Biochim Biophys Acta Mol Cell Res 2021 Jul 15:119099. Epub 2021 Jul 15.
Center for Integrative Biology, Faculty of Sciences, Universidad Mayor, Santiago, 8580745, Chile; Geroscience Center for Brain Health and Metabolism, Santiago, 8580745, Chile; Buck Institute for Research on Aging, Novato, CA 94945, USA; Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA. Electronic address:
Cellular senescence generates a permanent cell cycle arrest, characterized by apoptosis resistance and a pro-inflammatory senescence-associated secretory phenotype (SASP). Physiologically, senescent cells promote tissue remodeling during development and after injury. However, when accumulated over a certain threshold as happens during aging or after cellular stress, senescent cells contribute to the functional decline of tissues, participating in the generation of several diseases. Read More