1,288 results match your criteria death-censored graft

Beneficial effects of posttransplant dipeptidyl peptidase-4 inhibitor administration after pancreas transplantation to improve β cell function.

Ann Surg Treat Res 2021 Sep 31;101(3):187-196. Epub 2021 Aug 31.

Division of Kidney and Pancreas Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea.

Purpose: Dipeptidyl peptidase-4 (DPP-4) inhibitors lower blood glucose levels and enhance the function of pancreatic β cells. Yet, it is unknown whether posttransplant administration of DPP4 inhibitors is beneficial for pancreas transplant recipients.

Methods: We thus retrospectively analyzed the records of 312 patients who underwent pancreas transplantation between 2000 and 2018 at Asan Medical Center (Seoul, Korea) and compared the metabolic and survival outcomes according to DPP-4 inhibitor treatment. Read More

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September 2021

Comparison of Outcomes of Kidney Transplantation From Extremely Low Body Weight ≤5kg Larger Body Weight Pediatric Donors.

Front Immunol 2021 31;12:738749. Epub 2021 Aug 31.

Department of Kidney Transplantation, The Second Xiangya Hospital of Central South University, Changsha, China.

Background: Kidney transplantation from donors who weigh ≤5 kg is performed at only a few transplant centers owing to the high complication and low graft survival rates associated with this approach.

Methods: We retrospectively compared the results of kidney transplantation at our center between January 2015 and December 2019 based on the following pediatric donor criteria: donor body weight ≤5 kg (n=32), 5 kg< donor weight ≤20 kg (n=143), and donor weight >20 kg (n=110). We also perform subgroup analysis of kidney transplantation outcomes from ≤5 kg donors, using conventional (dual separate and classic en-bloc KTx)/novel (en-bloc KTx with outflow tract) surgical methods and allocating to adult/pediatric recipients. Read More

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Does the Side Matter? A Retrospective Cohort Study Comparing Left and Right Pure Laparoscopic Donor Nephrectomies.

Urol Int 2021 Aug 6:1-9. Epub 2021 Aug 6.

Department of Nephrology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humbold-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.

Objectives: Right laparoscopic donor nephrectomy (RLDN) is no longer regarded inferior to left LDN (LLDN). However, this knowledge is based on many studies suffering from inherent learning curves, center-specific imbalances, and different laparoscopic techniques.

Methods: Pure LDNs at a high-volume referral center from 2011 to 2016 were retrospectively analyzed. Read More

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Successful outcomes with transplanting kidneys from deceased donors with acute kidney injuryon temporary renal replacement therapy.

Clin Transplant 2021 Sep 12:e14465. Epub 2021 Sep 12.

Department of Surgery, Mayo Clinic, Phoenix, Arizona, USA.

Background And Objectives: We aimed to determine outcomes with transplanting kidneys from deceased donors with severe acute kidney injury requiring acute renal replacement therapy (RRT).

Materials And Methods: A total of 172 recipients received a kidney from donors with acute kidney injury stage 3 (AKIN3) requiring RRT. We compared the study group to 528 recipients who received a kidney from donors with AKIN stage 3 not on RRT and 463 recipients who received < 85% Kidney Donor Profile Index (KDPI) AKIN stage 0 kidney. Read More

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September 2021

Significance of Asymptomatic Pyelonephritis Found on Kidney Transplant Biopsy.

Transplant Direct 2021 Oct 7;7(10):e764. Epub 2021 Sep 7.

Division of Nephrology, Department of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, WI.

The clinical significance and appropriate management of graft pyelonephritis diagnosed by biopsy are poorly understood.

Methods: We analyzed data from all patients with pyelonephritis on transplant kidney biopsy from January 1998 to December 2019. Patients were divided into 2 groups: those whose urinalysis was positive for urinary tract infection (UA+) and those whose urinalysis was negative (UA-). Read More

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October 2021

Recipient APOL1 risk alleles associate with death-censored renal allograft survival and rejection episodes.

J Clin Invest 2021 Sep 9. Epub 2021 Sep 9.

Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, United States of America.

