43,796 results match your criteria decrease calcium


Neuromuscular junction instability and altered intracellular calcium handling as early determinants of force loss during unloading in humans.

J Physiol 2021 Apr 21. Epub 2021 Apr 21.

Department of Biomedical Sciences, University of Padova, Padova, 35131, Italy.

Key Points: Few days of unloading are sufficient to induce a decline of skeletal muscle mass and function; notably, contractile force is lost at a faster rate than mass. The reasons behind this disproportionate loss of muscle force are still poorly understood. We provide strong evidence of two mechanisms only hypothesized until now for the rapid muscle force loss in only 10 days of bed rest. Read More

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Fatty Acids from Different Fat Sources and Dietary Calcium Concentration Differentially Affect Fecal Soap Formation in Growing Pigs.

J Nutr 2021 Apr 20. Epub 2021 Apr 20.

Riddet Institute, Massey University, Palmerston North 4442, New Zealand.

Background: Calcium (Ca) can complex with free fatty acids in the gastrointestinal tract (GIT), leading to the formation of insoluble unabsorbable Ca-fatty acid soaps, contributing to the proposed effect of Ca on weight loss in humans.

Objectives: We determined the effect of dietary Ca concentration and the individual long-chain fatty acids on Ca-fatty acid soap formation and fatty acid digestibility.

Methods: Nine-week-old crossbreed male pigs (n = 144; mean ± SD body weight: 21. Read More

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Mechanisms of Doxorubicin-Mediated Reproductive Toxicity - A Review.

Reprod Toxicol 2021 Apr 17. Epub 2021 Apr 17.

Centre for Cardiovascular and Adverse Drug Reactions, Department of Biotechnology, School of Bio and Chemical Engineering, Kalasalingam Academy of Research and Education, Krishnankoil, Tamil Nadu, PIN 626126, India. Electronic address:

The anticancer drug Doxorubicin has been associated with several adverse side-effects including reproductive toxicity in both genders. The current review has complied the mechanisms of doxorubicin induced reproductive toxicity. The articles cited in the review were searched using Google Scholar, PubMed, Scopus, Science Direct. Read More

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Hemodynamic Instability and Abnormal Vasopressor Responsiveness in the Setting of Severe Metabolic Acidosis Treated With Adapted Alkalinization and Continuous Renal Replacement Therapy in the Emergency Department.

J Emerg Med 2021 Jan 22;60(1):67-72. Epub 2020 Oct 22.

Department of Emergency Medicine, Einstein Healthcare Network, Einstein Medical Center Philadelphia, Philadelphia, Pennsylvania.

Background: Whereas laboratory data and clinical experience suggest that metabolic acidosis deleteriously affects certain cardiovascular functions and may contribute to hemodynamic compromise, treatment of acidemia itself with alkalinization therapy, predominantly in the form of bolus dosing of intravenous sodium bicarbonate, has not been shown to improve hemodynamics or patient-oriented outcomes in clinical trials. Detailed examination of the biochemical effects of standard sodium bicarbonate administration reveals a possible explanation: ionized serum hypocalcemia, serum hypercarbia, and a paradoxical decrease in intracellular pH occur when bicarbonate is given alone and rapidly, without adjustment in minute ventilation or calcium supplementation. "Adapted alkalinization" treatment countering these side effects through hyperventilation, calcium supplementation, and slower sodium bicarbonate infusion has been studied in animals, but not yet described in humans. Read More

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January 2021

Outcomes of Calcium Hydroxide with Iodoform Pulpectomies in Primary Teeth.

J Dent Child (Chic) 2021 Jan;88(1):46-51

Dr. Moskovitz is a clinical associate professor, Department of Pediatric Dentistry, Hebrew University - Hadassah School of Dental Medicine, Jerusalem, Israel;, Email:

To assess retrospectively the success rate of calcium hydroxide with iodoform as a filling material in pulpectomies of primary molars with irreversible pulpitis or pulp necrosis, and to evaluate factors that affect outcomes.
This study consisted of records of 73 patients with primary molars treated with pulpectomy with high quality radiographs. Treatment was considered successful clinically if the tooth was not extracted and radiographs showed a decrease or no change in preexisting pathologic radiolucent defects. Read More

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January 2021

The biology of myco-heterotrophic ('saprophytic') plants.

Authors:
Jonathan R Leake

New Phytol 1994 Jun;127(2):171-216

Department of Animal & Plant Sciences, University of Sheffield, PO Box 60], Sheffield, S10 2UQ, UK.

