944,606 results match your criteria death


Predicting novel drug candidates against Covid-19 using generative deep neural networks.

J Mol Graph Model 2021 Oct 13;110:108045. Epub 2021 Oct 13.

National Institute of Technology, Waranagl, 506004, India.

The novel Coronavirus outbreak has created a massive economic crisis, and many succumb to death, disturbing the lives of mankind all over the world. Currently, there are no viable treatment for this condition, drug development approaches are being pursued with vigor. The major treatment options are to repurpose existing drugs or to find new ones. Read More

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October 2021

A pyroptosis-related lncRNA signature predicts prognosis and immune microenvironment in head and neck squamous cell carcinoma.

Int Immunopharmacol 2021 Oct 20;101(Pt B):108268. Epub 2021 Oct 20.

Department of Otolaryngology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China. Electronic address:

Background: Pyroptosis, a type of regulated cell death controlled by the gasdermin family of proteins to form plasma membrane pores is known. Nonetheless, the function of pyroptosis-related long non-coding RNAs (lncRNAs) in this process still lacks exhaustive elucidation in head and neck squamous cell carcinoma (HNSCC). Other attributes encompassing the function of such lncRNAs in the immune microenvironment and potential prognosis for HNSCC are yet to see the light of the day. Read More

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October 2021

Impact of heat waves and cold spells on cause-specific mortality in the city of São Paulo, Brazil.

Int J Hyg Environ Health 2021 Oct 20;239:113861. Epub 2021 Oct 20.

Department of Geography, School of Philosophy, Literature and Human Sciences of the University of São Paulo, São Paulo, SP, Brazil; Institute of Advanced Studies, of the University of São Paulo, São Paulo, SP, Brazil. Electronic address:

The impact of heat waves and cold spells on mortality has become a major public health problem worldwide, especially among older adults living in low-to middle-income countries. This study aimed to investigate the effects of heat waves and cold spells under different definitions on cause-specific mortality among people aged ≥65 years in São Paulo from 2006 to 2015. A quasi-Poisson generalized linear model with a distributed lag model was used to investigate the association between cause-specific mortality and extreme air temperature events. Read More

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October 2021

A systematic review of phase II trials exploring anti-PD-1/PD-L1 combinations in patients with solid tumors.

Cancer Treat Rev 2021 Oct 17;101:102300. Epub 2021 Oct 17.

Department of Oncology, Oncology Institute of Southern Switzerland, EOC, Bellinzona, Switzerland. Electronic address:

Background: A high number of combinations of PD-1/PD-L1 inhibitors with other anti-cancer therapies are in clinical development. The usefulness of phase II trials in evaluating their efficacy and safety is unclear.

Materials And Methods: We performed a systematic search on PubMed and Cochrane Library for phase II trials of PD-1/PD-L1 inhibitors in combination with other anti-cancer therapies (systemic therapy and/or radiotherapy) published between January 1st 2018 and December 31st 2020. Read More

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October 2021

Potential role of herbal medicines as a novel approach in sepsis treatment.

Biomed Pharmacother 2021 Oct 20;144:112337. Epub 2021 Oct 20.

Department of Pharmacology, School of Pharmaceutical Sciences & Research, Jamia Hamdard, New Delhi, India.

The growing number of deaths related to sepsis has become a major concern for past few years. Sepsis is a complex pathological reactions that is explained by series of host response to microbial insult. The resulted systemic reactions are manifested by early appearance of proinflammatory cytokines leading to hyperinflammatory phase which is followed by septic shock and death of the patient. Read More

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October 2021

Brachytherapy and non-cancer mortality in patients with oral cavity and oropharynx SCCs.

Oral Oncol 2021 Oct 20;122:105585. Epub 2021 Oct 20.

Department of Medicine and Yale Cancer Center, Yale School of Medicine, New Haven, CT, United States.

Background: Oral cavity and oropharyngeal squamous cell cancers (OC-OPSCC) display high cancer-specific mortality and increased non-cancer mortality. We examined cause of death in patients treated for OC-OPSCC with brachytherapy, chemotherapy, external beam radiation, surgery, or combination of modalities. We hypothesized that brachytherapy does not increase non-cancer mortality comparably with external beam radiation. Read More

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October 2021

Epidemiology of paediatric moderate and severe traumatic brain injury in the Netherlands.

