1,556,430 results match your criteria decreased apparent

Decreased level of miR-1301 promotes colorectal cancer progression via activation of STAT3 pathway.

Biol Chem 2021 May 13. Epub 2021 May 13.

Institute of Preventive Genomic Medicine, School of Life Sciences, Northwest University, Xi'an710069, China.

The molecular pathogenesis of colorectal cancer (CRC) has been widely investigated in recent years. Accumulating evidence has indicated that microRNA (miRNA) dysregulation participates in the processes of driving CRC initiation and progression. Aberrant expression of miR-1301 has been found in various tumor types. Read More

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An overview of the comparison of inhalation aromatherapy on emotional distress of female and male patients in preoperative period.

J Complement Integr Med 2021 May 13. Epub 2021 May 13.

Department of Midwifery, Maternal-Fetal Medicine Research Center, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran.

Objectives: Many patients experience anxiety and stress before surgery. Anxiety is also different in men and women so that the prevalence of anxiety disorders in women is higher than men. The present study aimed to compare the effect of inhalation aromatherapy on emotional distress of men and women before surgery. Read More

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Plasma levels of bigEndothelin-1 are associated with renal insufficiency and in-hospital mortality of immune thrombotic thrombocytopenic purpura.

Thromb Haemost 2021 May 13. Epub 2021 May 13.

Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, United States.

Immune thrombotic thrombocytopenic purpura (iTTP) is caused by severe deficiency of plasma ADAMTS13 activity. Despite advances in early diagnosis and management, the mortality rate of acute iTTP remains high in a large part of world where access to some of the most novel therapies is limited. To determine the role of plasma bigEndothelin-1 (bigET-1) or its bioactive product ET-1 as a biomarker and/or a pathogenic factor in acute iTTP, plasma levels of bigET-1 were determined using an immunoassay in patients with iTTP on admission and during remission, as well as in healthy controls; moreover, the biological effect of ET-1 in thrombus formation was determined by a microfluidic assay. Read More

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Does Higher Self-Reported Cardiorespiratory Fitness Reduce the Odds of Hospitalization From COVID-19?

J Phys Act Health 2021 May 12:1-7. Epub 2021 May 12.

Background: Regular physical activity and higher cardiorespiratory (CR) fitness enhance immune function, possibly reducing coronavirus disease 2019 (COVID-19) infection severity. The aim was to assess the association between physical activity and self-reported CR fitness on COVID-19 infection characteristics.

Methods: Participants formerly testing positive for COVID-19 completed an online questionnaire measuring COVID-19 infection characteristics and complications, self-reported CR fitness level, physical activity, and sociodemographic and health-related characteristics. Read More

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White matter microstructure alterations in cortico-striatal networks are associated with parkinsonism in schizophrenia spectrum disorders.

Eur Neuropsychopharmacol 2021 May 10;50:64-74. Epub 2021 May 10.

Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. Electronic address:

The specific role of white matter (WM) microstructure in parkinsonism among patients with schizophrenia spectrum disorders (SSD) is largely unknown. To determine whether topographical alterations of WM microstructure contribute to parkinsonism in SSD patients, we examined healthy controls (HC, n=16) and SSD patients with and without parkinsonism, as defined by Simpson-Angus Scale total score of ≥4 (SSD-P, n=33) or <4 (SSD-nonP, n=62). We used whole brain tract-based spatial statistics (TBSS), tractometry (along tract statistics using TractSeg) and graph analytics (clustering coefficient (CCO), local betweenness centrality (BC)) to provide a framework of specific WM microstructural changes underlying parkinsonism in SSD. Read More

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Masticatory coefficient and physical functioning in older frail patients admitted for a Comprehensive Gerontological Assessment.

Arch Gerontol Geriatr 2021 Apr 20;95:104421. Epub 2021 Apr 20.

Clinical Gerontology Department, CHU Bordeaux, 33000, Bordeaux, France; CRMSB, UMR 5536, CNRS/Bordeaux University, Bordeaux, France. Electronic address:

Background: Physical functioning may be limited in older, frail patients with missing teeth without prosthetic correction. This cross-sectional study examined the relationship between physical performance and the geriatric masticatory coefficient (GMC) in patients who underwent both a comprehensive gerontological assessment (CGA) to improve poly-pathology management and an intra-oral exam.

