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Results of surgical treatment in chronic anal fissure complicated by abscess or fistula in a retrospective cohort of patients.

Updates Surg 2021 Nov 27. Epub 2021 Nov 27.

General Surgery, Hospital Val Vibrata, Sant'omero, 64027, L'Aquila, TE, Italy.

We report the results of the surgical treatment of anal fissures complicated by abscess or fistula and formulate hypotheses about their nature. Among patients operated between 2012 and 2020 for anal fissure resistant to medical therapy, those affected by septic complications were selected for our inquiry. Surgical treatment consisted in the drainage of the sepsis, fissurectomy, posterior sphincterotomy and anoplasty. Read More

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November 2021

Temperature sensitivity of Antarctic soil-humic substance degradation by cold-adapted bacteria.

Environ Microbiol 2021 Nov 27. Epub 2021 Nov 27.

Division of Life Sciences, Korea Polar Research Institute, Incheon, 21990, Republic of Korea.

Heteropolymer humic substances (HS) are the largest constituents of soil organic matter and are key components that affect plant and microbial growth in maritime Antarctic tundra. We investigated HS decomposition in Antarctic tundra soils from distinct sites by incubating samples at 5°C or 8°C (within a natural soil thawing temperature range of -3.8°C to 9. Read More

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November 2021

Young Women with Breast Cancer: Chemotherapy or Surgery First? An Evaluation of Time to Treatment for Invasive Breast Cancer.

Ann Surg Oncol 2021 Nov 26. Epub 2021 Nov 26.

Department of Surgery, University of Toronto, Toronto, ON, Canada.

Background: Breast cancer in young women (ages 18-40 years) is rare, yet remains a leading cause of cancer-related death. Time to treatment (TTT) is an increasingly important factor in breast cancer outcomes, specifically time to systemic therapy. Our objective was to review patterns of care for young women presenting with invasive breast cancer and compare TTT for surgery first versus neoadjuvant chemotherapy (NAC). Read More

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November 2021

Changes in shoulder outcomes using ultrasonographic assessment of breast cancer survivors: a prospective longitudinal study with 6-month follow-up.

Sci Rep 2021 Nov 26;11(1):23016. Epub 2021 Nov 26.

Physiotherapy in Women's Health (FPSM) Research Group, Physiotherapy Department, Faculty of Medicine and Health Sciences, University of Alcalá, 28805, Madrid, Spain.

This study aimed to describe changes in supraspinatus tendon thickness, acromiohumeral distance, and the presence of fluid in the subacromial bursa as measured by ultrasound, as well as shoulder range of motion and strength, perceived shoulder disability, and health-related quality of life in women before and after breast cancer treatment. Women who underwent surgery for unilateral breast cancer who did not suffer from shoulder pain or difficulty performing activities of daily living in the 6 months prior to surgery were included. One pre-surgical (A) and three post-surgical assessments at 7-10 days (A), 3 months (A), and 6 months (A) after surgery were carried out. Read More

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November 2021

Associations between ambient air pollution and IVF outcomes in a heavily polluted city in China.

Reprod Biomed Online 2021 Oct 7. Epub 2021 Oct 7.

Assisted Reproductive Technology Unit, Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, China. Electronic address:

Research Question: Is air pollution related to IVF outcomes in a heavily polluted city in China?

Design: A retrospective cohort study of 8628 fresh, autologous IVF cycles was conducted for the first time at the Reproductive Medicine Center of The Third Affiliated Hospital of Zhengzhou University between May 2014 and December 2018 (oocyte retrieval date). The exposure was divided into four periods (gonadotrophin injection to oocyte retrieval [P1], oocyte retrieval to embryo transfer [P2], 1 day after embryo transfer to embryo transfer +14 days [P3] and gonadotrophin injection to embryo transfer +14 days [P4]) and four levels (Q1-Q4 according to their 25th, 50th and 75th percentiles).

Results: An interquartile range increase (Q2 versus Q1) in particulate matter ≤10 µm (PM10) during P3 and P4 and sulphur dioxide (SO) during P3 significantly decreased the clinical pregnancy rate (adjusted odds ratio [aOR] 0. Read More

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October 2021

Open repair versus thoracic endovascular aortic repair for treating traumatic aortic injury.

Asian J Surg 2021 Nov 23. Epub 2021 Nov 23.

Department of Emergency Medicine, Pusan National University School of Medicine, Biomedical Research Institute, Pusan National University Hospital, Busan, Republic of Korea.

