9,176 results match your criteria decrease arrhythmia

Changes in Thyroid Stimulating Hormone Receptor Antibody Levels Following Total Thyroidectomy or Radioiodine Therapy in Patients with Refractory Graves' Disease.

Thyroid 2021 May 5. Epub 2021 May 5.

Samsung Medical Center, 36626, Division of Endocrinology and Metabolism, Department of Medicine, Gangnam-gu, Seoul, Korea (the Republic of).

Background: The actions of thyrotropin-binding inhibitory immunoglobulins (TBIIs) against thyrotropin receptors in thyroid follicular cells have been studied as important etiological factors in Graves' disease (GD). The purpose of this study was to investigate changes in the TBII levels of patients undergoing total thyroidectomy (TTx) or radioactive iodine (RAI) therapy for GD refractory to antithyroid drugs (ATD).

Methods: We enrolled patients who underwent TTx or RAI for GD with previous ATD use between January 2011 and December 2017 at the Samsung Seoul Hospital in Seoul, Korea. Read More

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Post hoc assessment of relationship between coronary stenosis, ECG and ventricular function in patients with heart disease.

Can J Physiol Pharmacol 2021 May 3. Epub 2021 May 3.

USF Health Morsani College of Medicine, 33697, Tampa, Florida, United States;

Cardiovascular diseases including cardiac arrhythmias lead to fatal events in patients with coronary artery disease, however clinical associations from echocardiography, electrocardiography (ECG) and biomarkers remain unknown. We sought to identify the factors that may be related to elevated QRS intervals in patients with risk for coronary artery disease. In this study, we performed analysis of clinical data from 503 patients and divided into two groups, i. Read More

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Resiniferatoxin reduces cardiac sympathetic nerve activation to exert a cardioprotective effect during myocardial infarction.

Int J Clin Exp Pathol 2021 15;14(4):408-416. Epub 2021 Apr 15.

Department of Cardiology, Renmin Hospital of Wuhan University, Cardiovascular Research Institute of Wuhan University, Hubei Key Laboratory of Cardiology Wuhan 430000, People's Republic of China.

Background And Objective: Myocardial infarction (MI) is a common critical disease of the cardiovascular system. The process of MI is often accompanied by the excessive activation of cardiac sympathetic nerves, which leads to arrhythmia. Resiniferatoxin (RTX) is a transient receptor potential vanilloid 1 (TRPV1), involved in the cardiac sympathetic afferent reflex. Read More

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ST-segment elevation myocardial infarction: Management and association with prognosis during the COVID-19 pandemic in France.

Arch Cardiovasc Dis 2021 Apr 14. Epub 2021 Apr 14.

Cardiology Department, University Hospital of Montpellier, University of Montpellier, 34000 Montpellier, France.

Background: Systems of care have been challenged to control progression of the COVID-19 pandemic. Whether this has been associated with delayed reperfusion and worse outcomes in French patients with ST-segment elevation myocardial infarction (STEMI) is unknown.

Aim: To compare the rate of STEMI admissions, treatment delays, and outcomes between the first peak of the COVID-19 pandemic in France and the equivalent period in 2019. Read More

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P2Y12 inhibition in macrophages reduces ventricular arrhythmias in rats after myocardial ischemia-reperfusion.

Adv Clin Exp Med 2021 Apr;30(4):413-420

Department of Cardiology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China.

Background: Myocardial ischemia-reperfusion (I/R) injury is still thought to be an unsolved puzzle that may lead to reperfusion arrhythmias and sudden cardiac death. Inflammation plays a key role in myocardial I/R. Studies have indicated that purinoceptor 2Y12 (P2Y12) antagonists have anti-inflammatory properties that are cardioprotective. Read More

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Directed graph mapping exceeds phase mapping in discriminating true and false rotors detected with a basket catheter in a complex in-silico excitation pattern.

Comput Biol Med 2021 Apr 15;133:104381. Epub 2021 Apr 15.

Department of Physics and Astronomy, Ghent University, Ghent, Belgium.

Atrial fibrillation (AF) is the most frequently encountered arrhythmia in clinical practise. One of the major problems in the management of AF is the difficulty in identifying the arrhythmia sources from clinical recordings. That difficulty occurs because it is currently impossible to verify algorithms which determine these sources in clinical data, as high resolution true excitation patterns cannot be recorded in patients. Read More

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Diving Responses in Experienced Rebreather Divers: Short-Term Heart Rate Variability in Cold Water Diving.