Apolipoprotein L1 (APOL1) risk-alleles in donor kidneys associate with graft loss but whether recipient risk-allele expression impacts transplant outcomes is unclear. To test whether recipient APOL1 risk-alleles independently correlate with transplant outcomes, we analyzed genome-wide SNP genotyping data of donors and recipients from two kidney transplant cohorts, Genomics of Chronic Allograft Rejection (GOCAR) and Clinical Trials in Organ Transplantation (CTOT1/17). We estimated genetic ancestry (quantified as proportion of African ancestry or pAFR) by ADMIXTURE and correlated APOL1 genotypes and pAFR with outcomes. Read More

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September 2021

Functional Fc Gamma Receptor Gene Polymorphisms and Long-Term Kidney Allograft Survival.

Front Immunol 2021 23;12:724331. Epub 2021 Aug 23.

Institute of Immunology, Heidelberg University Hospital, Heidelberg, Germany.

The functional Fc gamma receptor (FcγR) IIIA polymorphism -V/F158 was earlier suggested to determine the potential of donor-specific HLA antibodies to trigger microcirculation inflammation, a key lesion of antibody-mediated renal allograft rejection. Associations with long-term transplant outcomes, however, have not been evaluated to date. To clarify the impact of -V/F158 polymorphism on kidney transplant survival, we genotyped a cohort of 1,940 recipient/donor pairs. Read More

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Association between early post-transplant hypertension or related antihypertensive use and prognosis of kidney transplant recipients: a nationwide observational study.

J Nephrol 2021 Sep 6. Epub 2021 Sep 6.

Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea.

Background: Additional research is warranted for the clinical significance of post-transplant hypertension and related antihypertensive medication use in kidney transplant (KT) recipients.

Methods: This observational study included nationwide KT recipients who maintained a functioning graft for at least 1 year after KT in South Korea, observed between 2008 and 2017. The use of antihypertensive medications lasting between 6 months and 1 year was the main exposure, and those who had inconsistent/transient use of antihypertensive drugs were excluded. Read More

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September 2021

Effect of Pregnancy on EGFR After Kidney Transplantation: a National Cohort Study.

Transplantation 2021 Aug 27. Epub 2021 Aug 27.

Erasmus MC Transplant Institute, Department of Internal Medicine, University Medical Center Rotterdam, Rotterdam, the Netherlands Department of Obstetrics, Wilhelmina Children's Hospital Birth Center, University Medical Center Utrecht, Utrecht, the Netherlands Department of Epidemiology, University of Groningen, Groningen, the Netherlands Department of Nephrology, Radboud University Medical Center, Nijmegen, the Netherlands Department of Nephrology, University Medical Center Groningen, Groningen, the Netherlands.

Background: The effect of pregnancy on the course of estimated glomerular filtration rate (eGFR) is unknown in kidney transplant recipients (KTRs).

Methods: We conducted a nationwide multicenter cohort study in KTRs with pregnancy (>20 weeks) after kidney transplantation (KT). Annual eGFR's after KT until death or graft loss and additional eGFR's before each pregnancy were collected according to protocol. Read More

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High Mortality and Graft Loss after Infective Endocarditis in Kidney Transplant Recipients: A Case-Controlled Study from Two Centers.

Pathogens 2021 Aug 13;10(8). Epub 2021 Aug 13.

Kidney Transplantation Department, Sorbonne Université, Assistance Publique-Hôpitaux de Paris APHP, Pitié-Salpêtrière Hospital, INSERM UMR 1138, FR-75013 Paris, France.

Kidney transplant recipients (KTRs) tend to develop infections with characteristic epidemiology, presentation, and outcome. While infective endocarditis (IE) is among such complications in KTRs, the literature is scarce. We describe the presentation, epidemiology, and factors associated with IE in KTRs. Read More

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Protocol Biopsies on de novo Renal-Transplants at 3 Months after Surgery: Impact on 5-Year Transplant Survival.

J Clin Med 2021 Aug 17;10(16). Epub 2021 Aug 17.

Nephrology, Hemodialysis, Apheresis and Kidney Transplantation Department, University Hospital Grenoble, 38043 Grenoble, France.

Background: In many centers, a protocol kidney biopsy (PKB) is performed at 3 months post-transplantation (M3), without a demonstrated benefit on death-censored graft survival (DCGS). In this study, we compared DCGS between kidney transplant recipients undergoing a PKB or without such biopsy while accounting for the obvious indication bias.