Background/objective: Blunt traumatic aortic injury (BTAI) is rare and fatal. Treatment has evolved with advances in imaging and the emergence of thoracic endovascular aortic repair (TEVAR). This study reports a single-center, 5-year experience of TEVAR and open repair for BTAI. Read More

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November 2021

Cytotoxic CD8-positive T-lymphocyte infiltration in the lungs as a histological pattern of SARS-CoV-2 pneumonitis.

Pathology 2021 Nov 8. Epub 2021 Nov 8.

Medical College of Wisconsin, Pathology Department, Milwaukee, WI, USA.

Despite millions of PCR confirmed cases of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection, the long-term pathophysiological changes induced by this infection in the lungs and their relationship with possible immune triggers remain incompletely understood. Acute respiratory distress syndrome and subsequent respiratory failure are the most common causes of mortality in hospitalised patients. Severe lung tissue destruction can be due to an overactive immune system that far exceeds the harm that would have been caused by direct virus replication. Read More

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November 2021

A machine learning based two-stage clinical decision support system for predicting patients' discontinuation from opioid use disorder treatment: retrospective observational study.

BMC Med Inform Decis Mak 2021 Nov 26;21(1):331. Epub 2021 Nov 26.

Department of Mechanical and Industrial Engineering, College of Engineering, Center for Health Policy and Healthcare Research, Northeastern University, 360 Huntington Avenue, Boston, MA, 02135, USA.

Background: Buprenorphine is a widely used treatment option for patients with opioid use disorder (OUD). Premature discontinuation from this treatment has many negative health and societal consequences.

Objective: To develop and evaluate a machine learning based two-stage clinical decision-making framework for predicting which patients will discontinue OUD treatment within less than a year. Read More

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November 2021

One-Pot Synthesis of Bright Blue Luminescent N-Doped GQDs: Optical Properties and Cell Imaging.

Nanomaterials (Basel) 2021 Oct 22;11(11). Epub 2021 Oct 22.

College of Food Science & Engineering, Ocean University of China, Qingdao 266003, China.

High fluorescent graphene quantum dots (GQDs) are promising in bioimaging and optoelectronics. In this paper, bright blue fluorescent N-doped GQDs were synthesized using a ultrasonic-assisted hydrothermal method. The morphology, structure, surface chemistry, optical properties, and stability subject to photo-bleaching, temperature, pH and preservation period for the N-GQDs were investigated in detail using various microscopy and spectroscopy techniques. Read More

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October 2021

Anti-Spike SARS-CoV-2 IgG Assessment with a Commercial Assay during a 4-Month Course after COVID-19 Vaccination.

Vaccines (Basel) 2021 Nov 20;9(11). Epub 2021 Nov 20.

Medical Department Diagnostyka S.A., 31-864 Krakow, Poland.

We intended to assess the humoral response induced by the Pfizer/BioNTech Comirnaty COVID-19 vaccine with commercially available immunoassays: anti-spike (S) IgG and IgM, and anti-nucleocapsid (N) IgG antibodies, over a 4-month course. One hundred subjects, including 15 COVID-19 convalescents, comprised the study cohort. The SARS-CoV-2 antibodies concentrations were measured on day 0' and 10', 20', 30', 60', 90', and 120' after the first dose administration. Read More

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November 2021

Side Effects of COVID-19 Pfizer-BioNTech mRNA Vaccine in Children Aged 12-18 Years in Saudi Arabia.

Vaccines (Basel) 2021 Nov 9;9(11). Epub 2021 Nov 9.

Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jazan University, Jazan 45142, Saudi Arabia.

: Massive vaccination campaigns have been undertaken globally to combat the spread of the Coronavirus Disease 2019 (COVID-19). While most COVID-19 vaccines have shown excellent efficacy and safety profiles in clinical studies, real-world monitoring of vaccine safety is still important. In this study, we aimed to investigate the early side effects of Pfizer-BioNTech (BNT162b2) mRNA vaccine in children between 12-18 years old in Saudi Arabia. Read More

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November 2021

Stability of Chimpanzee Adenovirus Vectored Vaccines (ChAdOx1 and ChAdOx2) in Liquid and Lyophilised Formulations.

Vaccines (Basel) 2021 Oct 28;9(11). Epub 2021 Oct 28.

Wellcome Trust Centre for Human Genetics, Jenner Institute, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK.

