Front Cell Infect Microbiol 2011 26;1:20. Epub 2011 Dec 26.
Department of Biology, South Texas Center for Emerging Infectious Diseases, University of Texas at San Antonio, San Antonio, TX, USA; Department of Biology, Center of Excellence in Infection Genomnics, The University of Texas at San Antonio, San Antonio, TX, USA.
Neutrophils form the first line of defense during infection and are indispensable in this function. The neutrophil elastase is a key effector molecule of the innate immune system with potent antimicrobial activity against Gram-negative bacteria, spirochaetes, and fungi. However, the release of neutrophil elastase during bacterial infection must be checked otherwise its release in the extracellular milieu will result in damage to surrounding tissues. Read More