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The Italian Society for Rheumatology clinical practice guidelines for the diagnosis and management of fibromyalgia Best practices based on current scientific evidence.

Reumatismo 2021 Aug 3;73(2):89-105. Epub 2021 Aug 3.

Epidemiology Unit, Italian Society for Rheumatology, Milan, Italy; Unità di Reumatologia, Azienda Ospedaliera Città della Salute e della Scienza di Torino.

Fibromyalgia or fibromyalgia syndrome (FMS) is defined as a central sensitization syndrome characterized by the dysfunction of neurocircuits detecting, transmitting and processing nociceptive stimuli; the prevalent manifestation is musculoskeletal pain. In addition to pain, there are multiple accompanying symptoms, in common with other algo-dysfunctional syndromes, which are reflected in a broad spectrum of somatic, neurocognitive and neuro-vegetative manifestations. An evidence-based approach is essential in FMS management, in order to improve patient health and to reduce its social burden. Read More

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Clinical utility of a rapid 'on-demand' laboratory-based SARS-CoV-2 diagnostic testing service in an acute hospital setting admitting COVID-19 patients.

Clin Infect Pract 2021 Nov 23;12:100086. Epub 2021 Jul 23.

Clinical Microbiology, University Hospitals of Leicester NHS Trust, Leicester, UK.

Background: With the onset of the COVID-19 pandemic in 2020, hospital clinical teams have realised that there is a need for a rapid, accurate testing facility that will allow them to move patients quickly into isolation rooms or specific COVID-19 cohort wards as soon as possible after admission.

Methods: Starting from July 2020, PCR-based test platforms, which could test 4-8 samples in parallel with turnaround (sample-to-result) times of 50-80 min, were placed in a satellite laboratory. This laboratory was on the same floor and within walking distance to the acute respiratory admissions ward. Read More

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November 2021

The Role and Contribution of Lumbar Myelography in the Diagnosis and Treatment of Patients With Lumbar Degenerative Disorders: Clinical and Statistical Evaluation of Post-Myelography Treatment of 63 Patients.

Cureus 2021 Jun 28;13(6):e15987. Epub 2021 Jun 28.

Neurological Surgery, Bakirkoy Prof. Dr. Mazhar Osman Training and Research Hospital for Psychiatric Neurological Diseases, Istanbul, TUR.

Introduction Myelography is a radiological examination method that has been used for the diagnosis of spinal canal pathologies for a long time. More than 90 years of experience has been improved by the development of increasingly less toxic contrast agents. Nowadays, although there are many advanced diagnostic tools, lumbar myelography is a direct imaging technique and so it is a powerful diagnostic method for patients whose treatment has not been decided. Read More

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[Prediction of Length of Artificial Chordae by Using Preoperative Cardiac Computed Tomography:Report of a Case].

Kyobu Geka 2021 Aug;74(8):606-609

Department of Cardiovascular Surgery, Sakai City Medical Center, Sakai, Japan.

A 51-year-old man was diagnosed as having mitral valve regurgitation( MR). Transesophageal echocardiography revealed severe MR due to A2 prolapse. We decided to perform a mitral valve plasty (MVP). Read More

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Targeting redox metabolism of the maize-Azospirillum brasilense interaction exposed to arsenic-affected groundwater.

Physiol Plant 2021 Jul 30. Epub 2021 Jul 30.

Instituto de Investigaciones Agrobiotecnológicas - Consejo Nacional de Investigaciones Científicas y Técnicas (INIAB-CONICET), Departamento de Ciencias Naturales, Facultad de Ciencias Exactas, Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto (UNRC), Córdoba, Argentina.

Arsenic in groundwater constitutes an agronomic problem due to its potential accumulation in the food chain. Among the agro-sustainable tools to reduce metal(oid)s toxicity, the use of Plant Growth-Promoting Bacteria (PGPB) becomes important. For that, and based on previous results in which significant differences of As translocation were observed when inoculating maize plants with Az39 or CD Azospirillum strains, we decided to decipher the redox metabolism changes and the antioxidant system response of maize plants inoculated when exposed to a realistic arsenate (As ) dose. Read More

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Why Service Users Choose Medication-Free Psychiatric Treatment: A Mixed-Method Study of User Accounts.