Front Physiol 2021 7;12:649319. Epub 2021 Apr 7.

Diving Medical Centre, Finnish Defence Forces, Helsinki, Finland.

Introduction: Technical diving is very popular in Finland throughout the year despite diving conditions being challenging, especially due to arctic water and poor visibility. Cold water, immersion, submersion, hyperoxia, as well as psychological and physiological stress, all have an effect on the autonomic nervous system (ANS).

Materials And Methods: To evaluate divers' ANS responses, short-term (5 min) heart rate variability (HRV) during dives in 2-4°C water was measured. Read More

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Genetically-Determined Serum Calcium Levels and Markers of Ventricular Repolarisation: A Mendelian Randomization Study in the UK Biobank.

Circ Genom Precis Med 2021 Apr 22. Epub 2021 Apr 22.

Department of Internal Medicine, Leiden University Medical Center, Leiden, the Netherlands.

- Electrocardiographic (ECG) markers of ventricular depolarisation and repolarisation are associated with an increased risk of arrhythmia and sudden cardiac death. Our prior work indicated lower serum calcium concentrations are associated with longer QT and JT intervals in the general population. Here, we investigate whether serum calcium is a causal risk factor for changes in ECG measures using Mendelian Randomization (MR). Read More

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Evaluation of high-dose atorvastatin pretreatment influence in patients preconditioning of post coronary artery bypass graft surgery: A prospective triple blind randomized clinical trial.

Ann Card Anaesth 2021 Apr-Jun;24(2):209-216

Anesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.

Context: Atorvastatin is considered as lipid reductive drugs with anti-inflammatory and pleotherapic effects in coronary artery bypass graph (CABG).

Aim: This study is conducted to evaluate the effects of atorvastatin in CABG.

Setting And Design: Patients with a coronary bypass graph procedure in Nemazee hospital in Shiraz were divided into two 50-groups receiving high-dose (80 mg) and low-dose (20 mg) atorvastatin. Read More

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ECG-Based Indices to Characterize Persistent Atrial Fibrillation Before and During Stepwise Catheter Ablation.

Front Physiol 2021 30;12:654053. Epub 2021 Mar 30.

Service of Cardiology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.

Consistently successful patient outcomes following catheter ablation (CA) for treatment of persistent atrial fibrillation (pers-AF) remain elusive. We propose an electrocardiogram (ECG) analysis designed to (1) refine selection of patients most likely to benefit from ablation, and (2) examine the temporal evolution of AF organization indices that could act as clinical indicators of ongoing ablation effectiveness and completeness. Twelve-lead ECG was continuously recorded in 40 patients (61 ± 8 years) during stepwise CA (step-CA) procedures for treatment of pers-AF (sustained duration 19 ± 11 months). Read More

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Lack of Macrophage Migration Inhibitory Factor Reduces Susceptibility to Ventricular Arrhythmias During the Acute Phase of Myocardial Infarction.

J Inflamm Res 2021 7;14:1297-1311. Epub 2021 Apr 7.

Department of Anesthesiology, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, 610072, People's Republic of China.

Background: Macrophages are involved in inflammatory responses and play a crucial role in aggravating ventricular arrhythmias (VAs) after myocardial infarction (MI). Macrophage migration inhibitory factor (MIF) participates in inflammatory responses during acute MI. In the present study, we hypothesized that knockout (KO) of MIF may prevent VAs during the acute phase of MI by inhibiting macrophage-derived pro-inflammatory mediators. Read More

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The Molecular Mechanisms of Cardiotoxicity Induced by HER2, VEGF, and Tyrosine Kinase Inhibitors: an Updated Review.

Cardiovasc Drugs Ther 2021 Apr 13. Epub 2021 Apr 13.

Department of Cardiology, The Affiliated Hospital of Qingdao University, No. 59 Haier Road, Qingdao, 266100, Shandong, China.

Aim: In recent decades, there has been a revolutionary decrease in cancer-related mortality and an increase in survival due to the introduction of novel targeted drugs. Nevertheless, drugs targeting human epidermal growth factor receptor 2 (HER-2), angiogenesis, and other tyrosine kinases also come with unexpected cardiac side effects, including heart failure, hypertension, arterial thrombosis, and arrhythmias, and have mechanisms that are unlike those of classic chemotherapeutic agents. In addition, it is challenging to address some problems, as the existing guidelines need to be more specific, and further large-scale clinical trials and experimental studies are required to confirm the benefit of administering cardioprotective agents to patients treated with targeted therapies. Read More

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Focal Impulse and Rotor Modulation Guided Ablation Versus Pulmonary Vein Isolation for Atrial Fibrillation: A Meta-Analysis of Head-to-Head Comparative Studies.