More than 400 species of vascular plants, in 87 genera, are acholophyllous and heterotrophic, but not directly parasitic upon autotrophs. They are usually, but incorrectly, described as 'saprophytes'since they are in fact nourished by means of specialized mycorrhizal associations. Although distributed world-wide, they are most abundant and show the greatest species-richness in the Neotropics and Palaeotropical regions. Read More

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Effect of nitrogen source on growth response to salinity stress in maize and wheat.

New Phytol 1989 Feb;111(2):155-160

Plant Adaptation Research Unit, The Jacob Blaustein Institute for Desert Research, Ben Gurion University of the Negev, Sede Boqer Campus, Israel 84993.

The effect of ammonium and nitrate nutrition on maize and wheat grown hydroponically and salinity stressed was assessed from measurements of growth rate and gas exchange. In both maize and wheat the ammonium-grown plains were much more sensitive to salinity toxicity than nitrate-grown plants particularly when exposed to 60-80 mM salinity. Shoot growth was retarded to a far greater extent than root growth in salinity-stressed plants of both wheat and maize with either nitrogen source. Read More

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February 1989

Effect of dietary treatment and fluid intake on the prevention of recurrent calcium stones and changes in urine composition: A meta-analysis and systematic review.

PLoS One 2021 19;16(4):e0250257. Epub 2021 Apr 19.

Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu, China.

To perform a systematic review and meta-analysis of randomized controlled trials (RCTs) for investigating the effect of dietary treatment and fluid intake on the prevention of recurrent calcium stones and changes in urine composition. PubMed, Web of Science, Embase, EBSCO, and Cochrane Library databases (updated November 2020) were searched for studies with the following keywords: diet, fluid, recurrent, prevention, randomized controlled trials, and nephrolithiasis. The search strategy and study selection process was conducted by following the PRISMA statement. Read More

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The Degradation of Airway Epithelial Tight Junctions in Asthma Under High Airway Pressure Is Probably Mediated by Piezo-1.

Front Physiol 2021 1;12:637790. Epub 2021 Apr 1.

Far Eastern Scientific Center of Physiology and Pathology of Respiration, Russian Academy of Medical Sciences, Blagoveshchensk, Russia.

Full functioning of the airway physical barrier depends on cellular integrity, which is coordinated by a series of tight junction (TJ) proteins. Due to airway spasm, edema, and mucus obstruction, positive end-expiratory alveolar pressure (also termed auto-PEEP) is a common pathophysiological phenomenon, especially in acute asthma attack. However, the influence of auto-PEEP on small airway epithelial TJs is currently unclear. Read More

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The Play of Citrate Infusion with Calcium in Plateletpheresis Donors.

Indian J Hematol Blood Transfus 2021 Apr 1;37(2):295-301. Epub 2020 Sep 1.

Department of Transfusion Medicine, Institute of Liver and Biliary Sciences, New Delhi, 110 070 India.

Citrate is the anticoagulant of choice for plateletpheresis. Citrate toxicity is common during plateletpheresis as citrate chelates calcium and causes hypocalcemia in donors. We have conducted this study to analyze the effects of routine citrate infusion during plateletpheresis on laboratory and clinical parameters. Read More

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Protonic Conduction in the BaNdInO Structure Achieved by Acceptor Doping.

Chem Mater 2021 Mar 10;33(6):2139-2146. Epub 2021 Mar 10.

Department of Materials, Imperial College London, Exhibition Road, London SW7 2AZ, U.K.

The potential of calcium-doped layered perovskite compounds, BaNd Ca InO (where is the excess Ca content), as protonic conductors was experimentally investigated. The acceptor-doped ceramics exhibit improved total conductivities that were 1-2 orders of magnitude higher than those of the pristine material, BaNdInO. The highest total conductivity of 2. Read More

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Low serum vitamin B levels are associated with degenerative rotator cuff tear.

BMC Musculoskelet Disord 2021 Apr 17;22(1):364. Epub 2021 Apr 17.

Department of Orthopaedic Surgery, CHA Bundang Medical Center, CHA University School of Medicine, 335 Pangyo-ro, Bundang-gu, Seongnam-si, Gyeonggi-do, 13488, Republic of Korea.

Background: Vitamin B (Vit B) deficiency results in elevated homocysteine levels and interference with collagen cross-linking, which may affect tendon integrity. The purpose of this study was to investigate whether serum Vit B levels were correlated with degenerative rotator cuff (RC) tear.