Methods: All patients were evaluated based on the following: (corrected) GMC, number of posterior occluding pairs (POPs), short physical performance battery (SPPB) or timed up and go (TUG) test, and mini-nutritional assessment (MNA). Read More

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Porcine circovirus type 2 infection attenuates the K63-linked ubiquitination of STING to inhibit IFN-β induction via p38-MAPK pathway.

Vet Microbiol 2021 May 4;258:109098. Epub 2021 May 4.

College of Veterinary Medicine, Northwest A&F University, Yangling, 712100, China. Electronic address:

Porcine circovirus 2 (PCV2) has been proved to increase the risk of other pathogens infection via immunosuppression. Although the co-infection of PCV2 and porcine parvovirus (PPV) is commonly observed in worldwide, the relative immune mechanisms promoting PPV infection in PCV2-infected piglets are currently unknown. Herein, we found that PCV2 infection suppressed IFN-β expression and promoted PPV infection in the piglets. Read More

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Host factor cyclophilin B affects Orf virus replication by interacting with viral ORF058 protein.

Vet Microbiol 2021 May 4;258:109099. Epub 2021 May 4.

Key Laboratory of Zoonosis, Ministry of Education, College of Veterinary Medicine, Jilin University, Changchun, China. Electronic address:

Poxviruses have evolved multiple strategies to modulate host-derived factors to create an optimal environment for viral efficient replication. Our previous study indicated that cyclophilin B (CypB) is a critical factor for ORFV replication in MDBK cells. However, the precise molecular mechanism by which CypB facilitates ORFV replication remains less understood. Read More

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Arsenic bioaccumulation in the soil fauna alters its gut microbiome and microbial arsenic biotransformation capacity.

J Hazard Mater 2021 May 5;417:126018. Epub 2021 May 5.

State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. Electronic address:

The biotransformation of arsenic mediated by microorganisms plays an important role in the arsenic biogeochemical cycle. However, the fate and biotransformation of arsenic in different soil fauna gut microbiota are largely unknown. Herein the effects of arsenic contamination on five types of soil fauna were compared by examining variations in arsenic bioaccumulation, gut microbiota, and arsenic biotransformation genes (ABGs). Read More

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Enantiomeric profiling of mefentrifluconazole in watermelon across China: Enantiochemistry, environmental fate, storage stability, and comparative dietary risk assessment.

J Hazard Mater 2021 May 5;417:125985. Epub 2021 May 5.

State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, PR China. Electronic address:

Elucidating the enantiomeric chemistry and enantioselective fate of the novel chiral triazole fungicide mefentrifluconazole is of vital importance for agroecosystem safety and human health. The absolute configuration of mefentrifluconazole was identified firstly as S-(+)-mefentrifluconazole and R-(-)-mefentrifluconazole on a cellulose tris(3-chloro-4-methylphenylcarbamate) chiral phase. A baseline resolution (Rs, 2. Read More

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3-Acetyldeoxynivalenol induces cell death through endoplasmic reticulum stress in mouse liver.

Environ Pollut 2021 Apr 27;286:117238. Epub 2021 Apr 27.

State Key Laboratory of Animal Nutrition, Department of Animal Nutrition and Feed Science, China Agricultural University, Beijing, 100193, China; Beijing Advanced Innovation Center for Food Nutrition and Human Health, China Agricultural University, Beijing, 100193, China.

Ingestion of food or cereal products contaminated by deoxynivalenol (DON) and related derivatives poses a threat to the health of humans and animals. However, the toxicity and underlying mechanisms of 3-acetyldeoxynivalenol (3-Ac-DON), an acetylated form of deoxynivalenol, have not been fully elucidated. In the present study, we showed that 3-Ac-DON caused significant oxidative damage, as shown by elevated aspartate aminotransferase (AST), alanine aminotransferase (ALT), and lactic dehydrogenase (LDH) in serum, increased lipid peroxidation products, such as hydrogen peroxide (HO) and malondialdehyde (MDA), decreased activities of antioxidant enzymes catalase (CAT) and superoxide dismutase (SOD). Read More

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Spatio-temporal changes of road traffic noise pollution at ecoregional scale.

Environ Pollut 2021 May 4;286:117291. Epub 2021 May 4.

Universidad Politécnica de Madrid, Madrid, Spain.

