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Genome-wide identification studies - A primer to explore new genes in plant species.

Plant Biol (Stuttg) 2021 Sep 23. Epub 2021 Sep 23.

State Key Laboratory of Rice Biology and China National Center for Rice Improvement, China National Rice Research Institute, Hangzhou, China.

Genome data have accumulated rapidly in recent years, doubling roughly after every 6 months due to the influx of next-generation sequencing technologies. A plethora of plant genomes are available in comprehensive public databases. This easy access to data provides an opportunity to explore genome datasets and recruit new genes in various plant species not possible a decade ago. Read More

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September 2021

'It was hell in the community': a qualitative study of maternal and child health care during health care worker strikes in Kenya.

Int J Equity Health 2021 Sep 23;20(1):210. Epub 2021 Sep 23.

Academic Model Providing Access to Healthcare (AMPATH), Eldoret, Kenya.

Background: Health care workers in Kenya have launched major strikes in the public health sector in the past decade but the impact of strikes on health systems is under-explored. We conducted a qualitative study to investigate maternal and child health care and services during nationwide strikes by health care workers in 2017 from the perspective of pregnant women, community health volunteers (CHVs), and health facility managers.

Methods: We conducted in-depth interviews and focus group discussions (FGDs) with three populations: women who were pregnant in 2017, CHVs, and health facility managers. Read More

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September 2021

PERSPECTIVE: The Digital Health App Policy Landscape: Regulatory Gaps and Choices Through the Lens of Mental Health.

J Ment Health Policy Econ 2021 Sep;24(3):101-108

330 Brookline Ave, Boston, MA, 02115, USA,

Background: Interest in and use of mental health apps have grown over the past decade, and now further with the COVID-19 pandemic. Digital mental health offers potential to increase access to care, but tangible risks around safety and poor efficacy remain common.

Methods: We conduct a select analysis of U. Read More

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September 2021

Biomimetic Synthesis of Natural Products: A Journey To Learn, To Mimic, and To Be Better.

Acc Chem Res 2021 Sep 22. Epub 2021 Sep 22.

School of Pharmaceutical Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing 100084, China.

ConspectusTotal synthesis of natural products has been one of the most exciting and dynamic areas in synthetic organic chemistry. Nowadays, the major challenge in this field is not whether a given target of interest can be synthesized but how to make it with commendable efficiency and practicality. To meet this grand challenge, a wise way is to learn from Mother Nature who is recognized for her superb capability of forging complicated and sometimes beyond-imagination molecules in her own delicate way. Read More

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September 2021

Engagement of ethics and regulatory authorities on human infection studies: Proceedings of an engagement workshop in Zambia.

Wellcome Open Res 2021 14;6:31. Epub 2021 Sep 14.

Research Department, The centre for Infectious Disease Research in Zambia, Lusaka, Zambia, 10101, Zambia.

Human infection studies (HIS) have generally been used as a tool in the pathway for vaccine development in high income settings. Over the last decade, this model has been implemented in LMICs with the aim of accelerating development of next generation vaccines that would perform better in these settings. However, in most LMICs, the ethics and regulatory framework for the conduct of these studies are not in place. Read More

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September 2021

Patient Portals: Objectives, Acceptance, and Effects on Health Outcome - A Scoping Review of Reviews.

Stud Health Technol Inform 2021 Sep;283:194-201

Technical University of Munich, School of Medicine, Medical Center rechts der Isar, Institute for Medical Informatics, Statistics and Epidemiology - IMedIS.

Patient portals provide patients access to their electronic health record and other functions as secure messaging. For over a decade, more and more patient portals are developed for various settings. The aim of this scoping review of reviews is to systematically search the literature for existing reviews to provide an overview of patient portals' objectives, acceptance and effects on outcome. Read More

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September 2021

Opportunities for the use of health information technology to support research.

JAMIA Open 2020 Oct 18;3(3):321-325. Epub 2020 Sep 18.

InterSystems Corporation, Cambridge, Massachusetts, USA.