J Cardiovasc Electrophysiol 2021 Apr 12. Epub 2021 Apr 12.

Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY.

Introduction: Empirical pulmonary vein isolation (PVI) remains the cornerstone for catheter ablation of atrial fibrillation (AF). Various ablation strategies and modalities are continually tested with the aim of improving ablation outcomes. Although focal impulse and rotor modulation (FIRM)-guided ablation is currently used as an adjunct to pulmonary vein isolation (PVI), evidence supporting this strategy is conflicting. Read More

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Melatonin as a therapy in cardiac ischemia-reperfusion injury: Potential mechanisms by which MT2 activation mediates cardioprotection.

J Adv Res 2021 03 28;29:33-44. Epub 2020 Sep 28.

Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.

Introduction: Previous studies reported the beneficial effects of pretreatment with melatonin on the heart during cardiac ischemia/reperfusion (I/R) injury. However, the effects of melatonin given after cardiac ischemia, as well as its comparative temporal effects are unknown. These include pretreatment, during ischemia, and at the onset of reperfusion. Read More

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Effects of SGLT2 inhibitors on cardiovascular, renal, and major safety outcomes in heart failure: A meta-analysis of randomized controlled trials.

Int J Cardiol 2021 Jun 8;332:119-126. Epub 2021 Apr 8.

Arrhythmia Center, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China. Electronic address:

Aims: Sodium-glucose co-transporter 2 inhibitor (SGLT2i), initially introduced for the treatment of diabetes mellitus (DM), demonstrates cardiovascular and renal benefits in patients with heart failure (HF). We aimed to conduct a meta-analysis of its effects on cardiovascular, renal, and major safety outcomes in HF.

Methods And Results: PubMed, Embase, Cochrane Library, and Web of Science were searched using the terms of "SGLT2i and HF" or "SGLT2i *". Read More

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Buprenorphine may be effective for treatment of paramyotonia congenita.

Muscle Nerve 2021 Apr 9. Epub 2021 Apr 9.

IRCCS Mondino Foundation, Pavia, Italy.

Introduction/aims: Paramyotonia congenita (PMC) is a skeletal muscle sodium channelopathy characterized by paradoxical myotonia, cold sensitivity, and exercise/cold-induced paralysis. Treatment with sodium-channel-blocking antiarrhythmic agents may expose patients to a risk of arrhythmia or may be poorly tolerated or ineffective. In this study we explored the effectiveness of non-antiarrhythmic sodium-channel blockers in two patients with PMC. Read More

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A Robust Percutaneous Myocardial Infarction Model in Pigs and Its Effect on Left Ventricular Function.

J Cardiovasc Transl Res 2021 Apr 8. Epub 2021 Apr 8.

Center for Clinical Research, Texas Heart Institute, 6770 Bertner Ave, Houston, TX, 77030, USA.

In this study, we created a reproducible myocardial infarction (MI) model in pigs characterized by a low mortality rate and significant changes in left ventricular function. After administering an arrhythmia prevention regimen, we created a 90-min balloon-induced percutaneous MI in 42 pigs below the first diagonal branch (D1) of the left anterior descending artery. Echocardiograms were performed before and 14 days after MI induction. Read More

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Utilization of the Transgastric View of the Left Atrial Appendange for Procedural Guidance during Left Atrial Appendage Clip Via Video-assisted Thoracoscopic Surgery.

J Cardiovasc Echogr 2020 Oct-Dec;30(4):211-213. Epub 2021 Jan 20.

Department of Anesthesiology, School of Medicine, Emory University, Atlanta, Georgia.

Left atrial appendage (LAA) ligation is procedure which isolates the LAA and can decrease the risk of thrombus and arrhythmias in patients with atrial fibrillation, allowing patients to come off home anticoagulation medications. This procedure can be done through minimally invasive thoracoscopic surgery and requires guidance by transesophageal echocardiography. Visualization of the LAA and associated intrathoracic structures is vital for the success of the procedure. Read More

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January 2021

Identification of an endogenous glutamatergic transmitter system controlling excitability and conductivity of atrial cardiomyocytes.