Adenovirus vectored vaccines have entered global use during the COVID-19 pandemic, and are in development for multiple other human and veterinary applications. An attraction of the technology is the suitability of the vaccines for storage at 2-8 °C for months. Widely used COVID-19 vaccine ChAdOx1 nCoV-19 (University of Oxford/AstraZeneca) is based on a species E simian adenovirus. Read More

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October 2021

Identification of African Swine Fever Virus Transcription within Peripheral Blood Mononuclear Cells of Acutely Infected Pigs.

Viruses 2021 Nov 22;13(11). Epub 2021 Nov 22.

Section of Veterinary Clinical Microbiology, Department of Veterinary and Animal Sciences, University of Copenhagen, 1870 Frederiksberg, Denmark.

African swine fever virus (ASFV) has become widespread in Europe, Asia and elsewhere, thereby causing extensive economic losses. The viral genome includes nearly 200 genes, but their expression within infected pigs has not been well characterized previously. In this study, four pigs were infected with a genotype II strain (ASFV POL/2015/Podlaskie); blood samples were collected before inoculation and at both 3 and 6 days later. Read More

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November 2021

Allele Types and Their Associations with Major Agronomic Traits in Korean Rice Cultivars.

Plants (Basel) 2021 Nov 8;10(11). Epub 2021 Nov 8.

National Institute of Crop Science, Rural Development Administration, Wanju 55365, Korea.

Optimizing flowering time in crop plants is critical for maximizing yield and quality under target environments. While there is a wide range of heading date variation in Korean rice cultivars, the underlying gene mechanisms are unclear. Here, we sequenced the protein coding regions of , the major rice heading date gene, from 293 Korean rice cultivars and investigated the associations between allele types and major agronomic traits under four different environments. Read More

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November 2021

Production of Genistein in var. and by Expression of .

Plants (Basel) 2021 Oct 27;10(11). Epub 2021 Oct 27.

Plant Genetic Engineering Laboratory, Department of Biotechnology, Bharathiar University, Coimbatore 641 046, India.

Isoflavonoids, the diverse group of secondary metabolites derived from the phenylpropanoid pathway, are distributed predominantly in leguminous plants. It has received considerable attention in recent days due to its health promoting benefits and is known to prevent certain diseases in humans. These isoflavonoids are synthesized from flavonoid intermediates of phenylpropanoid pathway by the enzyme isoflavone synthase. Read More

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October 2021

Circuitous Path to Live Donor Liver Transplantation from the Coordinator's Perspective.

J Pers Med 2021 Nov 10;11(11). Epub 2021 Nov 10.

Department of Surgery, National Taiwan University Hospital and College of Medicine, Taipei 100, Taiwan.

The live donor liver transplantation (LDLT) process is circuitous and requires a considerable amount of coordination and matching in multiple aspects that the literature does not completely address. From the coordinators' perspective, we systematically analyzed the time and risk factors associated with interruptions in the LDLT process. In this retrospective single center study, we reviewed the medical records of wait-listed hospitalized patients and potential live donors who arrived for evaluation. Read More

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November 2021

Quantitative Analysis of Residual COVID-19 Lung CT Features: Consistency among Two Commercial Software.

J Pers Med 2021 Oct 28;11(11). Epub 2021 Oct 28.

Division of Radiology, Università degli Studi della Campania Luigi Vanvitelli, 80125 Naples, Italy.

Objective: To investigate two commercial software and their efficacy in the assessment of chest CT sequelae in patients affected by COVID-19 pneumonia, comparing the consistency of tools.

Materials And Methods: Included in the study group were 120 COVID-19 patients (56 women and 104 men; 61 years of median age; range: 21-93 years) who underwent chest CT examinations at discharge between 5 March 2020 and 15 March 2021 and again at a follow-up time (3 months; range 30-237 days). A qualitative assessment by expert radiologists in the infectious disease field (experience of at least 5 years) was performed, and a quantitative evaluation using thoracic VCAR software (GE Healthcare, Chicago, Illinois, United States) and a pneumonia module of ANKE ASG-340 CT workstation (HTS Med & Anke, Naples, Italy) was performed. Read More

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October 2021

A Focused Review of Synthetic Applications of Lawesson's Reagent in Organic Synthesis.

Molecules 2021 Nov 17;26(22). Epub 2021 Nov 17.

Department of Chemistry, Faculty of Science, Universiti Putra Malaysia, Serdang 43400, Selangor, Malaysia.

Lawesson's reagent (LR) is a well-known classic example of a compound with unique construction and unusual chemical behavior, with a wide range of applications in synthetic organic chemistry. Its main functions were rounded for the thionation of various carbonyl groups in the early days, with exemplary results. However, the role of Lawesson's reagent in synthesis has changed drastically, and now its use can help the chemistry community to understand innovative ideas. Read More

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November 2021

Fabrication and Characterization of Polymeric Pharmaceutical Emulgel Co-Loaded with Eugenol and Linalool for the Treatment of Infections.