In the last decade, expanding use of health information technology (IT) across the United States has created opportunities for use of electronic health data for health services and biomedical research, but efforts may be hampered by limited data access, data quality, and system functionality. We identify five opportunities to advance the use of health IT for health services and biomedical research, which informed a federal government-led, collaborative effort to develop a relevant policy and development agenda. In particular, the health IT infrastructure should more effectively support the use of electronic health data for research; provide adaptable technologies; incorporate relevant research-related functionality; support patient and caregiver engagement in research; and support effective integration of knowledge into practice. Read More

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October 2020

Cervical Cancer Screening in South Florida Veteran Population, 2014 to 2020: Cytology and High-Risk Human Papillomavirus Correlation and Epidemiology.

Cureus 2021 Aug 17;13(8):e17247. Epub 2021 Aug 17.

Pathology and Laboratory Medicine, James A. Haley Veterans' Hospital, Tampa, USA.

Objective This project aims to use our robust women's health patient data to analyze the correlation between cytology and high-risk human papillomavirus (Hr-HPV) testing, study the performance of Hr-HPV testing for detecting cytology lesions, and examine epidemiologic measures of human papillomavirus (HPV) infections in the women's veteran population. Methods We collected patient data from 2014 to 2020 from our computerized patient record system. We performed HPV assays using the cobas® 4800 system (Roche Diagnostics, Basel, Switzerland). Read More

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Can a little bit of mindfulness do you good? A systematic review and meta-analyses of unguided mindfulness-based self-help interventions.

Clin Psychol Rev 2021 Aug 30;89:102078. Epub 2021 Aug 30.

School of Psychology, University of Sussex, Falmer, Brighton BN1 9QJ, UK; R&D Department, Sussex Partnership NHS Foundation Trust, Sussex Education Centre, Hove, BN3 7HZ, UK. Electronic address:

Over the last decade there has been an explosion of interest in mindfulness-based self-help (MBSH) interventions. While widely available and extensively promoted, there is little consensus on their impact in public health or healthcare contexts. We present a systematic review and meta-analyses of 83 randomized controlled trials, comparing unguided MBSH to control conditions on outcomes of depression, mindfulness, anxiety, stress and/or wellbeing/ quality of life. Read More

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Advancing Rights-Based Family Planning from 2020 to 2030.

Open Access J Contracept 2021 9;12:157-171. Epub 2021 Sep 9.

Public Health Consulting, Bethesda, MD, USA.

Introduction: An assessment in 2019 by Family Planning 2020 of progress on rights-based family planning since 2012 highlighted the development of tools and guidelines that identify and explain rights in relation to family planning, promotion of rights-based approaches to programing, strengthened accountability, and measurement of rights-focused outcomes. The assessment was also forward-looking, asking what aspects of rights-based family planning still need attention moving from 2020 to 2030.

Methods: This paper draws on interviews with 23 key informants from governments, civil society, and youth focused organizations, implementing partners, and bi-lateral and multilateral organizations from Africa, Asia and the Pacific, Europe and North America, all working on family planning and engaged in various roles with the FP2020 partnership at global and national levels, along with documentation of FP2030 partnership plans. Read More

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September 2021

Medical thoracoscopy in intensive care unit.

J Thorac Dis 2021 Aug;13(8):5232-5241

Division of Pulmonary Diseases, Critical Care and Environmental Medicine, Tulane University Health Sciences Center, New Orleans, LA, USA.

During the last decade, there has been a tremendous effort towards making procedures less invasive, which could reduce complications, decrease hospital stay and minimize overall health care cost. Medical thoracoscopy (MT) or pleuroscopy is a minimally invasive procedure commonly performed by interventional pulmonologist in United States. It has a favorable safety profile allowing access to the pleural cavity with a thoracoscope via a small chest wall incision to perform diagnostic or therapeutic interventions under direct visualization. Read More

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Secundum Atrial Septal Defect Closure via the Transhepatic Approach in a Patient With Situs Ambiguus and a Left-Sided Inferior Vena Cava.

J Investig Med High Impact Case Rep 2021 Jan-Dec;9:23247096211045255

Creighton University, Phoenix, AZ, USA.