Noise pollution is a pervasive factor that increasingly threatens natural resources and human health worldwide. In particular, large-scale changes in road networks have driven shifts in the acoustic environment of rural landscapes during the past few decades. Using sampling plots from the Spanish Landscape Monitoring System (SISPARES), 16 km each, we modelled the spatio-temporal changes in road traffic noise pollution in Ecoregion 1 of Spain (approximately 66,000 km). Read More

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Simultaneous bilateral opening-wedge high tibial osteotomy with structural allograft impaction results in excellent early recovery and pain reduction similar unilateral osteotomy.

Knee 2021 May 10;30:283-290. Epub 2021 May 10.

Department of Orthopaedic Surgery, AZ Herentals, Herentals, Belgium. Electronic address:

Background: Patients suffering from bilateral combined medial osteoarthritis and varus alignment of the knee are eligible for bilateral high tibial osteotomy (HTO) in two-staged surgery. The impact of bilateral HTO surgery on rehabilitation and early outcomes have not yet been reported in the literature, even though these features are decisive in establishing whether a patient is preferably treated in one or two stages.

Methods: A total of 29 patients were followed after simultaneous bilateral HTO surgery. Read More

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Absence of Toll-like receptor 7 protects mice against Pseudomonas aeruginosa pneumonia.

Int Immunopharmacol 2021 May 10;96:107739. Epub 2021 May 10.

Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China. Electronic address:

Toll-like receptor 7 (TLR7) is a sensor of microbial ssRNA that participates in the immune response process in many diseases. We herein sought to establish the role of TLR7 in Pseudomonas aeruginosa pneumonia. Pneumonia model was created by intratracheally injecting Pseudomonas aeruginosa and the effects of TLR7 on survival, bacterial burden, lung pathology, cytokine and chemokine production, and pulmonary leukocyte recruitment were measured after Pseudomonas aeruginosa challenge. Read More

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Concentration and atmospheric transport of PM-bound polycyclic aromatic hydrocarbons at Mount Tai, China.

Sci Total Environ 2021 May 5;786:147513. Epub 2021 May 5.

Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters, Key Laboratory for Aerosol-Cloud-Precipitation of China Meteorological Administration, Nanjing University of Information Science & Technology, Nanjing 210044, China.

Atmospheric PM-bound polycyclic aromatic hydrocarbons (PAHs) pose a major threat to human health. At present, studies on PAHs in the atmosphere have mostly focused on their concentration levels and source apportionment, whereas studies on the vertical transport of PAHs in the atmosphere are limited. However, the vertical transport of PAHs is important for their diffusion near the ground and their long-range transport at higher altitude. Read More

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Natalizumab differentially affects plasmablasts and B cells in multiple sclerosis.

Mult Scler Relat Disord 2021 May 1;52:102987. Epub 2021 May 1.

Danish Multiple Sclerosis Center, Department of Neurology, Rigshospitalet, Copenhagen University Hospital, Glostrup, Denmark. Electronic address:

Background: Natalizumab treatment increases the frequencies of B cells in blood but reduces IgG in blood and CSF. Plasmablasts are important in the production of IgG, and the development of plasmablasts is CD49d dependent.

Objective: We hypothesized that natalizumab treatment affects the development of plasmablasts. Read More

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Additive grain-size: An innovative perspective to investigate the transformation among heavy metal and phosphorus fractions during aerobic composting.

J Environ Manage 2021 May 10;292:112768. Epub 2021 May 10.

Key Laboratory of Wetland Ecology and Environment, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, Changchun, 130102, China; Jilin Provincial Engineering Center of CWs Design in Cold Region & Beautiful Country Construction, Northeast Institute of Geography and Agroecology, Chinese Academy of Sciences, Changchun, 130102, China; University of Chinese Academy of Sciences, Beijing, 100049, China.

Considerable researches have been devoted to ascertain the transformation among heavy metal (HM) or phosphorus (P) fractions during aerobic composting. However, available information that additives with different grain-sizes regulate the activation mechanism on P through influencing the passivation effect on HMs remains limited. Thus, this work aimed to investigate the dynamic changes in HM-fractions and P-fractions, and ascertain the interaction pathway between HMs and P during aerobic composting amended with medical stone (Coarse medical stone, 3-5 mm; Fine medical stone, < 0. Read More

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Effect of the gradual increase of NaSO on performance and microbial diversity of aerobic granular sludge.

J Environ Manage 2021 May 10;292:112696. Epub 2021 May 10.

Department of Civil and Environmental Engineering, Harbin Institute of Technology, Shenzhen, Shenzhen, 518055, China.