Eur J Paediatr Neurol 2021 Oct 9;35:123-129. Epub 2021 Oct 9.

Department of Surgery, University Medical Center Utrecht, Utrecht, the Netherlands.

Introduction: Traumatic brain injury (TBI) is the main cause of death in children around the world. The last Dutch epidemiological study described the incidence over 10 years ago. Mechanism of injury seems to change with the age of the child, therefore it is important to appreciate different age groups. Read More

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October 2021

Prevention of Bleeding After Percutaneous Biopsy with a Small Intestinal Submucosa Hemostatic Plug.

Acta Biomater 2021 Oct 20. Epub 2021 Oct 20.

Department of Biomedical Engineering, Universidad de los Andes; Research Department Fundación Cardioinfantil - Instituto de Cardiología. Electronic address:

Percutaneous biopsies (PBs) are the gold standard diagnostic procedures indicated for renal and hepatic disorders. Nevertheless, they can cause hemorrhages and are contraindicated for coagulopathic patients. In this study we designed, fabricated, and evaluated a small intestinal submucosa (SIS) plug to reduce, and potentially cease, bleeding to decrease death risk after percutaneous hepatic and renal biopsies in healthy and coagulopathic in vivo models. Read More

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October 2021

Molecular response mechanisms of silkworm (Bombyx mori L.) to the toxicity of 1-octyl-3-methylimidazole chloride based on transcriptome analysis of midguts and silk glands.

Ecotoxicol Environ Saf 2021 Oct 20;227:112915. Epub 2021 Oct 20.

College of Biotechnology, Jiangsu University of Science and Technology, Zhenjiang 212100, People's Republic of China. Electronic address:

In a previous study, silkworm larvae were used as a novel model to assess the biotoxicity of ILs, which showed that ILs could cause significant physiological and biochemical changes in midguts and silk glands of the larvae, and result in the death of larvae. In order to investigate the toxicity of 1-octyl-3-methylimidazole chloride ([Cmim]Cl) to the larvae at molecular level, RNA-sequencing technology was used to construct transcriptomic profiles of midguts and silk glands in this work. Results showed that a lot of differentially expressed genes (DEGs) were effectively screened out through bioinformatics software based on the transcriptome data and reference genome. Read More

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October 2021

Intestinal obstruction secondary to malformation in a child with Mayer-Rokitansky-Küster-Hauser Syndrome.

J Pediatr Adolesc Gynecol 2021 Oct 20. Epub 2021 Oct 20.

Department of Pathology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia. Electronic address:

Background: Mayer-Rokitansky-Küster-Hauser syndrome (MRKH) is a congenital disorder characterized by underdevelopment of the uterus and vagina.

Case: A 4-year-old girl was declared dead on arrival to the hospital with a history of chronic constipation since birth. Postmortem examination showed Müllerian remnants attached to abnormal fibrous tissue. Read More

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October 2021

Differences in Perioperative Outcomes after Carotid Revascularization between White and Non-white Patients.

Ann Vasc Surg 2021 Oct 20. Epub 2021 Oct 20.

University of California, San Diego, La Jolla, California. Electronic address:

Objectives: Racial disparities in carotid endarterectomy (CEA) and carotid artery stenting (CAS) continue to persist. We aimed to provide a large-scale analysis of racial disparities in perioperative outcomes of carotid revascularization in a nationally representative cohort of patients, with sub-analyses stratifying by procedure type and symptomatic status.

Methods: We studied all patients undergoing carotid revascularization between 2011 and 2018 in the American College of Surgeons (ACS) National Surgical Quality Improvement Program (NSQIP) Database. Read More

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October 2021

Designing health impact functions to assess marginal changes in outdoor fine particulate matter.

Environ Res 2021 Oct 20:112245. Epub 2021 Oct 20.

Department of Economics, Brigham Young University, Provo, UT, 84602, USA.

Estimating health benefits from improvements in ambient air quality requires the characterization of the magnitude and shape of the association between marginal changes in exposure and marginal changes in risk, and its uncertainty. Several attempts have been made to do this, each requiring different assumptions. These include the Log-Linear(LL), IntegratedExposure-Response(IER), and GlobalExposureMortalityModel(GEMM). Read More

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October 2021

Rhizosphere metabolism and its effect on phosphorus pools in the root zone of a submerged macrophyte, Isoëtes kirkii.