Polymers (Basel) 2021 Nov 11;13(22). Epub 2021 Nov 11.

Department of Pharmaceutics, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

() is the main cause of chronic dermatophytosis which is highly prevalent worldwide. This study was aimed to fabricate and characterize polymeric emulgel of eugenol and linalool for the treatment of infections. Using the slow emulsification method, the emulgel was prepared and characterized for thermodynamic stability, pH analysis, viscosity, spreadability, swelling behavior, %drug content, surface morphology, globules size, polydispersity index, surface charge (mV), thermal behavior, in vitro drug release and XRD studies. Read More

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November 2021

Highly Stable Potentiometric (Bio)Sensor for Urea and Urease Activity Determination.

Membranes (Basel) 2021 Nov 20;11(11). Epub 2021 Nov 20.

Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, Ks. Trojdena 4, 02-109 Warsaw, Poland.

There is growing interest for bioanalytical tools that might be designed for a specific user, primarily for research purposes. In this perspective, a new, highly stable potentiometric sensor based on glassy carbon/polyazulene/NH-selective membrane was developed and utilized for urease activity determination. Urease-urea interaction studies were carried out and the Michaelis-Menten constant was established for this enzymatic reaction. Read More

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November 2021

Pilot Plant for the Capture of Ammonia from the Atmosphere of Pig and Poultry Farms Using Gas-Permeable Membrane Technology.

Membranes (Basel) 2021 Nov 7;11(11). Epub 2021 Nov 7.

Instituto Universitario de Investigación en Ciencias Ambientales de Aragón (IUCA), EPS, Universidad de Zaragoza, Carretera Cuarte s/n, 22071 Huesca, Spain.

Gas-permeable membrane (GPM) technology is a possible solution to reduce ammonia (NH) emissions from livestock housing. This paper presents the results obtained with an NH-capture prototype based on the use of expanded polytetrafluoroethylene (ePTFE) membranes in real conditions in a gestating sow house and a free-range laying hen house, comparing them with the results obtained in controlled laboratory conditions for the same type of waste. The NH present in the air of the livestock housing was captured by reaction with an acidic solution flowing inside the membranes. Read More

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November 2021

Short-Term Cumulative Exposure to Ambient Traffic-Related Black Carbon and Blood Pressure: MMDA Traffic Enforcers' Health Study.

Int J Environ Res Public Health 2021 Nov 18;18(22). Epub 2021 Nov 18.

Department of Clinical Epidemiology, College of Medicine, University of the Philippines Manila, Manila 1000, Philippines.

Exposure to traffic-related air pollution is linked with acute alterations in blood pressure (BP). We examined the cumulative short-term effect of black carbon (BC) exposure on systolic (SBP) and diastolic (DBP) BP and assessed effect modification by participant characteristics. SBP and DBP were repeatedly measured on 152 traffic enforcers. Read More

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November 2021

Dose and Dose Rate-Dependent Effects of Low-Dose Irradiation on Inflammatory Parameters in ApoE-Deficient and Wild Type Mice.

Cells 2021 Nov 20;10(11). Epub 2021 Nov 20.

Department of Radiation Oncology, University of Rostock, 18059 Rostock, Germany.

Anti-inflammatory low-dose therapy is well established, whereas the immunomodulatory impact of doses below 0.1 Gy is much less clear. In this study, we investigated dose, dose rate and time-dependent effects in a dose range of 0. Read More

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November 2021

Impact of Lipoprotein(a) Levels on Perioperative Outcomes in Cardiac Surgery.

Cells 2021 Oct 21;10(11). Epub 2021 Oct 21.

Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.

Altered lipid metabolism has been shown to be of major importance in a range of metabolic diseases, with particular importance in cardiovascular disease (CVD). As a key metabolic product, altered lipoprotein(a) (Lp(a)) levels may be associated with adverse clinical outcomes in high-risk cardiovascular patients undergoing cardiac surgery. We aimed to investigate the impact of the important metabolite Lp(a) on complications and clinical outcomes in high-risk patients. Read More

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October 2021

Influence of Chlorhexidine and Cetylpyridine on Periodontal Status and Indicators of Oxidative Stress in Patients with Type 1 Diabetes.

Antioxidants (Basel) 2021 Oct 29;10(11). Epub 2021 Oct 29.

