epub 2021 Apr 26.

Micron Advanced Bioimaging Unit, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK.

Structured illumination microscopy (SIM) has emerged as an essential technique for three-dimensional (3D) and live-cell super-resolution imaging. However, to date, there has not been a dedicated workshop or journal issue covering the various aspects of SIM, from bespoke hardware and software development and the use of commercial instruments to biological applications. This special issue aims to recap recent developments as well as outline future trends. Read More

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Comparative database search engine analysis on massive tandem mass spectra of pork-based food products for halal proteomics.

J Proteomics 2021 Jun 21;241:104240. Epub 2021 Apr 21.

Laboratory of Halal Services, Halal Products Research Institute, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia; Consortium of Malaysia IPT Halal Institute, Ministry of Higher Education, Complex E, Federal Government Administrative Centre, 62604 Putrajaya, Malaysia; Department of Microbiology, Faculty of Biotechnology and Biomolecular Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia.

Mass spectrometry-based proteomics relies on dedicated software for peptide and protein identification. These software include open-source or commercial-based search engines; wherein, they employ different algorithms to establish their scoring and identified proteins. Although previous comparative studies have differentiated the proteomics results from different software, there are still yet studies specifically been conducted to compare and evaluate the search engine in the field of halal analysis. Read More

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Baseline total metabolic tumour volume on 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography-computed tomography as a promising biomarker in patients with advanced non-small cell lung cancer treated with first-line pembrolizumab.

Eur J Cancer 2021 Apr 20;150:99-107. Epub 2021 Apr 20.

Medical Oncology, IRCCS, Azienda Ospedaliero-Universitaria di Bologna, Italy.

Introduction: Immune checkpoint inhibitors (ICIs) have become the standard of care in the management of advanced non-small cell lung cancer (NSCLC). Nevertheless, only a small proportion of patients benefit from ICIs. The aim of the present study is to assess whether 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography-computed tomography ([18F]FDG-PET/CT)-derived parameters may be used as biomarkers in patients with advanced NSCLC receiving first-line pembrolizumab. Read More

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Scar channels in cardiac magnetic resonance to predict appropriate therapies in primary prevention.

Heart Rhythm 2021 Apr 21. Epub 2021 Apr 21.

Institut Clinic Cardiovascular, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain; Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. Electronic address:

Background: Scar characteristics analyzed by late gadolinium enhancement cardiac magnetic resonance (LGE-CMR) are related with ventricular arrhythmias. Current guidelines are based only on the left ventricular ejection fraction to recommend an implantable cardioverter-defibrillator (ICD) in primary prevention.

Objectives: Our study aims to analyze the role of imaging to stratify arrhythmogenic risk in patients with ICD for primary prevention. Read More

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Development of the GIMEMA-ALLIANCE Digital Health Platform for Patients with Hematologic Malignancies in the COVID-19 Pandemic and Post-Pandemic Era: A Study Protocol.

JMIR Res Protoc 2021 Apr 19. Epub 2021 Apr 19.

Data Center and Health Outcomes Research Unit, Italian Group for Adult Haematologic Diseases (GIMEMA), via Casilina 5, Rome, IT.

Background: The COVID-19 pandemic has raised unprecedented challenges in the management of cancer patients and has increased the demands for digital health tools that, for example, could facilitate remote monitoring of patients. On this ground, the Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) has recently developed a digital health tool dedicated to patients with hematologic malignancies: the GIMEMA-ALLIANCE platform.

Objective: The main objectives of this web-based platform are: to generate relevant data to better understand quality of life, symptoms and medication adherence during the COVID-19 pandemic and post-pandemic era; to develop a prospective real-life registry on outcomes of hematologic cancer patients, with or without a diagnosis of COVID-19; to facilitate patient-centered care in routine practice. Read More

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Platypus: an open-access software for integrating lymphocyte single-cell immune repertoires with transcriptomes.

NAR Genom Bioinform 2021 Jun 14;3(2):lqab023. Epub 2021 Apr 14.

Department of Biosystems Science and Engineering, ETH Zurich, 4058 Basel, Switzerland.

High-throughput single-cell sequencing (scSeq) technologies are revolutionizing the ability to molecularly profile B and T lymphocytes by offering the opportunity to simultaneously obtain information on adaptive immune receptor repertoires (VDJ repertoires) and transcriptomes. An integrated quantification of immune repertoire parameters, such as germline gene usage, clonal expansion, somatic hypermutation and transcriptional states opens up new possibilities for the high-resolution analysis of lymphocytes and the inference of antigen-specificity. While multiple tools now exist to investigate gene expression profiles from scSeq of transcriptomes, there is a lack of software dedicated to single-cell immune repertoires. Read More

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Clusters of Double Triggering Impact Clinical Outcomes: Insights From the EPIdemiology of Patient-Ventilator aSYNChrony (EPISYNC) Cohort Study.

Crit Care Med 2021 Apr 21. Epub 2021 Apr 21.

Divisao de Pneumologia, Instituto do Coracao, Hospital das Clinicas, Faculdade de Medicina Universidade de São Paulo, São Paulo, Brazil. Serviço de Fisioterapia, Instituto do Coracao, Hospital das Clinicas, Faculdade de Medicina Universidade de São Paulo, Faculdade de Medicina Universidade de São Paulo, São Paulo, Brazil. Critical Care Center, Hospital Universitari Parc Taulí, Institut d'Investigació i Innovació Parc Taulí I3PT, Universitat Autònoma de Barcelona, Sabadell, Spain. Centro de Investigación Biomédica en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain. Department of Respiratory Care, Massachusetts General Hospital, Harvard Medical School, Boston, MA. Department of Anesthesiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

Objectives: To measure the impact of clusters of double triggering on clinical outcomes.

Design: Prospective cohort study.

Setting: Respiratory ICU in Brazil. Read More

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Characterization of the ZAP-X® Peripheral Dose Fall-Off.

Cureus 2021 Mar 18;13(3):e13972. Epub 2021 Mar 18.

Treatment Planning, Zap Surgical Systems, Inc., San Carlos, USA.

Various small-field radiation dose detectors were systematically compared and their impact on measured beam performance of the ZAP-X® dedicated stereotactic radiosurgery system (ZAP Surgical Systems, Inc., San Carlos, CA, USA) was determined. Three Physikalische Technische Werkstaetten (PTW) diodes, i. Read More

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