Sci Total Environ 2021 Oct 20:151087. Epub 2021 Oct 20.

National Institute of Water and Atmospheric Research Ltd, PO Box 11-115, Hamilton, New Zealand.

The presence of oxygen in lake sediments reduces sediment oxygen demand, and potentially improves sediment phosphorus retention and coupled nitrification/denitrification. However, the release of oxygen from the roots of macrophytes has not previously been measured in highly reducing sediments. Here, in the highly reducing environments of a commercial garden soil and sediment from a hyper-eutrophic lake, we used nine oxygen optodes, placed onto scintillation vials to detect oxygen in the rhizosphere of Isoetes kirkii referred to as quillworts. Read More

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October 2021

CaMKIIα knockout protects from ischemic neuronal cell death after resuscitation from cardiac arrest.

Brain Res 2021 Oct 20:147699. Epub 2021 Oct 20.

Department of Pharmacology, University of Colorado Anschutz Medical Campus, Aurora, CO 80045; Program in Neuroscience, University of Colorado Anschutz Medical Campus, Aurora, CO 80045. Electronic address:

CaMKIIα plays a dual role in synaptic plasticity, as it can mediate synaptic changes in opposing directions. We hypothesized that CaMKIIα plays a similar dual role also in neuronal cell death and survival. Indeed, the CaMKII inhibitor tatCN21 is neuroprotective when added during or after excitotoxic/ischemic insults, but was described to cause sensitization when applied long-term prior to such insult. Read More

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October 2021

Digoxin associated with greater transplant-free survival in high versus low-risk interstage patients.

Ann Thorac Surg 2021 Oct 20. Epub 2021 Oct 20.

The Heart Institute, Cincinnati Children's Hospital Medical Center, Cincinnati OH.

Background: Digoxin has been associated with reduced interstage mortality for patients with functional single ventricles with aortic hypoplasia/ductal-dependent systemic circulation. The NEONATE score can stratify patients by risk of death or transplant (DTx) based on clinical factors. We suspected a variable transplant-free survival benefit of digoxin in high- versus low-risk patients. Read More

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October 2021

Alzheimer's disease associated with Down syndrome: a genetic form of dementia.

Lancet Neurol 2021 Nov;20(11):930-942

Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu y Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; Barcelona Down Medical Center, Fundació Catalana Síndrome de Down, Barcelona, Spain; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas. CIBERNED, Madrid, Spain.

Adults with Down syndrome develop the neuropathological hallmarks of Alzheimer's disease and are at very high risk of developing early-onset dementia, which is now the leading cause of death in this population. Diagnosis of dementia remains a clinical challenge because of the lack of validated diagnostic criteria in this population, and because symptoms are overshadowed by the intellectual disability associated with Down syndrome. In people with Down syndrome, fluid and imaging biomarkers have shown good diagnostic performances and a strikingly similar temporality of changes with respect to sporadic and autosomal dominant Alzheimer's disease. Read More

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November 2021

Apixaban versus no anticoagulation after anticoagulation-associated intracerebral haemorrhage in patients with atrial fibrillation in the Netherlands (APACHE-AF): a randomised, open-label, phase 2 trial.

Lancet Neurol 2021 Nov;20(11):907-916

Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, Netherlands; Department of Neurology and Neurosurgery, Brain Center, University Medical Center Utrecht, Utrecht, Netherlands. Electronic address:

Background: In patients with atrial fibrillation who survive an anticoagulation-associated intracerebral haemorrhage, a decision must be made as to whether restarting or permanently avoiding anticoagulation is the best long-term strategy to prevent recurrent stroke and other vascular events. In APACHE-AF, we aimed to estimate the rates of non-fatal stroke or vascular death in such patients when treated with apixaban compared with when anticoagulation was avoided, to inform the design of a larger trial.

Methods: APACHE-AF was a prospective, randomised, open-label, phase 2 trial with masked endpoint assessment, done at 16 hospitals in the Netherlands. Read More

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November 2021

Safety and efficacy of losartan for the reduction of brain atrophy in clinically diagnosed Alzheimer's disease (the RADAR trial): a double-blind, randomised, placebo-controlled, phase 2 trial.