Patient Prefer Adherence 2021 23;15:1647-1660. Epub 2021 Jul 23.

Department of Research and Development, Division of Mental Health Services, Akershus University Hospital, Lørenskog, Norway.

Purpose: Medication has been a central part of treatment for severe mental disorders in Western medicine since the 1950s. In 2015, Norwegian Health Authorities decided that Norwegian health regions must have treatment units devoted to medication-free mental health treatment to enhance service users' freedom of choice. The need for these units has been controversial. Read More

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Exploring the motivations of research participants who chose not to learn medically actionable secondary genetic findings about themselves.

Genet Med 2021 Jul 29. Epub 2021 Jul 29.

National Institutes of Health, Department of Bioethics; National Human Genome Research Institute, Bethesda, MD, USA.

Purpose: Proposals to return medically actionable secondary genetic findings (SFs) in the clinical and research settings have generated controversy regarding whether to solicit individuals' preferences about their "right not to know" genetic information. This study contributes to the debate by surveying research participants who have actively decided whether to accept or refuse SFs.

Methods: Participants were drawn from a large National Institutes of Health (NIH) environmental health study. Read More

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Haemodialysed patient with lung cancer in the COVID-19 era: a clinical challenge.

BMJ Case Rep 2021 Jul 29;14(7). Epub 2021 Jul 29.

Medical Oncology, Hospital do Espirito Santo de Evora EPE, Evora, Portugal.

A 66-year-old man was referred to the oncological pneumology consultation due to a mass in the right upper lobe observed in a routine X-ray of the chest. The CT scan confirmed a mass in the same location. The biopsy revealed a lung adenocarcinoma. Read More

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Robot-assisted enucleation of a giant submucosal tumor in the upper esophagus.

Asian J Endosc Surg 2021 Jul 29. Epub 2021 Jul 29.

Department of Gastroenterological Surgery, Aichi Cancer Center Hospital, Nagoya, Japan.

Few reports have demonstrated robotic surgery for large tumors in the upper esophagus. We report a case of a 52-year-old woman with a giant submucosal tumor in the upper esophagus successfully enucleated using robotic surgery. She presented with odynophagia and dysphagia, with subsequent evaluation revealing a submucosal mass measuring approximately 10 cm in diameter in the upper esophagus. Read More

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Updates on the Diagnosis and Management of Hepatocellular Carcinoma.

Euroasian J Hepatogastroenterol 2021 Jan-Jun;11(1):32-40

The Aga Khan University Hospital, Karachi, Pakistan.

Introduction: Globally, the incidence, as well as mortality, related to hepatocellular carcinoma (HCC) is on the rise, owing to relatively few curative options. Underlying cirrhosis is the most common etiology leading to HCC, but risk factors of cirrhosis show great regional variability. Over the years, there has been a steady development in the diagnostic and therapeutic modalities of HCC, including the availability of a wide range of systemic chemotherapeutic agents. Read More

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A laparoscopic pancreaticoduodenectomy for pancreatic adenocarcinoma in a patient with situs inversus totalis.

J Surg Case Rep 2021 Jul 23;2021(7):rjab316. Epub 2021 Jul 23.

Hepatobiliary Pancreatic Surgery Department, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.

Situs inversus totalis (SIT) is a congenital disorder in which the thoracic and abdominal viscera organs are mirrored from their normal anatomical position. Thus, the presence of any cancerous mass in one of the visceral organs of patients with SIT represents a great challenge due to the anatomical variation. We report a 52-year-old male with SIT who presented with obstructive jaundice and pancreatic-head mass. Read More

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Comparison of Ga-DOTA-FAPI and FDG PET/CT imaging modalities in the detection of liver metastases in patients with gastrointestinal system cancer.

Eur J Radiol 2021 Jul 22;142:109867. Epub 2021 Jul 22.