Methods: Eighty-seven consecutive patients with or without degenerative RC tear were enrolled as study participants. Read More

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Bioactive constituents and the molecular mechanism of Curcumae Rhizoma in the treatment of primary dysmenorrhea based on network pharmacology and molecular docking.

Phytomedicine 2021 Mar 27;86:153558. Epub 2021 Mar 27.

Department of Pharmacy, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, China; Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, 210028, China. Electronic address:

Background: Curcumae Rhizoma (CR) has a clinical efficacy in activating blood circulation to dissipate blood stasis and has been used for the clinical treatment of qi stagnation and blood stasis (QSBS) primary dysmenorrhea for many years. However, its molecular mechanism is unknown.

Objective: The present study aimed to demonstrate the multicomponent, multitarget and multipathway regulatory molecular mechanisms of CR in the treatment of QSBS primary dysmenorrhea. Read More

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Effect of different manipulations on the physical, chemical and microstructural characteristics of Biodentine.

Dent Mater 2021 Apr 13. Epub 2021 Apr 13.

School of Dentistry, University of Birmingham, Birmingham, UK.

Objective: The water to powder ratio and method of mixing is important for the properties of hydraulic cements. For this purpose a number of clinicians prefer premixed materials. Dental manufacturing companies provide predosed materials, however the manufacturer instructions are not always adhered to. Read More

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Quercetin inhibits histamine-induced calcium influx in human keratinocyte via histamine H4 receptors.

Int Immunopharmacol 2021 Apr 13;96:107620. Epub 2021 Apr 13.

Graduate Institute of Biomedical and Pharmaceutical Science, Fu Jen Catholic University, New Taipei City, Taiwan; Department of Fragrance and Cosmetic Science, Kaohsiung Medical University, Kaohsiung, Taiwan; School of Medicine, Fu Jen Catholic University, Xinzhuang, New Taipei City, Taiwan; Program in Pharmaceutical Biotechnology, Fu Jen Catholic University, New Taipei City, Taiwan. Electronic address:

Histamine is released from mast cells when tissues are inflamed or stimulated by allergens. Activation of histamine receptors and calcium influx via TRPV1 could be related to histamine-induced itch and skin inflammation. Quercetin is known to have anti-inflammatory and anti-itching effects. Read More

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Rate of force development is Ca-dependent and influenced by Ca-sensitivity in human single muscle fibres from older adults.

Exp Gerontol 2021 Apr 13:111348. Epub 2021 Apr 13.

Department of Human Health and Nutritional Sciences, College of Biological Sciences, University of Guelph, Guelph, Ontario, Canada. Electronic address:

Natural adult aging is associated with declines in skeletal muscle performance, including impaired Ca sensitivity and a slowing of rapid force production (rate of force redevelopment; k). The purpose of this study was to investigate the relationship between impaired Ca sensitivity and k of single muscle fibres from young and older adults. Participants included 8 young (22-35 yrs) and 8 older (60-81 yrs) males who were living independently. Read More

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An Observational Cohort Study of the 2-Month Use of Regional Citrate Anticoagulation in Maintenance Hemodialysis Patients with Cerebral Hemorrhage.

Med Sci Monit 2021 Apr 16;27:e930513. Epub 2021 Apr 16.

Division of Nephrology and Critical Care Nephrology Unit, Shanghai Ninth People's Hospital, Shanghai JiaoTong University, School of Medicine, Shanghai, China (mainland).

BACKGROUND Regional citrate anticoagulation (RCA) is a recommended anticoagulation alternative for patients at high risk of bleeding while undergoing intermittent hemodialysis. Previous reports implied the risk of citrate application on bone metabolism. It is unclear whether long-term use of RCA is safe for maintenance hemodialysis patients in terms of bone metabolism. Read More

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Fluoxetine affects cytosolic cAMP, ATP, Ca responses to forskolin, and survival of human ovarian granulosa tumor COV434 cells.

Korean J Physiol Pharmacol 2021 May;25(3):189-195

Physiologie de la Reproduction & des Comportements Laboratory, Centre National de la Recherche Scientifique (CNRS), Institut National de la Recherche Agronomique & Environnementale (INRAe), University of Tours, Nouzilly 37380, France.

Fluoxetine (FLX), a selective serotonin reuptake inhibitor antidepressant, exhibits various other mechanisms of action in numerous cell types and has been shown to induce cell death in cancer cells, paving the way for its potential use in cancer therapy. The aim of this study was to determine the off-target effects of the anti-depressant drug FLX, on the human ovarian granulosa tumor COV434 cells stimulated by forskolin (FSK), by measuring the real-time kinetics of intracellular cyclic AMP (cAMP), ATP level, cytoplasmic calcium ([Ca]) and survival of COV434 cells. We show that incubating COV434 cells with FLX (between 0. Read More

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Monetite-based composite cranial implants demonstrate long-term clinical volumetric balance by concomitant bone formation and degradation.