Lancet Neurol 2021 Nov;20(11):895-906

Translational Health Sciences, Population Health Sciences, University of Bristol, Bristol, UK; Bristol Trials Centre, University of Bristol, Bristol, UK.

Background: Drugs modifying angiotensin II signalling could reduce Alzheimer's disease pathology, thus decreasing the rate of disease progression. We investigated whether the angiotensin II receptor antagonist losartan, compared with placebo, could reduce brain volume loss, as a measure of disease progression, in clinically diagnosed mild-to-moderate Alzheimer's disease.

Methods: In this double-blind, multicentre, randomised controlled trial, eligible patients aged 55 years or older, previously untreated with angiotensin II drugs and diagnosed (National Institute of Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association criteria) with mild-to-moderate Alzheimer's disease, and who had capacity to consent, were recruited from 23 UK National Health Service hospital trusts. Read More

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November 2021

A new model for a palliative approach to care in Australia.

Rural Remote Health 2021 Oct 23;21(4):5947. Epub 2021 Oct 23.

Far West Local Health District, Broken Hill, NSW 2880, Australia

Introduction: There is an inconsistent provision of palliative and end-of-life (palliative) care across Australia, particularly in regional, rural and remote areas. Systematic solutions can help to address identified gaps and improve access to and quality of care and support for patients, their families and carers at the end of life. The Far West New South Wales (NSW) Palliative and End of Life Model of Care is a systematic solution for a rural and remote palliative approach to care. Read More

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October 2021

Lipase elevation in serum of COVID-19 patients: frequency, extent of increase and clinical value.

Clin Chem Lab Med 2021 Oct 25. Epub 2021 Oct 25.

Clinical Pathology Unit, ASST Fatebenefratelli-Sacco, Milan, Italy.

Objectives: Previous studies reported lipase elevations in serum of COVID-19 patients trying to establish a causal link between SARS-CoV-2 infection and pancreatic damage. However, the degree and prevalence of hyperlipasemia was not uniform across studies.

Methods: We retrospectively evaluated 1,092 hospitalized patients with COVID-19 and at least one available lipase result. Read More

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October 2021

Sibling Deaths, Racial/Ethnic Disadvantage, and Dementia in Later Life.

J Gerontol B Psychol Sci Soc Sci 2021 Oct 23. Epub 2021 Oct 23.

Department of Sociology, Center on Aging and Population Sciences and Population Research Center, The University of Texas at Austin, Austin.

Objectives: Sibling loss is understudied in the bereavement and health literature. The present study considers whether experiencing the death of siblings in mid-to-late life is associated with subsequent dementia risk and how differential exposure to sibling losses by race/ethnicity may contribute to racial/ethnic disparities in dementia risk.

Methods: We use discrete-time hazard regression models, a formal mediation test, and a counterfactual simulation to reveal how sibling loss in mid-to-late life affects dementia incidence and whether unequal exposures by race/ethnicity mediate the racial/ethnic disparities in dementia. Read More

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October 2021

COELOMIC STEATITIS IN TENTACLED SNAKES ().

J Zoo Wildl Med 2021 Sep;52(3):1061-1073

Department of Veterinary Anatomy, Physiology and Pathology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Neston CH64 7TE, United Kingdom.

A retrospective study revealed seven cases of coelomic steatitis in adult tentacled snakes (), including two males and five females, between May 2014 and August 2020. Common clinical signs included death after unusual floating, generalized weakness, inappetence, reduced body condition, coelomic distension, and reproductive pathology in females. Hematology of one specimen revealed marked monocytosis and lymphocytosis with mild heterophilia (chronic and active inflammation). Read More

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September 2021

A REVIEW OF MORTALITY IN TENTACLED SNAKES () IN A MULTI-INSTITUTION ZOOLOGICAL COLLECTION BETWEEN 1966 AND 2017.

J Zoo Wildl Med 2021 Sep;52(3):909-917

Wildlife Conservation Society, Bronx Zoo Herpetology Department, Central Park Zoo, and Zoological Health Program, Bronx, NY 10460 USA.

The tentacled snake () is a viviparous aquatic snake that is a desirable species to exhibit in zoological collections because of its unique appearance and feeding strategies. Despite its presence in zoo collections over the past 50 yr, a comprehensive review of mortality and morbidity in the species has not been published. This study retrospectively reviewed 125 pathology reports from tentacled snakes in a multi-institution zoological collection in New York (The Wildlife Conservation Society's Bronx and Central Park zoos) between 1966 and 2017. Read More

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September 2021

REVIEW OF HISTOLOGIC LESIONS AND MORTALITY IN RIO CAUCA CAECILIANS () OVER A 22-YEAR PERIOD.