Cell Res 2021 Apr 6. Epub 2021 Apr 6.

Department of Cardiology, East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.

As an excitatory transmitter system, the glutamatergic transmitter system controls excitability and conductivity of neurons. Since both cardiomyocytes and neurons are excitable cells, we hypothesized that cardiomyocytes may also be regulated by a similar system. Here, we have demonstrated that atrial cardiomyocytes have an intrinsic glutamatergic transmitter system, which regulates the generation and propagation of action potentials. Read More

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Deletion of Alters the Function of the Na1.5 Channel in Murine Cardiac Myocytes.

Int J Mol Sci 2021 Mar 26;22(7). Epub 2021 Mar 26.

Institute of Biochemistry and Molecular Medicine, and Swiss National Centre of Competence in Research (NCCR) TransCure, University of Bern, Bühlstrasse 28, 3012 Bern, Switzerland.

Transient receptor potential melastatin member 4 (TRPM4) encodes a Ca-activated, non-selective cation channel that is functionally expressed in several tissues, including the heart. Pathogenic mutants in have been reported in patients with inherited cardiac diseases, including conduction blockage and Brugada syndrome. Heterologous expression of mutant channels in cell lines indicates that these mutations can lead to an increase or decrease in TRPM4 expression and function at the cell surface. Read More

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Melatonin to Rescue the Aged Heart: Antiarrhythmic and Antioxidant Benefits.

Oxid Med Cell Longev 2021 13;2021:8876792. Epub 2021 Mar 13.

Biomedical Signal Interpretation and Computational Simulation (BSICoS), I3A, Universidad de Zaragoza, IIS Aragón and CIBER-BBN, Spain.

Aging comes with gradual loss of functions that increase the vulnerability to disease, senescence, and death. The mechanisms underlying these processes are linked to a prolonged imbalance between damage and repair. Damaging mechanisms include oxidative stress, mitochondrial dysfunction, chronodisruption, inflammation, and telomere attrition, as well as genetic and epigenetic alterations. Read More

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In vitro safety "clinical trial" of the cardiac liability of drug polytherapy.

Clin Transl Sci 2021 Mar 30. Epub 2021 Mar 30.

Department of Bioengineering and California Institute for Quantitative Biosciences (QB3), University of California at Berkeley, Berkeley, California, USA.

Only a handful of US Food and Drug Administration (FDA) Emergency Use Authorizations exist for drug and biologic therapeutics that treat severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) infection. Potential therapeutics include repurposed drugs, some with cardiac liabilities. We report on a chronic preclinical drug screening platform, a cardiac microphysiological system (MPS), to assess cardiotoxicity associated with repurposed hydroxychloroquine (HCQ) and azithromycin (AZM) polytherapy in a mock phase I safety clinical trial. Read More

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Characterization of the Insular Role in Cardiac Function through Intracranial Electrical Stimulation of the Human Insula.

Ann Neurol 2021 Mar 30. Epub 2021 Mar 30.

Epilepsy Monitoring Unit, Department of Neurology, Member of ERN EpiCARE, Hospital del Mar, Barcelona, Spain.

Objective: The link between brain function and cardiovascular dynamics is an important issue yet to be elucidated completely. The insula is a neocortical brain area that is thought to have a cardiac chronotropic regulatory function, but its role in cardiac contractility is unknown. We aimed to analyze the variability in heart rate and cardiac contractility after functional activation of different insular regions through direct electrical stimulation (E-stim) in humans. Read More

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Bradycardia Due to Donepezil in Adults: Systematic Analysis of FDA Adverse Event Reporting System.

J Alzheimers Dis 2021 Mar 23. Epub 2021 Mar 23.

Department of Pharmaceutical Science, Taneja College of Pharmacy, University of South Florida, Tampa, FL, USA.

Background: Bradycardia is a physiological condition characterized by a decrease in heart rate and is a side effect of many drug classes. Bradycardia has been reported as an adverse event for patients receiving donepezil for Alzheimer's disease (AD) treatment.

Objective: The purpose of the paper is to systematically investigate the association between the occurrence of bradycardia in adults and the usage of donepezil using clinical data derived from the FDA Adverse Event Reporting System (FAERS) database. Read More

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Electrophysiological and Pathological Impact of Medium-Dose External Carbon Ion and Proton Beam Radiation on the Left Ventricle in an Animal Model.

J Am Heart Assoc 2021 Apr 24;10(7):e019687. Epub 2021 Mar 24.