Gaziantep University Hospital, Department of Nuclear Medicine, Gaziantep, Turkey.

Purpose: We aimed to compare the diagnostic performance of PET/CT imaging performed with Ga-DOTA-FAPI and FDG in detection of liver metastases in patients with gastrointestinal system (GIS) cancer.

Methods: A total of 31 patients who underwent Ga-DOTA-FAPI and F-FDG PET/CT examinations and diagnosed with GIS cancer (15 colorectal, 9 pancreas, 4 stomach and 3 other cancers) were included in the study. The presence of liver metastasis was decided based on histopathologic diagnosis, PET/CT, other radiologic examinations or tumor biomarker findings, and both PET/CT imaging findings were compared on the patient and lesion basis. Read More

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A new strategy to uncover fragile X proteomic biomarkers using the nascent proteome of peripheral blood mononuclear cells (PBMCs).

Sci Rep 2021 Jul 26;11(1):15148. Epub 2021 Jul 26.

Department of Biochemistry and Functional Genomic, Faculty of Medicine and Health Sciences, Université de Sherbrooke and Centre de Recherche du CHUS, CIUSSS de l'Estrie-CHUS, Sherbrooke, QC, Canada.

Fragile X syndrome (FXS) is the most prevalent inherited cause of intellectual disabilities and autism spectrum disorders. FXS result from the loss of expression of the FMRP protein, an RNA-binding protein that regulates the expression of key synaptic effectors. FXS is also characterized by a wide array of behavioural, cognitive and metabolic impairments. Read More

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Population-based utility scores for HPV infection and oropharyngeal squamous cell carcinoma among Indigenous Australians.

BMC Public Health 2021 07 26;21(1):1455. Epub 2021 Jul 26.

Australian Research Centre for Population Oral Health, Adelaide Dental School, The University of Adelaide, Adelaide Health & Medical Sciences Building, Adelaide, 5005, Australia.

Background: Oropharyngeal squamous cell carcinoma (OPSCC) is associated with high mortality. Human papillomavirus (HPV) infection is a significant risk factor for OPSCC. Utilities are fundamental values representing the strength of individuals' preferences for specific health-related outcomes. Read More

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Analysis of MR Signs to Distinguish Between ARCO Stages 2 and 3A in Osteonecrosis of the Femoral Head.

J Magn Reson Imaging 2021 Jul 26. Epub 2021 Jul 26.

Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Background: MRI is the most effective diagnostic tool of osteonecrosis of the femoral head (ONFH), especially for early diagnosis, but its detection of subchondral or cortical fractures is less accurate than CT. Therefore, it is difficult to accurately stage ONFH in the peri-collapse period by MRI.

Purpose: To improve the accuracy of MR for distinguishing between Association Research Circulation Osseous (ARCO) stages 2 and 3A in ONFH. Read More

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A Case Report on Adenosquamous Carcinoma of Gallbladder: A Very Rare Malignancy.

Cureus 2021 Jun 21;13(6):e15791. Epub 2021 Jun 21.

Hematology and Oncology, Guthrie Robert Packer Hospital, Sayre, USA.

Gallbladder (GB) carcinoma is a rare carcinoma with a poor prognosis. The prevalence is 0.7-21/100,000 worldwide and 1-2/100,000 in the United States. Read More

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Circular RNA Expression: Its Potential Regulation and Function in Abdominal Aortic Aneurysms.

Oxid Med Cell Longev 2021 29;2021:9934951. Epub 2021 Jun 29.

Department of Vascular Surgery, The First Hospital, China Medical University, Shenyang, China.

Abdominal aortic aneurysms (AAAs) have posed a great threat to human life, and the necessity of its monitoring and treatment is decided by symptomatology and/or the aneurysm size. Accumulating evidence suggests that circular RNAs (circRNAs) contribute a part to the pathogenesis of AAAs. circRNAs are novel single-stranded RNAs with a closed loop structure and high stability, having become the candidate biomarkers for numerous kinds of human disorders. Read More

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Rare case of congenital coronary artery fistula coexistent and coalesced with aortopulmonary fistula.