J Zoo Wildl Med 2021 Sep;52(3):901-908

Zoological Pathology Program, Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Brookfield, IL 60513, USA.

Rio Cauca caecilians () are a unique, fully aquatic species of amphibian from the order Gymnophiona. They are housed in several zoological institutions and aquaria with limited information available regarding health and disease. This retrospective study evaluates common pathologic findings and causes of mortality of Rio Cauca caecilians from three different institutions over a 22-y period. Read More

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September 2021

PHARMACOKINETICS OF SUBCUTANEOUS ALPHA LIPOIC ACID, A PROPOSED THERAPEUTIC AID FOR DOMOIC ACID INTOXICATION IN CALIFORNIA SEA LIONS ().

J Zoo Wildl Med 2021 Sep;52(3):872-879

Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27607, USA.

Domoic acid (DA) is a potent neurotoxin produced by certain marine algae that can cause neurologic and cardiac dysfunction by activating glutamate receptors. Glutamate receptor overexcitation results in continuous cellular activation, oxidative damage, and cell death. DA toxicosis causes disorientation and seizures, and antiseizure medications are the primary treatment. Read More

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September 2021

LncRNA NEAT1 aggravates lipopolysaccharide-induced acute lung injury by regulating the miR-98-5p/TLR4 axis.

J Biochem Mol Toxicol 2021 Oct 23:e22927. Epub 2021 Oct 23.

Department of Respiratory Medicine, Huai'an Second People's Hospital and The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, Jiangsu, P. R. China.

Although long noncoding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) was reported to be associated with acute lung injury (ALI), its specific mechanism has not been well studied. Mouse and cell ALI models were constructed by lipopolysaccharide (LPS). Cell viability was evaluated by 3-(4,5)-dimethylthiahiazo (-z-y1)-3,5-di- phenytetrazoliumromide assay. Read More

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October 2021

Lactate and pyruvate levels correlation with lactate dehydrogenase gene expression and glucose consumption in Tamoxifen resistant MCF-7 cells using capillary electrophoresis with contactless conductivity detection (CE-C D).

Electrophoresis 2021 Oct 23. Epub 2021 Oct 23.

Department of Analytical Chemistry, Faculty of Pharmacy, Helwan University, Cairo, Egypt.

Breast cancer is the second leading cause of cancer death in women after lung cancer. The first line treatment of metastatic breast cancer in premenopausal women relies on tamoxifen. The development of tamoxifen resistance is not fully understood. Read More

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October 2021

The Mortality from Hereditary Angioedema Worldwide: a Review of the Real-World Data Literature.

Clin Rev Allergy Immunol 2021 Oct 23. Epub 2021 Oct 23.

Department of Pediatrics, Universidade Federal de Minas Gerais, Belo Horizonte, Av. Professor Alfredo Balena, 190/267, Minas Gerais, Brazil.

This study aims to review the global mortality secondary to laryngeal edema in patients diagnosed with hereditary angioedema and their relatives over the years, as well as to describe epidemiological and clinical findings associated with this outcome. An extensive search of the literature was made in PubMed, Scopus, and Embase to identify mortality rates secondary to laryngeal edema in patients with hereditary angioedema. The search was carried out in September of 2020 and in April of 2021, and keywords based on the MeSH terms were searched in three databases. Read More

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October 2021

Avelumab in Combination Regimens for Relapsed/Refractory DLBCL: Results from the Phase Ib JAVELIN DLBCL Study.

Target Oncol 2021 Oct 23. Epub 2021 Oct 23.

Mayo Clinic, Rochester, MN, USA.

Background: Relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL) is associated with a poor prognosis despite the availability of multiple treatment options. Preliminary evidence suggests that DLBCL may be responsive to programmed death ligand 1 (PD-L1)/programmed death 1 inhibitors.

Objective: The JAVELIN DLBCL study was conducted to assess whether a combination of agents could augment and sustain the antitumor immunity of avelumab, an anti-PD-L1 antibody, in R/R DLBCL. Read More

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October 2021