Section of Arrhythmia Division of Cardiovascular Medicine Department of Internal Medicine Kobe University Graduate School of Medicine Kobe Hyogo Japan.

Background Medium-dose (25 gray) x-ray radiation therapy has recently been performed on patients with refractory ventricular tachyarrhythmias. Unlike x-ray, carbon ion and proton beam radiation can deliver most of their energy to the target tissues. This study investigated the electrophysiological and pathological changes caused by medium-dose carbon ion and proton beam radiation in the left ventricle (LV). Read More

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Perioperative Milrinone Infusion Improves One-Year Survival After the Norwood-Sano Procedure.

J Cardiothorac Vasc Anesth 2021 Feb 10. Epub 2021 Feb 10.

Anesthesiology and Resuscitology, Okayama University Hospital, Kitaku, Okayama, Japan.

Objectives: The aim of this study was to investigate whether milrinone infusion improved one-year survival in patients who underwent the Norwood-Sano procedure.

Design: A retrospective observational study.

Setting: A single-institution university hospital. Read More

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February 2021

Admission rates and care pathways in patients with atrial fibrillation during the COVID-19 pandemic-insights from the German-wide Helios hospital network.

Eur Heart J Qual Care Clin Outcomes 2021 05;7(3):257-264

Department of Electrophysiology, Heart Center Leipzig at University of Leipzig, Strümpellstraße 39, Leipzig 04289, Germany.

Aims: Several reports indicate lower rates of emergency admissions in the cardiovascular sector and reduced admissions of patients with chronic diseases during the Coronavirus SARS-CoV-2 (COVID-19) pandemic. The aim of this study was therefore to evaluate numbers of admissions in incident and prevalent atrial fibrillation and flutter (AF) and to analyse care pathways in comparison to 2019.

Methods: A retrospective analysis of claims data of 74 German Helios hospitals was performed to identify consecutive patients hospitalized with a main discharge diagnosis of AF. Read More

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In Vivo Based Fluid-Structure Interaction Biomechanics of the Left Anterior Descending Coronary Artery.

J Biomech Eng 2021 Mar 17. Epub 2021 Mar 17.

Vascular Research Centre, Lifelong Health Theme, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, South Australia 5000, Australia; Adelaide Medical School, University of Adelaide, Adelaide, South Australia 5005, Australia; Department of Cardiology, Central Adelaide Local Health Network, Adelaide, South Australia 5000, Australia.

A fluid-structure interaction based biomechanical model of the entire left anterior descending coronary artery is developed from in vivo imaging via the finite element method in this paper. Included in this investigation is ventricle contraction, three-dimensional motion, all angiographically visible side branches, hyper/viscoelastic artery layers, non-Newtonian and pulsatile blood flow and the out-of-phase nature of blood velocity and pressure. The fluid-structure interaction model is based on in vivo angiography of an elite athlete's entire left anterior descending coronary artery where the influence of including all alternating side branches and the dynamical contraction of the ventricle is investigated for the first time. Read More

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Evolving ischemic stroke subtypes in 15 years: A hospital-based observational study.

Int J Stroke 2021 Apr 7:17474930211005953. Epub 2021 Apr 7.

Division of Neurology, Department of Medicine and Therapeutics, 26451The Chinese University of Hong Kong, Hong Kong.

Background: Depicting the time trends of ischemic stroke subtypes may inform healthcare resource allocation on etiology-based stroke prevention and treatment.

Aim: To reveal the evolving ischemic stroke subtypes from 2004 to 2018.

Methods: We determined the stroke etiologies of consecutive first-ever transient ischemic attack or ischemic stroke patients admitted to a regional hospital in Hong Kong from 2004 to 2018. Read More

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Effect of the Alterations in Contractility and Morphology Produced by Atrial Fibrillation on the Thrombosis Potential of the Left Atrial Appendage.

Front Bioeng Biotechnol 2021 26;9:586041. Epub 2021 Feb 26.

Bioengineering Unit, Ri. MED Foundation, Palermo, Italy.

Atrial fibrillation () is a common arrhythmia mainly affecting the elderly population, which can lead to serious complications such as stroke, ischaemic attack and vascular dementia. These problems are caused by thrombi which mostly originate in the left atrial appendage (), a small muscular sac protruding from left atrium. The abnormal heart rhythm associated with results in alterations in the heart muscle contractions and in some reshaping of the cardiac chambers. Read More

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February 2021