Department of Dental Surgery and Periodontology, Poznan University of Medical Sciences, 60-812 Poznan, Poland.

Objective: One of the treatment goals in type 1 diabetes and periodontitis is to address chronic inflammation to prevent the development of neurovascular complications. The aim of this study was to assess the local anti-inflammatory effects of chlorhexidine digluconate and cetylpyridine chloride on periodontal status and indicators of oxidative stress in saliva in patients with type 1 diabetes.

Materials And Methods: A total of 42 subjects aged 27 (interquartile range, IQR 22-35) years, with type 1 diabetes for a duration of 12 (IQR 9-18) years, and glycated hemoglobin 8. Read More

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October 2021

Clinical Characteristics and Outcomes of Fungal Keratitis in the United Kingdom 2011-2020: A 10-Year Study.

J Fungi (Basel) 2021 Nov 12;7(11). Epub 2021 Nov 12.

Academic Ophthalmology, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham NG7 2RD, UK.

Fungal keratitis (FK) is a serious ocular infection that often poses significant diagnostic and therapeutic dilemmas. This study aimed to examine the causes, clinical characteristics, outcomes, and prognostic factors of FK in the UK. All culture-positive and culture-negative presumed FK (with complete data) that presented to Queen's Medical Centre, Nottingham, and the Queen Victoria Hospital, East Grinstead, between 2011 and 2020 were included. Read More

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November 2021

Diagnostic Methods and Risk Factors for Severe Disease and Mortality in Blastomycosis: A Retrospective Cohort Study.

J Fungi (Basel) 2021 Oct 20;7(11). Epub 2021 Oct 20.

Department of Medicine, Division of Infectious Diseases, Mayo Clinic, 200 First St. SW, Rochester, MN 55905, USA.

Blastomycosis can cause severe disease with progressive respiratory failure and dissemination even in immunocompetent individuals. We sought to evaluate risk factors for severe disease and mortality using clinical and laboratory data within a large health system in an endemic area. We performed a retrospective cohort study of patients diagnosed with blastomycosis at all Mayo Clinic sites from 1 January 2004 through 31 March 2020. Read More

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October 2021

Minimally Invasive Modified Nuss Procedure for Repair of Pectus Excavatum in Pediatric Patients: Single-Centre Retrospective Observational Study.

Children (Basel) 2021 Nov 20;8(11). Epub 2021 Nov 20.

Department of Pediatric Surgery, University Hospital of Split, Spinčićeva 1, 21 000 Split, Croatia.

Background: The treatment of pectus excavatum can be conservative or surgical. The aim of this study was to determine the factors influencing the outcomes of treatment after a minimally invasive Nuss corrective surgery procedure in pediatric patients.

Methods: A total of 30 patient who underwent a minimally invasive Nuss corrective procedure for pectus excavatum from 1 January 2014 to 31 December 2020 were included in thisretrospective study. Read More

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November 2021

Settle Down! Ranging Behaviour Responses of Roe Deer to Different Capture and Release Methods.

Animals (Basel) 2021 Nov 18;11(11). Epub 2021 Nov 18.

Research and Innovation Centre, Biodiversity and Molecular Ecology Department, Fondazione Edmund Mach, Via Mach 1, 38010 San Michele all'Adige, Italy.

The fitting of tracking devices to wild animals requires capture and handling which causes stress and can potentially cause injury, behavioural modifications that can affect animal welfare and the output of research. We evaluated post capture and release ranging behaviour responses of roe deer () for five different capture methods. We analysed the distance from the centre of gravity and between successive locations, using data from 14 different study sites within the EURODEER collaborative project. Read More

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November 2021

Canine Mesenchymal Cell Lyosecretome Production and Safety Evaluation after Allogenic Intraarticular Injection in Osteoarthritic Dogs.

Animals (Basel) 2021 Nov 15;11(11). Epub 2021 Nov 15.

Department of Veterinary Medical Science, University of Parma, 43121 Parma, Italy.

In recent years, mesenchymal stromal cells (MSCs) have shown promise as a therapy in treating musculoskeletal diseases, and it is currently believed that their therapeutic effect is mainly related to the release of proteins and extracellular vesicles (EVs), known as secretome. In this work, three batches of canine MSC-secretome were prepared by standardized processes according to the current standard ISO9001 and formulated as a freeze-dried powder named Lyosecretome. The final products were characterized in protein and lipid content, EV size distribution and tested to ensure the microbiological safety required for intraarticular injection. Read More

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November 2021