Secundum atrial septal defect (ASD) is the most common type of ASD. Symptoms including dyspnea on exertion usually manifest in the third and fourth decade of life. The transcatheter closure is the treatment of choice for secundum ASD. Read More

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September 2021

Screening Strategies for Biosurfactant Discovery.

Adv Biochem Eng Biotechnol 2021 Sep 14. Epub 2021 Sep 14.

Institute for Microbial Biotechnology and Metagenomics, University of the Western Cape, Cape Town, South Africa.

The isolation and screening of bacteria and fungi for the production of surface-active compounds has been the basis for the majority of the biosurfactants discovered to date. Hence, a wide variety of well-established and relatively simple methods are available for screening, mostly focused on the detection of surface or interfacial activity of the culture supernatant. However, the success of any biodiscovery effort, specifically aiming to access novelty, relies directly on the characteristics being screened for and the uniqueness of the microorganisms being screened. Read More

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September 2021

[Drug use and drug trends in Sweden 2010-2020 - results from urine drug testing in the workplace].

Lakartidningen 2021 09 13;118. Epub 2021 Sep 13.

sjukhuskemist, klinisk farmakologi, Karolinska universitetslaboratoriet, Stockholm.

Workplace alcohol and drug testing is increasingly used at employment, for regular checks, and in case of accident, incident, or suspicion of drug exposure. The test results provide valuable objective information about drug use in the society. At the Karolinska University Laboratory (Stockholm, Sweden), the number of samples from drug testing in the workplace has quadrupled in the last decade. Read More

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September 2021

Health Care Disparities and the Future of Pancreatic Cancer Care.

Surg Oncol Clin N Am 2021 Oct;30(4):759-771

Boston Medical Center, Boston University School of Medicine, 88 East Newton Street, Collamore - C500, Boston, MA 02118, USA. Electronic address:

There have been tremendous advances in the diagnosis and treatment of pancreatic cancer in the past decade, yet we are failing to achieve equitable outcomes for all patient populations. Disparities exist in the incidence, diagnosis, treatment, and outcomes of patients with pancreatic cancer. Inequities are based on racial and ethnic group, sex, socioeconomic status, and geography. Read More

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October 2021

Decreasing Medicare Utilization, Reimbursement, and Reimbursement-to-Charge Ratio of Reconstructive Plastic Surgery Procedures: 2010 to 2019.

Ann Plast Surg 2021 Sep 10. Epub 2021 Sep 10.

From the Warren Alpert Medical School, Brown University, Providence, RI Johns Hopkins Bloomberg School of Public Health Johns Hopkins Carey Business School, Baltimore, MD Department of Radiology, Brigham and Women's Hospital, Boston, MA Curtis National Hand Center, MedStar Union Memorial Hospital Department of Plastic and Reconstructive Surgery, Johns Hopkins Hospital, Baltimore, MD.

Background: This study aimed to evaluate recent trends in utilization, reimbursement, and charges for reconstructive plastic surgery procedures billed to Medicare.

Methods: We queried the Physician/Supplier Procedure Summary from the Centers for Medicare and Medicaid Services for procedures billed by plastic surgeons to Medicare Part B between 2010 and 2019. We collected service counts, charges, and reimbursements. Read More

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September 2021

Site-selective C-H functionalization to access the arene backbone of indoles and quinolines.

Chem Soc Rev 2021 Sep 6. Epub 2021 Sep 6.

State Key Laboratory of Coordination Chemistry, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China.

The site-selective C-H bond functionalization of heteroarenes can eventually provide chemists with great techniques for editing and building complex molecular scaffolds. During the past decade, benzo-fused N-heterocycles such as indoles and quinolines have been among the most widely investigated organic templates. Early developments have led to site-selective C-H bond functionalization on the pyrrole and pyridine cores of indoles and quinolines; however, C-H functionalization on the benzenoid ring has remained a great challenge in catalysis. Read More

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September 2021

Assessing the Accuracy of Sales Forecasts Submitted by Pharmaceutical Companies Applying for Reimbursement in Austria.