Aerobic granular sludge (AGS) is a promising technology in treating saline wastewater. The effects of sodium sulfate on contaminant removal performance and sludge characteristics of AGS were studied. The results showed that under the stress of sodium sulfate, AGS kept good removal performance of ammonia nitrogen (NH+ 4-N), chemical oxygen demand (COD), and total nitrogen (TN), with removal efficiency reaching 98. Read More

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Canine mast cell tumour cells regulate tryptophan catabolism via the expression of indoleamine 2,3-dioxygenase.

Res Vet Sci 2021 Apr 30;137:159-162. Epub 2021 Apr 30.

Laboratory of Comparative Animal Medicine, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan.

Indoleamine 2,3-deoxygenase (IDO) produced by cancer cells catabolizes tryptophan (TRP) to kynurenine (KYN) in the environment, resulting induction of cancer immune escape through induction of T cell anergy and enhancement of regulatory T cells. Recently, inhibition of IDO has been recognized as one of therapeutic strategies for human neoplastic diseases. However, there have been few reports about IDO-expressing cancers in dogs. Read More

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Plasmalogen attenuates the development of hepatic steatosis and cognitive deficit through mechanism involving p75NTR inhibition.

Redox Biol 2021 May 7;43:102002. Epub 2021 May 7.

College of Food Science and Engineering, Ocean University of China, 5 Yushan Road, 266003, Qingdao, Shandong Province, China; Qingdao National Laboratory for Marine Science and Technology, 266235, Qingdao, Shandong Province, China. Electronic address:

Emerging evidence suggests that the reduction of ethanolamine plasmalogen (PlsEtn) is associated with in Alzheimer's disease and metabolic diseases. However, the mechanistic bases for PlsEtn on the these diseases are not well understood. Plasmalogens are primarily synthesized in the liver and enriched in brain. Read More

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Interactions of functional microorganisms and their contributions to methane bioconversion to short-chain fatty acids.

Water Res 2021 Apr 26;199:117184. Epub 2021 Apr 26.

Advanced Water Management Centre, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia. Electronic address:

Methane bioconversion to value-added liquid chemicals has been proposed as a promising solution to augment the petroleum-dominated chemical market. Recent investigations have reported that various electron acceptors (e.g. Read More

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Psychophysiological responses of firefighters to day and night rescue interventions.

Appl Ergon 2021 May 10;95:103457. Epub 2021 May 10.

University of Bourgogne-Franche-Comte, Laboratory C3S (EA 4660), Department Sport and Performance, UFR STAPS, 31 Chemin de l'Epitaphe, 25000, Besançon, France. Electronic address:

This study aimed 1) to assess the psychophysiological responses throughout a rescue intervention performed during the day and at night and 2) to determine if a vibrating alarm influences these psychophysiological responses at night. Sixteen male firefighters completed a simulated intervention under three different conditions: 1) during the day with a sound alarm signal (Day), 2) during the night with a sound alarm signal (Night), 3) during the night with a vibrating alarm signal (Night). Cardiovascular and psychological stress were recorded throughout the interventions. Read More

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The dose-dependent effects of polyphenols and malondialdehyde on the emulsifying and gel properties of myofibrillar protein-mulberry polyphenol complex.

Food Chem 2021 May 5;360:130005. Epub 2021 May 5.

Sericultural & Agri-Food Research Institute, Guangdong Academy of Agricultural Sciences, Key Laboratory of Functional Foods, Ministry of Agriculture and Rural Affairs, Guangdong Key Laboratory of Agricultural Products Processing, Guangzhou 510610, PR China. Electronic address:

The effects of mulberry polyphenols and malondialdehyde (MDA) on the emulsifying and gel properties of myofibrillar protein (MP) were studied. Emulsibility and gel properties of MP were compared in range of mulberry polyphenol/MDA concentrations by particle size, Zeta potential, antioxidant capacity, gel strength, water-holding capacity (WHC), rheological properties and microstructure. Mulberry polyphenols enhanced the inoxidizability of MP emulsion but decreased its emulsifying property. Read More

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Variations in phenolic acids and antioxidant activity of navel orange at different growth stages.

Food Chem 2021 May 6;360:129980. Epub 2021 May 6.