Methods: In this retrospective, single-center study conducted between 2007 and 2013, we compared DCGS with respect to the availability and features of a PKB. Read More

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Analysis of risk factors for donation after circulatory death kidney transplantation in Japan.

Clin Exp Nephrol 2021 Aug 26. Epub 2021 Aug 26.

Department of Transplantation and Regenerative Medicine, School of Medicine, Fujita Health University, 1-98 Dengakugakubo, Kutsukake-cho, Toyoake, Aichi, 470-1192, Japan.

Background: In Japan, donations after circulatory death kidney transplantation are widely performed due to legislation delays. The number of donations after brain death kidney transplantations is increasing, but the target remains unmet. We reviewed the outcomes of donation after circulatory death in Japan. Read More

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Can uric acid blood levels in renal transplant recipients predict allograft outcome?

Ren Fail 2021 Dec;43(1):1240-1249

Renal Transplant Center, Sheba Medical Center, Tel Aviv University, Tel Aviv, Israel.

Background: Hyperuricemia is common after renal transplantation, especially in those receiving calcineurin inhibitors. Little, however, is known about the relationship between uric acid (UA) levels and allograft outcome.

Methods: We conducted a retrospective single-center analysis ( = 368) in order to assess UA blood levels post-transplant association with allograft outcome. Read More

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December 2021

Outcomes of Small Pediatric Donor Kidney Transplants According to Donor Weight.

Transpl Int 2021 Aug 24. Epub 2021 Aug 24.

David Geffen School of Medicine, University of California, Los Angeles, Department of Nephrology and Kidney Transplant, USA.

A small pediatric deceased donor (SPD) weight cut-off whether to transplant as en bloc (EB) or single pediatric (SP) kidney is uncertain. Using UNOS/OPTN data (2000-2019), 27,875 SPDs were divided by 1) EB (11.4%) or SP (88. Read More

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Patient and Graft Survival After Dual Kidney Transplantation With Marginal Donors in Comparison to Matched Control Groups.

Transplant Proc 2021 Sep 21;53(7):2180-2187. Epub 2021 Aug 21.

Vth Department of Medicine, University Hospital Mannheim, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany; Transplant Center Mannheim, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany; European Center of Angioscience Ecas, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany; Mannheim Institute for Innate Immunoscience, Medical Faculty Mannheim of the University of Heidelberg, Mannheim, Germany. Electronic address:

Background: Postmortal organ donor rates remain low in Germany, whereas donor age has been increasing considerably in the last decades. As a consequence of low donation rates older and more marginal donor kidneys are accepted for transplantation. However, procured kidneys from very old a/o marginal donors may be considered as not suitable for transplantation as a single organ and subsequently be discarded. Read More

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September 2021

Association Between Deceased Donor Acute Kidney Injury Assessed Using Baseline Serum Creatinine Back-Estimation and Graft Survival: Results From the French National CRISTAL Registry.

Am J Kidney Dis 2021 Aug 5. Epub 2021 Aug 5.

Department of Nephrology, Lille University Hospital, Lille, France.

Rationale & Objective: While deceased donor acute kidney injury (AKI) frequently leads to kidney discards, its impact on long-term graft survival in kidney transplant recipients remains unclear. We investigated the association between deceased donor AKI assessed using back-estimation of baseline serum creatinine (Scr) and graft survival.

Study Design: Observational cohort study. Read More

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Risk factors and outcomes of post-transplant erythrocytosis among adult kidney transplant recipients: a systematic review and meta-analysis.

Transpl Int 2021 Aug 19. Epub 2021 Aug 19.

Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN, USA.

Post-transplant erythrocytosis (PTE) can occur in up to 10-16% after kidney transplant (KT). However, the post-transplant outcomes of recipients with PTE in the literature were conflicting. We performed systematic review and meta-analysis of published studies to evaluate risk factors of PTE as well as outcomes of recipients who developed PTE compared with controls. Read More

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Outcome of Husband-to-Wife Kidney Transplantation With Mutual Children: Single Center Experience Using T Cell-Depleting Induction and Review of the Literature.

Front Med (Lausanne) 2021 2;8:724851. Epub 2021 Aug 2.

Clinic for Transplantation Immunology and Nephrology, University Hospital Basel, Basel, Switzerland.