Acta Biomater 2021 Apr 12. Epub 2021 Apr 12.

Department of Materials Science and Engineering, Uppsala University, Uppsala, Sweden.

The use of calcium phosphates (CaPs) as synthetic bone substitutes should ideally result in a volumetric balance with concomitant bone formation and degradation. Clinical data on such properties is nevertheless lacking, especially for monetite-based CaPs. However, a monetite-based composite implant has recently shown promising cranial reconstructions, with both CaP degradation and bone formation. Read More

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Formulation, Characterization, and Mineral Absorption of Fruit Extract Nanoemulsion.

J Am Coll Nutr 2021 Apr 15:1-10. Epub 2021 Apr 15.

Lovely Professional University, Phagwara, Punjab, India.

Objective: Loss of vital bioactive components of fruit extract during food processing is a major issue. Therefore, to retain the antioxidant potential and to increase the mineral bioavailability, gum arabic stabilized nanoemulsion of Fig fruit extract was prepared.

Method: . Read More

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Neuroinflammation decreased hippocampal microtubule dynamics in the acute behavioral deficits induced by intracerebroventricular injection of lipopolysaccharide in male adult rats.

Neuroreport 2021 Apr 12. Epub 2021 Apr 12.

Department of Psychiatry, Renmin Hospital of Wuhan University, Jiefang, Wuhan, China.

Neuroinflammation plays a vital role in the pathology of depression. Microtubule dynamics produces an immediate response to stress, but the effect of microtubule dynamics in the rats with acute behavioral deficits following a central immune challenge remains elusive. Adult male Sprague-Dawley rats were subjected to the intracerebroventricular (icv) injection of lipopolysaccharide (. Read More

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Dopamine agonists for preventing ovarian hyperstimulation syndrome.

Cochrane Database Syst Rev 2021 Apr 14;4:CD008605. Epub 2021 Apr 14.

School of Women's and Infants' Health, The University of Western Australia, King Edward Memorial Hospital and Fertility Specialists of Western Australia, Subiaco, Perth, Australia.

Background: Ovarian hyperstimulation syndrome (OHSS) is a potentially serious complication of ovarian stimulation in assisted reproduction technology (ART). It is characterised by enlarged ovaries and an acute fluid shift from the intravascular space to the third space, resulting in bloating, increased risk of venous thromboembolism, and decreased organ perfusion. Most cases are mild, but forms of moderate or severe OHSS appear in 3% to 8% of in vitro fertilisation (IVF) cycles. Read More

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Massive efflux of adenosine triphosphate into the extracellular space immediately after experimental traumatic brain injury.

Exp Ther Med 2021 Jun 31;21(6):575. Epub 2021 Mar 31.

Brain Injury Research Center, Department of Neurosurgery, David Geffen School of Medicine, University of California, LA 90095-6901, USA.

The aim of the current study was to determine effects of mild traumatic brain injury (TBI), with or without blockade of purinergic ATP Y1 (P2Y1) receptors or store-operated calcium channels, on extracellular levels of ATP, glutamate, glucose and lactate. Concentrations of ATP, glutamate, glucose and lactate were measured in cerebral microdialysis samples obtained from the ipsilateral cortex and underlying hippocampus of rats with mild unilateral controlled cortical impact (CCI) or sham injury. Immediately after CCI, a large release of ATP was observed in the cortex (3. Read More

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Neuroinflammation decreased hippocampal microtubule dynamics in the acute behavioral deficits induced by intracerebroventricular injection of lipopolysaccharide in male adult rats.

Neuroreport 2021 May;32(7):603-611

Department of Psychiatry, Renmin Hospital of Wuhan University, Jiefang, Wuhan, China.

Neuroinflammation plays a vital role in the pathology of depression. Microtubule dynamics produces an immediate response to stress, but the effect of microtubule dynamics in the rats with acute behavioral deficits following a central immune challenge remains elusive. Adult male Sprague-Dawley rats were subjected to the intracerebroventricular (icv) injection of lipopolysaccharide (. Read More

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Plasma S100β and neuron-specific enolase, but not neuroglobin, are associated with early cognitive dysfunction after total arch replacement surgery: A pilot study.