State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, Jiangxi, China. Electronic address:

Ripe navel orange has abundant amounts of phenolic compounds. Few studies monitored changes in these compounds during ripening. In this study, the effects of navel orange maturation on dynamic changes in antioxidant activity, total phenolic content (TPC), total flavonoid content (TFC) and phenolic acids were investigated. Read More

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Burosumab treatment for fibrous dysplasia.

Bone 2021 May 10:116004. Epub 2021 May 10.

Metabolic Bone Disorders Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA. Electronic address:

Background: Fibrous dysplasia/McCune-Albright syndrome (FD/MAS) is a rare mosaic disorder of Gα activation. Fibroblast Growth Factor 23 (FGF23)-mediated hypophosphatemia is a feature of FD/MAS that has been associated with poor skeletal outcomes. Standard therapy includes oral phosphorus and vitamin D analogs; however, treatment is limited by potential adverse renal and gastrointestinal effects. Read More

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High silver concentrations in biological samples following different exposures: Two case reports.

J Trace Elem Med Biol 2021 May 7;67:126775. Epub 2021 May 7.

Centre anti-poison-toxicovigilance, CHU Angers, France.

Background: Silver is used in various industrial applications, but also in confectioneries and for therapeutic use due to its antibiotic properties. Its toxicity is not well documented and most often only in the context of professional exposure.

Aim: Here we report two cases of high silver concentrations in biological samples in two women: the first patient presented grey marks around her cuticles, probably due to her consumption of silvered sweets and the second patient presented agranulocytosis and thrombocytopenia occurring within 24 h after the topical application of a cream containing sulfadiazine and silver to burns over a large surface area. Read More

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The protective effect of zinc on morphine-induced testicular toxicity via p53 and Akt pathways: An in vitro and in vivo approach.

J Trace Elem Med Biol 2021 May 8;67:126776. Epub 2021 May 8.

Department of Physiology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran. Electronic address:

Background: Chronic use of morphine is associated with reproductive complications, such as hypogonadism and infertility. While the side effects of morphine have been extensively studied in the testis, much less is known regarding the effects of morphine on Sertoli cells and the effects of zinc on morphine-induced testicular injury as well as their underlying mechanisms. Therefore, the purpose of this study was to investigate the effect of morphine (alone and co-administered with zinc) on cell viability and apoptosis of the testicular (Sertoli) cells as well as the tumor suppressor p53 and phosphorylated-protein kinase B (p-Akt) protein levels in both in vitro and in vivo models. Read More

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Whole Exome Sequencing and Functional Characterization Increase Diagnostic Yield in Siblings with a 46, XY Difference of Sexual Development (DSD).

J Steroid Biochem Mol Biol 2021 May 10:105908. Epub 2021 May 10.

Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine and St. Louis Children's Hospital, St. Louis, MO, USA. Electronic address:

Pathogenic biallelic variants in HSD17B3 result in 17β-hydroxysteroid dehydrogenase 3 (17β-HSD3) deficiency, variable disruption of testosterone production, and phenotypic diversity among 46, XY individuals with differences of sexual development (DSDs). We performed quad whole exome sequencing (WES) on two male siblings with microphallus, perineal hypospadias, and bifid scrotum and their unaffected parents. Both male siblings were compound heterozygous for a rare pathogenic HSD17B3 variant (c. Read More

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Epidemiological and clinical features of SARS-CoV-2 cluster infection in Anhui Province, Eastern China.

Int J Infect Dis 2021 May 10. Epub 2021 May 10.

Anhui Provincial Center for Disease Control and Prevention, Hefei, China. Electronic address:

Background: COVID-19 has spread worldwide and become a pandemic. We report the epidemiological and clinical characteristics of cluster infections.

Methods: Data of clustered cases were retrieved from the public health emergency monitoring information system of China. Read More

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Cardiovascular responses to putative chemoreceptor stimulation of embryonic common snapping turtles (Chelydra serpentina) chronically incubated in hypoxia (10% O).

Comp Biochem Physiol A Mol Integr Physiol 2021 May 10:110977. Epub 2021 May 10.

Department of Biological Sciences, University of North Texas, 1155 Union Circle #310559, Denton, TX 76203, United States of America. Electronic address:

Developmental hypoxia has been shown to result in significant changes in cardiovascular development of American alligators and common snapping turtles. These include similar effects on cardiac mass and aspects of cardiovascular function. However, given the distant phylogenetic relationship between crocodilians and chelonians, we hypothesized that snapping turtles would also exhibit differences in the effects of developmental hypoxia on cardiovascular regulation. Read More

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