BMJ Case Rep 2021 Jul 23;14(7). Epub 2021 Jul 23.

Department of Cardiovascular Medicine, Mito Medical Center, Mito, Ibaraki, Japan.

Coronary artery fistula (CAF) is an uncommon congenital heart disease. Furthermore, aortopulmonary fistula is a rare congenital heart disease of adult onset. We report the case of a 79-year-old man who presented with chest pain. Read More

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Penile schwannoma mistaken for hemangioma: a rare case report and literature review.

Transl Androl Urol 2021 Jun;10(6):2512-2520

Department of Urology, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Korea.

Penile neoplasm is uncommon. Schwannomas of the penis are especially rare. For this reason, it is difficult to get an accurate impression to enable decision making. Read More

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UK Vessel Health and Preservation (VHP) Framework: a commentary on the updated VHP 2020.

J Infect Prev 2021 Jul 14;22(4):147-155. Epub 2020 Dec 14.

The Christie NHS Foundation Trust, Manchester, UK.

Background: In 2016, a UK vessel health and preservation (VHP) framework was developed to support healthcare staff to select the most appropriate vascular access device for patients requiring intravenous therapy. The VHP framework was based on available evidence and expert consensus. The VHP was based on available evidence and expert consensus. Read More

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Primary Fibular Sarcomas: Do They Behave Differently? An Institutional Review of 14 Patients.

Indian J Surg Oncol 2021 Jun 12;12(2):298-305. Epub 2021 Feb 12.

Department of Pathology, Rajiv Gandhi Cancer Institute and Research Centre, New Delhi, India.

Surgical resection with wide margins is pivotal for sarcoma treatment but achieving the same for fibular sarcomas is a surgical challenge. Thus, we decided to evaluate our own institutional database of primary fibular sarcomas for surgical treatment, margins and pattern of relapse. From July 2014 to October 2018, we identified fourteen patients with histologically confirmed fibular sarcomas. Read More

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Diagnostic values of HNP 1-3 and procalcitonin levels in synovial fluid aspirates in the differential diagnosis between septic arthritis and noninfectious arthritis.

J Infect Chemother 2021 Jul 19. Epub 2021 Jul 19.

Department of Medical Microbiology, Health Sciences Institute, University of Süleyman Demirel, Isparta, 32260, Turkey. Electronic address:

Introduction: Although early diagnosis of septic arthritis may reduce mortality rates, and limit unnecessary surgical interventions, clinical parameters alone are not adequate for making the diagnosis of septic arthritis. Therefore, relevant laboratory parameters are used to enhance diagnostic sensitivity. The aim of our study was to assist in making the diagnosis of septic arthritis, and prevent delays in the diagnosis. Read More

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Safety Priority, Safety Rules, Safety Participation, and Safety Behaviour: The Mediating Role of Safety Training.

Int J Occup Saf Ergon 2021 Jul 23:1-36. Epub 2021 Jul 23.

Labour Economics and Industrial Relations Department, Sakarya University, Sakarya, Turkey.

Objectives: This study explores the effects of employee perception of the management's safety priority, safety rules, and safety training on safety participation and safety behaviour decided by management, as well as the mediating role of safety training on the other four dimensions.

Methods: The study covers employees working in 27 metal companies classed as hazardous/very hazardous in Turkey. The research data was collected by surveying 822 metal sector employees. Read More

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Kimura's disease: a rare cause of chronic neck lymphadenopathy.

J Surg Case Rep 2021 Jul 19;2021(7):rjab318. Epub 2021 Jul 19.

Department of Pathology, Raja Isteri Pengiran Anak Saleha Hospital, Bandar Seri Begawan, Brunei Darussalam.