Few data on husband-to-wife transplantations with mutual children (H2W) exist in the current era. We investigated the outcome of H2W transplantations ( = 25) treated with T cell-depleting induction compared to women with prior pregnancies also receiving their first HLA-mismatched kidney transplant, but from a different donor source: (i) other living donor ( = 52) and (ii) deceased donor ( = 120). Seventy-four percent of the women had ≥2 pregnancies; median follow-up time was 5 years. Read More

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Survival benefit of the homologous kidney allograft in simultaneous pancreas-kidney transplants and its potential protective role.

Clin Transplant 2021 Aug 17. Epub 2021 Aug 17.

Division of Transplantation, Department of Surgery, University of Minnesota, Minneapolis, MN, USA.

The superior death-censored graft survival of the pancreas allograft in simultaneous pancreas kidney transplants (SPK) over pancreas alone transplants (PTA) has long been recognized. Using data from the Scientific Registry of Transplant Recipients (SRTR) and a high-volume pancreas transplant program, we investigated the possible protective role of the kidney allograft in SPK transplants. We analyzed 19,043 primary pancreas transplants between 2000 and 2020, including 735 transplants performed at the University of Minnesota. Read More

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Impact of cardiopulmonary resuscitation on outcome of kidney transplantations from braindead donors aged ≥65 years.

Clin Transplant 2021 Aug 13:e14452. Epub 2021 Aug 13.

Department of Nephrology, Klinikum Stuttgart - Katharinenhospital, Stuttgart, Germany.

Introduction: Patients with a history of cardiopulmonary resuscitation (CPR) and subsequent brain death are frequently evaluated for organ donation. Whether kidneys from ≥65-year-old braindead donors with a history of CPR can be transplanted with satisfactory outcomes is unknown.

Material & Methods: All kidney transplants (KTs) from ≥65-year-old donors performed at our center from 1999 to 2018 (n = 185) were retrospectively analyzed and outcome was compared for KTs from donors with and without a history of CPR (n = 27 and n = 158, respectively). Read More

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US deceased kidney transplantation: Estimated GFR, donor age and KDPI association with graft survival.

EClinicalMedicine 2021 Jul 23;37:100980. Epub 2021 Jun 23.

United Network for Organ Sharing, 700N 4th St, Richmond, VA 23219, United States.

Background: Despite a significant shortage of kidneys for transplantation in the US, kidneys from older deceased donors are infrequently transplanted. This is primarily over concern of graft quality and transplant durability.

Methods: The US national transplant database (2000-2018) was assessed for deceased donor kidney transplant patient and graft survival, graft durability and stratified by donor age (<65 years>), Kidney Donor Profile Index (KDPI) and estimated glomerual filtration rate (GFR) one year post-transplantation (eGFR-1) were calculated. Read More

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Association of Admission, Nadir, and Terminal Donor Creatinine With Kidney Transplantation Outcomes.

Kidney Int Rep 2021 Aug 15;6(8):2075-2083. Epub 2021 May 15.

Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry, South Australian Health and Medical Research Institute (SAHMRI), Adelaide, Australia.

Introduction: When assessing deceased kidney donors, a key factor in organ acceptance and allocation is donor kidney function. It is unclear whether terminal, admission, or the highest of terminal and admission donor estimated glomerular filtration rate (eGFR) most predicts recipient outcomes.

Methods: We examined which measurement best predicts outcomes. Read More

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Outcomes of Spousal versus Parental Donor Kidney Transplants: A Comparative Study.

Indian J Nephrol 2021 May-Jun;31(3):261-265. Epub 2020 Nov 7.

Department of Psychiatry, Iqraa International Hospital and Research Centre, Calicut, Kerala, India.

Introduction: Parents and spouse constitute 70% of organ donors in India. Some centres use induction immunosuppression (IS) for all spousal transplants considering it as an immunologically high risk. This study was designed to compare the outcomes of transplant recipients who received parental donors (PDs) and spousal donors (SDs) without any induction IS. Read More

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November 2020

Deceased Donor Renal Transplantation: A Single Center Experience.

Indian J Nephrol 2021 May-Jun;31(3):254-260. Epub 2021 Apr 10.