Front Pharmacol 2021 13;12:726758. Epub 2021 Aug 13.

Institute of Pharmacology, Centre of Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria.

Reimbursement decisions on new medicines require an assessment of their value. In Austria, when applying for reimbursement of new medicines, pharmaceutical companies are also obliged to submit forecasts of future sales. We systematically examined the accuracy of these pharmaceutical sales forecasts and hence the usefulness of these forecasts for reimbursement evaluations. Read More

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The role of digital health technology in rural cancer care delivery: A systematic review.

J Rural Health 2021 Sep 4. Epub 2021 Sep 4.

School of Medicine, Virginia Commonwealth University, Richmond, Virginia, USA.

Purpose: Rural residents face higher cancer incidence rates and mortality rates, disparities that could be mitigated with health technology interventions, yet a digital divide is also apparent. This paper systematically and critically examines existing literature to understand how digital technologies have been used to support rural oncology care.

Methods: PubMed, CINAHL Complete, PsycINFO, and Embase were searched using Medical Subject Headings terms and keywords. Read More

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September 2021

Radiotherapy resources in Africa: an International Atomic Energy Agency update and analysis of projected needs.

Lancet Oncol 2021 09;22(9):e391-e399

Division of Human Health, International Atomic Energy Agency, Vienna, Austria. Electronic address:

The number of patients with cancer in Africa has been predicted to increase from 844 279 in 2012 to more than 1·5 million in 2030. However, many countries in Africa still lack access to radiotherapy as a part of comprehensive cancer care. The objective of this analysis is to present an updated overview of radiotherapy resources in Africa and to analyse the gaps and needs of the continent for 2030 in the context of the UN Sustainable Development Goals. Read More

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September 2021

Economic Aspects of Delivering Primary Care Services: An Evidence Synthesis to Inform Policy and Research Priorities.

Milbank Q 2021 Sep 2. Epub 2021 Sep 2.

London School of Economics and Political Science.

Policy Points The 2018 Declaration of Astana reemphasized the importance of primary health care and its role in achieving universal health coverage. While there is a large amount of literature on the economic aspects of delivering primary care services, there is a need for more comprehensive overviews of this evidence. In this article, we offer such an overview. Read More

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September 2021

[Social media for continuing education in nephrology. Myth or reality?]

G Ital Nefrol 2021 Aug 30;38(4). Epub 2021 Aug 30.

Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milano, Italy.

About 60% of the world population has access to the Internet in 2021, making it the main tool in fostering communication between people. Lately, digital information and communication have especially taken place on platforms known as Social Media (SoMe) or Social Networks. In the last decade the usefulness of these tools in carrying information aimed at updating professionals in Medicine and Nephrology has become evident. Read More

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A retrospective study of the impact of health worker strikes on maternal and child health care utilization in western Kenya.

BMC Health Serv Res 2021 Sep 1;21(1):898. Epub 2021 Sep 1.

Academic Model Providing Access to Healthcare (AMPATH), Eldoret, Kenya.

Background: There have been dozens of strikes by health workers in Kenya in the past decade, but there are few studies of their impact on maternal and child health services and outcomes. We conducted a retrospective survey study to assess the impact of nationwide strikes by health workers in 2017 on utilization of maternal and child health services in western Kenya.

Methods: We utilized a parent study to enroll women who were pregnant in 2017 when there were prolonged strikes by health workers ("strike group") and women who were pregnant in 2018 when there were no major strikes ("control group"). Read More

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September 2021

Identifying the top research priorities in postmastectomy breast cancer reconstruction: a James Lind Alliance priority setting partnership.

BMJ Open 2021 08 30;11(8):e047589. Epub 2021 Aug 30.

University of Toronto, Toronto, Ontario, Canada.

Background: Major improvements in breast cancer treatment in the last decade include advancements in postmastectomy breast reconstruction (PMBR). Unfortunately, the studies in PMBR are primarily researcher or industry led with minimal input from patients and caregivers. The aim of this study is to use the James Lind Alliance (JLA) approach to bring together the patients, caregivers and clinicians in a priority setting partnership to identify the most important unanswered research questions in PMBR. Read More

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Genotoxicity test battery - An assessment of its utility in early drug development.