Medicine (Baltimore) 2021 Apr;100(15):e25446

Department of Cardiovascular Anesthesiology.

Abstract: To investigate whether plasma concentrations of S100β protein, neuron-specific enolase (NSE), and neuroglobin (NGB) correlate with early postoperative cognitive dysfunction (POCD) in patients undergoing total arch replacement.This prospective study analyzed 40 patients who underwent total arch replacement combined with stented elephant trunk implantation at our hospital between March 2017 and January 2019. Cognitive function was assessed using the Mini-mental State Examination (MMSE) preoperatively, on the day after extubation and on day 7 after surgery. Read More

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The effect of Artichoke (Cynara scolymus L.) on the expression of calcium-binding proteins in the eggshell gland of laying hens.

Pol J Vet Sci 2021 Mar;24(1):127-133

Institute of Biology and Immunology of Reproduction - Bulgarian Academy of Sciences 1113 Sofia, Tzarigradsko shosse 73, Bulgaria.

The purpose of the present work is to investigate the effect of dietary-supplemented artichoke (Cynara scolymus L.) on the mRNA expression of calbindin 1 (Calb1), osteopontin (Spp1), albumin (Alb) and CALB1 protein in the eggshell gland (ESG) of laying hens. A total of 80 ISA Brown hens (each at 40 weeks of age) were randomly divided into two groups: a control and a treated group. Read More

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Photobiomodulation Therapy on Myocardial Infarction in Rats: Transcriptional and Posttranscriptional Implications to Cardiac Remodeling.

Lasers Surg Med 2021 Apr 13. Epub 2021 Apr 13.

Universidade Nove de Julho, Rua Vergueiro 249, Liberdade, São Paulo, SP, 01504-001, Brazil.

Background And Objectives: Induction of myocardial infarction (MI) in rats by occlusion of the left anterior descending coronary artery is an experimental model used in research to elucidate functional, structural, and molecular modifications associated with ischemic heart disease. Photobiomodulation therapy (PBMT) has become a therapeutic alternative by modulating various biological processes eliciting several effects, including anti-inflammatory and pro-proliferative actions. The main objective of this work was to evaluate the effect of PBMT in the modulation of transcriptional and post-transcriptional changes that occurred in myocardium signal transduction pathways after MI. Read More

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Serum sodium variation is a major determinant of peridialytic blood pressure trends in haemodialysis outpatients.

Sci Rep 2021 Apr 12;11(1):7882. Epub 2021 Apr 12.

UCL Department of Nephrology, Royal Free Hospital, University College London, London, UK.

Intradialytic hypotension (IDH) and peridialytic blood pressure (BP) trends are associated with morbidity and mortality in haemodialysis (HD) patients. We aimed to characterise the respective influence of volume status and small solutes variation on peridialytic systolic BP (SBP) trends during HD. We retrospectively analysed the relative peridialytic SBP decrease in 647 prevalent outpatients attending for their mid-week session with corresponding pre- and post-HD bioelectrical impedance analysis. Read More

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Autonomous Purkinje cell activation instructs bidirectional motor learning through evoked dendritic calcium signaling.

Nat Commun 2021 04 12;12(1):2153. Epub 2021 Apr 12.

Max Planck Florida Institute for Neuroscience, Jupiter, FL, USA.

The signals in cerebellar Purkinje cells sufficient to instruct motor learning have not been systematically determined. Therefore, we applied optogenetics in mice to autonomously excite Purkinje cells and measured the effect of this activity on plasticity induction and adaptive behavior. Ex vivo, excitation of channelrhodopsin-2-expressing Purkinje cells elicits dendritic Ca transients with high-intensity stimuli initiating dendritic spiking that additionally contributes to the Ca response. Read More

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Opportunities for diet quality improvement: the potential role of staple grain foods.

Public Health Nutr 2021 Apr 12:1-26. Epub 2021 Apr 12.

Department of Nutrition, School of Public Health, University of São Paulo, Avenida Dr. Arnaldo, 715, Cerqueira Cesar, São Paulo, SP, Brazil,

Objective: Given the high disease burden associated with the low intake of whole grains, modelling studies that estimate the impact of dietary strategies to increase more healthful grain foods consumption are essential to inform evidence-based and culturally-specific policies. This study investigated the potential nutritional impact of replacing staple grain foods with more healthful options.

Design: Based on the 2015 Health Survey of São Paulo, a cross-sectional, population-based study, we modelled the substitution of white rice and white bread with brown rice and whole-wheat bread. Read More

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