Dev Biol 2021 Jul 11;478:144-154. Epub 2021 Jul 11.
Departments of Neurobiology, Ophthalmology, and Cell Biology, Duke University School of Medicine, Durham, NC, 27710, USA. Electronic address:
Throughout the central nervous system, astrocytes adopt precisely ordered spatial arrangements of their somata and arbors, which facilitate their many important functions. Astrocyte pattern formation is particularly important in the retina, where astrocytes serve as a template that dictates the pattern of developing retinal vasculature. Thus, if astrocyte patterning is disturbed, there are severe consequences for retinal angiogenesis and ultimately for vision - as seen in diseases such as retinopathy of prematurity. Read More