Department of Hepatology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Introduction: Deceased donor kidney transplant are still not common across India. This study was done to assess various measures taken at a single center level to increase organ donation rate and to analyse the outcomes of transplants performed from these donors.

Methods: All deceased donor renal transplants performed from November 2011 to February 2017 were analysed for patient and death censored graft survival, rate of delayed graft function, rate of rejection and mortality. Read More

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Alemtuzumab as Second-Line Treatment for Late Antibody-Mediated Rejection of Transplanted Kidneys.

Transplant Proc 2021 Sep 8;53(7):2206-2211. Epub 2021 Aug 8.

Nephrology and Transplantation, Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.

Whether the anti-CD52 monoclonal antibody alemtuzumab can be an effective treatment option for late antibody-mediated rejection (ABMR) is not known. In a single-center pilot study, 12 patients with late ABMR were given 30 mg subcutaneous alemtuzumab.Median time from transplantation to biopsy was 22 months with 10 of 12 recipients fulfilling criteria for the histologic diagnosis chronic-active ABMR. Read More

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September 2021

Post-transplantation erythrocytosis in kidney transplant recipients-A retrospective cohort study.

Eur J Haematol 2021 Aug 9. Epub 2021 Aug 9.

Institute of Hematology, Davidoff Cancer Center, Rabin Medical Center, Petah Tikva, Israel.

Objectives: To characterize risk factors for the development of post-transplant erythrocytosis (PTE), and its long-term effect on mortality, graft failure, and thrombosis.

Methods: Retrospective study including all kidney transplant recipients in Rabin Medical Center (RMC) during the years 2005-2014. The primary outcome was a composite outcome of all-cause mortality or graft failure at the end of follow-up. Read More

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Association of Bw4/Bw6 mismatch across class I HLA loci with renal graft outcomes in first time transplants.

Hum Immunol 2021 Oct 3;82(10):767-774. Epub 2021 Aug 3.

Department of Pathology and Immunology, Washington University in St Louis, MO, United States. Electronic address:

Bw4 and Bw6 are strongly immunogenic epitopes routinely assigned based on HLA-B typing results per Organ Procurement and Transplantation Network (OPTN) policies. These public epitopes and their variants are shared by some cross-reactive HLA-A and -C antigens. Although epitope mismatch has been associated with poor transplant outcomes, previous studies did not find such associations for Bw4/6 mismatch as defined by HLA-B antigens only. Read More

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October 2021

The Framingham Risk Score Is Associated with Chronic Graft Failure in Renal Transplant Recipients.

J Clin Med 2021 Jul 26;10(15). Epub 2021 Jul 26.

Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institutet, SE-171 64 Stockholm, Sweden.

Predicting chronic graft failure in renal transplant recipients (RTR) is an unmet clinical need. Chronic graft failure is often accompanied by transplant vasculopathy, the formation of de novo atherosclerosis in the transplanted kidney. Therefore, we determined whether the 10-year Framingham risk score (FRS), an established atherosclerotic cardiovascular disease prediction module, is associated with chronic graft failure in RTR. Read More

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Comparing outcomes of third and fourth kidney transplantation in older and younger patients.

Am J Transplant 2021 Aug 5. Epub 2021 Aug 5.

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Performing third or fourth kidney transplantation (3KT and 4KT) in older patients is rare due to surgical and immunologic challenges. We aimed to analyze and compare the outcomes of younger (18-64 years) and older (≥65 years) recipients of 3KT and 4KT. Between 1990 and 2016, we identified 5816 recipients of 3KTs (153 were older) and 886 recipients of 4KTs (18 were older). Read More

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Cytomegalovirus nephritis in kidney transplant recipients: Epidemiology and outcomes of an uncommon diagnosis.

Transpl Infect Dis 2021 Jul 29. Epub 2021 Jul 29.

Division of Nephrology, Department of Medicine, University of Wisconsin, Madison, Wisconsin, USA.

Background: Data on epidemiology and outcomes of cytomegalovirus (CMV) nephritis in kidney transplant patients are limited due to the rarity of this condition.

Methods: A retrospective review of all kidney transplant recipients (KTR) (n = 6490) and biopsy-proven CMV nephritis between 1/1997 and 12/2020 was performed.

Results: The prevalence of CMV nephritis was low: 13/6490 (0. Read More

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