Authors:
Paul Baldrick

Mutat Res 2021 Aug-Sep;868-869:503388. Epub 2021 Jul 27.

Product Development and Market Access Consulting, Clinical Development & Commercialisation Services, Labcorp Drug Development Inc. (formerly Covance), Harrogate, North Yorkshire, HG3 1PY, United Kingdom. Electronic address:

Formal requirements for genotoxicity testing of drug candidates to support clinical entry have been in place since the issue of initial regulatory guidance over 25 years ago and subsequent update a decade ago. An evaluation of such testing, supporting first clinical entry of 108 small molecule drug candidates over the last decade, showed that the most common approach (75 % of tested compounds) was for a Good Laboratory Practice test battery in the form of 2 in vitro (a bacterial reverse mutation and a mammalian cell) assays and one in vivo assay. The majority of other tested compounds involved in vitro testing only in bacterial reverse mutation and mammalian cell assays. Read More

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Workforce safety in the remote health sector of Australia: a scoping review.

BMJ Open 2021 08 27;11(8):e051345. Epub 2021 Aug 27.

College of Healthcare Sciences, James Cook University, Townsville, Queensland, Australia.

Objectives: To scope the evidence surrounding workplace health and safety risks for the remote health workforce in Australia and to collate the recommendations to address those risks.

Design: A five-stage scoping review framework refined by Cooper was used for this review. Informit Health Collection, Ovid Emcare, Medline, Web of Science Core Collection, ProQuest and the grey literature were searched in October 2020 using a combination of key words derived from the eligibility criteria. Read More

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Morbidity, mortality, and systems safety in non-operating room anaesthesia: a narrative review.

Br J Anaesth 2021 Aug 24. Epub 2021 Aug 24.

Department of Anesthesia and Perioperative Medicine, Medical University of South Carolina, Charleston, SC, USA. Electronic address:

Non-operating room anaesthesia (NORA) describes anaesthesia delivered outside a traditional operating room (OR) setting. Non-operating room anaesthesia cases have increased significantly in the last 20 yr and are projected to account for half of all anaesthetics delivered in the next decade. In contrast to most other medication administration contexts, NORA is performed in high-volume fast-paced environments not optimised for anaesthesia care. Read More

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The ANT Home Care Model in Palliative and End-of-Life Care. An Investigation on Family Caregivers' Satisfaction with the Services Provided.

Transl Med UniSa 2020 Sep 1;23:1-6. Epub 2020 Oct 1.

ANT Italia Foundation, Bologna, Italy.

The World Health Organization plan for a has established some priorities in the field of palliative and end-of-life care. It states that "people require non-discriminatory access to good-quality palliative and end-of-life care" and recommends the "implementation of strategies for the provision of information, training, respite and support for informal caregivers". The priorities described are in line with the home care services that National Tumor Assistance (ANT) Foundation has been providing in Italy. Read More

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September 2020

The convergence of financial inclusion across provinces in Vietnam: A novel approach.

PLoS One 2021 26;16(8):e0256524. Epub 2021 Aug 26.

Research Centre in Business, Economics & Resources, Ho Chi Minh City Open University Vietnam, Ho Chi Minh City, Vietnam.

Financial inclusion has generally been considered an effective mechanism to support economic growth and reduce Vietnam's poverty for the last decade. While the importance of financial inclusion to economic growth or macroeconomic stability has been widely examined, it appears that the degree of financial inclusion across Vietnam has not attracted attention from academics and policymakers. In particular, a convergence of financial inclusion across provinces in Vietnam has never been examined. Read More

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Reforming solitary confinement: the development, implementation, and processes of a restrictive housing step down reentry program in Oregon.

Health Justice 2021 Aug 26;9(1):23. Epub 2021 Aug 26.

Department of Sociology, University of Colorado Boulder, Boulder, CO, 80309, USA.

Background: Over the past decade there have been numerous and impassioned calls to reform the practice of solitary confinement in U.S. prisons. Read More

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