Kimura's disease is a rare chronic inflammatory disorder of unknown etiology which typically presents with subcutaneous nodules in the head and neck region and is frequently associated with regional lymphadenopathy or salivary gland enlargement. Peripheral blood eosinophilia and elevated serum immunoglobulin E levels are constant features of the disease. We present herein a 31-year-old male patient who presented with chronic neck lymphadenopathy. Read More

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Proposal of use of the autotransplantation of the third molar as space maintainer in growing patients: a review of literature and a clinical case.

J Biol Regul Homeost Agents 2021 May-Jun;35(3 Suppl. 1):179-184

Department of Neuroscience, School of Dentistry, University of Padua, Italy.

The review of literature shows that 48,22% of the autotranspated teeth were orthodontically treated. A 13-year-old male patient presented a destructive decay in the element 3.6, which was underoccluded. Read More

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Patient's perception of intraoral scanning: a comparison between traditional and digital dental impression.

J Biol Regul Homeost Agents 2021 May-Jun;35(3 Suppl. 1):19-28

Department of Clinical Science and Translational Medicine, University of Rome Tor Vergata, Rome, Italy.

The purpose of this work was to assess the discomfort perceived by the patient during the intraoral scan procedure using the iTero Scanner. A sample of 33 patients was selected on the basis of parameters that identify a complete dentition. All treated patients underwent a traditional polyvinylsiloxane impression with double procedure and an intraoral scan in the same session. Read More

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The importance of adequate diagnosis of pediatric forearm bowing fractures: A case report.

Trauma Case Rep 2021 Aug 1;34:100508. Epub 2021 Jul 1.

AZ St-Blasius Dendermonde, Department of Orthopaedic Surgery and Traumatology, Kroonveldlaan 50, 9200 Dendermonde, Belgium.

Introduction: Correct diagnosis of pediatric bowing fractures has proven to be challenging. Consequently, these entities are often underdiagnosed both at the initial presentation and at further follow-up. We present a case of an ulnar fracture with subsequent non-union and initially missed associated plastic deformity of the radius to highlight the importance of adequate diagnosis of bowing fractures and obtaining appropriate imaging in pediatric forearm trauma to prevent sequelae. Read More

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A Report of 2 Infant Siblings with Progressive Intrahepatic Familial Cholestasis Type 1 and a Novel Homozygous Mutation in the ATP8B1 Gene Treated with Partial External Biliary Diversion and Liver Transplant.

Am J Case Rep 2021 Jul 20;22:e932374. Epub 2021 Jul 20.

Department of Gastroenterology, Hepatology, Nutritional Disorders and Pediatrics, The Children's Memorial Health Institute, Warsaw, Poland.

BACKGROUND Current treatment options for progressive intrahepatic familial cholestasis type 1 (PFIC-1) comprise ursodeoxycholic acid (UDCA), partial external biliary diversion (PEBD), and liver transplantation (LTx). The role and timing of LTx in PFIC-1 remains debated. We present 2 case reports of male siblings with PFIC-1 who benefited from different treatments. Read More

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Rare side effect caused by atezolizumab, an immune checkpoint inhibitor: Cold agglutinin disease.

J Oncol Pharm Pract 2021 Jul 20:10781552211033009. Epub 2021 Jul 20.

Department of Hematology, Istanbul Medipol University School of Medicine, Istanbul, Turkey.

Introduction: Immune checkpoint inhibitors are drugs that are included in the guidelines of hematological and solid cancer treatments, give highly effective results and increase T cell functionality. However, these drugs can cause immune-related adverse events resembling autoimmune diseases.

Case Report: A 50-year-old male patient was admitted to an external center with complaints of chest pain and dyspnea. Read More

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Prenatal diagnosis of de novo small supernumerary marker chromosome 4q (4q11-q12): A case report.

Int J Reprod Biomed 2021 May 23;19(5):477-482. Epub 2021 Jun 23.

Genetic Laboratory, Shiraz Fertility Center, Zargari St., Shiraz, Iran.

Background: Small supernumerary marker chromosomes (sSMCs) are chromosomal fragments with abnormal structures found in patients with fertility problems and developmental delay. They may be detected in amniotic cell karyotypes. sSMCs are categorized as hereditary or de novo. Read More

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